US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
US6514500B1
(en)
*
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
US6887470B1
(en)
*
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US20040266673A1
(en)
*
|
2002-07-31 |
2004-12-30 |
Peter Bakis |
Long lasting natriuretic peptide derivatives
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
US7601691B2
(en)
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
CA2501421A1
(en)
*
|
1999-05-17 |
2000-11-23 |
Conjuchem Inc. |
Long lasting exendin-4
|
US6849714B1
(en)
*
|
1999-05-17 |
2005-02-01 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
US6447772B1
(en)
*
|
1999-10-01 |
2002-09-10 |
Klaire Laboratories, Inc. |
Compositions and methods relating to reduction of symptoms of autism
|
UA81897C2
(uk)
*
|
2000-12-07 |
2008-02-25 |
Эли Лилли Энд Компани |
Гетерологічний пептидильований глюкагон-1-подібний білок та його застосування для для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння та/або інсулінонезалежний діабет
|
EP1355941A2
(en)
|
2001-02-02 |
2003-10-29 |
ConjuChem, Inc. |
Long lasting growth hormone releasing factor derivatives
|
US7112567B2
(en)
*
|
2001-02-16 |
2006-09-26 |
Conjuchem Inc. |
Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
|
CN1162446C
(zh)
*
|
2001-05-10 |
2004-08-18 |
上海华谊生物技术有限公司 |
促胰岛素分泌肽衍生物
|
DE60229677D1
(de)
|
2001-05-31 |
2008-12-11 |
Conjuchem Biotechnologies Inc |
Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion
|
DE60228972D1
(de)
*
|
2001-07-31 |
2008-10-30 |
Us Gov Health & Human Serv |
Glp 1 exendin 4 peptidanaloga und deren verwendungen
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
US20030226155A1
(en)
*
|
2001-08-30 |
2003-12-04 |
Biorexis Pharmaceutical Corporation |
Modified transferrin-antibody fusion proteins
|
US8129504B2
(en)
|
2001-08-30 |
2012-03-06 |
Biorexis Technology, Inc. |
Oral delivery of modified transferrin fusion proteins
|
ATE490969T1
(de)
*
|
2001-08-30 |
2010-12-15 |
Biorexis Pharmaceutical Corp |
Modifizierte transferrin-fusionsproteine
|
US20070031440A1
(en)
*
|
2001-08-30 |
2007-02-08 |
Prior Christopher P |
Modified transferin-antibody fusion proteins
|
US7176278B2
(en)
*
|
2001-08-30 |
2007-02-13 |
Biorexis Technology, Inc. |
Modified transferrin fusion proteins
|
EP2277910A1
(en)
|
2001-12-21 |
2011-01-26 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP1463752A4
(en)
*
|
2001-12-21 |
2005-07-13 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
US20030166512A1
(en)
*
|
2002-02-13 |
2003-09-04 |
Medbridge, Inc. |
Protein carrier system for therapeutic oligonucleotides
|
RU2332229C2
(ru)
*
|
2002-02-20 |
2008-08-27 |
Эмисфире Текнолоджис Инк. |
Способ введения молекул glp-1
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
US20060252916A1
(en)
*
|
2002-06-04 |
2006-11-09 |
Eli Lilly And Company |
Modified glucagon-like peptide-1 analogs
|
EP1837031B1
(en)
*
|
2002-06-07 |
2009-10-14 |
Waratah Pharmaceuticals, Inc. |
Compositions and methods for treating diabetes
|
ATE432289T1
(de)
|
2002-07-04 |
2009-06-15 |
Zealand Pharma As |
Glp-1 und behandlungsmethode für diabetes
|
ES2347144T3
(es)
*
|
2002-08-30 |
2010-10-26 |
Biorexis Pharmaceutical Corporation |
Proteinas de fusion de la transferrina modificada que comprenden dominos aino o carboxilo de transferrina duplicados.
|
EA007918B1
(ru)
*
|
2002-09-24 |
2007-02-27 |
Франтиэ Биотекнолоджиз Ко., Лтд. |
Пептидные производные-ингибиторы слияния при вич-инфекции
|
EP1546200A2
(en)
*
|
2002-10-02 |
2005-06-29 |
Zealand Pharma A/S |
Stabilized exendin-4 compounds
|
US20040229810A1
(en)
*
|
2002-10-22 |
2004-11-18 |
Antonio Cruz |
Gastrin compositions and formulations, and methods of use and preparation
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
US7790681B2
(en)
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
US7731947B2
(en)
|
2003-11-17 |
2010-06-08 |
Intarcia Therapeutics, Inc. |
Composition and dosage form comprising an interferon particle formulation and suspending vehicle
|
WO2004060387A1
(en)
*
|
2002-12-27 |
2004-07-22 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
US7655618B2
(en)
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
US20070060512A1
(en)
*
|
2003-03-04 |
2007-03-15 |
Homayoun Sadeghi |
Dipeptidyl-peptidase protected protein
|
WO2004087053A2
(en)
|
2003-03-25 |
2004-10-14 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
CN1771080B
(zh)
*
|
2003-04-08 |
2010-12-15 |
诺沃挪第克公司 |
包括至少一个色谱处理步骤的生产治疗用多肽或其前体的方法
|
WO2004089985A1
(en)
*
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
Stable pharmaceutical compositions
|
CA2523267C
(en)
|
2003-04-23 |
2013-09-03 |
Biovalve Technologies, Inc. |
Hydraulically actuated pump for long duration medicament administration
|
NZ543741A
(en)
|
2003-05-30 |
2009-10-30 |
Ranbaxy Lab Ltd |
Substituted pyrrole derivatives and their use as HMG-Co inhibitors
|
CN1802386B
(zh)
|
2003-06-12 |
2010-12-15 |
伊莱利利公司 |
Glp-1类似物融合蛋白质
|
CN1964989B
(zh)
*
|
2003-07-25 |
2012-02-01 |
康久化学生物技术公司 |
长效胰岛素衍生物及其方法
|
WO2005012346A1
(en)
*
|
2003-07-25 |
2005-02-10 |
Conjuchem, Inc. |
Long lasting insulin derivatives and methods thereof
|
EP1506967B1
(en)
|
2003-08-13 |
2007-11-21 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
WO2005021579A2
(en)
*
|
2003-08-28 |
2005-03-10 |
Biorexis Pharmaceutical Corporation |
Epo mimetic peptides and fusion proteins
|
US20060205037A1
(en)
*
|
2003-08-28 |
2006-09-14 |
Homayoun Sadeghi |
Modified transferrin fusion proteins
|
US20070275877A1
(en)
*
|
2003-08-29 |
2007-11-29 |
Amylin Pharmaceuticals, Inc. |
Methods for Treating or Ameliorating Ghrelin-Associated Diseases and Disorders
|
EP1699777B1
(en)
*
|
2003-09-08 |
2012-12-12 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US7214190B1
(en)
|
2003-09-09 |
2007-05-08 |
Kitchener Clark Wilson |
Apparatus and method for noninvasive monitoring of analytes in body fluids
|
RU2006120077A
(ru)
*
|
2003-12-18 |
2008-01-27 |
Ново Нордиск А/С (DK) |
Аналоги глюкагоноподобного пептида-1 (glp-1), связанные с альбуминоподобными агентами
|
US20060286129A1
(en)
*
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
AU2005207870B2
(en)
*
|
2004-01-30 |
2010-08-19 |
Waratah Pharmaceuticals, Inc. |
The combined use of GLP-1 agonists and gastrin for regulating blood glucose levels
|
PL1729795T3
(pl)
|
2004-02-09 |
2016-08-31 |
Human Genome Sciences Inc |
Białka fuzyjne albuminy
|
US8076288B2
(en)
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
GEP20094679B
(en)
*
|
2004-03-15 |
2009-05-10 |
Takeda Pharmaceuticals Co |
Dipeptidyl peptidase inhibitors
|
PL2100904T3
(pl)
*
|
2004-04-23 |
2011-05-31 |
Conjuchem Biotechnologies Inc |
Stała faza do zastosowania w sposobie oczyszczania koniugatów albuminy
|
CN1318587C
(zh)
*
|
2004-04-30 |
2007-05-30 |
成都芝田生物工程有限公司 |
酰胺化Exendin-4多肽的重组制备方法
|
WO2006014425A1
(en)
|
2004-07-02 |
2006-02-09 |
Biovalve Technologies, Inc. |
Methods and devices for delivering glp-1 and uses thereof
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
AU2012202855B2
(en)
*
|
2004-09-03 |
2015-02-26 |
Philipps-Universitat Marburg |
GLP-1 and exendin related invention
|
US8030273B2
(en)
|
2004-10-07 |
2011-10-04 |
Novo Nordisk A/S |
Protracted exendin-4 compounds
|
JP2008515856A
(ja)
|
2004-10-07 |
2008-05-15 |
ノボ ノルディスク アクティーゼルスカブ |
遅延性glp−1化合物
|
US20080125361A1
(en)
*
|
2004-11-12 |
2008-05-29 |
Novo Nordisk A/S |
Stable Formulations Of Peptides
|
JP2008524331A
(ja)
*
|
2004-12-21 |
2008-07-10 |
武田薬品工業株式会社 |
ジペプチジルペプチダーゼ阻害剤
|
US8716221B2
(en)
*
|
2005-01-14 |
2014-05-06 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Modified exendins and uses thereof
|
TWI376234B
(en)
|
2005-02-01 |
2012-11-11 |
Msd Oss Bv |
Conjugates of a polypeptide and an oligosaccharide
|
WO2006083761A2
(en)
|
2005-02-03 |
2006-08-10 |
Alza Corporation |
Solvent/polymer solutions as suspension vehicles
|
US11246913B2
(en)
|
2005-02-03 |
2022-02-15 |
Intarcia Therapeutics, Inc. |
Suspension formulation comprising an insulinotropic peptide
|
TWI362392B
(en)
|
2005-03-18 |
2012-04-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
CA2596926A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Extended glp-1 compounds
|
AU2006279680B2
(en)
*
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
CA2622608C
(en)
*
|
2005-09-14 |
2014-08-19 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors for treating diabetes
|
MY147393A
(en)
|
2005-09-14 |
2012-11-30 |
Takeda Pharmaceutical |
Administration of dipeptidyl peptidase inhibitors
|
PE20070622A1
(es)
*
|
2005-09-14 |
2007-08-22 |
Takeda Pharmaceutical |
Administracion de inhibidores de dipeptidil peptidasa
|
EP2073810B1
(en)
*
|
2006-09-13 |
2011-08-31 |
Takeda Pharmaceutical Company Limited |
Use of 2-6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile for treating diabetes, cancer, autoimmune disorders and hiv infection
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
CN102675221A
(zh)
*
|
2005-09-16 |
2012-09-19 |
武田药品工业株式会社 |
用于制备嘧啶二酮衍生物的方法中的中间体
|
WO2007051987A1
(en)
*
|
2005-11-01 |
2007-05-10 |
Activotec Spp Limited |
Insulinotropic compounds and uses thereof
|
US8026377B2
(en)
|
2005-11-08 |
2011-09-27 |
Ranbaxy Laboratories, Limited |
Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
|
US8039432B2
(en)
|
2005-11-09 |
2011-10-18 |
Conjuchem, Llc |
Method of treatment of diabetes and/or obesity with reduced nausea side effect
|
US20080280328A1
(en)
*
|
2005-11-18 |
2008-11-13 |
Novozymes A/S |
Glucoamylase Variants
|
JP2009520469A
(ja)
*
|
2005-12-22 |
2009-05-28 |
コンジュクヘム ビオテクフノロギエス インコーポレイテッド |
アルブミンと治療薬との前もって形成された抱合体の産生のための方法
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
AU2007214088B2
(en)
|
2006-02-08 |
2012-03-22 |
Polypeptide Laboratories Holding (Ppl) Ab |
Synthesis of glucagon-like peptide
|
EP1999108A1
(en)
*
|
2006-03-28 |
2008-12-10 |
Takeda Pharmaceutical Company Limited |
Preparation of (r)-3-aminopiperidine dihydrochloride
|
WO2007115039A2
(en)
|
2006-03-30 |
2007-10-11 |
Valeritas, Llc |
Multi-cartridge fluid delivery device
|
CN101453982B
(zh)
|
2006-05-30 |
2011-05-04 |
精达制药公司 |
两件式内部通道渗透递送系统流动调节器
|
KR100886783B1
(ko)
|
2006-06-12 |
2009-03-04 |
성균관대학교산학협력단 |
N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도
|
BRPI0714334A2
(pt)
|
2006-07-18 |
2013-05-14 |
Centocor Inc |
mimeticorpos de glp-1 humano aperfeiÇoados, composiÇÕes, mÉtodos e usos
|
CN101511868B
(zh)
|
2006-07-24 |
2013-03-06 |
比奥雷克西斯制药公司 |
毒蜥外泌肽融合蛋白
|
WO2008021133A2
(en)
|
2006-08-09 |
2008-02-21 |
Intarcia Therapeutics, Inc. |
Osmotic delivery systems and piston assemblies
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
CL2007002634A1
(es)
*
|
2006-09-13 |
2008-05-16 |
Smithkline Beecham Corp |
Uso de una composicion que comprende al menos un polipeptido que tiene actividad de peptido-1 semejante a glucagon (glp-1) como agente hipoglucemiante de larga duracion.
|
TW200838536A
(en)
*
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
AU2011254001B2
(en)
*
|
2007-01-05 |
2012-08-02 |
Covx Technologies Ireland Limited |
Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
|
US20090098130A1
(en)
*
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
US20090099074A1
(en)
*
|
2007-01-10 |
2009-04-16 |
Conjuchem Biotechnologies Inc. |
Modulating food intake
|
CA2677932A1
(en)
|
2007-02-15 |
2008-08-21 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
EP2157967B1
(en)
|
2007-04-23 |
2013-01-16 |
Intarcia Therapeutics, Inc |
Suspension formulations of insulinotropic peptides and uses thereof
|
US8835381B2
(en)
|
2007-06-12 |
2014-09-16 |
Glaxosmithkline Llc |
Methods for detecting protein in plasma
|
US20090054332A1
(en)
*
|
2007-06-21 |
2009-02-26 |
Conjuchem Biotechnologies, Inc. |
Thombopoietin peptide conjugates
|
US7960336B2
(en)
*
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
CN101868476B
(zh)
|
2007-09-05 |
2015-02-25 |
诺沃-诺迪斯克有限公司 |
胰高血糖素样肽-1衍生物及其制药用途
|
CN101842386A
(zh)
|
2007-09-05 |
2010-09-22 |
诺沃-诺迪斯克有限公司 |
截短的glp-1衍生物和它们的治疗用途
|
JP5606314B2
(ja)
|
2007-09-05 |
2014-10-15 |
ノボ・ノルデイスク・エー/エス |
A−b−c−d−で誘導体化されたペプチドとその治療用途
|
CN101835794A
(zh)
*
|
2007-10-27 |
2010-09-15 |
霍夫曼-拉罗奇有限公司 |
使用固相和溶液相组合技术的促胰岛素肽合成法
|
EP2231191A2
(en)
*
|
2007-12-11 |
2010-09-29 |
ConjuChem Biotechnologies Inc. |
Formulation of insulinotropic peptide conjugates
|
EP2240155B1
(en)
|
2008-02-13 |
2012-06-06 |
Intarcia Therapeutics, Inc |
Devices, formulations, and methods for delivery of multiple beneficial agents
|
WO2009143285A2
(en)
|
2008-05-21 |
2009-11-26 |
Amylin Pharmaceuticals, Inc. |
Exendins to lower cholestrol and triglycerides
|
CN102105159B
(zh)
|
2008-06-17 |
2015-07-08 |
印第安纳大学研究及科技有限公司 |
基于gip的混合激动剂用于治疗代谢紊乱和肥胖症
|
PE20100255A1
(es)
|
2008-06-17 |
2010-04-25 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1
|
EP4074327A1
(en)
|
2008-06-27 |
2022-10-19 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
WO2010015668A1
(en)
|
2008-08-06 |
2010-02-11 |
Novo Nordisk A/S |
Conjugated proteins with prolonged in vivo efficacy
|
TW201012829A
(en)
*
|
2008-09-22 |
2010-04-01 |
Ipsen Mfg Ireland Ltd |
Process for the synthesis of (Aib8,35)hGLP-1(7-36)-NH2
|
BRPI0920209A2
(pt)
|
2008-10-15 |
2015-12-22 |
Angiochem Inc |
conjugados de agonistas de glp-1 e usos dos mesmos
|
DK2349324T3
(en)
|
2008-10-17 |
2017-12-11 |
Sanofi Aventis Deutschland |
COMBINATION OF AN INSULIN AND A GLP-1 AGONIST
|
MX2011005963A
(es)
|
2008-12-05 |
2011-09-01 |
Angiochem Inc |
Conjugados de neurotensina o analogos de neurotensina y sus usos.
|
PT2373681T
(pt)
|
2008-12-10 |
2017-04-11 |
Glaxosmithkline Llc |
Composições farmacêuticas de albiglutida
|
AU2010207725B2
(en)
|
2009-01-22 |
2015-06-11 |
Novo Nordisk Health Care Ag |
Stable growth hormone compounds
|
EP2401378B1
(en)
|
2009-02-25 |
2013-08-14 |
Merck Sharp & Dohme Corp. |
Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
|
WO2010118384A2
(en)
|
2009-04-10 |
2010-10-14 |
Amylin Pharmaceuticals, Inc. |
Amylin agonist compounds for estrogen-deficient mammals
|
IN2012DN00377A
(no)
|
2009-06-16 |
2015-08-21 |
Univ Indiana Res & Tech Corp |
|
CN102596993A
(zh)
*
|
2009-07-02 |
2012-07-18 |
安吉奥开米公司 |
多聚体肽结合物以及其应用
|
CN101987868B
(zh)
*
|
2009-07-30 |
2013-09-04 |
江苏豪森医药集团有限公司 |
Glp-1类似物的衍生物或其可药用盐和用途
|
US8841249B2
(en)
|
2009-08-06 |
2014-09-23 |
Novo Nordisk A/S |
Growth hormones with prolonged in-vivo efficacy
|
CN104323981B
(zh)
|
2009-09-28 |
2019-03-12 |
精达制药公司 |
基本稳态药物递送的快速建立和/或终止
|
US9238083B2
(en)
*
|
2009-09-30 |
2016-01-19 |
Kyoto University |
Molecular probe for imaging of pancreatic islets and use of the same
|
US20120264685A1
(en)
|
2009-10-22 |
2012-10-18 |
Rajesh Bahekar |
Short chain peptidomimetics based orally active glp 1 agonist and glucagon receptor antagonist
|
JP5973918B2
(ja)
|
2009-11-13 |
2016-08-23 |
サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
Glp−1アゴニスト及びメチオニンを含む薬学的組成物
|
KR101836070B1
(ko)
|
2009-11-13 |
2018-03-09 |
사노피-아벤티스 도이칠란트 게엠베하 |
Glp-1 작용제, 인슐린 및 메티오닌을 포함하는 약제학적 조성물
|
EP2504021A4
(en)
|
2009-11-23 |
2013-05-15 |
Amylin Pharmaceuticals Llc |
POLYPEPTIDE CONJUGATE
|
AU2011208625C1
(en)
|
2010-01-22 |
2022-08-18 |
Novo Nordisk Health Care Ag |
Growth hormones with prolonged in-vivo efficacy
|
CA2787895A1
(en)
|
2010-01-22 |
2011-07-28 |
Novo Nordisk Health Care Ag |
Stable growth hormone compounds
|
MX2012008603A
(es)
|
2010-01-27 |
2013-01-25 |
Univ Indiana Res & Tech Corp |
Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad.
|
EP2539430B1
(en)
|
2010-02-24 |
2016-09-14 |
Merck Sharp & Dohme Corp. |
Method for increasing n-glycosylation site occupancy on therapeutic glycoproteins produced in pichia pastoris
|
JP6054861B2
(ja)
*
|
2010-03-26 |
2016-12-27 |
ノヴォ ノルディスク アー/エス |
新規のグルカゴン類似体
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
CA2797133C
(en)
|
2010-04-27 |
2019-08-06 |
Zealand Pharma A/S |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
JP2013525491A
(ja)
|
2010-05-04 |
2013-06-20 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
心血管障害を治療または予防し心血管保護を提供する方法
|
ES2661228T3
(es)
|
2010-05-13 |
2018-03-28 |
Indiana University Research And Technology Corporation |
Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona
|
CA2797089A1
(en)
|
2010-05-13 |
2011-11-17 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
|
PT2611458T
(pt)
|
2010-08-30 |
2016-12-16 |
Sanofi Aventis Deutschland |
Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
|
RS56998B1
(sr)
|
2010-12-16 |
2018-05-31 |
Novo Nordisk As |
Čvrste kompozicije koje sadrže agonist glp-1 i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline
|
WO2012088116A2
(en)
|
2010-12-22 |
2012-06-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting gip receptor activity
|
US20120208755A1
(en)
|
2011-02-16 |
2012-08-16 |
Intarcia Therapeutics, Inc. |
Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
|
EP3450568A3
(en)
*
|
2011-03-04 |
2019-04-24 |
Intrexon Corporation |
Vectors conditionally expressing protein
|
MX355361B
(es)
|
2011-04-12 |
2018-04-17 |
Novo Nordisk As |
Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados.
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
DK2723367T3
(en)
|
2011-06-22 |
2017-07-17 |
Univ Indiana Res & Tech Corp |
Glucagon / GLP-1 receptor-CO-AGONISTS
|
BR112013032717A2
(pt)
|
2011-06-22 |
2017-01-24 |
Univ Indiana Res & Tech Corp |
coagonistas do receptor de glucagon/glp-1
|
KR101357117B1
(ko)
*
|
2011-06-28 |
2014-02-06 |
비앤엘델리팜 주식회사 |
폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물
|
CN108079281A
(zh)
|
2011-08-29 |
2018-05-29 |
赛诺菲-安万特德国有限公司 |
用于2型糖尿病患者中的血糖控制的药物组合
|
AR087744A1
(es)
|
2011-09-01 |
2014-04-16 |
Sanofi Aventis Deutschland |
Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
|
CN103189389B
(zh)
*
|
2011-09-03 |
2017-08-11 |
深圳市健元医药科技有限公司 |
新的glp‑ⅰ类似物及其制备方法和用途
|
CN102286092B
(zh)
|
2011-09-14 |
2014-01-01 |
深圳翰宇药业股份有限公司 |
利拉鲁肽的固相合成方法
|
JP6352806B2
(ja)
|
2011-09-23 |
2018-07-04 |
ノヴォ ノルディスク アー/エス |
新規のグルカゴン類似体
|
MX2014005351A
(es)
|
2011-11-03 |
2014-05-28 |
Zealand Pharma As |
Conjugados de gastrina peptidicos de agonistas de receptor glp-1.
|
WO2013112548A1
(en)
|
2012-01-23 |
2013-08-01 |
University Of South Florida |
Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
|
RU2641198C3
(ru)
|
2012-03-22 |
2021-12-10 |
Ново Нордиск А/С |
Композиции glp-1 пептидов и их получение
|
DK2827845T3
(en)
|
2012-03-22 |
2019-04-01 |
Novo Nordisk As |
COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF
|
US20150111246A1
(en)
*
|
2012-04-24 |
2015-04-23 |
Astrazeneca Pharmaceuticals Lp |
Site-specific enzymatic modification of exendins and analogs thereof
|
NZ701573A
(en)
|
2012-05-17 |
2017-04-28 |
Extend Biosciences Inc |
Carriers for improved drug delivery
|
ES2871328T3
(es)
|
2012-06-20 |
2021-10-28 |
Novo Nordisk As |
Formulación de comprimido que comprende un péptido y un agente de suministro
|
US20140051834A1
(en)
|
2012-06-21 |
2014-02-20 |
Hoffmann-La Roche, Inc. |
Incretin Receptor Ligand Polypeptide Fc-Region Fusion Polypeptides And Conjugates With Altered Fc-Effector Function
|
TWI599575B
(zh)
|
2012-06-21 |
2017-09-21 |
印第安納大學科技研究公司 |
表現gip受體活性之胰高血糖素類似物
|
MX356957B
(es)
|
2012-07-23 |
2018-06-20 |
Zealand Pharma As |
Analogos del glucagon.
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
AR094180A1
(es)
|
2012-12-21 |
2015-07-15 |
Sanofi Sa |
Derivados de exendina-4
|
TWI641381B
(zh)
|
2013-02-04 |
2018-11-21 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
RS60026B1
(sr)
|
2013-02-18 |
2020-04-30 |
Vegenics Pty Ltd |
Molekuli koji vezuju ligande i njihove upotrebe
|
JP6538645B2
(ja)
|
2013-03-14 |
2019-07-03 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
インスリン‐インクレチン複合物
|
CN104592380A
(zh)
*
|
2013-03-15 |
2015-05-06 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
CN104650212A
(zh)
*
|
2013-03-15 |
2015-05-27 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
AR095986A1
(es)
*
|
2013-04-03 |
2015-11-25 |
Sanofi Sa |
Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
|
US11045523B2
(en)
|
2013-04-05 |
2021-06-29 |
Novo Nordisk Healthcare Ag |
Formulation of growth hormone albumin-binder conjugate
|
CN105307672B
(zh)
|
2013-04-18 |
2021-01-05 |
诺和诺德股份有限公司 |
用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂
|
MX368436B
(es)
|
2013-10-17 |
2019-10-03 |
Zealand Pharma As |
Analogos de glucagon acilados.
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
EP3065767B1
(en)
|
2013-11-06 |
2020-12-30 |
Zealand Pharma A/S |
Gip-glp-1 dual agonist compounds and methods
|
WO2015067716A1
(en)
|
2013-11-06 |
2015-05-14 |
Zealand Pharma A/S |
Glucagon-glp-1-gip triple agonist compounds
|
EP3080149A1
(en)
|
2013-12-13 |
2016-10-19 |
Sanofi |
Dual glp-1/glucagon receptor agonists
|
EP3080150B1
(en)
|
2013-12-13 |
2018-08-01 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
WO2015086729A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/gip receptor agonists
|
EP3080152A1
(en)
|
2013-12-13 |
2016-10-19 |
Sanofi |
Non-acylated exendin-4 peptide analogues
|
WO2015095684A1
(en)
|
2013-12-20 |
2015-06-25 |
Indiana University Research And Technology Corporation |
Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides
|
CN114939156A
(zh)
|
2014-01-09 |
2022-08-26 |
赛诺菲 |
门冬胰岛素的稳定化药物制剂
|
SG11201604710XA
(en)
|
2014-01-09 |
2016-07-28 |
Sanofi Sa |
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
CN105899191B
(zh)
|
2014-01-09 |
2020-06-16 |
赛诺菲 |
胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
|
WO2015138638A1
(en)
|
2014-03-11 |
2015-09-17 |
Theraly Pharmaceuticals, Inc. |
Long acting trail receptor agonists for treatment of autoimmune diseases
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
JP2017525656A
(ja)
|
2014-06-04 |
2017-09-07 |
ノヴォ ノルディスク アー/エス |
医療用のglp−1/グルカゴン受容体コアゴニスト
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
US10232020B2
(en)
|
2014-09-24 |
2019-03-19 |
Indiana University Research And Technology Corporation |
Incretin-insulin conjugates
|
US9889085B1
(en)
|
2014-09-30 |
2018-02-13 |
Intarcia Therapeutics, Inc. |
Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
AU2015340586B2
(en)
|
2014-10-29 |
2020-04-30 |
Zealand Pharma A/S |
GIP agonist compounds and methods
|
CN107206058A
(zh)
|
2014-12-12 |
2017-09-26 |
赛诺菲-安万特德国有限公司 |
甘精胰岛素/利西拉来固定比率配制剂
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
BR112017022009A2
(pt)
|
2015-04-16 |
2018-07-03 |
Zealand Pharma A/S |
?composto, método de produção e síntese do mesmo e seu uso, composição e conjunto terapêutico?
|
WO2016196851A2
(en)
|
2015-06-03 |
2016-12-08 |
Intarcia Therapeutics, Inc. |
Implant placement and removal systems
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
JP6823055B2
(ja)
|
2015-06-15 |
2021-01-27 |
アンジオケム インコーポレーテッド |
軟髄膜癌腫症の治療方法
|
AR105284A1
(es)
|
2015-07-10 |
2017-09-20 |
Sanofi Sa |
Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
|
CN108601819B
(zh)
|
2015-12-17 |
2022-03-15 |
约翰霍普金斯大学 |
用死亡受体激动剂改善系统性硬化症
|
ES2968038T3
(es)
|
2015-12-23 |
2024-05-06 |
Univ Johns Hopkins |
Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas
|
JP7281795B2
(ja)
|
2016-04-07 |
2023-05-26 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法
|
MX2018014016A
(es)
|
2016-05-16 |
2019-08-01 |
Intarcia Therapeutics Inc |
Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos.
|
USD840030S1
(en)
|
2016-06-02 |
2019-02-05 |
Intarcia Therapeutics, Inc. |
Implant placement guide
|
USD860451S1
(en)
|
2016-06-02 |
2019-09-17 |
Intarcia Therapeutics, Inc. |
Implant removal tool
|
CN108070030B
(zh)
*
|
2016-11-17 |
2023-06-23 |
江苏豪森药业集团有限公司 |
洛塞那肽及其类似物的制备方法
|
BR112019010624A2
(pt)
|
2016-12-09 |
2019-10-22 |
Zealand Pharma As |
agonistas duplos de glp-1/glp-2 acilados e composição
|
CN110225762A
(zh)
|
2017-01-03 |
2019-09-10 |
因塔西亚制药公司 |
包括glp-1受体激动剂的连续施用和药物的共同施用的方法
|
JOP20180028A1
(ar)
|
2017-03-31 |
2019-01-30 |
Takeda Pharmaceuticals Co |
مركب ببتيد
|
CN109503700A
(zh)
*
|
2017-09-14 |
2019-03-22 |
南京安吉生物科技有限公司 |
马来酰亚胺基团修饰的血管生成抑制剂hm-1及其应用
|
US10905750B2
(en)
|
2017-11-10 |
2021-02-02 |
Donald J. Davidson |
GRP78 antagonist that block binding of receptor tyrosine kinase orphan receptors as immunotherapy anticancer agents
|
IL275778B2
(en)
|
2018-02-02 |
2023-12-01 |
Novo Nordisk As |
Solid compounds that make up glp-1 agonist n-8-2-hydroxybenzoyl salt
|
WO2019200594A1
(zh)
|
2018-04-19 |
2019-10-24 |
杭州先为达生物科技有限公司 |
酰化的glp-1衍生物
|
CA3116023A1
(en)
|
2018-10-11 |
2020-04-16 |
Intarcia Therapeutics, Inc. |
Human amylin analog polypeptides and methods of use
|
CN109400695B
(zh)
|
2018-10-31 |
2020-06-30 |
中南大学湘雅医院 |
一种多肽的修饰方法及应用
|
CN110183531A
(zh)
*
|
2019-05-17 |
2019-08-30 |
河北常山生化药业股份有限公司 |
一种艾本那肽前体的制备方法
|
CN111333714A
(zh)
*
|
2020-03-05 |
2020-06-26 |
成都奥达生物科技有限公司 |
一种长效glp-1化合物
|
WO2021195508A1
(en)
*
|
2020-03-27 |
2021-09-30 |
Epivax, Inc. |
Tregitope constructs useful in the prevention and treatment of type 1 diabetes
|