US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
DK1180121T3
(da)
*
|
1999-05-17 |
2004-03-01 |
Conjuchem Inc |
Langtidsvirkende insulinotrope peptider
|
US7601691B2
(en)
|
1999-05-17 |
2009-10-13 |
Conjuchem Biotechnologies Inc. |
Anti-obesity agents
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
US6514500B1
(en)
*
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
US6887470B1
(en)
*
|
1999-09-10 |
2005-05-03 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US20040266673A1
(en)
*
|
2002-07-31 |
2004-12-30 |
Peter Bakis |
Long lasting natriuretic peptide derivatives
|
US6849714B1
(en)
*
|
1999-05-17 |
2005-02-01 |
Conjuchem, Inc. |
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
US6447772B1
(en)
*
|
1999-10-01 |
2002-09-10 |
Klaire Laboratories, Inc. |
Compositions and methods relating to reduction of symptoms of autism
|
SI1355942T1
(sl)
*
|
2000-12-07 |
2009-02-28 |
Lilly Co Eli |
Glp-1 fuzijski proteini
|
EA006484B1
(ru)
|
2001-02-02 |
2005-12-29 |
Конджачем, Инк. |
Долгоживущие производные рилизинг-фактора гормона роста
|
US7112567B2
(en)
|
2001-02-16 |
2006-09-26 |
Conjuchem Inc. |
Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
|
CN1162446C
(zh)
|
2001-05-10 |
2004-08-18 |
上海华谊生物技术有限公司 |
促胰岛素分泌肽衍生物
|
DE60216151T2
(de)
|
2001-05-31 |
2007-09-27 |
ConjuChem Biotechnologies Inc., Montreal |
Langwirkende Fusionspeptidinhibitoren gegen HIV-Infektion
|
AU2002317599B2
(en)
|
2001-07-31 |
2008-04-03 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
GLP-1 exendin-4 peptide analogs and uses thereof
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
US20030226155A1
(en)
*
|
2001-08-30 |
2003-12-04 |
Biorexis Pharmaceutical Corporation |
Modified transferrin-antibody fusion proteins
|
CA2457520A1
(en)
*
|
2001-08-30 |
2003-03-13 |
Biorexis Pharmaceutical Corporation |
Modified transferrin fusion proteins
|
US7176278B2
(en)
*
|
2001-08-30 |
2007-02-13 |
Biorexis Technology, Inc. |
Modified transferrin fusion proteins
|
US20070031440A1
(en)
*
|
2001-08-30 |
2007-02-08 |
Prior Christopher P |
Modified transferin-antibody fusion proteins
|
US8129504B2
(en)
|
2001-08-30 |
2012-03-06 |
Biorexis Technology, Inc. |
Oral delivery of modified transferrin fusion proteins
|
CA2471363C
(en)
*
|
2001-12-21 |
2014-02-11 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP1463752A4
(en)
*
|
2001-12-21 |
2005-07-13 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
US20030166512A1
(en)
*
|
2002-02-13 |
2003-09-04 |
Medbridge, Inc. |
Protein carrier system for therapeutic oligonucleotides
|
MXPA04008068A
(es)
*
|
2002-02-20 |
2004-11-26 |
Lilly Co Eli |
Metodo para administrar moleculas de glp-1.
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
US20060252916A1
(en)
*
|
2002-06-04 |
2006-11-09 |
Eli Lilly And Company |
Modified glucagon-like peptide-1 analogs
|
EP1837031B1
(en)
*
|
2002-06-07 |
2009-10-14 |
Waratah Pharmaceuticals, Inc. |
Compositions and methods for treating diabetes
|
ATE432289T1
(de)
|
2002-07-04 |
2009-06-15 |
Zealand Pharma As |
Glp-1 und behandlungsmethode für diabetes
|
CN102268094A
(zh)
*
|
2002-08-30 |
2011-12-07 |
比奥雷克西斯药物公司 |
被修饰的转铁蛋白抗体的融合蛋白
|
CA2500248C
(en)
*
|
2002-09-24 |
2013-03-19 |
Frontier Biotechnologies Co., Ltd. |
Peptide derivative fusion inhibitors of hiv infection
|
RU2376314C2
(ru)
*
|
2002-10-02 |
2009-12-20 |
Зилэнд Фарма А/С |
Стабилизированные соединения эксендина-4
|
US20040229810A1
(en)
*
|
2002-10-22 |
2004-11-18 |
Antonio Cruz |
Gastrin compositions and formulations, and methods of use and preparation
|
US7790681B2
(en)
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
US7731947B2
(en)
|
2003-11-17 |
2010-06-08 |
Intarcia Therapeutics, Inc. |
Composition and dosage form comprising an interferon particle formulation and suspending vehicle
|
US7655618B2
(en)
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
AU2003303634B2
(en)
*
|
2002-12-27 |
2009-10-01 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
US20070060512A1
(en)
*
|
2003-03-04 |
2007-03-15 |
Homayoun Sadeghi |
Dipeptidyl-peptidase protected protein
|
CN1894234A
(zh)
*
|
2003-03-25 |
2007-01-10 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
BRPI0408978B8
(pt)
*
|
2003-04-08 |
2021-07-27 |
Novo Nordisk As |
processos para regenerar uma fase estacionária cromatográfica
|
WO2004089985A1
(en)
*
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
Stable pharmaceutical compositions
|
JP4565193B2
(ja)
|
2003-04-23 |
2010-10-20 |
バレリタス, インコーポレイテッド |
長い持続時間の医薬投与のための液圧作動式ポンプ
|
JP4901474B2
(ja)
|
2003-05-30 |
2012-03-21 |
ランバクシー ラボラトリーズ リミテッド |
置換ピロール誘導体
|
MXPA05013565A
(es)
|
2003-06-12 |
2006-03-09 |
Lilly Co Eli |
Proteinas de fusion analogas al glp-1.
|
CN1964989B
(zh)
*
|
2003-07-25 |
2012-02-01 |
康久化学生物技术公司 |
长效胰岛素衍生物及其方法
|
ATE433994T1
(de)
*
|
2003-07-25 |
2009-07-15 |
Conjuchem Biotechnologies Inc |
Insulinderivative mit langanhaltender wirkung und verfahren zu deren herstellung
|
US7723344B2
(en)
*
|
2003-08-13 |
2010-05-25 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
EP1663278A4
(en)
*
|
2003-08-28 |
2009-07-29 |
Biorexis Pharmaceutical Corp |
EPO MIMETIC PEPTIDES AND FUSION PROTEINS
|
US20060205037A1
(en)
*
|
2003-08-28 |
2006-09-14 |
Homayoun Sadeghi |
Modified transferrin fusion proteins
|
EP1663289A2
(en)
*
|
2003-08-29 |
2006-06-07 |
Amylin Pharmaceuticals, Inc. |
Methods for treating or ameliorating ghrelin-associated diseases and disorders
|
EP1699777B1
(en)
*
|
2003-09-08 |
2012-12-12 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US7214190B1
(en)
|
2003-09-09 |
2007-05-08 |
Kitchener Clark Wilson |
Apparatus and method for noninvasive monitoring of analytes in body fluids
|
CA2550050A1
(en)
*
|
2003-12-18 |
2005-06-30 |
Novo Nordisk A/S |
Novel glp-1 analogues linked to albumin-like agents
|
US20060286129A1
(en)
*
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
US20090202494A1
(en)
*
|
2004-01-30 |
2009-08-13 |
Antonio Cruz |
Combined use of glp-1 agonists and gastrin for regulating blood glucose levels
|
PL1729795T3
(pl)
|
2004-02-09 |
2016-08-31 |
Human Genome Sciences Inc |
Białka fuzyjne albuminy
|
US8076288B2
(en)
|
2004-02-11 |
2011-12-13 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides having glucose lowering activity
|
CN102134230B
(zh)
*
|
2004-03-15 |
2019-06-28 |
武田药品工业株式会社 |
二肽基肽酶抑制剂
|
DE602005022239D1
(de)
*
|
2004-04-23 |
2010-08-19 |
Conjuchem Biotechnologies Inc |
Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten
|
CN1318587C
(zh)
*
|
2004-04-30 |
2007-05-30 |
成都芝田生物工程有限公司 |
酰胺化Exendin-4多肽的重组制备方法
|
US9089636B2
(en)
|
2004-07-02 |
2015-07-28 |
Valeritas, Inc. |
Methods and devices for delivering GLP-1 and uses thereof
|
AU2012202855B2
(en)
*
|
2004-09-03 |
2015-02-26 |
Philipps-Universitat Marburg |
GLP-1 and exendin related invention
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
WO2006037810A2
(en)
|
2004-10-07 |
2006-04-13 |
Novo Nordisk A/S |
Protracted glp-1 compounds
|
JP5107713B2
(ja)
*
|
2004-10-07 |
2012-12-26 |
ノヴォ ノルディスク アー/エス |
遅延性のエキセンディン−4化合物
|
EP1828192B1
(en)
*
|
2004-12-21 |
2014-12-03 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
US8716221B2
(en)
*
|
2005-01-14 |
2014-05-06 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Modified exendins and uses thereof
|
TWI376234B
(en)
|
2005-02-01 |
2012-11-11 |
Msd Oss Bv |
Conjugates of a polypeptide and an oligosaccharide
|
WO2006083761A2
(en)
|
2005-02-03 |
2006-08-10 |
Alza Corporation |
Solvent/polymer solutions as suspension vehicles
|
US11246913B2
(en)
|
2005-02-03 |
2022-02-15 |
Intarcia Therapeutics, Inc. |
Suspension formulation comprising an insulinotropic peptide
|
WO2006097538A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Extended glp-1 compounds
|
TWI372629B
(en)
|
2005-03-18 |
2012-09-21 |
Novo Nordisk As |
Acylated glp-1 compounds
|
AU2006279680B2
(en)
*
|
2005-08-11 |
2012-12-06 |
Amylin Pharmaceuticals, Llc |
Hybrid polypeptides with selectable properties
|
SI1942898T2
(sl)
|
2005-09-14 |
2014-08-29 |
Takeda Pharmaceutical Company Limited |
Dipeptidil-peptidazni inhibitorji za zdravljenje diabetesa
|
CN102935081B
(zh)
*
|
2005-09-14 |
2015-03-04 |
武田药品工业株式会社 |
用于治疗糖尿病的二肽基肽酶抑制剂
|
PE20070622A1
(es)
*
|
2005-09-14 |
2007-08-22 |
Takeda Pharmaceutical |
Administracion de inhibidores de dipeptidil peptidasa
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
CN102675221A
(zh)
*
|
2005-09-16 |
2012-09-19 |
武田药品工业株式会社 |
用于制备嘧啶二酮衍生物的方法中的中间体
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
EP1943275B1
(en)
*
|
2005-11-01 |
2010-06-16 |
Activotec SPP Limited |
Insulinotropic compounds and uses thereof
|
AU2006313430B2
(en)
|
2005-11-08 |
2012-09-06 |
Ranbaxy Laboratories Limited |
Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
WO2007053946A1
(en)
*
|
2005-11-09 |
2007-05-18 |
Conjuchem Biotechnologies Inc. |
Method of treating diabetes and/or obesity with reduced nausea side effects using an insulinotropic peptide conjugated to albumin
|
US20080280328A1
(en)
*
|
2005-11-18 |
2008-11-13 |
Novozymes A/S |
Glucoamylase Variants
|
AU2006329215A1
(en)
*
|
2005-12-22 |
2007-06-28 |
Conjuchem Biotechnologies Inc. |
Process for the production of preformed conjugates of albumin and a therapeutic agent
|
EP1816201A1
(en)
|
2006-02-06 |
2007-08-08 |
CSL Behring GmbH |
Modified coagulation factor VIIa with extended half-life
|
JP5199126B2
(ja)
*
|
2006-02-08 |
2013-05-15 |
ロンザ アーゲー |
グルカゴン様ペプチドの合成
|
US20100029941A1
(en)
*
|
2006-03-28 |
2010-02-04 |
Takeda Pharmaceutical Company Limited |
Preparation of (r)-3-aminopiperidine dihydrochloride
|
EP2982399B1
(en)
|
2006-03-30 |
2017-12-06 |
Valeritas, Inc. |
Multi-cartridge fluid delivery device
|
JP5143131B2
(ja)
|
2006-05-30 |
2013-02-13 |
インターシア セラピューティクス,インコーポレイティド |
浸透圧送出システムの二片構成内部チャネル型の流れモジュレータ
|
KR100886783B1
(ko)
|
2006-06-12 |
2009-03-04 |
성균관대학교산학협력단 |
N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도
|
JP2010500868A
(ja)
|
2006-07-18 |
2010-01-14 |
セントカー・インコーポレーテツド |
ヒトglp−1ミメティボディ、組成物、方法および用途
|
CN101511868B
(zh)
|
2006-07-24 |
2013-03-06 |
比奥雷克西斯制药公司 |
毒蜥外泌肽融合蛋白
|
PL2359808T3
(pl)
|
2006-08-09 |
2013-10-31 |
Intarcia Therapeutics Inc |
Osmotyczne systemy dostawcze i zespoły tłokowe
|
PT2073810E
(pt)
*
|
2006-09-13 |
2011-09-30 |
Takeda Pharmaceutical |
Utilização de 2-6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo- 3,4-di-hidro-2h-pirimidin-1-ilmetil-4-fluoro-benzonitrilo para tratamento de diabetes, cancro, distúrbios auto-imunes e infecção por vih
|
TWI430806B
(zh)
*
|
2006-09-13 |
2014-03-21 |
Smithkline Beecham Corp |
用於投與長效降血糖藥劑之方法
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
TW200838536A
(en)
*
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
AU2011254001B2
(en)
*
|
2007-01-05 |
2012-08-02 |
Covx Technologies Ireland Limited |
Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
|
US20090098130A1
(en)
*
|
2007-01-05 |
2009-04-16 |
Bradshaw Curt W |
Glucagon-like protein-1 receptor (glp-1r) agonist compounds
|
US20090099074A1
(en)
*
|
2007-01-10 |
2009-04-16 |
Conjuchem Biotechnologies Inc. |
Modulating food intake
|
EP2111414B1
(en)
|
2007-02-15 |
2014-07-02 |
Indiana University Research and Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
CA2683610C
(en)
|
2007-04-23 |
2013-01-08 |
Intarcia Therapeutics, Inc. |
Suspension formulations of insulinotropic peptides and uses thereof
|
WO2008154619A1
(en)
*
|
2007-06-12 |
2008-12-18 |
Smithkline Beecham Corporation |
Methods for detecting protein in plasma
|
WO2008157824A2
(en)
*
|
2007-06-21 |
2008-12-24 |
Conjuchem Biotechnologies Inc. |
Thrombopoietin peptide conjugates
|
US7960336B2
(en)
*
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
WO2009030738A1
(en)
|
2007-09-05 |
2009-03-12 |
Novo Nordisk A/S |
Glucagon-like peptide-1 derivatives and their pharmaceutical use
|
ES2532116T3
(es)
|
2007-09-05 |
2015-03-24 |
Novo Nordisk A/S |
Péptidos derivados con A-B-C-D y sus usos terapéuticos
|
CN101842386A
(zh)
|
2007-09-05 |
2010-09-22 |
诺沃-诺迪斯克有限公司 |
截短的glp-1衍生物和它们的治疗用途
|
WO2009053315A1
(en)
*
|
2007-10-27 |
2009-04-30 |
F. Hoffmann-La Roche Ag |
Insulinotropic peptide synthesis using solid and solution phase combination techniques
|
JP2011506442A
(ja)
*
|
2007-12-11 |
2011-03-03 |
コンジュケム バイオテクノロジーズ インコーポレイテッド |
インスリン分泌性ペプチド結合体の製剤
|
DK2240155T3
(da)
|
2008-02-13 |
2012-09-17 |
Intarcia Therapeutics Inc |
Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
|
EP2303313B1
(en)
|
2008-05-21 |
2015-10-28 |
Amylin Pharmaceuticals, LLC |
Exendins to lower cholestrol and triglycerides
|
US9062124B2
(en)
|
2008-06-17 |
2015-06-23 |
Indiana University Research And Technology Corporation |
GIP-based mixed agonists for treatment of metabolic disorders and obesity
|
EA019203B9
(ru)
|
2008-06-17 |
2014-03-31 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Коагонисты глюкагонового рецептора/glp-1-рецептора
|
EP3412300A1
(en)
|
2008-06-27 |
2018-12-12 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
AU2009279090A1
(en)
|
2008-08-06 |
2010-02-11 |
Novo Nordisk Health Care Ag |
Conjugated proteins with prolonged in vivo efficacy
|
TW201012829A
(en)
*
|
2008-09-22 |
2010-04-01 |
Ipsen Mfg Ireland Ltd |
Process for the synthesis of (Aib8,35)hGLP-1(7-36)-NH2
|
BRPI0920209A2
(pt)
|
2008-10-15 |
2015-12-22 |
Angiochem Inc |
conjugados de agonistas de glp-1 e usos dos mesmos
|
MX344293B
(es)
|
2008-10-17 |
2016-12-13 |
Sanofi Aventis Deutschland |
Combinacion de una insulina y un agonista de glp-1.
|
US9914754B2
(en)
|
2008-12-05 |
2018-03-13 |
Angiochem Inc. |
Conjugates of neurotensin or neurotensin analogs and uses thereof
|
HUE031900T2
(en)
|
2008-12-10 |
2017-08-28 |
Glaxosmithkline Llc |
Pharmaceutical compositions containing Albiglutide
|
JP5816097B2
(ja)
|
2009-01-22 |
2015-11-18 |
ノヴォ・ノルディスク・ヘルス・ケア・アーゲー |
安定な成長ホルモン化合物
|
CA2751730A1
(en)
|
2009-02-25 |
2010-09-02 |
Merck Sharp & Dohme Corp. |
Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
|
EP2416797A4
(en)
|
2009-04-10 |
2013-04-24 |
Amylin Pharmaceuticals Llc |
AMYLINAGONIST COMPOUNDS FOR OXYGEN ANIMAL MICE
|
MX2011013625A
(es)
|
2009-06-16 |
2012-01-20 |
Univ Indiana Res & Tech Corp |
Compuestos glucagon activo de receptor de gip.
|
IN2012DN00248A
(no)
*
|
2009-07-02 |
2015-05-01 |
Angiochem Inc |
|
CN101987868B
(zh)
*
|
2009-07-30 |
2013-09-04 |
江苏豪森医药集团有限公司 |
Glp-1类似物的衍生物或其可药用盐和用途
|
US8841249B2
(en)
|
2009-08-06 |
2014-09-23 |
Novo Nordisk A/S |
Growth hormones with prolonged in-vivo efficacy
|
KR101823699B1
(ko)
|
2009-09-28 |
2018-01-30 |
인타르시아 세라퓨틱스 인코포레이티드 |
실질 항정상태 약물 전달의 신속 확립 및/또는 종결
|
US9238083B2
(en)
*
|
2009-09-30 |
2016-01-19 |
Kyoto University |
Molecular probe for imaging of pancreatic islets and use of the same
|
US20120264685A1
(en)
|
2009-10-22 |
2012-10-18 |
Rajesh Bahekar |
Short chain peptidomimetics based orally active glp 1 agonist and glucagon receptor antagonist
|
BR112012011403B8
(pt)
|
2009-11-13 |
2021-05-25 |
Sanofi Aventis Deutschland |
composição farmacêutica líquida compreendendo um agonista glp-1 e metionina e uso da mesma
|
PT2498802E
(pt)
|
2009-11-13 |
2015-04-13 |
Sanofi Aventis Deutschland |
Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
|
WO2011063414A1
(en)
|
2009-11-23 |
2011-05-26 |
Amylin Pharmaceuticals, Inc. |
Polypeptide conjugate
|
AU2011208625C1
(en)
|
2010-01-22 |
2022-08-18 |
Novo Nordisk Health Care Ag |
Growth hormones with prolonged in-vivo efficacy
|
AU2011208620B2
(en)
|
2010-01-22 |
2015-04-16 |
Novo Nordisk Health Care Ag |
Stable growth hormone compounds
|
MX2012008603A
(es)
|
2010-01-27 |
2013-01-25 |
Univ Indiana Res & Tech Corp |
Conjugados de antagonista de glucagon-agonista de gip y composiciones para el tratamiento de desordenes metabolicos y obesidad.
|
JP5976549B2
(ja)
|
2010-02-24 |
2016-08-24 |
メルク・シャープ・エンド・ドーム・コーポレイション |
ピチア・パストリスにおいて産生される治療用糖タンパク質上のn−グリコシル化部位占拠を増加させるための方法
|
EP2552950A1
(en)
*
|
2010-03-26 |
2013-02-06 |
Novo Nordisk A/S |
Novel glucagon analogues
|
EP2555791B1
(en)
|
2010-04-09 |
2017-11-01 |
Sinai Health System |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
JP5969461B2
(ja)
|
2010-04-27 |
2016-08-17 |
ジーランド ファーマ アクティーゼルスカブ |
Glp−1受容体作動薬とガストリンとのペプチド複合体及びその使用
|
EP2566502A4
(en)
|
2010-05-04 |
2013-10-09 |
Glaxosmithkline Llc |
METHODS OF TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND PROVIDING CARDIOVASCULAR PROTECTION
|
EP2568993A4
(en)
|
2010-05-13 |
2014-02-19 |
Univ Indiana Res & Tech Corp |
GLUCAGON SUPERFAMILY PEPTIDES EXPRESSING G PROTEIN-COUPLED RECEPTOR ACTIVITY
|
ES2661228T3
(es)
|
2010-05-13 |
2018-03-28 |
Indiana University Research And Technology Corporation |
Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona
|
RU2546520C2
(ru)
|
2010-08-30 |
2015-04-10 |
Санофи-Авентис Дойчланд Гмбх |
Применение ave0010 для производства лекарственного средства для лечения сахарного диабета 2 типа
|
HUE036066T2
(hu)
|
2010-12-16 |
2018-06-28 |
Novo Nordisk As |
GLP-1 agonistát és N-(8-(2-hidroxibenzoil)amino)kaprilsav sóját tartalmazó szilárd készítmények
|
PE20140186A1
(es)
|
2010-12-22 |
2014-02-13 |
Univ Indiana Res & Tech Corp |
Analogos de glucagon que presentan actividad de receptor de gip
|
US20120208755A1
(en)
|
2011-02-16 |
2012-08-16 |
Intarcia Therapeutics, Inc. |
Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
|
SG10201600912SA
(en)
|
2011-03-04 |
2016-03-30 |
Intrexon Corp |
Vectors conditionally expressing protein
|
PT2696687T
(pt)
|
2011-04-12 |
2017-02-02 |
Novo Nordisk As |
Derivados de glp-1 duplamente acilados
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
MX2013015168A
(es)
|
2011-06-22 |
2014-03-31 |
Univ Indiana Res & Tech Corp |
Co-agonista del receptor de glucagon/glp-1.
|
GEP20176629B
(en)
|
2011-06-22 |
2017-02-27 |
Indiana Unversity Research And Tech Corporation |
Glucagon/glp-1 receptor co-agonists
|
KR101357117B1
(ko)
*
|
2011-06-28 |
2014-02-06 |
비앤엘델리팜 주식회사 |
폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물
|
US9408893B2
(en)
|
2011-08-29 |
2016-08-09 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
|
TWI559929B
(en)
|
2011-09-01 |
2016-12-01 |
Sanofi Aventis Deutschland |
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
|
CN103189389B
(zh)
*
|
2011-09-03 |
2017-08-11 |
深圳市健元医药科技有限公司 |
新的glp‑ⅰ类似物及其制备方法和用途
|
CN102286092B
(zh)
|
2011-09-14 |
2014-01-01 |
深圳翰宇药业股份有限公司 |
利拉鲁肽的固相合成方法
|
EP2758426B1
(en)
|
2011-09-23 |
2019-08-07 |
Novo Nordisk A/S |
Novel glucagon analogues
|
MX2014005351A
(es)
|
2011-11-03 |
2014-05-28 |
Zealand Pharma As |
Conjugados de gastrina peptidicos de agonistas de receptor glp-1.
|
WO2013112548A1
(en)
|
2012-01-23 |
2013-08-01 |
University Of South Florida |
Gamma-aapeptides with potent and broad-spectrum antimicrobial activity
|
DK2827845T3
(en)
|
2012-03-22 |
2019-04-01 |
Novo Nordisk As |
COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF
|
RU2641198C3
(ru)
|
2012-03-22 |
2021-12-10 |
Ново Нордиск А/С |
Композиции glp-1 пептидов и их получение
|
US20150111246A1
(en)
*
|
2012-04-24 |
2015-04-23 |
Astrazeneca Pharmaceuticals Lp |
Site-specific enzymatic modification of exendins and analogs thereof
|
KR102238317B1
(ko)
|
2012-05-17 |
2021-04-12 |
익스텐드 바이오사이언시즈, 인크. |
개선된 약물 전달용 캐리어
|
EP2863895B1
(en)
|
2012-06-20 |
2021-04-14 |
Novo Nordisk A/S |
Tablet formulation comprising a peptide and a delivery agent
|
EP2863954A1
(en)
|
2012-06-21 |
2015-04-29 |
Indiana University Research and Technology Corporation |
Incretin receptor ligand polypeptide fc-region fusion polypeptides and conjugates with altered fc-effector function
|
JP6311708B2
(ja)
|
2012-06-21 |
2018-04-18 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Gip受容体活性を示すグルカゴンアナローグ
|
CA2878991C
(en)
|
2012-07-23 |
2021-12-07 |
Zealand Pharma A/S |
Glucagon analogues
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
JP2016503771A
(ja)
|
2012-12-21 |
2016-02-08 |
サノフイ |
エキセンジン−4誘導体
|
TWI641381B
(zh)
|
2013-02-04 |
2018-11-21 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
PT2956476T
(pt)
|
2013-02-18 |
2020-02-21 |
Vegenics Pty Ltd |
Moléculas de ligação e usos destas
|
KR20150131213A
(ko)
|
2013-03-14 |
2015-11-24 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
인슐린-인크레틴 접합체들
|
CN104592380A
(zh)
*
|
2013-03-15 |
2015-05-06 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
CN104650212A
(zh)
*
|
2013-03-15 |
2015-05-27 |
深圳君圣泰生物技术有限公司 |
一种多肽、多肽衍生物、多肽的可药用盐、药物组合物及其应用
|
AR095986A1
(es)
*
|
2013-04-03 |
2015-11-25 |
Sanofi Sa |
Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
|
CN105120887A
(zh)
|
2013-04-05 |
2015-12-02 |
诺和诺德保健股份有限公司 |
生长激素化合物制剂
|
AU2014255608B2
(en)
|
2013-04-18 |
2018-01-25 |
Novo Nordisk A/S |
Stable, protracted GLP-1/glucagon receptor co-agonists for medical use
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
AR098065A1
(es)
|
2013-10-17 |
2016-04-27 |
Zealand Pharma As |
Análogos de glucagón acilados
|
WO2015067715A2
(en)
|
2013-11-06 |
2015-05-14 |
Zealand Pharma A/S |
Gip-glp-1 dual agonist compounds and methods
|
EA035688B1
(ru)
|
2013-11-06 |
2020-07-27 |
Зилэнд Фарма А/С |
Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip
|
EP3080150B1
(en)
|
2013-12-13 |
2018-08-01 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
WO2015086729A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/gip receptor agonists
|
EP3080149A1
(en)
|
2013-12-13 |
2016-10-19 |
Sanofi |
Dual glp-1/glucagon receptor agonists
|
TW201609796A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
非醯化之艾塞那肽-4(exendin-4)胜肽類似物
|
EP3082847A1
(en)
|
2013-12-20 |
2016-10-26 |
Indiana University Research and Technology Corporation |
Lipidated incretin receptor ligand human immunoglobulin fc-region fusion polypeptides
|
CN105899190B
(zh)
|
2014-01-09 |
2022-06-14 |
赛诺菲 |
门冬胰岛素的稳定化药物制剂
|
SG11201604708VA
(en)
|
2014-01-09 |
2016-07-28 |
Sanofi Sa |
Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
WO2015104314A1
(en)
|
2014-01-09 |
2015-07-16 |
Sanofi |
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
US11299528B2
(en)
|
2014-03-11 |
2022-04-12 |
D&D Pharmatech Inc. |
Long acting TRAIL receptor agonists for treatment of autoimmune diseases
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
EP3151852A1
(en)
|
2014-06-04 |
2017-04-12 |
Novo Nordisk A/S |
Glp-1/glucagon receptor co-agonists for medical use
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
US10232020B2
(en)
|
2014-09-24 |
2019-03-19 |
Indiana University Research And Technology Corporation |
Incretin-insulin conjugates
|
US9889085B1
(en)
|
2014-09-30 |
2018-02-13 |
Intarcia Therapeutics, Inc. |
Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
|
US9616109B2
(en)
|
2014-10-22 |
2017-04-11 |
Extend Biosciences, Inc. |
Insulin vitamin D conjugates
|
US9789197B2
(en)
|
2014-10-22 |
2017-10-17 |
Extend Biosciences, Inc. |
RNAi vitamin D conjugates
|
US9585934B2
(en)
|
2014-10-22 |
2017-03-07 |
Extend Biosciences, Inc. |
Therapeutic vitamin D conjugates
|
EP3985016A1
(en)
|
2014-10-29 |
2022-04-20 |
Zealand Pharma A/S |
Gip agonist compounds and methods
|
LT3229828T
(lt)
|
2014-12-12 |
2023-06-12 |
Sanofi-Aventis Deutschland Gmbh |
Insulino glargino/liksisenatido fiksuoto santykio kompozicija
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
KR20170137198A
(ko)
|
2015-04-16 |
2017-12-12 |
질랜드 파마 에이/에스 |
아실화된 글루카곤 유사체
|
MX2017015504A
(es)
|
2015-06-03 |
2018-05-15 |
Intarcia Therapeutics Inc |
Sistemas de colocacion y remoción de implante.
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
ES2826827T3
(es)
|
2015-06-15 |
2021-05-19 |
Angiochem Inc |
Métodos para el tratamiento de carcinomatosis leptomeníngea
|
AR105284A1
(es)
|
2015-07-10 |
2017-09-20 |
Sanofi Sa |
Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
|
EA038551B1
(ru)
|
2015-12-17 |
2021-09-14 |
Дзе Джонс Хопкинс Юниверсити |
Способ лечения или профилактики системного склероза
|
US11123405B2
(en)
|
2015-12-23 |
2021-09-21 |
The Johns Hopkins University |
Long-acting GLP-1R agonist as a therapy of neurological and neurodegenerative conditions
|
EA201892260A1
(ru)
|
2016-04-07 |
2019-03-29 |
Дзе Джонс Хопкинс Юниверсити |
Композиции и способы для лечения панкреатита и боли с применением агонистов рецептора смерти
|
AU2017268161B2
(en)
|
2016-05-16 |
2020-03-12 |
Intarcia Therapeutics, Inc. |
Glucagon-receptor selective polypeptides and methods of use thereof
|
USD840030S1
(en)
|
2016-06-02 |
2019-02-05 |
Intarcia Therapeutics, Inc. |
Implant placement guide
|
USD860451S1
(en)
|
2016-06-02 |
2019-09-17 |
Intarcia Therapeutics, Inc. |
Implant removal tool
|
CN108070030B
(zh)
*
|
2016-11-17 |
2023-06-23 |
江苏豪森药业集团有限公司 |
洛塞那肽及其类似物的制备方法
|
SG11201903938XA
(en)
|
2016-12-09 |
2019-05-30 |
Zealand Pharma As |
Acylated glp-1/glp-2 dual agonists
|
AU2018206539A1
(en)
|
2017-01-03 |
2019-07-18 |
Intarcia Therapeutics, Inc. |
Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
|
JOP20180028A1
(ar)
|
2017-03-31 |
2019-01-30 |
Takeda Pharmaceuticals Co |
مركب ببتيد
|
CN109503700A
(zh)
*
|
2017-09-14 |
2019-03-22 |
南京安吉生物科技有限公司 |
马来酰亚胺基团修饰的血管生成抑制剂hm-1及其应用
|
US10905750B2
(en)
|
2017-11-10 |
2021-02-02 |
Donald J. Davidson |
GRP78 antagonist that block binding of receptor tyrosine kinase orphan receptors as immunotherapy anticancer agents
|
PE20210453A1
(es)
|
2018-02-02 |
2021-03-08 |
Novo Nordisk As |
Composiciones solidas que comprenden un agonista de glp-1, una sal del acido n-(8-(2-hidroxibenzoil)amino)caprilico y un lubricante
|
WO2019200594A1
(zh)
|
2018-04-19 |
2019-10-24 |
杭州先为达生物科技有限公司 |
酰化的glp-1衍生物
|
CN113195524A
(zh)
|
2018-10-11 |
2021-07-30 |
因塔西亚治疗公司 |
人类胰淀素类似物多肽和使用方法
|
CN109400695B
(zh)
|
2018-10-31 |
2020-06-30 |
中南大学湘雅医院 |
一种多肽的修饰方法及应用
|
CN110183531A
(zh)
*
|
2019-05-17 |
2019-08-30 |
河北常山生化药业股份有限公司 |
一种艾本那肽前体的制备方法
|
CN111333714A
(zh)
*
|
2020-03-05 |
2020-06-26 |
成都奥达生物科技有限公司 |
一种长效glp-1化合物
|
EP4126907A1
(en)
*
|
2020-03-27 |
2023-02-08 |
Epivax, Inc. |
Tregitope constructs useful in the prevention and treatment of type 1 diabetes
|