ATE218892T1 - Affinitätsmarkierer für menschliches serum albumin - Google Patents
Affinitätsmarkierer für menschliches serum albuminInfo
- Publication number
- ATE218892T1 ATE218892T1 AT98959387T AT98959387T ATE218892T1 AT E218892 T1 ATE218892 T1 AT E218892T1 AT 98959387 T AT98959387 T AT 98959387T AT 98959387 T AT98959387 T AT 98959387T AT E218892 T1 ATE218892 T1 AT E218892T1
- Authority
- AT
- Austria
- Prior art keywords
- serum albumin
- human serum
- affinity marker
- molecule
- affinity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6470597P | 1997-11-07 | 1997-11-07 | |
| US7792798P | 1998-03-13 | 1998-03-13 | |
| PCT/US1998/023705 WO1999024075A2 (en) | 1997-11-07 | 1998-11-06 | Affinity markers for human serum albumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE218892T1 true ATE218892T1 (de) | 2002-06-15 |
Family
ID=26744806
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98959387T ATE218892T1 (de) | 1997-11-07 | 1998-11-06 | Affinitätsmarkierer für menschliches serum albumin |
| AT01126379T ATE406577T1 (de) | 1997-11-07 | 1998-11-06 | Methoden zum screening von affinitätsmarker- bibliotheken |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01126379T ATE406577T1 (de) | 1997-11-07 | 1998-11-06 | Methoden zum screening von affinitätsmarker- bibliotheken |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7166695B2 (de) |
| EP (2) | EP1056474B1 (de) |
| AT (2) | ATE218892T1 (de) |
| AU (1) | AU1519699A (de) |
| CA (2) | CA2305597C (de) |
| DE (2) | DE69839946D1 (de) |
| ES (1) | ES2178854T3 (de) |
| WO (1) | WO1999024075A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7144854B1 (en) | 1999-09-10 | 2006-12-05 | Conjuchem, Inc. | Long lasting anti-angiogenic peptides |
| US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
| DK1180121T3 (da) * | 1999-05-17 | 2004-03-01 | Conjuchem Inc | Langtidsvirkende insulinotrope peptider |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| EP1171582A2 (de) * | 1999-05-17 | 2002-01-16 | Conjuchem, Inc. | Lang wirksame antiangiogene peptide |
| EP1105409B1 (de) * | 1999-05-17 | 2006-03-01 | Conjuchem, Inc. | Schutz endogener, therapeutisch aktiver peptide vor peptidaseaktivität durch konjugation an blutbestandteile |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| ES2185595T5 (es) | 1999-05-17 | 2009-12-17 | Conjuchem Biotechnologies Inc. | Peptidos antivirales modificados y sus composiciones para la prevencion y/o el tratamiento de infecciones viricas. |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
| US7090851B1 (en) | 1999-09-10 | 2006-08-15 | Conjuchem Inc. | Long lasting fusion peptide inhibitors of viral infection |
| BR0206919A (pt) | 2001-02-02 | 2004-07-06 | Conjuchem Inc | Derivados de fator de liberação de hormÈnio de crescimento de longa duração |
| US7112567B2 (en) | 2001-02-16 | 2006-09-26 | Conjuchem Inc. | Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders |
| ES2242860T3 (es) | 2001-05-31 | 2005-11-16 | Conjuchem, Inc. | Inhibidores peptidicos de fusion de larga vida contra infecciones por vih. |
| DE602004027000D1 (de) | 2003-01-17 | 2010-06-17 | Advanced Proteome Therapeutics | Verfahren zur Identifizierung aktivierter Polymer-Komplexe zur sekundären Stellen-spezifischen Modifikation von Protein Ziel-Gruppen. |
| AU2005235634B2 (en) * | 2004-04-23 | 2011-10-20 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| MX2008008076A (es) * | 2005-12-22 | 2008-11-28 | Conjuchem Biotechnologies Inc | Procesos para la produccion de conjugados preformados de albumina y un agente terapeutico. |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| CN102026666B (zh) * | 2007-12-11 | 2013-10-16 | 常山凯捷健生物药物研发（河北）有限公司 | 促胰岛素肽缀合物制剂 |
| EP3413921A4 (de) * | 2016-02-09 | 2019-08-14 | Alexander Krantz | Ortsselektive funktionalisierung von proteinen mittels spurloser affinitätsmarkierungen |
| AU2018259856B2 (en) * | 2017-04-28 | 2025-05-01 | Ajinomoto Co., Inc. | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862928A (en) * | 1969-07-09 | 1975-01-28 | Akzona Inc | Psychopharmacological hexa-peptides containing a d-phenylalanyl residue |
| US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4933288A (en) * | 1986-11-21 | 1990-06-12 | Cetus Corporation | Use of a modified soluble Pseudomonas exotoxin A in immunoconjugates |
| US4808705A (en) * | 1986-12-19 | 1989-02-28 | Cetus Corporation | Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor |
| GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
| US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| DE3731297C1 (de) | 1987-09-17 | 1989-05-18 | Rexroth Mannesmann Gmbh | Schaltventilanordnung |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| KR100195632B1 (ko) * | 1988-07-23 | 1999-06-15 | 스티븐 조지 가랜드 | 펩티드 및 dna 배열 |
| WO1990003799A1 (en) * | 1988-10-12 | 1990-04-19 | Centocor, Inc. | Radiotherapeutic immunoconjugates labeled with iodine-125 |
| US5250662A (en) * | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
| US5116944A (en) * | 1989-12-29 | 1992-05-26 | Neorx Corporation | Conjugates having improved characteristics for in vivo administration |
| US5182366A (en) | 1990-05-15 | 1993-01-26 | Huebner Verena D | Controlled synthesis of peptide mixtures using mixed resins |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5843440A (en) | 1990-10-03 | 1998-12-01 | Redcell Canada, Inc. | Cellular and serum protein anchors for modulating pharmacokinetics |
| US5612034A (en) | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| WO1992009300A1 (en) | 1990-11-21 | 1992-06-11 | Iterex Pharmaceuticals Ltd. Partnership | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
| US5616311A (en) * | 1991-01-15 | 1997-04-01 | Hemosphere, Inc. | Non-crosslinked protein particles for therapeutic and diagnostic use |
| JP2001524926A (ja) | 1991-09-18 | 2001-12-04 | アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ | オリゴマーの雑多ライブラリーの集合体を合成する方法 |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| JPH0692968A (ja) * | 1992-09-16 | 1994-04-05 | Nakarai Tesuku Kk | ビオチン導入試薬 |
| HUT72614A (en) | 1992-09-24 | 1996-05-28 | Chiron Corp | Synthesis of n-substituted oligomers |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5741893A (en) * | 1993-08-16 | 1998-04-21 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5571681A (en) * | 1994-03-10 | 1996-11-05 | The Scripps Research Institute | Chemical event selection by suicide substrate conjugates |
| ATE240347T1 (de) | 1995-12-18 | 2003-05-15 | Praecis Pharm Inc | Verfahren zum nachweis von verbindungen die bestimmte zielmoleküle binden |
| CA2215152A1 (en) * | 1996-01-12 | 1997-07-17 | Redcell Canada, Inc. | Cellular and serum protein anchors for diagnostic imaging |
| US6277583B1 (en) * | 1996-02-07 | 2001-08-21 | Conjuchem, Inc. | Affinity labeling libraries and applications thereof |
| US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| WO1998011437A1 (en) | 1996-09-16 | 1998-03-19 | Conjuchem, Inc. | Affinity labeling libraries with tagged leaving groups |
| US6203820B1 (en) * | 1998-05-28 | 2001-03-20 | Brice E. Vickery | Compositions and methods for enhancing protein anabolism and detoxification |
-
1998
- 1998-11-06 AT AT98959387T patent/ATE218892T1/de active
- 1998-11-06 ES ES98959387T patent/ES2178854T3/es not_active Expired - Lifetime
- 1998-11-06 EP EP98959387A patent/EP1056474B1/de not_active Expired - Lifetime
- 1998-11-06 WO PCT/US1998/023705 patent/WO1999024075A2/en not_active Ceased
- 1998-11-06 EP EP08162256A patent/EP2033661A1/de not_active Withdrawn
- 1998-11-06 DE DE69839946T patent/DE69839946D1/de not_active Expired - Fee Related
- 1998-11-06 CA CA002305597A patent/CA2305597C/en not_active Expired - Fee Related
- 1998-11-06 AU AU15196/99A patent/AU1519699A/en not_active Abandoned
- 1998-11-06 AT AT01126379T patent/ATE406577T1/de not_active IP Right Cessation
- 1998-11-06 CA CA002628053A patent/CA2628053A1/en not_active Abandoned
- 1998-11-06 DE DE69806066T patent/DE69806066T2/de not_active Expired - Lifetime
-
2004
- 2004-09-02 US US10/934,841 patent/US7166695B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2033661A1 (de) | 2009-03-11 |
| US20050037974A1 (en) | 2005-02-17 |
| CA2628053A1 (en) | 1999-05-20 |
| DE69806066D1 (de) | 2002-07-18 |
| DE69806066T2 (de) | 2003-02-06 |
| DE69839946D1 (de) | 2008-10-09 |
| EP1056474B1 (de) | 2002-06-12 |
| US7166695B2 (en) | 2007-01-23 |
| EP1056474A2 (de) | 2000-12-06 |
| CA2305597A1 (en) | 1999-05-20 |
| AU1519699A (en) | 1999-05-31 |
| WO1999024075A2 (en) | 1999-05-20 |
| CA2305597C (en) | 2008-07-29 |
| ATE406577T1 (de) | 2008-09-15 |
| WO1999024075A3 (en) | 1999-09-02 |
| ES2178854T3 (es) | 2003-01-01 |
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