CN1491233A - 长效生长激素释放因子衍生物 - Google Patents
长效生长激素释放因子衍生物 Download PDFInfo
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- CN1491233A CN1491233A CNA028044975A CN02804497A CN1491233A CN 1491233 A CN1491233 A CN 1491233A CN A028044975 A CNA028044975 A CN A028044975A CN 02804497 A CN02804497 A CN 02804497A CN 1491233 A CN1491233 A CN 1491233A
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Abstract
Description
名称 | 三字母缩写 | 单字母缩写 |
丙氨酸 | Ala | A |
精氨酸 | Arg | R |
天冬酰胺 | Asn | N |
天冬氨酸 | Asp | D |
半胱氨酸 | Cys | C |
谷氨酸 | Glu | E |
谷氨酰胺 | Gln | Q |
甘氨酸 | Gly | G |
组氨酸 | His | H |
异亮氨酸 | Ile | I |
亮氨酸 | Leu | L |
赖氨酸 | Lys | K |
甲硫氨酸 | Met | M |
苯丙氨酸 | Phe | F |
脯氨酸 | Pro | P |
丝氨酸 | Ser | S |
苏氨酸 | Thr | T |
色氨酸 | Trp | W |
酪氨酸 | Tyr | Y |
缬氨酸 | Val | V |
参数 | 皮下给药 | 静脉内给药 |
λ | 0.027 | 0.037 |
半衰期(小时) | 25.8±2.1 | 18.7±1.4 |
AUC(nM×h) | 8864.5 | 23277.5 |
%生物可利用率(SC/IV) | 3.8 | N/A |
Claims (19)
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EP (1) | EP1355941A2 (zh) |
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CN (2) | CN1491233A (zh) |
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CA (1) | CA2435563A1 (zh) |
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CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
CN107056929A (zh) * | 2009-12-21 | 2017-08-18 | Ambrx 公司 | 经过修饰的猪促生长素多肽和其用途 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107056929A (zh) * | 2009-12-21 | 2017-08-18 | Ambrx 公司 | 经过修饰的猪促生长素多肽和其用途 |
CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
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BR0206919A (pt) | 2004-07-06 |
EA200300856A1 (ru) | 2004-08-26 |
WO2002062844A2 (en) | 2002-08-15 |
JP2004520395A (ja) | 2004-07-08 |
ZA200305641B (en) | 2004-05-25 |
AU2002233082B2 (en) | 2005-11-10 |
CN101696240A (zh) | 2010-04-21 |
EP1355941A2 (en) | 2003-10-29 |
JP2009024017A (ja) | 2009-02-05 |
CA2435563A1 (en) | 2002-08-15 |
JP2008106073A (ja) | 2008-05-08 |
US7268113B2 (en) | 2007-09-11 |
US20030073630A1 (en) | 2003-04-17 |
WO2002062844A3 (en) | 2003-08-21 |
EA006484B1 (ru) | 2005-12-29 |
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