CN101696240A - 长效生长激素释放因子衍生物 - Google Patents
长效生长激素释放因子衍生物 Download PDFInfo
- Publication number
- CN101696240A CN101696240A CN200910163485A CN200910163485A CN101696240A CN 101696240 A CN101696240 A CN 101696240A CN 200910163485 A CN200910163485 A CN 200910163485A CN 200910163485 A CN200910163485 A CN 200910163485A CN 101696240 A CN101696240 A CN 101696240A
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- CN
- China
- Prior art keywords
- leu
- ala
- lys
- arg
- fmoc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
名称 | 三字母缩写 | 单字母缩写 |
丙氨酸 | Ala | A |
精氨酸 | Arg | R |
天冬酰胺 | Asn | N |
天冬氨酸 | Asp | D |
名称 | 三字母缩写 | 单字母缩写 |
半胱氨酸 | Cys | C |
谷氨酸 | Glu | E |
谷氨酰胺 | Gln | Q |
甘氨酸 | Gly | G |
组氨酸 | His | H |
异亮氨酸 | Ile | I |
亮氨酸 | Leu | L |
赖氨酸 | Lys | K |
甲硫氨酸 | Met | M |
苯丙氨酸 | Phe | F |
脯氨酸 | Pro | P |
丝氨酸 | Ser | S |
苏氨酸 | Thr | T |
色氨酸 | Trp | W |
酪氨酸 | Tyr | Y |
缬氨酸 | Val | V |
参数 | 皮下给药 | 静脉内给药 |
λ | 0.027 | 0.037 |
半衰期(小时) | 25.8±2.1 | 18.7±1.4 |
AUC(nMxh) | 8864.5 | 23277.5 |
%生物可利用率(SC/IV) | 3.8 | N/A |
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26642401P | 2001-02-02 | 2001-02-02 | |
US60/266,424 | 2001-02-02 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028044975A Division CN1491233A (zh) | 2001-02-02 | 2002-02-01 | 长效生长激素释放因子衍生物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101696240A true CN101696240A (zh) | 2010-04-21 |
Family
ID=23014533
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028044975A Pending CN1491233A (zh) | 2001-02-02 | 2002-02-01 | 长效生长激素释放因子衍生物 |
CN200910163485A Pending CN101696240A (zh) | 2001-02-02 | 2002-02-01 | 长效生长激素释放因子衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA028044975A Pending CN1491233A (zh) | 2001-02-02 | 2002-02-01 | 长效生长激素释放因子衍生物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US7268113B2 (zh) |
EP (1) | EP1355941A2 (zh) |
JP (3) | JP2004520395A (zh) |
CN (2) | CN1491233A (zh) |
AU (1) | AU2002233082B2 (zh) |
BR (1) | BR0206919A (zh) |
CA (1) | CA2435563A1 (zh) |
EA (1) | EA006484B1 (zh) |
WO (1) | WO2002062844A2 (zh) |
ZA (1) | ZA200305641B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103897053A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
CN108623694A (zh) * | 2017-03-24 | 2018-10-09 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
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US20090175821A1 (en) * | 1999-05-17 | 2009-07-09 | Bridon Dominique P | Modified therapeutic peptides with extended half-lives in vivo |
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US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
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CA2708762A1 (en) * | 2007-12-11 | 2009-06-18 | Conjuchem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
US20100267636A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechnologies Inc. | Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy |
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CN104017063A (zh) * | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
US8980249B2 (en) | 2010-06-03 | 2015-03-17 | University Of Miami | Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets |
CA2807685C (en) | 2010-08-13 | 2020-10-06 | Aileron Therapeutics, Inc. | P53 derived peptidomimetic macrocycle |
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US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
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JP6450192B2 (ja) | 2012-02-15 | 2019-01-09 | エイルロン セラピューティクス,インコーポレイテッド | トリアゾール架橋した、およびチオエーテル架橋したペプチドミメティック大環状化合物 |
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EP2935317B1 (en) | 2012-12-21 | 2019-03-27 | University of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
EP2934565B1 (en) | 2012-12-21 | 2019-03-13 | University of Miami | Ghrh agonists for the treatment of ischemic disorders |
CN103665147A (zh) * | 2013-11-26 | 2014-03-26 | 深圳翰宇药业股份有限公司 | 一种生长激素释放因子衍生物的合成方法 |
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2002
- 2002-02-01 BR BR0206919-9A patent/BR0206919A/pt not_active Application Discontinuation
- 2002-02-01 WO PCT/CA2002/000123 patent/WO2002062844A2/en active IP Right Grant
- 2002-02-01 CA CA002435563A patent/CA2435563A1/en not_active Abandoned
- 2002-02-01 US US10/203,809 patent/US7268113B2/en not_active Expired - Fee Related
- 2002-02-01 EA EA200300856A patent/EA006484B1/ru not_active IP Right Cessation
- 2002-02-01 JP JP2002563196A patent/JP2004520395A/ja not_active Withdrawn
- 2002-02-01 AU AU2002233082A patent/AU2002233082B2/en not_active Ceased
- 2002-02-01 CN CNA028044975A patent/CN1491233A/zh active Pending
- 2002-02-01 CN CN200910163485A patent/CN101696240A/zh active Pending
- 2002-02-01 EP EP02700072A patent/EP1355941A2/en not_active Withdrawn
-
2003
- 2003-07-22 ZA ZA200305641A patent/ZA200305641B/en unknown
-
2007
- 2007-12-28 JP JP2007341449A patent/JP2008106073A/ja active Pending
-
2008
- 2008-08-12 JP JP2008208279A patent/JP2009024017A/ja active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103897053A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
CN103897053B (zh) * | 2012-12-25 | 2019-01-15 | 深圳先进技术研究院 | 化学修饰的胸腺肽α1及其合成方法 |
CN108623694A (zh) * | 2017-03-24 | 2018-10-09 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
CN108623694B (zh) * | 2017-03-24 | 2021-09-17 | 北京市肿瘤防治研究所 | 血管内皮细胞生长因子受体拮抗肽f56的衍生物及应用 |
Also Published As
Publication number | Publication date |
---|---|
EA200300856A1 (ru) | 2004-08-26 |
CA2435563A1 (en) | 2002-08-15 |
JP2004520395A (ja) | 2004-07-08 |
AU2002233082B2 (en) | 2005-11-10 |
EA006484B1 (ru) | 2005-12-29 |
US7268113B2 (en) | 2007-09-11 |
BR0206919A (pt) | 2004-07-06 |
ZA200305641B (en) | 2004-05-25 |
WO2002062844A2 (en) | 2002-08-15 |
EP1355941A2 (en) | 2003-10-29 |
JP2008106073A (ja) | 2008-05-08 |
WO2002062844A3 (en) | 2003-08-21 |
CN1491233A (zh) | 2004-04-21 |
JP2009024017A (ja) | 2009-02-05 |
US20030073630A1 (en) | 2003-04-17 |
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