CN1690079A - 聚乙二醇修饰的胸腺肽1衍生物 - Google Patents
聚乙二醇修饰的胸腺肽1衍生物 Download PDFInfo
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- CN1690079A CN1690079A CNA200410037523XA CN200410037523A CN1690079A CN 1690079 A CN1690079 A CN 1690079A CN A200410037523X A CNA200410037523X A CN A200410037523XA CN 200410037523 A CN200410037523 A CN 200410037523A CN 1690079 A CN1690079 A CN 1690079A
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- glu
- thymus peptide
- ser
- polyoxyethylene glycol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/02—Immunomodulators
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Abstract
Description
IFN-r(pg/ml) | IL-2(pg/ml) | ||||
样品 | 浓度(ug/ml) | Mean | SD | Mean | SD |
对照 | 4122 | 77 | 2920 | 24 | |
日达仙 | 0.0010.010.1110100 | 417741184106483648324095 | 17713419120836427 | 323135823434369236143840 | 302518419304476 |
PEG样品 | 0.0010.010.1110100 | 480946034141494938745467 | 151234200367373 | 350534383339321433483582 | 2961171345529325 |
Time/h | 1# | 2# | 3# | Mean±SD | RSD% |
0.51246812243648 | 169-722636-936216319761091926 | 1352375658802099267724681716663463 | -119510341244995-745965985- | 152±24716±678773±239920±3061547±7801807±12311792±9191553±525913±223695±328 | 15953133506851342447 |
参数 | 单位 | mean±SD | RSD% |
AUC(0-48h)AUC(0-∝)AUC(48h-∝)AUC(48h-∝)%MRTCL/FVSSt1/2Kel | ng.h.mL-1ng.h.mL-1ng.U.h.mL-1%hmL.h-1.kg-1mL.kg-1h- | 60221±1689680742±3232420521±1827725.4±17.859.2±0.76.6±2.861±2720±60.03385±0.011 | 28408970843443134 |
Claims (18)
Priority Applications (2)
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CNB200410037523XA CN100355786C (zh) | 2004-04-28 | 2004-04-28 | 聚乙二醇修饰的胸腺肽1衍生物 |
PCT/CN2005/000452 WO2005105151A1 (fr) | 2004-04-28 | 2005-04-06 | Derives pegyles de thymosine 1 |
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CNB200410037523XA CN100355786C (zh) | 2004-04-28 | 2004-04-28 | 聚乙二醇修饰的胸腺肽1衍生物 |
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CN1690079A true CN1690079A (zh) | 2005-11-02 |
CN100355786C CN100355786C (zh) | 2007-12-19 |
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CN (1) | CN100355786C (zh) |
WO (1) | WO2005105151A1 (zh) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007054030A1 (fr) * | 2005-11-10 | 2007-05-18 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Modifications polyethylene glycole de thymosine alpha-1 |
CN101062950B (zh) * | 2006-04-25 | 2010-04-21 | 江苏豪森药业股份有限公司 | 聚乙二醇修饰的胸腺肽1衍生物 |
US20100184653A1 (en) * | 2008-07-14 | 2010-07-22 | Jiangsu Hansen Pharmaceutical Co., Ltd. | Derivates of Polyethylene Glycol Modified Thymosin Alpha 1 |
CN102268067A (zh) * | 2011-06-29 | 2011-12-07 | 河北师范大学 | 一种含ldv序列短肽的聚乙二醇化衍生物 |
CN102757500B (zh) * | 2005-11-10 | 2014-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效胸腺素α1 的聚乙二醇化修饰物 |
CN108239147A (zh) * | 2016-12-27 | 2018-07-03 | 江苏豪森药业集团有限公司 | 胸腺素α1衍生物的制备方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007013400A (es) * | 2005-05-04 | 2008-04-29 | Lonza Ag | Metodo de sintesis de peptidos. |
EP2350118B1 (en) | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
WO2010033227A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of thymosin alpha 1 peptides |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US5321095A (en) * | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
US5298410A (en) * | 1993-02-25 | 1994-03-29 | Sterling Winthrop Inc. | Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life |
UA78726C2 (en) * | 2001-11-01 | 2007-04-25 | Sciclone Pharmaceuticals Inc | Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment |
CN100372870C (zh) * | 2003-03-21 | 2008-03-05 | 中国人民解放军军事医学科学院毒物药物研究所 | 胸腺素α1的聚乙二醇化衍生物 |
-
2004
- 2004-04-28 CN CNB200410037523XA patent/CN100355786C/zh not_active Expired - Fee Related
-
2005
- 2005-04-06 WO PCT/CN2005/000452 patent/WO2005105151A1/zh active Application Filing
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007054030A1 (fr) * | 2005-11-10 | 2007-05-18 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Modifications polyethylene glycole de thymosine alpha-1 |
CN100577685C (zh) * | 2005-11-10 | 2010-01-06 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效胸腺素α1的聚乙二醇化修饰物 |
US8080522B2 (en) | 2005-11-10 | 2011-12-20 | Institute of Pharmacology and Toxicology Academy of Military Mecical Sciences, P.L.A., China | Polyethlene glycol modifications of thymosin alpha-1 |
CN102757500B (zh) * | 2005-11-10 | 2014-06-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 长效胸腺素α1 的聚乙二醇化修饰物 |
CN101062950B (zh) * | 2006-04-25 | 2010-04-21 | 江苏豪森药业股份有限公司 | 聚乙二醇修饰的胸腺肽1衍生物 |
US20100184653A1 (en) * | 2008-07-14 | 2010-07-22 | Jiangsu Hansen Pharmaceutical Co., Ltd. | Derivates of Polyethylene Glycol Modified Thymosin Alpha 1 |
CN102268067A (zh) * | 2011-06-29 | 2011-12-07 | 河北师范大学 | 一种含ldv序列短肽的聚乙二醇化衍生物 |
CN108239147A (zh) * | 2016-12-27 | 2018-07-03 | 江苏豪森药业集团有限公司 | 胸腺素α1衍生物的制备方法 |
CN108239147B (zh) * | 2016-12-27 | 2023-11-10 | 江苏豪森药业集团有限公司 | 胸腺素α1衍生物的制备方法 |
Also Published As
Publication number | Publication date |
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WO2005105151A1 (fr) | 2005-11-10 |
CN100355786C (zh) | 2007-12-19 |
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