ATE383430T1 - Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren - Google Patents
Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumorenInfo
- Publication number
- ATE383430T1 ATE383430T1 AT98912977T AT98912977T ATE383430T1 AT E383430 T1 ATE383430 T1 AT E383430T1 AT 98912977 T AT98912977 T AT 98912977T AT 98912977 T AT98912977 T AT 98912977T AT E383430 T1 ATE383430 T1 AT E383430T1
- Authority
- AT
- Austria
- Prior art keywords
- tumors
- recombinant antibodies
- bearing cells
- immune conjugates
- conjugates targeted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4143797P | 1997-03-20 | 1997-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE383430T1 true ATE383430T1 (de) | 2008-01-15 |
Family
ID=21916511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98912977T ATE383430T1 (de) | 1997-03-20 | 1998-03-19 | Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7541034B1 (de) |
| EP (1) | EP0970227B1 (de) |
| JP (3) | JP2002501488A (de) |
| AT (1) | ATE383430T1 (de) |
| AU (1) | AU740904B2 (de) |
| CA (1) | CA2284665C (de) |
| DE (1) | DE69838979T2 (de) |
| ES (1) | ES2300122T3 (de) |
| WO (1) | WO1998041641A1 (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE383430T1 (de) | 1997-03-20 | 2008-01-15 | Us Gov Health & Human Serv | Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren |
| US6183744B1 (en) * | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| EP0975674B1 (de) | 1997-05-02 | 2005-08-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Immuntoxine, die ein onc protein enthalten, gegen bösartige zellen |
| US7696325B2 (en) | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| EP1299128A2 (de) | 2000-06-20 | 2003-04-09 | Idec Pharmaceuticals Corporation | Kaltes anti-cd20 antikörper/radiomarkiertes anti-cd22 antikörper kombination |
| US8034903B2 (en) | 2000-10-20 | 2011-10-11 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
| US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| ATE468348T1 (de) * | 2001-09-26 | 2010-06-15 | Government Of The Us Secretary | Mutierte anti-cd22-antikörper mit erhöhter affinität zu cd22-exprimierenden leukämiezellen |
| GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
| DK1507556T3 (en) * | 2002-05-02 | 2016-09-12 | Wyeth Holdings Llc | Calicheamicin derivative-carrier conjugates |
| JP2004279086A (ja) | 2003-03-13 | 2004-10-07 | Konica Minolta Holdings Inc | 放射線画像変換パネル及び放射線画像変換パネルの製造方法 |
| ATE468356T1 (de) | 2003-11-25 | 2010-06-15 | Us Gov Health & Human Serv | Mutierte anti-cd22-antikörper und immunkonjugate |
| TWI671403B (zh) | 2005-03-31 | 2019-09-11 | 中外製藥股份有限公司 | 控制組裝之多肽的製造方法 |
| EP1870458B1 (de) | 2005-03-31 | 2018-05-09 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2-STRUKTURISOMERE |
| KR20080051113A (ko) | 2005-05-02 | 2008-06-10 | 콜드스프링하버러보러토리 | Ｍｉｒ 17-92 클러스터를 이용한 암 진단용 조성물 및 방법 |
| CA2610987C (en) | 2005-06-10 | 2013-09-10 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
| CN101262885B (zh) | 2005-06-10 | 2015-04-01 | 中外制药株式会社 | 含有sc(Fv)2的药物组合物 |
| GEP20135917B (en) | 2006-03-17 | 2013-09-10 | Biogen Idec Inc | Stabilized polypeptide compositions |
| WO2007114325A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 二重特異性抗体を精製するための抗体改変方法 |
| US8591889B2 (en) | 2008-04-04 | 2013-11-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Human monoclonal antibodies specific for CD22 |
| WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| WO2011031441A1 (en) | 2009-08-28 | 2011-03-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Therapy with a chimeric molecule and a pro-apoptotic agent |
| EP2475398B1 (de) | 2009-09-11 | 2015-05-20 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Verbessertes pseudomonas-exotoxin a mit verminderter immunogenität |
| US9580461B2 (en) | 2010-07-30 | 2017-02-28 | Medimmune, Llc | Method for purifying active polypeptides or immunoconjugates |
| US9540438B2 (en) | 2011-01-14 | 2017-01-10 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof |
| US9402916B2 (en) | 2011-03-17 | 2016-08-02 | The University Of Birmingham | Re-directed immunotherapy |
| EP3231812B1 (de) | 2011-06-09 | 2020-03-25 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Pseudomonas exotoxin a mit weniger immunogenen t-zell- und/oder b-zellepitopen |
| US8932586B2 (en) | 2011-09-06 | 2015-01-13 | Intrexon Corporation | Modified forms of Pseudomonas exotoxin A |
| PL2755993T3 (pl) | 2011-09-16 | 2018-04-30 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Egzotoksyna A Pseudomonas z mniej immunogennymi epitopami komórek B |
| CA2851795C (en) | 2011-10-20 | 2018-11-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd22 chimeric antigen receptors |
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| WO2014014821A1 (en) * | 2012-07-19 | 2014-01-23 | Redwood Biosciences, Inc. | Antibody specific for cd22 and methods of use thereof |
| WO2014100443A2 (en) | 2012-12-20 | 2014-06-26 | Medimmune, Llc | Methods of producing immunoconjugates |
| US9890369B2 (en) | 2013-06-20 | 2018-02-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cytolethal distending toxin subunit B conjugated or fused to Bacillus anthracis toxin lethal factor |
| SG10201803449VA (en) | 2013-09-27 | 2018-05-30 | Chugai Pharmaceutical Co Ltd | Method for producing polypeptide heteromultimer |
| JP6584012B2 (ja) | 2013-10-06 | 2019-10-02 | アメリカ合衆国 | 改変シュードモナス外毒素ａ |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| EP3253419A1 (de) | 2015-02-02 | 2017-12-13 | The University of Birmingham | Zieleinheit-peptidepitopkomplexe mit einer vielzahl von t-zell-epitopen |
| WO2016146833A1 (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
| JP6771492B2 (ja) | 2015-05-30 | 2020-10-21 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 脱免疫化された志賀毒素ａサブユニット足場及びそれを含む細胞標的化分子 |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| ES2908470T3 (es) | 2015-11-09 | 2022-04-29 | Scherer Technologies Llc R P | Conjugados de anticuerpo anti-CD22-maitansina y métodos de uso de los mismos |
| PT3377103T (pt) | 2015-11-19 | 2021-05-26 | Revitope Ltd | Complementação de fragmento de anticorpo funcional para um sistema de dois componentes para exterminação redirecionada de células indesejadas |
| CA3004288C (en) | 2015-12-28 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PROMOTING THE CLEARANCE EFFICIENCY OF A POLYPEPTIDE CONTAINING THE FC REGION |
| CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
| US11795235B2 (en) | 2017-09-18 | 2023-10-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotoxins with albumin binding domain |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| EP4159760A1 (de) | 2020-06-01 | 2023-04-05 | Innobation Bio Co., Ltd. | Antikörper spezifisch gegen cd22, und dessen verwendung |
| EP4178985A1 (de) | 2020-07-10 | 2023-05-17 | F. Hoffmann-La Roche AG | An krebszellen bindende antikörper und target-radionuklide an diese zellen |
| CN115210262B (zh) * | 2020-09-29 | 2023-07-14 | 昆明赛诺制药股份有限公司 | 人源化抗-cd22重组免疫毒素及其应用 |
| KR102393776B1 (ko) | 2020-12-30 | 2022-05-04 | (주)이노베이션바이오 | Cd22에 특이적인 인간화 항체 및 이를 이용한 키메라 항원 수용체 |
| JP2024501971A (ja) | 2020-12-31 | 2024-01-17 | サナ バイオテクノロジー，インコーポレイテッド | Ｃａｒ－ｔ活性を調節するための方法及び組成物 |
| TW202242121A (zh) | 2021-01-11 | 2022-11-01 | 美商薩那生物科技公司 | 靶向cd8之病毒載體之用途 |
| WO2022152701A1 (en) | 2021-01-13 | 2022-07-21 | F. Hoffmann-La Roche Ag | Combination therapy |
| TW202300648A (zh) | 2021-03-25 | 2023-01-01 | 美商當康生物科技有限公司 | 抗-igfbp7構築體及其用途 |
| IL308637A (en) | 2021-05-19 | 2024-01-01 | Sana Biotechnology Inc | Primary hypoimmunogenic T cells are RHD negative |
| US20240226164A1 (en) | 2021-05-27 | 2024-07-11 | Sana Biotechnology, Inc. | Hypoimmunogenic cells comprising engineered hla-e or hla-g |
| AU2022309875A1 (en) | 2021-07-14 | 2024-01-25 | Sana Biotechnology, Inc. | Altered expression of y chromosome-linked antigens in hypoimmunogenic cells |
| TW202321457A (zh) | 2021-08-04 | 2023-06-01 | 美商薩那生物科技公司 | 靶向ｃｄ４之病毒載體之用途 |
| AU2022325955A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions |
| WO2023019226A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy |
| AU2022325231A1 (en) | 2021-08-11 | 2024-02-08 | Sana Biotechnology, Inc. | Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions |
| WO2023019203A1 (en) | 2021-08-11 | 2023-02-16 | Sana Biotechnology, Inc. | Inducible systems for altering gene expression in hypoimmunogenic cells |
| KR20240073006A (ko) | 2021-08-11 | 2024-05-24 | 사나 바이오테크놀로지, 인크. | 동종이계 세포 요법을 위한 유전자 변형된 1차 세포 |
| EP4419117A1 (de) | 2021-10-22 | 2024-08-28 | Sana Biotechnology, Inc. | Verfahren zur züchtung allogener t-zellen mit einem transgen in einem tcr-lokus sowie zugehörige zusammensetzungen und verfahren |
| WO2023115041A1 (en) | 2021-12-17 | 2023-06-22 | Sana Biotechnology, Inc. | Modified paramyxoviridae attachment glycoproteins |
| EP4448549A2 (de) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modifizierte paramyxoviridae-fusionsglycoproteine |
| CN119072319A (zh) | 2021-12-23 | 2024-12-03 | 萨那生物技术股份有限公司 | 用于治疗自身免疫性疾病的嵌合抗原受体(car)t细胞及相关方法 |
| EP4463135A2 (de) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Verfahren zur ex-vivo-dosierung und -verabreichung von lipidpartikeln oder viralen vektoren sowie entsprechende systeme und verwendungen |
| WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| EP4473097A1 (de) | 2022-02-02 | 2024-12-11 | Sana Biotechnology, Inc. | Verfahren zur wiederholungsdosierung und verabreichung von lipidpartikeln oder viralen vektoren sowie entsprechende systeme und verwendungen |
| US20250302953A1 (en) | 2022-02-14 | 2025-10-02 | Sana Biotechnology, Inc. | Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells |
| AU2023220128A1 (en) | 2022-02-17 | 2024-08-22 | Sana Biotechnology, Inc. | Engineered cd47 proteins and uses thereof |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
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| WO2024064838A1 (en) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
| EP4602174A1 (de) | 2022-10-13 | 2025-08-20 | Sana Biotechnology, Inc. | Auf hämatopoetische stammzellen abzielende virale partikel |
| WO2024097311A2 (en) | 2022-11-02 | 2024-05-10 | Sana Biotechnology, Inc. | Hypoimmunogenic mail cells, methods of making and methods of using same |
| WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
| EP4698666A1 (de) | 2023-04-18 | 2026-02-25 | Sana Biotechnology, Inc. | Universelle protein-g-fusogene und adaptersysteme davon sowie zugehörige lipidpartikel und verwendungen |
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| EP4698665A1 (de) | 2023-04-18 | 2026-02-25 | Sana Biotechnology, Inc. | Manipulierte protein-g-fusogene und zugehörige lipidpartikel und verfahren dafür |
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| WO2025043172A1 (en) | 2023-08-23 | 2025-02-27 | Sana Biotechnology, Inc. | Modified cd47 proteins and their uses |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56145222A (en) * | 1980-04-28 | 1981-11-11 | Toshiyuki Hamaoka | Improved antibody and its preparation |
| US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US5476659A (en) | 1982-11-09 | 1995-12-19 | The Scripps Research Institute | Cancerous B cell treatment using substituted nucleoside derivatives |
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5258498A (en) * | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
| US5506126A (en) | 1988-02-25 | 1996-04-09 | The General Hospital Corporation | Rapid immunoselection cloning method |
| US5045451A (en) | 1988-10-26 | 1991-09-03 | Board Of Regents | Methods for screening antibodies for use as immunotoxins |
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| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US5591629A (en) * | 1994-04-29 | 1997-01-07 | Mayo Foundation For Medical Education & Research | Monoclonal antibodies which promote central nervous system remyelination |
| ATE383430T1 (de) * | 1997-03-20 | 2008-01-15 | Us Gov Health & Human Serv | Rekombinante antikörper und immunkonjugate gezielt auf cd22-tragende zellen und tumoren |
-
1998
- 1998-03-19 AT AT98912977T patent/ATE383430T1/de active
- 1998-03-19 AU AU67646/98A patent/AU740904B2/en not_active Expired
- 1998-03-19 ES ES98912977T patent/ES2300122T3/es not_active Expired - Lifetime
- 1998-03-19 CA CA2284665A patent/CA2284665C/en not_active Expired - Lifetime
- 1998-03-19 WO PCT/US1998/005453 patent/WO1998041641A1/en not_active Ceased
- 1998-03-19 EP EP98912977A patent/EP0970227B1/de not_active Expired - Lifetime
- 1998-03-19 US US09/381,497 patent/US7541034B1/en not_active Expired - Fee Related
- 1998-03-19 DE DE69838979T patent/DE69838979T2/de not_active Expired - Lifetime
- 1998-03-19 JP JP54081298A patent/JP2002501488A/ja not_active Withdrawn
-
2008
- 2008-03-18 JP JP2008070484A patent/JP2008208131A/ja active Pending
-
2009
- 2009-04-30 US US12/433,737 patent/US9592304B2/en not_active Expired - Fee Related
-
2010
- 2010-03-31 JP JP2010084519A patent/JP2010200752A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010200752A (ja) | 2010-09-16 |
| DE69838979T2 (de) | 2008-12-24 |
| CA2284665A1 (en) | 1998-09-24 |
| AU6764698A (en) | 1998-10-12 |
| US9592304B2 (en) | 2017-03-14 |
| CA2284665C (en) | 2010-08-17 |
| EP0970227B1 (de) | 2008-01-09 |
| JP2008208131A (ja) | 2008-09-11 |
| AU740904B2 (en) | 2001-11-15 |
| EP0970227A1 (de) | 2000-01-12 |
| US20090305411A1 (en) | 2009-12-10 |
| JP2002501488A (ja) | 2002-01-15 |
| WO1998041641A1 (en) | 1998-09-24 |
| ES2300122T3 (es) | 2008-06-01 |
| US7541034B1 (en) | 2009-06-02 |
| DE69838979D1 (de) | 2008-02-21 |
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