DE69939820D1 - Internalisierende erbb2 antikörper - Google Patents
Internalisierende erbb2 antikörperInfo
- Publication number
- DE69939820D1 DE69939820D1 DE69939820T DE69939820T DE69939820D1 DE 69939820 D1 DE69939820 D1 DE 69939820D1 DE 69939820 T DE69939820 T DE 69939820T DE 69939820 T DE69939820 T DE 69939820T DE 69939820 D1 DE69939820 D1 DE 69939820D1
- Authority
- DE
- Germany
- Prior art keywords
- internalizing
- antibodies
- erbb2
- erbb2 antibodies
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 title 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
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- C07K16/3053—Skin, nerves, brain
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
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- C07K2317/626—Diabody or triabody
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- C07—ORGANIC CHEMISTRY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8295398P | 1998-04-24 | 1998-04-24 | |
US09/250,056 US7244826B1 (en) | 1998-04-24 | 1999-02-12 | Internalizing ERB2 antibodies |
PCT/US1999/007395 WO1999055367A1 (en) | 1998-04-24 | 1999-04-23 | INTERNALIZING ErbB2 ANTIBODIES |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69939820D1 true DE69939820D1 (de) | 2008-12-11 |
Family
ID=26768027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69939820T Expired - Lifetime DE69939820D1 (de) | 1998-04-24 | 1999-04-23 | Internalisierende erbb2 antikörper |
Country Status (9)
Country | Link |
---|---|
US (6) | US7244826B1 (de) |
EP (1) | EP1071460B1 (de) |
JP (1) | JP2002524024A (de) |
AT (1) | ATE412432T1 (de) |
AU (1) | AU769304B2 (de) |
CA (1) | CA2326377C (de) |
DE (1) | DE69939820D1 (de) |
ES (1) | ES2316186T3 (de) |
WO (1) | WO1999055367A1 (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7563874B2 (en) * | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
ATE384744T1 (de) * | 1999-07-29 | 2008-02-15 | Medarex Inc | Menschliche antikörper gegen her2/neu |
US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
EP2308982B1 (de) | 2000-04-17 | 2014-11-26 | Dyax Corp. | Verfahren zur Einrichtung von Bibliotheken für genetische Verpackungen unterschiedlicher Familien von Peptiden |
PL217410B1 (pl) | 2000-05-19 | 2014-07-31 | Genentech Inc | Zastosowanie antagonisty ErbB, antagonista ErbB do zastosowania w metodzie leczenia raka i sposób identyfikacji pacjenta skłonnego do korzystnej odpowiedzi na antagonistę ErbB przy leczeniu raka |
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1999
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- 1999-04-23 DE DE69939820T patent/DE69939820D1/de not_active Expired - Lifetime
- 1999-04-23 CA CA2326377A patent/CA2326377C/en not_active Expired - Fee Related
- 1999-04-23 ES ES99919786T patent/ES2316186T3/es not_active Expired - Lifetime
- 1999-04-23 AT AT99919786T patent/ATE412432T1/de not_active IP Right Cessation
- 1999-04-23 AU AU37429/99A patent/AU769304B2/en not_active Revoked
- 1999-04-23 EP EP99919786A patent/EP1071460B1/de not_active Expired - Lifetime
- 1999-04-23 WO PCT/US1999/007395 patent/WO1999055367A1/en active IP Right Grant
- 1999-04-23 JP JP2000545565A patent/JP2002524024A/ja active Pending
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2007
- 2007-06-01 US US11/809,773 patent/US7892554B2/en not_active Expired - Fee Related
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2010
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- 2012-04-06 US US13/441,651 patent/US8974792B2/en not_active Expired - Fee Related
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- 2015-02-20 US US14/627,773 patent/US9388244B2/en not_active Expired - Fee Related
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CA2326377C (en) | 2016-12-06 |
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US20160279262A1 (en) | 2016-09-29 |
JP2002524024A (ja) | 2002-08-06 |
US7892554B2 (en) | 2011-02-22 |
WO1999055367A1 (en) | 1999-11-04 |
EP1071460A4 (de) | 2004-09-08 |
US20110218333A1 (en) | 2011-09-08 |
EP1071460A1 (de) | 2001-01-31 |
US20150239976A1 (en) | 2015-08-27 |
CA2326377A1 (en) | 1999-11-04 |
US20130337039A1 (en) | 2013-12-19 |
ATE412432T1 (de) | 2008-11-15 |
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