MX363188B - Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. - Google Patents
Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1.Info
- Publication number
- MX363188B MX363188B MX2015006756A MX2015006756A MX363188B MX 363188 B MX363188 B MX 363188B MX 2015006756 A MX2015006756 A MX 2015006756A MX 2015006756 A MX2015006756 A MX 2015006756A MX 363188 B MX363188 B MX 363188B
- Authority
- MX
- Mexico
- Prior art keywords
- patient
- need
- inhibitor cotherapy
- therapy
- cotherapy
- Prior art date
Links
- 239000012271 PD-L1 inhibitor Substances 0.000 title abstract 4
- 229940121656 pd-l1 inhibitor Drugs 0.000 title abstract 4
- 238000002560 therapeutic procedure Methods 0.000 abstract 3
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 2
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 2
- 101150029707 ERBB2 gene Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000019491 signal transduction Effects 0.000 abstract 2
- 229960000575 trastuzumab Drugs 0.000 abstract 2
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70532—B7 molecules, e.g. CD80, CD86
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7033—Non-proliferative mechanisms
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
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- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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Abstract
La presente invención se refiere a medios y métodos para determinar si un paciente necesita una coterapia del inhibidor de PD-L1. Se determina que un paciente necesita la coterapia del inhibidor de PD-L1 si se mide in vitro en una muestra proveniente del paciente un bajo o ausente nivel de expresión de ER y un nivel de expresión del ligando 1 de muerte programada (PD-L1) que se encuentra incrementado en comparación con un control. El paciente se somete a una terapia que comprende un modulador de la trayectoria de señalización de HER2/neu (ErbB2) (como trastuzumab) y un agente quimioterapéutico (como dodetaxel) o se contempla tal terapia para el paciente. También se proporcionan en la presente medios y métodos para tratar un cáncer en un paciente con cáncer para quien se contempla una terapia que comprende un modulador de la trayectoria de señalización de HER2/neu (ErbB2) (como trastuzumab) y un agente quimioterapéutico (como dodetaxel), en donde el paciente va a recibir coterapia del inhibidor de PD-L1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12195182 | 2012-11-30 | ||
EP12196177 | 2012-12-07 | ||
PCT/EP2013/075162 WO2014083178A1 (en) | 2012-11-30 | 2013-11-29 | Identification of patients in need of pd-l1 inhibitor cotherapy |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015006756A MX2015006756A (es) | 2015-08-05 |
MX363188B true MX363188B (es) | 2019-03-13 |
Family
ID=49886877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015006756A MX363188B (es) | 2012-11-30 | 2013-11-29 | Identificación de pacientes con necesidad de coterapia del inhibidor de pd-l1. |
Country Status (11)
Country | Link |
---|---|
US (6) | US20160333414A1 (es) |
EP (2) | EP2926142B2 (es) |
JP (2) | JP6998646B2 (es) |
KR (1) | KR102291355B1 (es) |
CN (1) | CN104813168B (es) |
BR (1) | BR112015012644A2 (es) |
CA (1) | CA2889298C (es) |
HK (1) | HK1208911A1 (es) |
MX (1) | MX363188B (es) |
RU (1) | RU2692773C2 (es) |
WO (1) | WO2014083178A1 (es) |
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BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
CN114835812A (zh) | 2008-12-09 | 2022-08-02 | 霍夫曼-拉罗奇有限公司 | 抗-pd-l1抗体及它们用于增强t细胞功能的用途 |
US20130330761A1 (en) | 2012-06-12 | 2013-12-12 | Celcuity, LLC | Whole cell assays and methods |
SG10201701380TA (en) | 2013-03-15 | 2017-04-27 | Genentech Inc | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
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- 2013-11-29 JP JP2015544488A patent/JP6998646B2/ja active Active
- 2013-11-29 EP EP13814848.1A patent/EP2926142B2/en active Active
- 2013-11-29 CN CN201380062234.2A patent/CN104813168B/zh active Active
- 2013-11-29 EP EP18204426.3A patent/EP3511718A1/en active Pending
- 2013-11-29 RU RU2015125638A patent/RU2692773C2/ru active
- 2013-11-29 BR BR112015012644A patent/BR112015012644A2/pt not_active Application Discontinuation
- 2013-11-29 CA CA2889298A patent/CA2889298C/en active Active
- 2013-11-29 WO PCT/EP2013/075162 patent/WO2014083178A1/en active Application Filing
- 2013-11-29 KR KR1020157014102A patent/KR102291355B1/ko active IP Right Grant
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- 2015-10-02 HK HK15109664.9A patent/HK1208911A1/xx unknown
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- 2021-09-23 US US17/483,396 patent/US20220090212A1/en not_active Abandoned
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US20200199690A1 (en) | 2020-06-25 |
US20220090212A1 (en) | 2022-03-24 |
CN104813168A (zh) | 2015-07-29 |
RU2015125638A (ru) | 2017-01-11 |
JP6998646B2 (ja) | 2022-02-04 |
EP2926142A1 (en) | 2015-10-07 |
EP2926142B1 (en) | 2018-11-07 |
JP2020099324A (ja) | 2020-07-02 |
KR102291355B1 (ko) | 2021-08-19 |
KR20150091058A (ko) | 2015-08-07 |
US20220170115A1 (en) | 2022-06-02 |
US20160333414A1 (en) | 2016-11-17 |
EP2926142B2 (en) | 2022-07-06 |
JP7181854B2 (ja) | 2022-12-01 |
WO2014083178A1 (en) | 2014-06-05 |
CN104813168B (zh) | 2017-10-20 |
JP2016508028A (ja) | 2016-03-17 |
BR112015012644A2 (pt) | 2017-12-19 |
EP3511718A1 (en) | 2019-07-17 |
CA2889298A1 (en) | 2014-06-05 |
US20220282337A1 (en) | 2022-09-08 |
HK1208911A1 (en) | 2016-03-18 |
CA2889298C (en) | 2024-01-02 |
RU2692773C2 (ru) | 2019-06-27 |
US20180274038A1 (en) | 2018-09-27 |
MX2015006756A (es) | 2015-08-05 |
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