BR112016007864A2 - método para a prognose e tratamento de metástase de câncer - Google Patents
método para a prognose e tratamento de metástase de câncerInfo
- Publication number
- BR112016007864A2 BR112016007864A2 BR112016007864A BR112016007864A BR112016007864A2 BR 112016007864 A2 BR112016007864 A2 BR 112016007864A2 BR 112016007864 A BR112016007864 A BR 112016007864A BR 112016007864 A BR112016007864 A BR 112016007864A BR 112016007864 A2 BR112016007864 A2 BR 112016007864A2
- Authority
- BR
- Brazil
- Prior art keywords
- present
- metastasis
- breast cancer
- relates
- bone metastasis
- Prior art date
Links
- 206010027476 Metastases Diseases 0.000 title abstract 9
- 230000009401 metastasis Effects 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 238000004393 prognosis Methods 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 206010006187 Breast cancer Diseases 0.000 abstract 5
- 208000026310 Breast neoplasm Diseases 0.000 abstract 5
- 210000000988 bone and bone Anatomy 0.000 abstract 5
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 abstract 2
- 101150095688 maf gene Proteins 0.000 abstract 2
- 230000004544 DNA amplification Effects 0.000 abstract 1
- 102000007987 Proto-Oncogene Proteins c-maf Human genes 0.000 abstract 1
- 108010089507 Proto-Oncogene Proteins c-maf Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000005945 translocation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
resumo método para a prognose e tratamento de metástase de câncer a presente invenção refere-se a um método para a prognose de metástase óssea em câncer de mama her2+, que compreende determinar se o gene maf é amplificado em uma amostra de tumor primário. do mesmo modo, a presente inven-ção também refere-se a um método para determinar a tendência a desenvolver me-tástase óssea com respeito a metástase em outros órgãos, que compreendem de-terminar o nível de expressão do gene maf, amplificação ou translocação. a pre-sente invenção também refere-se a um método para prognosticar metástase óssea precoce em um sujeito sofrendo de câncer de mama. a presente invenção também refere-se a um inibidor de c-maf como agente terapêutico para o uso no tratamento de metástase de câncer de mama her2+. a presente invenção refere-se a kits para prognosticar metástase óssea e prognosticar o resultado clínico de um sujeito so-frendo de metástase óssea. finalmente, a presente invenção refere-se a um método para tipificar um sujeito sofrendo de câncer de mama e para classificar um sujeito de câncer de mama em um grupo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361888984P | 2013-10-09 | 2013-10-09 | |
| PCT/IB2014/002675 WO2015052583A2 (en) | 2013-10-09 | 2014-10-07 | Method for the prognosis and treatment of cancer metastasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016007864A2 true BR112016007864A2 (pt) | 2017-12-05 |
Family
ID=52292968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016007864A BR112016007864A2 (pt) | 2013-10-09 | 2014-10-07 | método para a prognose e tratamento de metástase de câncer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170101683A1 (pt) |
| EP (2) | EP3524698A1 (pt) |
| JP (1) | JP6550045B2 (pt) |
| KR (1) | KR20160061424A (pt) |
| CN (1) | CN105980576B (pt) |
| AU (1) | AU2014333513B2 (pt) |
| BR (1) | BR112016007864A2 (pt) |
| CA (1) | CA2926894A1 (pt) |
| DK (1) | DK3055429T3 (pt) |
| ES (1) | ES2727904T3 (pt) |
| MX (2) | MX362041B (pt) |
| TR (1) | TR201907389T4 (pt) |
| WO (1) | WO2015052583A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10047398B2 (en) | 2010-10-06 | 2018-08-14 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of breast cancer metastasis |
| EP2650682A1 (en) | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
| JP6386450B2 (ja) | 2012-06-06 | 2018-09-05 | フンダシオ、インスティトゥト、デ、レセルカ、ビオメディカ（イエレベ、バルセロナ）Ｆｕｎｄａｃｉｏ Ｉｎｓｔｉｔｕｔ Ｄｅ Ｒｅｃｅｒｃａ Ｂｉｏｍｅｄｉｃａ （Ｉｒｂ Ｂａｒｃｅｌｏｎａ） | 肺がん転移の診断、予後診断および処置のための方法 |
| DK2906718T3 (da) | 2012-10-12 | 2019-07-01 | Inbiomotion Sl | Fremgangsmåde til diagnose, prognose og behandling af prostatakræftmetastase under anvendelse af c-maf |
| US10119171B2 (en) | 2012-10-12 | 2018-11-06 | Inbiomotion S.L. | Method for the diagnosis, prognosis and treatment of prostate cancer metastasis |
| EP3272880B1 (en) | 2013-03-15 | 2020-11-25 | Fundació Institut de Recerca Biomèdica (IRB Barcelona) | Method for the diagnosis, prognosis and treatment of metastatic cancer |
| KR20170093182A (ko) | 2014-12-11 | 2017-08-14 | 인바이오모션 에스.엘. | 인간 c-maf에 대한 결합 구성원 |
| KR102571924B1 (ko) * | 2016-05-25 | 2023-08-28 | 인바이오모션 에스.엘. | c-MAF 상태에 기초한 유방암의 치료 |
| CN105907886A (zh) * | 2016-07-07 | 2016-08-31 | 蔡维泺 | miR-124在乳腺癌骨转移疾病中的应用 |
| EP3713581A1 (en) | 2017-11-22 | 2020-09-30 | Inbiomotion S.L. | Therapeutic treatment of breast cancer based on c-maf |
| US20210206820A1 (en) * | 2018-05-30 | 2021-07-08 | Purdue Research Foundation | Targeting anabolic drugs for accelerated fracture repair |
| RU2766248C1 (ru) * | 2021-01-11 | 2022-02-10 | Федеральное государственное бюджетное научное учреждение "Томский национальной исследовательский медицинский центр Российской академии наук ("Томский НИМЦ") | Способ прогнозирования статуса рецептора эпидермального фактора роста her2/neu в первичной опухоли у больных раком молочной железы |
| RU2757960C1 (ru) * | 2021-01-11 | 2021-10-25 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") | Способ прогнозирования статуса рецептора эпидермального фактора роста her2/neu в метастатических лимфатических узлах у больных раком молочной железы |
| CN113667748B (zh) * | 2021-07-19 | 2023-07-25 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | circIKBKB的抑制剂及其检测试剂在乳腺癌骨转移诊断、治疗和预后试剂盒的应用 |
| CN114512183B (zh) * | 2022-01-27 | 2022-09-20 | 北京吉因加医学检验实验室有限公司 | 一种预测met基因扩增或多倍体的方法及装置 |
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| SE0201980D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
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| US10047398B2 (en) * | 2010-10-06 | 2018-08-14 | Fundacio Institut De Recerca Biomedica (Irb Barcelona) | Method for the diagnosis, prognosis and treatment of breast cancer metastasis |
| EP2685988A4 (en) * | 2011-03-15 | 2014-08-20 | Univ North Carolina | METHOD FOR THE TREATMENT OF BREAST CANCER WITH ANTHRACYCLIN THERAPY |
| EP2650682A1 (en) * | 2012-04-09 | 2013-10-16 | Fundació Privada Institut de Recerca Biomèdica | Method for the prognosis and treatment of cancer metastasis |
-
2014
- 2014-10-07 CA CA2926894A patent/CA2926894A1/en not_active Abandoned
- 2014-10-07 AU AU2014333513A patent/AU2014333513B2/en active Active
- 2014-10-07 ES ES14824529T patent/ES2727904T3/es active Active
- 2014-10-07 US US15/027,946 patent/US20170101683A1/en not_active Abandoned
- 2014-10-07 KR KR1020167011949A patent/KR20160061424A/ko not_active Application Discontinuation
- 2014-10-07 TR TR2019/07389T patent/TR201907389T4/tr unknown
- 2014-10-07 EP EP19165007.6A patent/EP3524698A1/en not_active Withdrawn
- 2014-10-07 DK DK14824529.3T patent/DK3055429T3/en active
- 2014-10-07 JP JP2016521355A patent/JP6550045B2/ja active Active
- 2014-10-07 MX MX2016004557A patent/MX362041B/es active IP Right Grant
- 2014-10-07 BR BR112016007864A patent/BR112016007864A2/pt not_active Application Discontinuation
- 2014-10-07 CN CN201480064111.7A patent/CN105980576B/zh active Active
- 2014-10-07 EP EP14824529.3A patent/EP3055429B1/en active Active
- 2014-10-07 WO PCT/IB2014/002675 patent/WO2015052583A2/en active Application Filing
-
2016
- 2016-04-08 MX MX2019000091A patent/MX2019000091A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3055429B1 (en) | 2019-03-27 |
| DK3055429T3 (en) | 2019-04-23 |
| JP2016539625A (ja) | 2016-12-22 |
| US20170101683A1 (en) | 2017-04-13 |
| MX2016004557A (es) | 2016-07-22 |
| MX2019000091A (es) | 2023-04-27 |
| CN105980576B (zh) | 2021-07-16 |
| TR201907389T4 (tr) | 2019-06-21 |
| EP3055429A2 (en) | 2016-08-17 |
| KR20160061424A (ko) | 2016-05-31 |
| WO2015052583A3 (en) | 2015-07-23 |
| MX362041B (es) | 2019-01-07 |
| AU2014333513A1 (en) | 2016-04-28 |
| CN105980576A (zh) | 2016-09-28 |
| ES2727904T3 (es) | 2019-10-21 |
| EP3524698A1 (en) | 2019-08-14 |
| WO2015052583A2 (en) | 2015-04-16 |
| JP6550045B2 (ja) | 2019-07-24 |
| AU2014333513B2 (en) | 2020-11-26 |
| CA2926894A1 (en) | 2015-04-16 |
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