MX368513B - Métodos in vitro para el pronóstico, diagnóstico y diseño de una terapia de metástasis de cáncer de pulmón. - Google Patents

Métodos in vitro para el pronóstico, diagnóstico y diseño de una terapia de metástasis de cáncer de pulmón.

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Publication number
MX368513B
MX368513B MX2014014802A MX2014014802A MX368513B MX 368513 B MX368513 B MX 368513B MX 2014014802 A MX2014014802 A MX 2014014802A MX 2014014802 A MX2014014802 A MX 2014014802A MX 368513 B MX368513 B MX 368513B
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MX
Mexico
Prior art keywords
lung cancer
prognosis
diagnosis
metastasis
treatment
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MX2014014802A
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English (en)
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MX2014014802A (es
Inventor
Planet Evarist
Gomis Roger
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Fundacio Inst De Recerca Biomedica Irb Barcelona
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Publication of MX2014014802A publication Critical patent/MX2014014802A/es
Publication of MX368513B publication Critical patent/MX368513B/es

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
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    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G01N2333/82—Translation products from oncogenes
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

La presente invención se refiere a un método in vitro para el diagnóstico de metástasis en un sujeto con cáncer de pulmón y/o para el pronóstico de la tendencia a desarrollar metástasis en un sujeto con cáncer de pulmón, caracterizado porque comprende: (i) cuantificar el número de copias de c-MAF en una muestra de tumor del sujeto, y (ii) comparar el número de copias previamente obtenido con el número de copias del gen en una muestra control, en donde, si el número de copias del gen se incrementa con respecto al número de copias del gen en la muestra control, entonces el sujeto tiene un diagnóstico positivo para metástasis o una tendencia mayor a desarrollar metástasis.
MX2014014802A 2012-06-06 2013-06-06 Métodos in vitro para el pronóstico, diagnóstico y diseño de una terapia de metástasis de cáncer de pulmón. MX368513B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656372P 2012-06-06 2012-06-06
PCT/IB2013/001859 WO2013182912A2 (en) 2012-06-06 2013-06-06 Method for the diagnosis, prognosis and treatment of lung cancer metastasis

Publications (2)

Publication Number Publication Date
MX2014014802A MX2014014802A (es) 2015-05-11
MX368513B true MX368513B (es) 2019-10-07

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MX2014014802A MX368513B (es) 2012-06-06 2013-06-06 Métodos in vitro para el pronóstico, diagnóstico y diseño de una terapia de metástasis de cáncer de pulmón.

Country Status (14)

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US (2) US10006091B2 (es)
EP (2) EP2859120B1 (es)
JP (1) JP6386450B2 (es)
KR (1) KR102226219B1 (es)
CN (1) CN104603288B (es)
AU (2) AU2013273242B2 (es)
BR (1) BR112014030750A2 (es)
CA (1) CA2875918A1 (es)
DK (1) DK2859120T3 (es)
ES (1) ES2705237T3 (es)
HK (1) HK1208501A1 (es)
MX (1) MX368513B (es)
TR (1) TR201819859T4 (es)
WO (1) WO2013182912A2 (es)

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US11352673B2 (en) 2022-06-07
JP6386450B2 (ja) 2018-09-05
ES2705237T3 (es) 2019-03-22
US20150152506A1 (en) 2015-06-04
US20190119757A1 (en) 2019-04-25
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CA2875918A1 (en) 2013-12-12
EP3467124A1 (en) 2019-04-10
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DK2859120T3 (en) 2019-01-14
JP2015521050A (ja) 2015-07-27
TR201819859T4 (tr) 2019-01-21
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US10006091B2 (en) 2018-06-26
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EP2859120A2 (en) 2015-04-15
EP2859120B1 (en) 2018-11-14
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CN104603288A (zh) 2015-05-06
WO2013182912A3 (en) 2014-02-20

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