BR112017016808A2 - biomarcadores para câncer pancreático - Google Patents
biomarcadores para câncer pancreáticoInfo
- Publication number
- BR112017016808A2 BR112017016808A2 BR112017016808A BR112017016808A BR112017016808A2 BR 112017016808 A2 BR112017016808 A2 BR 112017016808A2 BR 112017016808 A BR112017016808 A BR 112017016808A BR 112017016808 A BR112017016808 A BR 112017016808A BR 112017016808 A2 BR112017016808 A2 BR 112017016808A2
- Authority
- BR
- Brazil
- Prior art keywords
- biomarkers
- pancreatic cancer
- diagnosis
- present
- ductal adenocarcinoma
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title abstract 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 title abstract 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title 1
- 201000002528 pancreatic cancer Diseases 0.000 title 1
- 208000008443 pancreatic carcinoma Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 abstract 2
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 abstract 2
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Databases & Information Systems (AREA)
- Data Mining & Analysis (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
a presente invenção refere-se a cânceres pancreáticos e ao uso de biomarcadores em amostras biológicas para o diagnóstico de tais condições, em particular adenocarcinoma ductal pancreático. o painel do biomarcador compreende lyve1, reg1 e tff1. também são fornecidos métodos de tratamento, bem como kits úteis no diagnóstico e tratamento de adenocarcinoma ductal pancreático. a presente invenção é particularmente útil na detecção de pdac no estágio inicial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1501930.0A GB201501930D0 (en) | 2015-02-05 | 2015-02-05 | Biomarkers for pancreatic cancer |
PCT/GB2016/050277 WO2016124947A1 (en) | 2015-02-05 | 2016-02-05 | Biomarkers for pancreatic cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017016808A2 true BR112017016808A2 (pt) | 2018-04-03 |
Family
ID=52746188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017016808A BR112017016808A2 (pt) | 2015-02-05 | 2016-02-05 | biomarcadores para câncer pancreático |
Country Status (15)
Country | Link |
---|---|
US (2) | US10782301B2 (pt) |
EP (2) | EP4458849A2 (pt) |
JP (1) | JP6786499B2 (pt) |
KR (1) | KR102569984B1 (pt) |
CN (1) | CN107533062B (pt) |
AU (1) | AU2016214140B2 (pt) |
BR (1) | BR112017016808A2 (pt) |
CA (1) | CA2974775C (pt) |
CL (1) | CL2017001972A1 (pt) |
GB (1) | GB201501930D0 (pt) |
HK (1) | HK1247276A1 (pt) |
IL (1) | IL253710B (pt) |
MX (1) | MX2017009998A (pt) |
SG (1) | SG11201706223VA (pt) |
WO (1) | WO2016124947A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10782301B2 (en) | 2015-02-05 | 2020-09-22 | Queen Mary University Of London | Biomarkers for pancreatic cancer |
Families Citing this family (10)
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CN101680896A (zh) | 2007-03-27 | 2010-03-24 | 伊缪诺维亚公司 | 检测腺癌的蛋白标志/标记 |
GB201517028D0 (en) * | 2015-09-25 | 2015-11-11 | Univ London Queen Mary | Novel biomarkers for pancreatic cancer |
CN107674884A (zh) * | 2017-09-05 | 2018-02-09 | 上海速创诊断产品有限公司 | 一种用于检测胰腺癌标记物reg1a的生物素化脂质体及其制备方法和应用 |
TWI643869B (zh) * | 2017-12-14 | 2018-12-11 | 國立高雄大學 | Molecular extension printing material and preparation method thereof, magnetic molecular extension printing material and preparation method thereof |
US20210052231A1 (en) * | 2017-12-14 | 2021-02-25 | Salcit Technologies Private Limited | Method and system for analyzing risk associated with respiratory sounds |
KR102000387B1 (ko) * | 2018-02-13 | 2019-07-15 | 서울대학교산학협력단 | 췌관내유두상점액종양의 악성도를 감별할 수 있는 단백질 바이오마커 및 그 용도 |
CN109358055A (zh) * | 2018-12-18 | 2019-02-19 | 沈阳理工大学 | 增敏测定空气中氨的混合指示剂试纸及其制备和检测方法 |
CN111303281A (zh) * | 2019-05-14 | 2020-06-19 | 长春恒晓生物科技有限责任公司 | 制备胰石蛋白抗体及建立检测psp方法 |
GB202010970D0 (en) * | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
CN113248609B (zh) * | 2021-07-14 | 2021-09-10 | 深圳市盛波尔生命科学技术有限责任公司 | 针对再生胰岛衍生蛋白1α的抗体组合以及包含其的检测试剂盒 |
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GB9827228D0 (en) | 1998-12-10 | 1999-02-03 | Univ Nottingham | Cancer detection method and reagents |
EP1556518B1 (en) | 2002-09-30 | 2008-12-31 | Oncotherapy Science, Inc. | Genes and polypeptides relating to human pancreatic cancers |
AU2003900747A0 (en) | 2003-02-18 | 2003-03-06 | Garvan Institute Of Medical Research | Diagnosis and treatment of pancreatic cancer |
WO2004099432A2 (en) | 2003-05-02 | 2004-11-18 | The Johns Hopkins University | Identification of biomarkers for detecting pancreatic cancer |
CA2525740A1 (en) | 2003-05-15 | 2004-11-25 | Europroteome Ag | Biomarkers for the differential diagnosis of pancreatitis and pancreatic cancer |
DE102004042822A1 (de) | 2004-08-31 | 2006-03-16 | Technische Universität Dresden | Verbindungen und Methoden zur Behandlung, Diagnose und Prognose bei Pankreaserkrankungen |
EP1842065B1 (en) | 2005-01-28 | 2010-12-01 | Children's Medical Center Corporation | Methods for diagnosis and prognosis of bladder cancer |
US20070031867A1 (en) | 2005-06-27 | 2007-02-08 | John Wayne Cancer Institute | Molecular/genetic aberrations in surgical margins of resected pancreatic cancer represents neoplastic disease that correlates with disease outcome |
WO2007035684A2 (en) | 2005-09-16 | 2007-03-29 | Primera Biosystems, Inc. | Method for quantitative detection of short rna molecules |
WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
CN101421622A (zh) | 2006-02-17 | 2009-04-29 | 儿童医学中心公司 | 作为癌症生物标志物的游离ngal |
US20070231822A1 (en) | 2006-02-28 | 2007-10-04 | Michael Mitas | Methods for the detection and treatment of cancer |
AU2007299828C1 (en) | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
JP2010505847A (ja) | 2006-10-03 | 2010-02-25 | ニューレン ファーマシューティカルズ リミテッド | トレフォイル因子に結合する高次構造特異的抗体とこれを用いた癌および増殖障害の治療法 |
WO2008063479A2 (en) * | 2006-11-17 | 2008-05-29 | Fred Hutchinson Cancer Research Center | Pancreatic cancer biomarkers |
CN101827941B (zh) | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
CA2723972A1 (en) * | 2008-05-12 | 2009-11-19 | Genomic Health Inc. | Tests to predict responsiveness of cancer patients to chemotherapy treatment options |
US20090304700A1 (en) | 2008-06-06 | 2009-12-10 | Neuren Pharmaceuticals, Ltd. | Conformation specific antibodies that bind trefoil factors |
JP2012100536A (ja) * | 2009-03-02 | 2012-05-31 | Genescience Co Ltd | 血液試料に含まれる単核球細胞を用いた癌関連遺伝子の発現解析による癌の遺伝子検査方法 |
CN102725000B (zh) | 2010-01-19 | 2015-10-07 | 免疫医疗公司 | 靶向胰岛素-样生长因子i型受体(igf-1r)的新型单特异性和双特异性人源化抗体 |
EP2415877A3 (en) * | 2010-02-17 | 2012-02-15 | Deutsches Krebsforschungszentrum | Means and methods for diagnosing pancreatic cancer |
WO2011137288A2 (en) | 2010-04-30 | 2011-11-03 | The Ohio State University | Mirna networks in cancers and leukemias and uses thereof |
WO2012100339A1 (en) * | 2011-01-27 | 2012-08-02 | University Health Network | Methods and compositions for the detection of pancreatic cancer |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
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GB201501930D0 (en) | 2015-02-05 | 2015-03-25 | Univ London Queen Mary | Biomarkers for pancreatic cancer |
GB201517028D0 (en) | 2015-09-25 | 2015-11-11 | Univ London Queen Mary | Novel biomarkers for pancreatic cancer |
-
2015
- 2015-02-05 GB GBGB1501930.0A patent/GB201501930D0/en not_active Ceased
-
2016
- 2016-02-05 EP EP24188089.7A patent/EP4458849A2/en active Pending
- 2016-02-05 KR KR1020177024461A patent/KR102569984B1/ko active IP Right Grant
- 2016-02-05 US US15/548,240 patent/US10782301B2/en active Active
- 2016-02-05 CN CN201680018784.8A patent/CN107533062B/zh active Active
- 2016-02-05 WO PCT/GB2016/050277 patent/WO2016124947A1/en active Application Filing
- 2016-02-05 JP JP2017541693A patent/JP6786499B2/ja active Active
- 2016-02-05 MX MX2017009998A patent/MX2017009998A/es unknown
- 2016-02-05 AU AU2016214140A patent/AU2016214140B2/en active Active
- 2016-02-05 EP EP16703840.5A patent/EP3254111A1/en active Pending
- 2016-02-05 BR BR112017016808A patent/BR112017016808A2/pt not_active Application Discontinuation
- 2016-02-05 CA CA2974775A patent/CA2974775C/en active Active
- 2016-02-05 SG SG11201706223VA patent/SG11201706223VA/en unknown
-
2017
- 2017-07-28 IL IL253710A patent/IL253710B/en active IP Right Grant
- 2017-08-02 CL CL2017001972A patent/CL2017001972A1/es unknown
-
2018
- 2018-05-17 HK HK18106404.7A patent/HK1247276A1/zh unknown
-
2020
- 2020-08-26 US US17/003,139 patent/US11977077B2/en active Active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10782301B2 (en) | 2015-02-05 | 2020-09-22 | Queen Mary University Of London | Biomarkers for pancreatic cancer |
Also Published As
Publication number | Publication date |
---|---|
CN107533062B (zh) | 2021-03-23 |
HK1247276A1 (zh) | 2018-09-21 |
CA2974775A1 (en) | 2016-08-11 |
EP3254111A1 (en) | 2017-12-13 |
GB201501930D0 (en) | 2015-03-25 |
US20190204323A1 (en) | 2019-07-04 |
US20220042998A1 (en) | 2022-02-10 |
WO2016124947A1 (en) | 2016-08-11 |
IL253710B (en) | 2020-08-31 |
JP2018504609A (ja) | 2018-02-15 |
CN107533062A (zh) | 2018-01-02 |
AU2016214140A1 (en) | 2017-08-17 |
KR102569984B1 (ko) | 2023-08-22 |
SG11201706223VA (en) | 2017-08-30 |
AU2016214140B2 (en) | 2021-11-04 |
CL2017001972A1 (es) | 2018-03-23 |
KR20170129118A (ko) | 2017-11-24 |
EP4458849A2 (en) | 2024-11-06 |
US11977077B2 (en) | 2024-05-07 |
IL253710A0 (en) | 2017-09-28 |
JP6786499B2 (ja) | 2020-11-18 |
MX2017009998A (es) | 2018-02-01 |
US10782301B2 (en) | 2020-09-22 |
CA2974775C (en) | 2023-11-07 |
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |