BRPI0408978B8 - processos para regenerar uma fase estacionária cromatográfica - Google Patents

processos para regenerar uma fase estacionária cromatográfica

Info

Publication number
BRPI0408978B8
BRPI0408978B8 BRPI0408978A BRPI0408978A BRPI0408978B8 BR PI0408978 B8 BRPI0408978 B8 BR PI0408978B8 BR PI0408978 A BRPI0408978 A BR PI0408978A BR PI0408978 A BRPI0408978 A BR PI0408978A BR PI0408978 B8 BRPI0408978 B8 BR PI0408978B8
Authority
BR
Brazil
Prior art keywords
stationary phase
regenerating
processes
chromatographic stationary
chromatographic
Prior art date
Application number
BRPI0408978A
Other languages
English (en)
Inventor
Schroder Rasmussen Eigil
Schou Ole
Larsen Per
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36118397&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0408978(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority claimed from PCT/DK2004/000234 external-priority patent/WO2004089504A1/en
Publication of BRPI0408978A publication Critical patent/BRPI0408978A/pt
Publication of BRPI0408978B1 publication Critical patent/BRPI0408978B1/pt
Publication of BRPI0408978B8 publication Critical patent/BRPI0408978B8/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/203—Equilibration or regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/3425—Regenerating or reactivating of sorbents or filter aids comprising organic materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
    • B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/3433—Regenerating or reactivating of sorbents or filter aids other than those covered by B01J20/3408 - B01J20/3425

Abstract

"processos para regenerar uma fase estacionária cromatográfica e para produzir um polipeptídeo terapêutico ou um precursor do mesmo, uso do mesmo, fase estacionária cromatográfica, produto de polipeptídeo, equipamento cromatográfico automatizado, e, composição farmacêutica". processo para regenerar fases estacionárias cromatográficas.
BRPI0408978A 2003-04-08 2004-04-02 processos para regenerar uma fase estacionária cromatográfica BRPI0408978B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200300536 2003-04-08
DKPA200300536 2003-04-08
DKPA200400098 2004-01-26
DKPA200400098 2004-01-26
PCT/DK2004/000234 WO2004089504A1 (en) 2003-04-08 2004-04-02 Regeneration of chromatographic stationary phases

Publications (3)

Publication Number Publication Date
BRPI0408978A BRPI0408978A (pt) 2006-04-04
BRPI0408978B1 BRPI0408978B1 (pt) 2018-05-15
BRPI0408978B8 true BRPI0408978B8 (pt) 2021-07-27

Family

ID=36118397

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408978A BRPI0408978B8 (pt) 2003-04-08 2004-04-02 processos para regenerar uma fase estacionária cromatográfica

Country Status (4)

Country Link
US (2) US20060102561A1 (pt)
KR (1) KR101198346B1 (pt)
CN (1) CN1771080B (pt)
BR (1) BRPI0408978B8 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007121271A (ja) * 2005-09-30 2007-05-17 National Institute Of Advanced Industrial & Technology ８−ヒドロキシ−２’−デオキシグアノシンの測定方法及び測定のための装置
WO2010066676A1 (en) * 2008-12-09 2010-06-17 Upfront Chromatography A/S Method of removal of unbound, entrained and/or non-specifically adsorbed material from an affinity chromatography column
US8357301B2 (en) * 2009-06-24 2013-01-22 Hoffmann-La Roche, Inc. Chromatography equipment characterization
HUE034308T2 (en) 2013-03-21 2018-02-28 Sanofi Aventis Deutschland Preparation of hydantoin-containing peptide products
DK2976325T3 (en) 2013-03-21 2017-06-06 Sanofi Aventis Deutschland SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID
JP6602765B2 (ja) * 2013-09-05 2019-11-06 ジェネンテック， インコーポレイテッド クロマトグラフィー再使用のための方法
CN105424839A (zh) * 2015-12-15 2016-03-23 袁泳 高效液相色谱仪中反相填料柱的再生方法
CN105964606B (zh) * 2016-04-22 2018-07-10 内蒙古蒙牛乳业（集团）股份有限公司 延长色谱柱使用寿命的清洗方法
CN109011698B (zh) * 2018-08-25 2020-12-01 江苏曼氏生物科技股份有限公司 一种硅胶填料分离柱在线清洗及储存方法
CN112933660A (zh) * 2020-09-11 2021-06-11 石家庄新奥环保科技有限公司 一种离子色谱保护柱再生方法
CN112843789A (zh) * 2020-12-29 2021-05-28 上海赛梵科分离技术有限公司 大麻二酚纯化中色谱填料和层析介质的再生方法
WO2022167891A1 (en) * 2021-02-02 2022-08-11 Biocon Biologics Limited A process for the regeneration of silica based reverse phase chromatography material
IL308179A (en) * 2021-05-07 2024-01-01 Genzyme Corp Compound and methods for disinfection

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164481A (en) * 1978-01-27 1979-08-14 The Dow Chemical Company Process of regenerating a noble metal catalyst used in the reduction of organic nitro compounds
SU1270689A1 (ru) 1984-12-17 1986-11-15 Предприятие П/Я В-8644 Способ регенерации хроматографической колонки
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
EP0420964A4 (en) 1989-04-11 1991-09-25 Immunobiology Research Institute, Inc. Lyophilized peptide formulations
DE4028120C2 (de) 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5837826A (en) * 1995-02-27 1998-11-17 Regents Of The University Of Minnesota Protein adsorption by very dense porous zirconium oxide particles in expanded beds
US6852690B1 (en) * 1995-08-22 2005-02-08 Amylin Pharmaceuticals, Inc. Method and composition for enhanced parenteral nutrition
US6115233A (en) 1996-06-28 2000-09-05 Lsi Logic Corporation Integrated circuit device having a capacitor with the dielectric peripheral region being greater than the dielectric central region
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
DE19652713C2 (de) 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
JPH10221323A (ja) * 1997-02-10 1998-08-21 Teijin Ltd 吸着カラムの連続使用方法及び装置
AU724141B2 (en) * 1997-03-31 2000-09-14 Battelle Memorial Institute Apparatus and method for ammonia removal from waste streams
AU2610799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives with helix-content exceeding 25 per cent, forming partially structured micellar-like aggregates
JP2002504527A (ja) 1998-02-27 2002-02-12 ノボ ノルディスク アクティーゼルスカブ 部分的に組織化したミセル様凝集物を形成する２５％を越えるヘリックス成分を有するｇｌｐ−２誘導体
WO2000037098A1 (en) 1998-12-22 2000-06-29 Eli Lilly And Company Shelf-stable formulation of glucagon-like peptide-1
CA2356706C (en) 1999-01-14 2014-09-30 Amylin Pharmaceuticals, Inc. Novel exendin agonist formulations and methods of administration thereof
US6248683B1 (en) 1999-04-07 2001-06-19 Silicycle Inc. Process for the regeneration of used silica gel
SI1180121T1 (en) * 1999-05-17 2004-04-30 Conjuchem, Inc. Long lasting insulinotropic peptides
IL147745A0 (en) 1999-08-09 2002-08-14 Pharmacia & Upjohn Spa Formulations for parenteral use of estramustine phosphate and albumin
JP2001133446A (ja) 1999-08-20 2001-05-18 Sekisui Chem Co Ltd 液体クロマトグラフ装置及びこれに用いる洗浄液
CA2385179A1 (en) 1999-10-08 2001-04-19 David J. Hammond Isoagglutinin-depleted blood compositions and methods of making same
JP4473999B2 (ja) 2000-01-17 2010-06-02 積水化学工業株式会社 カラム洗浄液
US6550320B1 (en) 2000-05-31 2003-04-22 Continental Ag System and method for predicting tire forces using tire deformation sensors
AU2001287550B2 (en) 2000-09-13 2007-03-22 Novo Nordisk Health Care Ag Human coagulation factor VII variants
CA2434237C (en) 2000-12-07 2012-05-15 Eli Lilly And Company Glp-1 fusion proteins
JPWO2002068116A1 (ja) * 2001-02-28 2004-06-24 出光興産株式会社 吸着剤の再生方法
JP2002265383A (ja) 2001-03-14 2002-09-18 Mitsubishi Pharma Corp インターフェロンα注射用液状製剤
FI20010977A (fi) * 2001-05-09 2002-11-10 Danisco Sweeteners Oy Kromatografinen erotusmenetelmä
WO2003002136A2 (en) 2001-06-28 2003-01-09 Novo Nordisk A/S Stable formulation of modified glp-1
EP1487838B1 (en) * 2002-02-28 2008-09-03 Mallinckrodt Inc. Method and system for separation and purification of at least one narcotic alkaloid using reverse phase preparative chromatography
US20060252916A1 (en) 2002-06-04 2006-11-09 Eli Lilly And Company Modified glucagon-like peptide-1 analogs
EP1545574B8 (en) * 2002-09-13 2014-09-24 Biogen Idec Inc. Method of purifying polypeptides by simulated moving bed chromatography
DE10347975B4 (de) 2002-10-24 2008-10-09 Siemens Ag Einrichtung der programmierbaren Logik
RU2239827C1 (ru) 2003-05-12 2004-11-10 Государственный научно-исследовательский институт органической химии и технологии Восстановление аналитических и препаративных колонок для высокоэффективной жидкостной хроматографии (вэжх)
EP1506809A1 (en) * 2003-08-11 2005-02-16 Boehringer Ingelheim Pharma GmbH & Co. KG Regeneration of hydrolysis sensitive adsorbent matrices
US7449116B2 (en) * 2004-10-01 2008-11-11 Agilent Technologies, Inc. Methods and systems for protein separation

Also Published As

Publication number Publication date
BRPI0408978B1 (pt) 2018-05-15
US20060102561A1 (en) 2006-05-18
KR101198346B1 (ko) 2012-11-06
BRPI0408978A (pt) 2006-04-04
KR20060015496A (ko) 2006-02-17
CN1771080B (zh) 2010-12-15
CN1771080A (zh) 2006-05-10
US20080312131A1 (en) 2008-12-18
US9364772B2 (en) 2016-06-14

Similar Documents

Publication Publication Date Title
BRPI0408978B8 (pt) processos para regenerar uma fase estacionária cromatográfica
BRPI0413644A (pt) métodos para separar as duas formas de um polipeptìdeo tendo uma única racemização de aminoácido, e para separar dois polipeptìdeos, produto de polipeptìdeo, e, composição farmacêutica
HK1095815A1 (zh) 細胞粘着調節劑
CL2004001267A1 (es) Compuestos derivados de quinazolina, inhibidor de quinasa; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y su uso para preparar un medicamento para tratar trastornos proliferativos celulares tales como ateroesclerosis,
ZA200501082B (en) Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof
TW200519075A (en) Novel compounds
CL2004000889A1 (es) COMPUESTOS DERIVADOS DE PIRAZOLO[4,3-d]PIRIMIDINA; COMPUESTOS INTERMEDIARIOS; COMPOSICION FARMACEUTICA; PROCEDIMIENTO DE PREPARACION Y SU USO EN LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE LA HIPERTENSION.
ATE552274T1 (de) Mhc-oligomer und verfahren zu dessen herstellung
BR0008815B1 (pt) processo para a condensação fracionada de uma mistura gasosa do produto, e, coluna de separação.
SE0301009D0 (sv) Novel compounds
MXPA03008419A (es) Amidas de acido antranilico, metodo para su produccion, su uso como agentes anti-arritmia, y preparaciones farmaceuticas de las mismas.
AU2793102A (en) Ortho-substituted and meta-substituted bis-aryl compounds, method for the production thereof, their use as a medicament, and pharmaceutical preparations containing these compounds
DE602004031301D1 (de) Nichtsymmetrisches geliermittel
ATE425179T1 (de) Reinigung von glykopeptiden
IL165012A0 (en) (S)-4-Amino-5-chloro-2-methoxy-N-Ä1-(-tetrahydrofurylcarbonyl)-4-piperidinylmethylÜ-4-piperidinylÜbenzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor
HUP0600854A2 (en) Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use thereof as medicaments, in addition to a medicament containing same
BR0007610A (pt) Método para preparação de cloridrato del-fenilefrina
BR9807936A (pt) Preparação farmacêutica imuno-tolerante de complexo de pró-trombina, processo para a produção de uma preparação, e, utilização de uma preparação
MXPA03007635A (es) P-tienilbencilamidas que sirven como agonistas de receptores para angiotensina-(1-7), metodo para su produccion, su uso y preparaciones farmaceuticas que las contienen.
BRPI9914571B1 (pt) composto, processo para sua preparação, uso do mesmo, bem como composição farmacêutica.
WO2005012271A3 (en) Process for the synthesis of biaryl oxazolidinones
CL2004001068A1 (es) Compuestos derivados de 2,3,4,5-tetrahidrobenzo[f][1,4]oxazepina; procedimientos de preparacion; composicion farmaceutica que los contiene y su uso en la elaboracion de un medicamento util para el tratamiento de la enfermedad de alzheimer.
BR0315836A (pt) Derivados de [6,7-dihidro-5h-imidazol[1,2-alfa]imadazol-3-sulfonila mino]-propionamida, composição farmacêutica, uso do mesmo, bem como processo para sua preparação
CA2296560A1 (en) Amino acid derivatives useful to treat stroke
ATE454386T1 (de) Neue indolizinderivate, verfahren zu deren herstellung und therapeutische zusammensetzungen, die diese enthalten

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/04/2004, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B22O Other matters related to patents and certificates of addition of invention: legal action concerning patent

Free format text: INPI NO 52402.012649/2021-87 ORIGEM: 22A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 1087272-97.2021.4.01.3400 ACAO DE PROCEDIMENTO COMUM AUTOR: NOVO NORDISK A/S E NOVO NORDISK FARMACEUTICA DO BRASIL LTDA. REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI