DK0400583T3 - Imidazoquinoxalinoner,deres azaanaloger og fremgangsmåde til fremstilling deraf - Google Patents
Imidazoquinoxalinoner,deres azaanaloger og fremgangsmåde til fremstilling derafInfo
- Publication number
- DK0400583T3 DK0400583T3 DK90110191T DK90110191T DK0400583T3 DK 0400583 T3 DK0400583 T3 DK 0400583T3 DK 90110191 T DK90110191 T DK 90110191T DK 90110191 T DK90110191 T DK 90110191T DK 0400583 T3 DK0400583 T3 DK 0400583T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazoquinoxalinones
- preparation
- methods
- aza analogues
- aza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/359,182 US5055465A (en) | 1989-05-31 | 1989-05-31 | Imidazoquinoxalinones, their aza analogs and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0400583T3 true DK0400583T3 (da) | 2000-03-13 |
Family
ID=23412679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90110191T DK0400583T3 (da) | 1989-05-31 | 1990-05-29 | Imidazoquinoxalinoner,deres azaanaloger og fremgangsmåde til fremstilling deraf |
Country Status (7)
Country | Link |
---|---|
US (1) | US5055465A (da) |
EP (1) | EP0400583B1 (da) |
AT (1) | ATE186728T1 (da) |
DE (1) | DE69033355T2 (da) |
DK (1) | DK0400583T3 (da) |
ES (1) | ES2138956T3 (da) |
GR (1) | GR3032611T3 (da) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602252A (en) * | 1989-11-17 | 1997-02-11 | Berlex Laboratories, Inc. | Tricyclic pteridinones and a process for their preparation |
US5854419A (en) * | 1989-11-17 | 1998-12-29 | Schering Aktiengesellschaft | Tricyclic pteridinones and a process for their preparation |
US5182386A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
AU672617B2 (en) * | 1992-06-22 | 1996-10-10 | Regents Of The University Of California, The | Glycine receptor antagonists and the use thereof |
DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
US5306819A (en) * | 1992-08-27 | 1994-04-26 | Neurogen Corporation | Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands |
DE4310523A1 (de) * | 1993-03-31 | 1994-10-06 | Basf Ag | Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen |
US5631373A (en) | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
JPH09510695A (ja) * | 1994-01-03 | 1997-10-28 | エイシア・ファーマシュウティカルズ,インコーポレイテッド | 8−アザ、6−アザ、および6,8−ジアザ−1,4−ジヒドロキノキサリン−2,3−ジオン類およびそのグリシン/nmdaリセプターに対するアンタゴニストとしての使用 |
JPH09508632A (ja) * | 1994-02-11 | 1997-09-02 | ノボ ノルディスク アクティーゼルスカブ | 複素環式化合物並びにそれらの製造及び使用 |
JPH10513435A (ja) * | 1994-09-30 | 1998-12-22 | ビーエーエスエフ アクチェンゲゼルシャフト | 複素環で置換された新規イミダゾロキノキサリノン、その製造および使用 |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
DE19611476A1 (de) * | 1996-03-22 | 1997-09-25 | Basf Ag | Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung |
DE19961302A1 (de) * | 1999-12-18 | 2001-06-21 | Dresden Arzneimittel | Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen |
IL144156A0 (en) * | 1999-01-20 | 2002-05-23 | Dresden Arzneimittel | Use of imidazo [1,5-a]-pyrido [3,2-e] -pyrazinones as medicaments |
JP2002540102A (ja) * | 1999-03-22 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | cGMPホスホジエステラーゼの縮合ピリドピリダジン阻害剤 |
DE10012373A1 (de) * | 2000-03-14 | 2001-09-20 | Dresden Arzneimittel | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
EP1312363A1 (en) * | 2001-09-28 | 2003-05-21 | Pfizer Products Inc. | Methods of treatment and kits comprising a growth hormone secretagogue |
US7342884B2 (en) * | 2002-03-13 | 2008-03-11 | Harmonic, Inc. | Method and apparatus for one directional communications in bidirectional communications channel |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
CN101553491B (zh) * | 2006-12-13 | 2013-05-29 | Aska制药株式会社 | 喹喔啉衍生物 |
AU2008329072A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-A) pyrazines as inhibitors of phosphodiesterase 10 |
JP2011505366A (ja) * | 2007-11-30 | 2011-02-24 | ワイス・エルエルシー | ホスホエステラーゼ10の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ[1,5−a]ピラジン |
US20090143361A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 |
US7928105B2 (en) * | 2009-01-23 | 2011-04-19 | Takeda Pharmaceutical Company Limited | Substituted 6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-ones |
US8541417B2 (en) | 2009-07-30 | 2013-09-24 | Takeda Pharmaceutical Company Limited | Poly (ADP-ribose) polymerase (PARP) inhibitors |
US20110190192A1 (en) * | 2009-12-15 | 2011-08-04 | Cebix Inc. | Methods for treating erectile dysfunction in patients with insulin-dependent diabetes |
ES2747423T3 (es) | 2010-09-07 | 2020-03-10 | Astellas Pharma Inc | Compuesto de quinoxalina |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138564A (en) * | 1977-08-03 | 1979-02-06 | American Home Products Corporation | Tetrahydro[1H]pyrazino[1,2-a]azaquinoxalin-5(6H)-ones and derivatives thereof |
SE441449B (sv) * | 1979-02-09 | 1985-10-07 | Roussel Uclaf | Heterocykliska derivat och farmaceutiska kompositioner innehallande dessa derivat |
US4333394A (en) * | 1979-12-31 | 1982-06-08 | Brown Stanford M | Method for handling and baling metallic scrap material |
US4440929A (en) * | 1981-07-16 | 1984-04-03 | Usv Pharmaceutical Corporation | Imidazoquinoxaline compounds |
US4761414A (en) * | 1986-08-19 | 1988-08-02 | G. D. Searle & Co. | Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides |
-
1989
- 1989-05-31 US US07/359,182 patent/US5055465A/en not_active Expired - Fee Related
-
1990
- 1990-05-29 ES ES90110191T patent/ES2138956T3/es not_active Expired - Lifetime
- 1990-05-29 DK DK90110191T patent/DK0400583T3/da active
- 1990-05-29 AT AT90110191T patent/ATE186728T1/de not_active IP Right Cessation
- 1990-05-29 DE DE69033355T patent/DE69033355T2/de not_active Expired - Fee Related
- 1990-05-29 EP EP90110191A patent/EP0400583B1/en not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400310T patent/GR3032611T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5055465A (en) | 1991-10-08 |
EP0400583B1 (en) | 1999-11-17 |
DE69033355T2 (de) | 2000-05-11 |
GR3032611T3 (en) | 2000-05-31 |
DE69033355D1 (de) | 1999-12-23 |
EP0400583A1 (en) | 1990-12-05 |
ES2138956T3 (es) | 2000-02-01 |
ATE186728T1 (de) | 1999-12-15 |
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