DK0402322T3 - Fremgangsmåde til fremstilling af R(+)-aminocarnitin og S(-)-aminocarnitin - Google Patents
Fremgangsmåde til fremstilling af R(+)-aminocarnitin og S(-)-aminocarnitinInfo
- Publication number
- DK0402322T3 DK0402322T3 DK90830159.1T DK90830159T DK0402322T3 DK 0402322 T3 DK0402322 T3 DK 0402322T3 DK 90830159 T DK90830159 T DK 90830159T DK 0402322 T3 DK0402322 T3 DK 0402322T3
- Authority
- DK
- Denmark
- Prior art keywords
- aminocarnitine
- chloride
- preparation
- diastereoisomers
- methylbenzyl
- Prior art date
Links
- SKMSOHALMZCXFM-UHFFFAOYSA-N 3-amino-3-hydroxy-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)CC(N)(O)CC([O-])=O SKMSOHALMZCXFM-UHFFFAOYSA-N 0.000 title 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 3
- DAWBGYHPBBDHMQ-ZCFIWIBFSA-N (3r)-3-amino-4-(trimethylazaniumyl)butanoate Chemical compound C[N+](C)(C)C[C@H](N)CC([O-])=O DAWBGYHPBBDHMQ-ZCFIWIBFSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947842A IT1231751B (it) | 1989-04-12 | 1989-04-12 | Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0402322T3 true DK0402322T3 (da) | 1994-10-24 |
Family
ID=11262871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90830159.1T DK0402322T3 (da) | 1989-04-12 | 1990-04-11 | Fremgangsmåde til fremstilling af R(+)-aminocarnitin og S(-)-aminocarnitin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5041643A (da) |
| EP (1) | EP0402322B1 (da) |
| JP (1) | JP2941350B2 (da) |
| AT (1) | ATE108174T1 (da) |
| DE (1) | DE69010405T2 (da) |
| DK (1) | DK0402322T3 (da) |
| ES (1) | ES2056431T3 (da) |
| HK (1) | HK1005866A1 (da) |
| IT (1) | IT1231751B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1238344B (it) * | 1989-10-20 | 1993-07-13 | Sigma Tau Ind Farmaceuti | Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma |
| IT1240760B (it) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
| IT1254136B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica. |
| IT1254135B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
| FR2688499B1 (fr) * | 1992-03-10 | 1994-05-06 | Rhone Poulenc Rorer Sa | Procede de preparation de la beta-phenylisoserine et de ses analogues. |
| US5939561A (en) * | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| HUT65327A (en) * | 1992-06-11 | 1994-05-02 | Sandoz Ag | Process for producing phosphinyloxy-propyl-ammonium inner sact derwatives ang pharmateutical preparations containing them |
| IT1261230B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. |
| IT1261828B (it) * | 1993-07-14 | 1996-06-03 | Sigma Tau Ind Farmaceuti | Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. |
| IT1261489B (it) * | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
| US7776915B2 (en) * | 2005-03-24 | 2010-08-17 | Tracie Martyn International, Llc | Topical formulations and methods of use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767781A (en) * | 1981-11-26 | 1988-08-30 | Takeda Chemical Industries, Ltd. | Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use |
| US4521432A (en) * | 1981-11-26 | 1985-06-04 | Takeda Chemical Industries, Ltd. | Physiologically active substance FA-5859, its derivative, their production and use |
| CH652270GA3 (da) * | 1983-05-19 | 1985-11-15 | ||
| US4781863A (en) * | 1984-04-02 | 1988-11-01 | Cornell Research Foundation, Inc. | Aminocarnitines |
| IT1205758B (it) * | 1987-03-18 | 1989-03-31 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di (-) n-acetil ammino carnitina e di (+) n-acetil ammino carnitina |
-
1989
- 1989-04-12 IT IT8947842A patent/IT1231751B/it active
-
1990
- 1990-04-10 US US07/506,823 patent/US5041643A/en not_active Expired - Lifetime
- 1990-04-11 DK DK90830159.1T patent/DK0402322T3/da active
- 1990-04-11 AT AT90830159T patent/ATE108174T1/de not_active IP Right Cessation
- 1990-04-11 ES ES90830159T patent/ES2056431T3/es not_active Expired - Lifetime
- 1990-04-11 DE DE69010405T patent/DE69010405T2/de not_active Expired - Lifetime
- 1990-04-11 JP JP2096137A patent/JP2941350B2/ja not_active Expired - Lifetime
- 1990-04-11 EP EP90830159A patent/EP0402322B1/en not_active Expired - Lifetime
-
1998
- 1998-06-05 HK HK98104944A patent/HK1005866A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02304049A (ja) | 1990-12-17 |
| HK1005866A1 (en) | 1999-01-29 |
| IT1231751B (it) | 1991-12-21 |
| EP0402322B1 (en) | 1994-07-06 |
| US5041643A (en) | 1991-08-20 |
| ES2056431T3 (es) | 1994-10-01 |
| JP2941350B2 (ja) | 1999-08-25 |
| ATE108174T1 (de) | 1994-07-15 |
| DE69010405T2 (de) | 1994-10-20 |
| EP0402322A2 (en) | 1990-12-12 |
| DE69010405D1 (de) | 1994-08-11 |
| IT8947842A0 (it) | 1989-04-12 |
| EP0402322A3 (en) | 1991-01-02 |
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