IT1240760B - Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. - Google Patents

Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.

Info

Publication number
IT1240760B
IT1240760B IT47618A IT4761890A IT1240760B IT 1240760 B IT1240760 B IT 1240760B IT 47618 A IT47618 A IT 47618A IT 4761890 A IT4761890 A IT 4761890A IT 1240760 B IT1240760 B IT 1240760B
Authority
IT
Italy
Prior art keywords
acid
coma
gamma
acyl
treatment
Prior art date
Application number
IT47618A
Other languages
English (en)
Other versions
IT9047618A1 (it
IT9047618A0 (it
Inventor
Maria Ornella Tinti
Domenico Misiti
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT9047618A0 publication Critical patent/IT9047618A0/it
Priority to IT47618A priority Critical patent/IT1240760B/it
Priority to AT91830024T priority patent/ATE109128T1/de
Priority to DE69103037T priority patent/DE69103037T2/de
Priority to ES91830024T priority patent/ES2057837T3/es
Priority to EP91830024A priority patent/EP0442850B1/en
Priority to DK91830024.5T priority patent/DK0442850T3/da
Priority to JP3039174A priority patent/JP2930749B2/ja
Publication of IT9047618A1 publication Critical patent/IT9047618A1/it
Application granted granted Critical
Publication of IT1240760B publication Critical patent/IT1240760B/it
Priority to US08/317,750 priority patent/US5543556A/en
Priority to US08/395,914 priority patent/US5534549A/en
Priority to HK98104934.4A priority patent/HK1005859B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT47618A 1990-02-12 1990-02-12 Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. IT1240760B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT47618A IT1240760B (it) 1990-02-12 1990-02-12 Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
EP91830024A EP0442850B1 (en) 1990-02-12 1991-01-28 Esters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
DE69103037T DE69103037T2 (de) 1990-02-12 1991-01-28 Ester von Acyl L-Carnitin mit Gamma-Hydroxybuttersäure und diese enthaltende pharmazeutische Zusammensetzungen zur Inhibierung von neuronaler Degeneration und zur Behandlung von Koma.
ES91830024T ES2057837T3 (es) 1990-02-12 1991-01-28 Esteres de acil l-carnitinas con acido gamma-hidroxibutirico y composiciones farmaceuticas que los contienen para inhibir degeneracion neuronal y para el tratamiento de coma.
AT91830024T ATE109128T1 (de) 1990-02-12 1991-01-28 Ester von acyl l-carnitin mit gamma- hydroxybuttersäure und diese enthaltende pharmazeutische zusammensetzungen zur inhibierung von neuronaler degeneration und zur behandlung von koma.
DK91830024.5T DK0442850T3 (da) 1990-02-12 1991-01-28 Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma
JP3039174A JP2930749B2 (ja) 1990-02-12 1991-02-08 アシル−Ｌ−カルニチンとγ−ヒドロキシ酪酸とのエステル
US08/317,750 US5543556A (en) 1990-02-12 1994-10-04 Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
US08/395,914 US5534549A (en) 1990-02-12 1995-02-28 Easters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
HK98104934.4A HK1005859B (en) 1990-02-12 1998-06-05 Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT47618A IT1240760B (it) 1990-02-12 1990-02-12 Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.

Publications (3)

Publication Number Publication Date
IT9047618A0 IT9047618A0 (it) 1990-02-12
IT9047618A1 IT9047618A1 (it) 1991-08-13
IT1240760B true IT1240760B (it) 1993-12-17

Family

ID=11261466

Family Applications (1)

Application Number Title Priority Date Filing Date
IT47618A IT1240760B (it) 1990-02-12 1990-02-12 Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.

Country Status (8)

Country Link
US (2) US5543556A (it)
EP (1) EP0442850B1 (it)
JP (1) JP2930749B2 (it)
AT (1) ATE109128T1 (it)
DE (1) DE69103037T2 (it)
DK (1) DK0442850T3 (it)
ES (1) ES2057837T3 (it)
IT (1) IT1240760B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1242020B (it) * 1990-11-20 1994-02-02 Sigma Tau Ind Farmaceuti Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono.
IT1244636B (it) * 1991-01-04 1994-08-08 Sigma Tau Ind Farmaceuti Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
IT1248321B (it) * 1991-05-15 1995-01-05 Sigma Tau Ind Farmaceuti Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1263013B (it) * 1992-10-20 1996-07-23 Avantgarde Spa Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261432B (it) * 1993-03-26 1996-05-23 Sigma Tau Ind Farmaceuti Uso di acil l- carnitina gammaidrossibutirrato per il trattamento dell'alcolismo.
IT1261984B (it) * 1993-06-22 1996-06-11 Avantgarde Spa Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
IT1261828B (it) * 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1276253B1 (it) 1995-12-15 1997-10-27 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US5863940A (en) 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
DE69820029T3 (de) 1998-03-19 2011-05-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Kombinierte Zusammensetzung bestehend aus L-Karnitin oder L-Alkanoylkarnitin, einem Glycosaminoglycan und/oder einem seiner Bestandteile
US7015200B2 (en) 2000-09-22 2006-03-21 Orphan Medical, Inc. Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers
WO2012069221A1 (en) 2010-11-22 2012-05-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutical method for the treatment of the leber optic
US20140294921A1 (en) 2010-12-09 2014-10-02 Sigma-Tau Industrie Famaceutiche Riunite S.P.A. Composition for tipical use for treating skin disorders
EP2783695A1 (en) 2013-03-28 2014-10-01 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Physiological supplement or medicament for ophthalmic use containing L-carnitine or alkanoyl L-carnitines in combination with eledoisin
EP4585270A3 (en) 2016-06-07 2025-09-24 The J. David Gladstone Institutes Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
EP3654963A4 (en) 2017-07-21 2021-04-14 Buck Institute for Research on Aging BETA-HYDROXYBUTYRATE AND BUTANEDIOL S ENANTIOMERS AND THEIR METHODS OF USE
US12037317B2 (en) 2018-01-25 2024-07-16 Buck Institute For Research On Aging Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032641A (en) * 1976-06-09 1977-06-28 Tanabe Seiyaku Co., Ltd. Nicotinoyl carnitine derivatives
AU518617B2 (en) * 1977-04-29 1981-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Therapeutic application of acetyl-d, 1-carnitine
IT1116037B (it) * 1979-04-23 1986-02-10 Sigma Tau Ind Farmaceuti Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1177874B (it) * 1984-07-04 1987-08-26 Sigma Tau Ind Farmaceuti Estere della acetil carnitina,procedimenti per la sua preparazione e composizioni farmaceutiche che lo contengono
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Also Published As

Publication number Publication date
ATE109128T1 (de) 1994-08-15
US5543556A (en) 1996-08-06
DE69103037T2 (de) 1994-11-17
IT9047618A1 (it) 1991-08-13
EP0442850A1 (en) 1991-08-21
ES2057837T3 (es) 1994-10-16
HK1005859A1 (en) 1999-01-29
US5534549A (en) 1996-07-09
JP2930749B2 (ja) 1999-08-03
EP0442850B1 (en) 1994-07-27
DE69103037D1 (de) 1994-09-01
IT9047618A0 (it) 1990-02-12
DK0442850T3 (da) 1994-09-05
JPH06179642A (ja) 1994-06-28

Similar Documents

Publication Publication Date Title
IT1240760B (it) Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1240775B (it) Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.
IT1238344B (it) Estere della l-carnitina con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che lo contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma
EP0150688B1 (en) Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
ZA93162B (en) Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antibacterial activity.
ITRM910333A1 (it) Ammidi con amminoacidi naturali di alcanoil l-carnitine quali inibitori della degenerazione neuronale e attivatori dei processi di apprendimento e memorizzazione e per il trattamento del coma e composizioni farmaceutiche comprendenti tali composti
DE69207479T2 (de) Verwendung der Ester von Acyl-L-Carnitin mit Gamma-Hydroxy-Buttersäure zur Herstellung von pharmazeutischen Zusammensetzungen zur Behandlung von Lebererkrankungen
HK1005848B (en) Use of esters of acyl l-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
KR940006576A (ko) 에이즈 및 에이즈 관련 증후군 환자 및 무증후성 hiv혈청양성 환자치료를 위한 l-카르니틴 및 아실 l-카르니틴의 용도
DE69410866D1 (de) Verwendung von Ester von Acyl-L-Carnitin mit Gammahydroxybuttersäure zur Behandlung von Alkoholismus
HK1005859B (en) Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
NZ616467A (en) Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940113