IT1242020B - Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono. - Google Patents
Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono.Info
- Publication number
- IT1242020B IT1242020B IT48494A IT4849490A IT1242020B IT 1242020 B IT1242020 B IT 1242020B IT 48494 A IT48494 A IT 48494A IT 4849490 A IT4849490 A IT 4849490A IT 1242020 B IT1242020 B IT 1242020B
- Authority
- IT
- Italy
- Prior art keywords
- carnitine
- alkyl
- taken together
- phtalidylidene
- pharmaceutical compositions
- Prior art date
Links
- 229960004203 carnitine Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical class C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 abstract 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 abstract 1
- 102000012440 Acetylcholinesterase Human genes 0.000 abstract 1
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract 1
- 206010027654 Allergic conditions Diseases 0.000 abstract 1
- 206010002199 Anaphylactic shock Diseases 0.000 abstract 1
- 229940022698 acetylcholinesterase Drugs 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 208000003455 anaphylaxis Diseases 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48494A IT1242020B (it) | 1990-11-20 | 1990-11-20 | Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono. |
| EP91830506A EP0488965B1 (en) | 1990-11-20 | 1991-11-19 | Phthalidilidene derivatives of carnitine and alkanoylcarnitines and pharmaceutical compositions containing them |
| DE69112785T DE69112785T2 (de) | 1990-11-20 | 1991-11-19 | Phthalidylidenderivate von Carnitin und Alkanoylcarnitinen sowie diese enthaltende pharmazeutische Mittel. |
| AT91830506T ATE127462T1 (de) | 1990-11-20 | 1991-11-19 | Phthalidylidenderivate von carnitin und alkanoylcarnitinen sowie diese enthaltende pharmazeutische mittel. |
| DK91830506.1T DK0488965T3 (da) | 1990-11-20 | 1991-11-19 | Phthalidylidenderivater af carnitin og alkanoylcarnitider samt farmaceutiske præparater med indhold heraf |
| ES91830506T ES2077210T3 (es) | 1990-11-20 | 1991-11-19 | Derivados de ftalidilideno de carnitina y alcanoilcarnitinas y composiciones farmaceuticas que los contienen. |
| GR950403218T GR3018094T3 (en) | 1990-11-20 | 1995-11-15 | Phthalidilidene derivatives of carnitine and alkanoylcarnitines and pharmaceutical compositions containing them. |
| HK98104927.3A HK1005870B (en) | 1990-11-20 | 1998-06-05 | Phthalidilidene derivatives of carnitine and alkanoylcarnitines and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48494A IT1242020B (it) | 1990-11-20 | 1990-11-20 | Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT9048494A0 IT9048494A0 (it) | 1990-11-20 |
| IT9048494A1 IT9048494A1 (it) | 1992-05-20 |
| IT1242020B true IT1242020B (it) | 1994-02-02 |
Family
ID=11266907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT48494A IT1242020B (it) | 1990-11-20 | 1990-11-20 | Ftalidilidene derivati della carnitina e di alcanoil carnitine e composizioni farmaceutiche che li contengono. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0488965B1 (it) |
| AT (1) | ATE127462T1 (it) |
| DE (1) | DE69112785T2 (it) |
| DK (1) | DK0488965T3 (it) |
| ES (1) | ES2077210T3 (it) |
| GR (1) | GR3018094T3 (it) |
| IT (1) | IT1242020B (it) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN178310B (it) * | 1993-06-25 | 1997-03-22 | Mobius Consultancy Pty Ltd | |
| IT1261828B (it) * | 1993-07-14 | 1996-06-03 | Sigma Tau Ind Farmaceuti | Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico. |
| IT1273987B (it) | 1994-09-29 | 1997-07-14 | Sigma Tau Ind Farmaceuti | Uso di esteri ftalidilidenici della carnitina e di alcanoil carnitine per il trattamento dello shock endotossico |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1240760B (it) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
-
1990
- 1990-11-20 IT IT48494A patent/IT1242020B/it active IP Right Grant
-
1991
- 1991-11-19 DK DK91830506.1T patent/DK0488965T3/da active
- 1991-11-19 ES ES91830506T patent/ES2077210T3/es not_active Expired - Lifetime
- 1991-11-19 DE DE69112785T patent/DE69112785T2/de not_active Expired - Fee Related
- 1991-11-19 AT AT91830506T patent/ATE127462T1/de not_active IP Right Cessation
- 1991-11-19 EP EP91830506A patent/EP0488965B1/en not_active Expired - Lifetime
-
1995
- 1995-11-15 GR GR950403218T patent/GR3018094T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0488965A1 (en) | 1992-06-03 |
| DE69112785D1 (de) | 1995-10-12 |
| ES2077210T3 (es) | 1995-11-16 |
| DE69112785T2 (de) | 1996-07-25 |
| HK1005870A1 (en) | 1999-01-29 |
| GR3018094T3 (en) | 1996-02-29 |
| EP0488965B1 (en) | 1995-09-06 |
| DK0488965T3 (da) | 1995-12-18 |
| ATE127462T1 (de) | 1995-09-15 |
| IT9048494A0 (it) | 1990-11-20 |
| IT9048494A1 (it) | 1992-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19940915 |