IT1244636B - Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. - Google Patents
Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.Info
- Publication number
- IT1244636B IT1244636B ITRM910002A ITRM910002A IT1244636B IT 1244636 B IT1244636 B IT 1244636B IT RM910002 A ITRM910002 A IT RM910002A IT RM910002 A ITRM910002 A IT RM910002A IT 1244636 B IT1244636 B IT 1244636B
- Authority
- IT
- Italy
- Prior art keywords
- treatment
- carnitine
- acetyl
- coma
- pharmaceutical compositions
- Prior art date
Links
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 title abstract 3
- 206010010071 Coma Diseases 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Viene descritto l'uso dell'acetil L-carnitina e dei suoi sali farmacologicamente accettabili nel trattamento terapeutico del coma.1000-2000 mg/giorno di acetil L-carnitina o una quantità equivalente di un suo sale farmacologicamente accettabile, vengono somministrati preferibilmente per via parenterale.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910002A IT1244636B (it) | 1991-01-04 | 1991-01-04 | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
ZA9110037A ZA9110037B (en) | 1991-01-04 | 1991-12-20 | The use of acetyl l-carnitine in the therapeutic treatment of coma and pharmacological compositions useful in such treatment |
JP34691591A JP3145451B2 (ja) | 1991-01-04 | 1991-12-27 | 昏睡治療のためのアセチル−l−カルニチンおよび医薬組成物 |
IE456891A IE66025B1 (en) | 1991-01-04 | 1991-12-30 | Use of acetyl L-carnitine in the therapeutic treatment of coma |
ES91830583T ES2070478T3 (es) | 1991-01-04 | 1992-01-01 | El empleo de acetil l-carnitina en el tratamiento terapeutico de coma. |
AT91830583T ATE119770T1 (de) | 1991-01-04 | 1992-01-01 | Verwendung von acetyl l-carnitin zur therapeutischen behandlung von coma. |
EP91830583A EP0498144B1 (en) | 1991-01-04 | 1992-01-01 | Use of acetyl L-carnitine in the therapeutic treatment of coma |
DK91830583.0T DK0498144T3 (da) | 1991-01-04 | 1992-01-01 | Anvendelse af acetyl-L-carnitin ved terapeutisk behandling af coma |
DE69201660T DE69201660T2 (de) | 1991-01-04 | 1992-01-01 | Verwendung von Acetyl L-Carnitin zur therapeutischen Behandlung von Coma. |
US07/816,224 US5192805A (en) | 1991-01-04 | 1992-01-03 | Use of acetyl l-carnitine in the therapeutic treatment of coma |
GR940403979T GR3015431T3 (en) | 1991-01-04 | 1995-03-16 | Use of acetyl L-carnitine in the therapeutic treatment of coma. |
HK98104930A HK1005847A1 (en) | 1991-01-04 | 1998-06-05 | Use of acetyl l-carnitine in the therapeutic treatment of coma |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM910002A IT1244636B (it) | 1991-01-04 | 1991-01-04 | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM910002A0 ITRM910002A0 (it) | 1991-01-04 |
ITRM910002A1 ITRM910002A1 (it) | 1992-07-04 |
IT1244636B true IT1244636B (it) | 1994-08-08 |
Family
ID=11399703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM910002A IT1244636B (it) | 1991-01-04 | 1991-01-04 | Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5192805A (it) |
EP (1) | EP0498144B1 (it) |
JP (1) | JP3145451B2 (it) |
AT (1) | ATE119770T1 (it) |
DE (1) | DE69201660T2 (it) |
DK (1) | DK0498144T3 (it) |
ES (1) | ES2070478T3 (it) |
GR (1) | GR3015431T3 (it) |
HK (1) | HK1005847A1 (it) |
IE (1) | IE66025B1 (it) |
IT (1) | IT1244636B (it) |
ZA (1) | ZA9110037B (it) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1254314B (it) * | 1992-03-27 | 1995-09-14 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari. |
IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
IT1277898B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie |
IT1276225B1 (it) * | 1995-10-17 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per |
IT1276253B1 (it) | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
US5872008A (en) * | 1996-02-09 | 1999-02-16 | Bair; Glenn O. | Methods for diagnosing pre-menstrual syndrome |
IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
IT1291113B1 (it) * | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
US6090848A (en) * | 1997-12-01 | 2000-07-18 | Sigma-Tau Healthscience S.P.A. | Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans |
US5863940A (en) | 1997-12-01 | 1999-01-26 | Sigma-Tau Healthscience S.P.A. | Medicament and therapeutical method for treating idiopathic asthenozoospermia |
SI0951909T2 (sl) | 1998-03-19 | 2010-11-30 | Sigma Tau Ind Farmaceuti | Kombinirana zmes ki vsebuje L karnitin ali alkanoil L karnitin glikozaminoglikan in ali njegov sestavni del |
US8173618B2 (en) * | 2003-07-25 | 2012-05-08 | University Of Massachusetts | Formulations for reducing neuronal degeneration |
US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
US8597640B2 (en) * | 2007-10-31 | 2013-12-03 | University Of Massachusetts Lowell | Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging |
AU2011267186B2 (en) | 2010-06-16 | 2017-01-19 | Alfasigma S.P.A. | Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue |
EP2586438A1 (en) | 2011-10-28 | 2013-05-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Compound useful for preventing cognitive deficit disorders in a new born from HIV-seropositive pregnant female who is in treatment with azidothymidine |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
IT1184655B (it) * | 1985-10-14 | 1987-10-28 | Sigma Tau Ind Farmaceuti | Imiego di acetil l-carnitina nel trattamento terapeutico degli stati di shock |
IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
IT1240760B (it) * | 1990-02-12 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma. |
-
1991
- 1991-01-04 IT ITRM910002A patent/IT1244636B/it active IP Right Grant
- 1991-12-20 ZA ZA9110037A patent/ZA9110037B/xx unknown
- 1991-12-27 JP JP34691591A patent/JP3145451B2/ja not_active Expired - Fee Related
- 1991-12-30 IE IE456891A patent/IE66025B1/en not_active IP Right Cessation
-
1992
- 1992-01-01 EP EP91830583A patent/EP0498144B1/en not_active Expired - Lifetime
- 1992-01-01 DE DE69201660T patent/DE69201660T2/de not_active Expired - Fee Related
- 1992-01-01 AT AT91830583T patent/ATE119770T1/de not_active IP Right Cessation
- 1992-01-01 ES ES91830583T patent/ES2070478T3/es not_active Expired - Lifetime
- 1992-01-01 DK DK91830583.0T patent/DK0498144T3/da active
- 1992-01-03 US US07/816,224 patent/US5192805A/en not_active Expired - Lifetime
-
1995
- 1995-03-16 GR GR940403979T patent/GR3015431T3/el unknown
-
1998
- 1998-06-05 HK HK98104930A patent/HK1005847A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH04295424A (ja) | 1992-10-20 |
GR3015431T3 (en) | 1995-06-30 |
EP0498144B1 (en) | 1995-03-15 |
DK0498144T3 (da) | 1995-07-24 |
ITRM910002A0 (it) | 1991-01-04 |
ATE119770T1 (de) | 1995-04-15 |
US5192805A (en) | 1993-03-09 |
DE69201660D1 (de) | 1995-04-20 |
DE69201660T2 (de) | 1995-07-20 |
IE914568A1 (en) | 1992-07-15 |
ZA9110037B (en) | 1992-09-30 |
ITRM910002A1 (it) | 1992-07-04 |
HK1005847A1 (en) | 1999-01-29 |
JP3145451B2 (ja) | 2001-03-12 |
IE66025B1 (en) | 1996-01-10 |
EP0498144A1 (en) | 1992-08-12 |
ES2070478T3 (es) | 1995-06-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19931202 |