IT1196564B - Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche - Google Patents

Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche

Info

Publication number
IT1196564B
IT1196564B IT48358/86A IT4835886A IT1196564B IT 1196564 B IT1196564 B IT 1196564B IT 48358/86 A IT48358/86 A IT 48358/86A IT 4835886 A IT4835886 A IT 4835886A IT 1196564 B IT1196564 B IT 1196564B
Authority
IT
Italy
Prior art keywords
carnitine
acetyl
therapeutic treatment
peripheral neuropathies
symptomatological
Prior art date
Application number
IT48358/86A
Other languages
English (en)
Other versions
IT8648358A0 (it
Inventor
Menotti Calvani
Luigi Mosconi
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT8648358A0 publication Critical patent/IT8648358A0/it
Priority to IT48358/86A priority Critical patent/IT1196564B/it
Priority to US07/078,152 priority patent/US4751242A/en
Priority to ZA875643A priority patent/ZA875643B/xx
Priority to ES198787830298T priority patent/ES2039262T3/es
Priority to AT87830298T priority patent/ATE70439T1/de
Priority to EP87830298A priority patent/EP0256999B1/en
Priority to CA000543534A priority patent/CA1298197C/en
Priority to DE8787830298T priority patent/DE3775301D1/de
Priority to DK403587A priority patent/DK164641C/da
Priority to JP62194285A priority patent/JPH085786B2/ja
Application granted granted Critical
Publication of IT1196564B publication Critical patent/IT1196564B/it
Priority to GR91401991T priority patent/GR3003405T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IT48358/86A 1986-08-04 1986-08-04 Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche IT1196564B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT48358/86A IT1196564B (it) 1986-08-04 1986-08-04 Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche
US07/078,152 US4751242A (en) 1986-08-04 1987-07-27 Use of acetyl L-carnitine in the therapeutical treatment of peripheral neuropathies
ZA875643A ZA875643B (en) 1986-08-04 1987-07-30 Use of acetyl l-carnitine in the therapeutical treatment of peripheral neuropathies
AT87830298T ATE70439T1 (de) 1986-08-04 1987-07-31 Verwendung von acetyl-l-carnitin zur herstellung eines medikamentes zur therapeutischen behandlung von peripheren neuropathien.
ES198787830298T ES2039262T3 (es) 1986-08-04 1987-07-31 Uso de acetil l-carnitina para la preparacion de un medicamento para el tratamiento terapeutico de neuropatias perifericas.
EP87830298A EP0256999B1 (en) 1986-08-04 1987-07-31 Use of acetyl l-carnitine for the preparation of a medicament for the therapeutical treatment of peripheral neuropathies
CA000543534A CA1298197C (en) 1986-08-04 1987-07-31 Use of acetyl l-carnitine in the therapeutical treatment of peripheral neuropathies
DE8787830298T DE3775301D1 (de) 1986-08-04 1987-07-31 Verwendung von acetyl-l-carnitin zur herstellung eines medikamentes zur therapeutischen behandlung von peripheren neuropathien.
DK403587A DK164641C (da) 1986-08-04 1987-08-03 Anvendelse af acetyl-l-carnitin og farmaologisk acceptable salte deraf til fremstilling af laegemidler til behandling af perifere neuropathier
JP62194285A JPH085786B2 (ja) 1986-08-04 1987-08-03 末梢神経障害の治療処置におけるアセチル−ｌ−カルニチンの使用
GR91401991T GR3003405T3 (en) 1986-08-04 1991-12-19 Use of acetyl l-carnitine for the preparation of a medicament for the therapeutical treatment of peripheral neuropathies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48358/86A IT1196564B (it) 1986-08-04 1986-08-04 Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche

Publications (2)

Publication Number Publication Date
IT8648358A0 IT8648358A0 (it) 1986-08-04
IT1196564B true IT1196564B (it) 1988-11-16

Family

ID=11266089

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48358/86A IT1196564B (it) 1986-08-04 1986-08-04 Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche

Country Status (11)

Country Link
US (1) US4751242A (it)
EP (1) EP0256999B1 (it)
JP (1) JPH085786B2 (it)
AT (1) ATE70439T1 (it)
CA (1) CA1298197C (it)
DE (1) DE3775301D1 (it)
DK (1) DK164641C (it)
ES (1) ES2039262T3 (it)
GR (1) GR3003405T3 (it)
IT (1) IT1196564B (it)
ZA (1) ZA875643B (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1224842B (it) * 1988-12-27 1990-10-24 Sigma Tau Ind Farmaceuti Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso
US5641764A (en) * 1989-03-31 1997-06-24 Peter Maccallum Institute Halogenated DNA ligand radiosensitizers for cancer therapy
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1244636B (it) * 1991-01-04 1994-08-08 Sigma Tau Ind Farmaceuti Uso dell'acetil l-carnitina nel trattamento terapeutico del coma e composizioni farmaceutiche utili in tale trattamento.
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1263004B (it) * 1992-10-08 1996-07-23 Sigma Tau Ind Farmaceuti Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti.
IT1276225B1 (it) * 1995-10-17 1997-10-27 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche contenenti l-carnitina e alcanoil l- carnitine in associazione con resveratrolo o suoi derivati utili per
IT1291127B1 (it) * 1997-04-01 1998-12-29 Sigma Tau Ind Farmaceuti Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
IT1294227B1 (it) * 1997-08-01 1999-03-24 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione
IT1298487B1 (it) * 1997-12-19 2000-01-10 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche comprendenti pentraxina lunga ptx3 per la terapia di patologie di tipo infettivo, infiammatorio o tumorale,
JPH11298323A (ja) 1998-04-16 1999-10-29 Nec Yamagata Ltd 高速ロックアップｐｌｌ回路
US20030199535A1 (en) * 1998-07-30 2003-10-23 Claudio Cavazza Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent
PT1100589E (pt) * 1998-07-30 2005-05-31 Sigma Tau Ind Farmaceuti Utilizacao de propionil-l-carnitina e acetil-l-carnitina na preparacao de medicamentos com actividade anticancerigena
IT1306178B1 (it) * 1999-07-27 2001-05-30 Sigma Tau Ind Farmaceuti Uso della l-carnitina e dei suoi alcanoil derivati per la preparazionedi un medicamento utile nel trattamento del paziente affetto da
US6562869B1 (en) * 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
US6479069B1 (en) * 1999-09-23 2002-11-12 Juvenon, Inc. Nutritional supplement for increased energy and stamina
ITRM20010293A1 (it) * 2001-05-29 2002-11-29 Sigma Tau Ind Farmaceuti Uso della acetil-l-carnetina per la preparazione di un medicamento per la prevenzione del dolore.
ITRM20010294A1 (it) * 2001-05-29 2002-11-29 Sigma Tau Ind Farmaceuti Uso della acetil l-carnetina in associazione con la biotina per il trattamento di pazienti affetti da diabete mellito di tipo ii insulino re
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
ITRM20040327A1 (it) * 2004-07-01 2004-10-01 Sigma Tau Ind Farmaceuti Uso della acetil l-carnitina per la preparazione di un medicamento per il trattamento del dolore neuropatico in pazienti diabetici.
US8569366B2 (en) 2005-04-26 2013-10-29 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Acetyl L-carnitine for prevention of painful peripheral neuropathy in patients with type 2 diabetes
EP1874288B1 (en) * 2005-04-26 2013-07-17 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Acetyl l-carnitine for preventing painful peripheral diabetic neuropathy
US20080161604A1 (en) * 2005-04-26 2008-07-03 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Acetyl L-Carnitine For Preventing Painful Peripheral Diabetic Neuropathy
JP2006347935A (ja) * 2005-06-15 2006-12-28 Masanori Ogata 炎症性サイトカインの産生が関与する疾患の予防及び／又は治療のための医薬
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
SG10201503032UA (en) 2010-06-16 2015-06-29 Sigma Tau Ind Farmaceuti Acetyl-carnitine for use in a method for increasing neurogenesis in neural tissue
WO2016157053A1 (en) * 2015-03-31 2016-10-06 Kolinpharma S.P.A. A composition for the treatment of neuropathies and/or neuropathic pain
US10036011B2 (en) * 2016-02-11 2018-07-31 Qiagen Waltham, Inc. Scavenger compounds for improved sequencing-by-synthesis
AU2021272292A1 (en) 2020-05-15 2023-02-02 Alfasigma S.P.A. Composition comprising methylfolate
EP4364730A1 (en) 2022-11-02 2024-05-08 Chiesi Italia S.p.A. Pharmaceutical composition comprising l-acetyl carnitine and beta-caryophyllene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346107A (en) * 1979-02-12 1982-08-24 Claudio Cavazza Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism

Also Published As

Publication number Publication date
CA1298197C (en) 1992-03-31
JPH085786B2 (ja) 1996-01-24
DK164641C (da) 1992-12-14
EP0256999A2 (en) 1988-02-24
ES2039262T3 (es) 1993-09-16
JPS6344522A (ja) 1988-02-25
EP0256999A3 (en) 1989-05-31
GR3003405T3 (en) 1993-02-17
US4751242A (en) 1988-06-14
IT8648358A0 (it) 1986-08-04
DK164641B (da) 1992-07-27
ZA875643B (en) 1988-11-30
EP0256999B1 (en) 1991-12-18
DE3775301D1 (de) 1992-01-30
DK403587A (da) 1988-02-05
DK403587D0 (da) 1987-08-03
ATE70439T1 (de) 1992-01-15

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Legal Events

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ITCP Complementary protection certificate

Free format text: CCP 394

MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 394, 19920630; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SPA

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970626