IT1181682B - Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto - Google Patents
Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indottoInfo
- Publication number
- IT1181682B IT1181682B IT48206/85A IT4820685A IT1181682B IT 1181682 B IT1181682 B IT 1181682B IT 48206/85 A IT48206/85 A IT 48206/85A IT 4820685 A IT4820685 A IT 4820685A IT 1181682 B IT1181682 B IT 1181682B
- Authority
- IT
- Italy
- Prior art keywords
- idiopathic
- carnitine
- alcanoil
- therapeutic treatment
- induced parkinsonism
- Prior art date
Links
- 208000027089 Parkinsonian disease Diseases 0.000 title abstract 2
- 206010034010 Parkinsonism Diseases 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- -1 alkanoyl L-carnitines Chemical class 0.000 abstract 2
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000002117 illicit drug Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48206/85A IT1181682B (it) | 1985-06-11 | 1985-06-11 | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
US06/869,083 US4663352A (en) | 1985-06-11 | 1986-05-30 | Use of some alkanoyl L-carnitines for the therapeutical treatment of idiopathic and induced Parkinsonism |
DE8686830150T DE3686520T2 (de) | 1985-06-11 | 1986-06-03 | Verwendung von einigen alkanoyl-l-carnitinen zur herstellung eines arzneimittels zur therapeutischen behandlung von ideopathischem oder induziertem parkinsonismus. |
AT86830150T ATE79749T1 (de) | 1985-06-11 | 1986-06-03 | Verwendung von einigen alkanoyl-l-carnitinen zur herstellung eines arzneimittels zur therapeutischen behandlung von ideopathischem oder induziertem parkinsonismus. |
EP86830150A EP0207011B1 (en) | 1985-06-11 | 1986-06-03 | Use of some alkanoyl l-carnitines for the manufacture of a medicament for therapeutical treatment of idiopathic and induced parkinsonism |
JP61135868A JPH0684298B2 (ja) | 1985-06-11 | 1986-06-10 | パ−キンソン病治療薬 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT48206/85A IT1181682B (it) | 1985-06-11 | 1985-06-11 | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
Publications (2)
Publication Number | Publication Date |
---|---|
IT8548206A0 IT8548206A0 (it) | 1985-06-11 |
IT1181682B true IT1181682B (it) | 1987-09-30 |
Family
ID=11265224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT48206/85A IT1181682B (it) | 1985-06-11 | 1985-06-11 | Impiego di alcanoil l-carnitine per il trattamento terapeutico del parkinsonismo idiopatico o indotto |
Country Status (6)
Country | Link |
---|---|
US (1) | US4663352A (it) |
EP (1) | EP0207011B1 (it) |
JP (1) | JPH0684298B2 (it) |
AT (1) | ATE79749T1 (it) |
DE (1) | DE3686520T2 (it) |
IT (1) | IT1181682B (it) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1208753B (it) * | 1986-07-02 | 1989-07-10 | Sigma Tau Ind Farmaceuti | L-amminoacil derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche ad attivita' epatoprotettrice che li contengono |
IT1224842B (it) * | 1988-12-27 | 1990-10-24 | Sigma Tau Ind Farmaceuti | Uso di derivati della l-carnitina nel trattamento terapeutico delle alterazioni degenerative del sistema nervoso |
US5641764A (en) * | 1989-03-31 | 1997-06-24 | Peter Maccallum Institute | Halogenated DNA ligand radiosensitizers for cancer therapy |
IT1245699B (it) * | 1991-05-29 | 1994-10-14 | Sigma Tau Ind Farmaceuti | Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi |
IT1263004B (it) * | 1992-10-08 | 1996-07-23 | Sigma Tau Ind Farmaceuti | Impiego della l-carnitina e acil l-carnitine nel trattamento a lungo termine di pazienti diabetici non insulino-dipendenti. |
IT1284661B1 (it) * | 1996-06-06 | 1998-05-21 | Sigma Tau Ind Farmaceuti | Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali. |
IT1305308B1 (it) * | 1999-03-26 | 2001-05-04 | Biosint S P A | Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione |
US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
US20060252775A1 (en) * | 2005-05-03 | 2006-11-09 | Henderson Samuel T | Methods for reducing levels of disease associated proteins |
KR101170266B1 (ko) | 2008-05-30 | 2012-08-01 | 케이씨아이 라이센싱 인코포레이티드 | 감압으로 선형적인 상처를 폐쇄하는 볼스터 및 시스템 |
AU2009262881B2 (en) | 2008-05-30 | 2013-05-23 | Solventum Intellectual Properties Company | Reduced-pressure, compression systems and apparatuses for use on a curved body part |
EP2586438A1 (en) | 2011-10-28 | 2013-05-01 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Compound useful for preventing cognitive deficit disorders in a new born from HIV-seropositive pregnant female who is in treatment with azidothymidine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4346107A (en) * | 1979-02-12 | 1982-08-24 | Claudio Cavazza | Pharmaceutical composition comprising acyl-carnitine for the treatment of impaired cerebral metabolism |
IT1206954B (it) * | 1979-02-12 | 1989-05-17 | Sigma Tau Ind Farmaceuti | Agenti terapeutici a base di un acil derivato della carnitina per la cura di vasculopatie periferiche |
IT1150396B (it) * | 1982-12-09 | 1986-12-10 | Sigma Tau Ind Farmaceuti | Impiego di alcanoil l-carnitine per il trattamento terapeutico di miopa tie e distrofie muscolari |
US4537772A (en) * | 1984-05-02 | 1985-08-27 | Merck & Co., Inc. | Enhancing absorption of drugs from gastrointestinal tract using acylcarnitines |
-
1985
- 1985-06-11 IT IT48206/85A patent/IT1181682B/it active
-
1986
- 1986-05-30 US US06/869,083 patent/US4663352A/en not_active Expired - Lifetime
- 1986-06-03 DE DE8686830150T patent/DE3686520T2/de not_active Expired - Fee Related
- 1986-06-03 EP EP86830150A patent/EP0207011B1/en not_active Expired - Lifetime
- 1986-06-03 AT AT86830150T patent/ATE79749T1/de not_active IP Right Cessation
- 1986-06-10 JP JP61135868A patent/JPH0684298B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4663352A (en) | 1987-05-05 |
DE3686520D1 (de) | 1992-10-01 |
JPH0684298B2 (ja) | 1994-10-26 |
EP0207011A3 (en) | 1989-11-29 |
EP0207011A2 (en) | 1986-12-30 |
DE3686520T2 (de) | 1993-02-18 |
ATE79749T1 (de) | 1992-09-15 |
EP0207011B1 (en) | 1992-08-26 |
IT8548206A0 (it) | 1985-06-11 |
JPS61286326A (ja) | 1986-12-16 |
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Legal Events
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Effective date: 19970515 |