BR9306841A - Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico - Google Patents

Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico

Info

Publication number
BR9306841A
BR9306841A BR9306841A BR9306841A BR9306841A BR 9306841 A BR9306841 A BR 9306841A BR 9306841 A BR9306841 A BR 9306841A BR 9306841 A BR9306841 A BR 9306841A BR 9306841 A BR9306841 A BR 9306841A
Authority
BR
Brazil
Prior art keywords
antihistamine treatment
human patient
cardiac arrhythmia
providing
treatment
Prior art date
Application number
BR9306841A
Other languages
English (en)
Inventor
James W Young
Raymond L Woosley
Nancy M Gray
Yiwang Chen
Original Assignee
Sepracor Inc
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27129882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9306841(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sepracor Inc, Univ Georgetown filed Critical Sepracor Inc
Publication of BR9306841A publication Critical patent/BR9306841A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
BR9306841A 1992-08-03 1993-08-03 Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico BR9306841A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92418292A 1992-08-03 1992-08-03
US92415692A 1992-08-03 1992-08-03
PCT/US1993/007260 WO1994003170A1 (en) 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Publications (1)

Publication Number Publication Date
BR9306841A true BR9306841A (pt) 1998-12-08

Family

ID=27129882

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9306841A BR9306841A (pt) 1992-08-03 1993-08-03 Composição farmacêutica processo para proporcionar um tratamento anti-histamínico o qual não induz qualquer arritmia cardíaca significativa em um paciente ser humano e uso de uma composição para a mnaufactura de um medicamento para uso em um tratamento anti-histamínico

Country Status (24)

Country Link
US (1) US5375693A (pt)
EP (4) EP0701443B2 (pt)
JP (6) JP3041954B2 (pt)
KR (1) KR950702420A (pt)
AT (3) ATE363283T1 (pt)
AU (3) AU675240B2 (pt)
BR (1) BR9306841A (pt)
CA (1) CA2141572C (pt)
CZ (1) CZ27495A3 (pt)
DE (5) DE69334145T2 (pt)
DK (3) DK0815860T3 (pt)
ES (3) ES2284740T3 (pt)
FI (1) FI950467A (pt)
GB (1) GB2284351B (pt)
GR (3) GR960300024T1 (pt)
HK (1) HK1045806B (pt)
HU (1) HU226242B1 (pt)
NO (1) NO310644B1 (pt)
PL (1) PL174373B1 (pt)
PT (2) PT815860E (pt)
RO (1) RO116043B1 (pt)
RU (1) RU2167657C2 (pt)
SK (1) SK12495A3 (pt)
WO (1) WO1994003170A1 (pt)

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HU223774B1 (hu) * 1992-05-11 2005-01-28 Merrell Dow Pharmaceuticals Inc. Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására
ATE363283T1 (de) 1992-08-03 2007-06-15 Sepracor Inc Terfenadin-carboxylat und die behandlung von hautreizung
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DE69415319T2 (de) 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
CA2449419C (en) 1994-05-18 2011-09-06 Aventis Pharmaceuticals Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US5455049A (en) * 1995-01-04 1995-10-03 Ascent Pharmaceuticals, Inc. Terfenadine oral powder
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
GB9513972D0 (en) * 1995-07-08 1995-09-06 Merck Sharp & Dohme Pharmaceutical compositions
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US5922736A (en) 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US5908850A (en) * 1995-12-04 1999-06-01 Celgene Corporation Method of treating attention deficit disorders with d-threo methylphenidate
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5733756A (en) * 1996-01-05 1998-03-31 Celgene Corporation Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US6355656B1 (en) 1995-12-04 2002-03-12 Celgene Corporation Phenidate drug formulations having diminished abuse potential
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
IL133420A (en) * 1997-08-26 2004-07-25 Aventis Pharma Inc Tablet-shaped pharmaceutical preparation containing a combination of piperidinoalkanol and antihistamines and reduces symptomatic congestion
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE19913862C2 (de) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
WO2002080857A2 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2003020274A1 (en) * 2001-08-30 2003-03-13 Aventis Pharmaceuticals Inc. Treatment of atopic dermatitis
US20040044038A1 (en) * 2002-06-10 2004-03-04 Barnaba Krochmal Polymorphic form XVI of fexofenadine hydrochloride
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
JP4515121B2 (ja) 2004-03-15 2010-07-28 東芝テック株式会社 ワイヤドットプリンタヘッド及びワイヤドットプリンタ
JP4473021B2 (ja) 2004-03-22 2010-06-02 東芝テック株式会社 窒化層形成方法、磁気回路形成部材、アーマチュア、ワイヤドットプリンタヘッド及びワイヤドットプリンタ
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
MXPA06012281A (es) * 2004-04-26 2007-07-18 Teva Pharma Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion.
US7498443B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US20060148851A1 (en) * 2004-09-28 2006-07-06 Shlomit Wizel Fexofenadine crystal form and processes for its preparation thereof
AU2005313887B2 (en) * 2004-12-09 2011-10-27 Celgene Corporation Treatment using D-threo methylphenidate
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
CN101940571A (zh) * 2007-04-13 2011-01-12 南方研究所 抗血管生成剂和使用方法
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20150238473A1 (en) * 2012-09-27 2015-08-27 University Of Rochester Methods and compositions for treating infection
CA2980162C (en) * 2015-03-26 2024-06-18 Jacqueline M. Iversen Methods and compositions to inhibit symptoms associated with veisalgia
DE102017130361A1 (de) 2017-12-18 2019-07-04 Lsp Innovative Automotive Systems Gmbh Statorzahn und Stator mit guter elektrischer Isolierung und gleichzeitig sehr hoher Wärmeleitfähigkeit zur Leistungssteigerung von Elektromotoren

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US880801A (en) † 1908-03-03 Harold Larsen Vibrator.
US922890A (en) † 1907-03-26 1909-05-25 Peder Joergen Hansen Stream-motor.
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4552899A (en) † 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4829064A (en) † 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4996061A (en) † 1987-10-07 1991-02-26 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol-decongestant combination
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
WO1993021156A1 (en) * 1992-04-10 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-diphenylmethyl piperidine derivatives and process for their preparation
HU223774B1 (hu) 1992-05-11 2005-01-28 Merrell Dow Pharmaceuticals Inc. Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására
ATE363283T1 (de) 1992-08-03 2007-06-15 Sepracor Inc Terfenadin-carboxylat und die behandlung von hautreizung
DE69415319T2 (de) * 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
ATE230395T1 (de) * 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
CA2128821A1 (en) * 1993-07-27 1995-01-28 Dilip J. Gole Freeze-dried pharmaceutical dosage form and process for separation thereof
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate

Also Published As

Publication number Publication date
SK12495A3 (en) 1997-01-08
GR960300024T1 (en) 1996-05-31
EP1214937A3 (en) 2002-10-30
PT1214937E (pt) 2007-07-25
JPH08500348A (ja) 1996-01-16
DE69316660T3 (de) 2001-04-05
AU675240B2 (en) 1997-01-30
DE701443T1 (de) 1997-01-30
JP2000086512A (ja) 2000-03-28
ES2086270T3 (es) 1998-03-01
ES2257757T3 (es) 2006-08-01
PL307339A1 (en) 1995-05-15
ES2284740T3 (es) 2007-11-16
DK0815860T3 (da) 2006-08-14
GB2284351A (en) 1995-06-07
EP0701443A1 (en) 1996-03-20
RO116043B1 (ro) 2000-10-30
EP0701443B2 (en) 2000-11-22
EP1214937A2 (en) 2002-06-19
HUT71889A (en) 1996-02-28
JP2000086513A (ja) 2000-03-28
JP3041954B2 (ja) 2000-05-15
US5375693A (en) 1994-12-27
GR3026530T3 (en) 1998-07-31
ATE322899T1 (de) 2006-04-15
ATE162399T1 (de) 1998-02-15
JP3288660B2 (ja) 2002-06-04
HU226242B1 (en) 2008-07-28
AU4798693A (en) 1994-03-03
AU1842999A (en) 1999-04-29
GB9502183D0 (en) 1995-03-22
GB2284351B (en) 1996-11-27
EP0815860A3 (en) 1998-01-14
FI950467A0 (fi) 1995-02-02
EP1688142A1 (en) 2006-08-09
RU95107881A (ru) 1996-11-27
PL174373B1 (pl) 1998-07-31
NO950374L (no) 1995-03-29
KR950702420A (ko) 1995-07-29
JP2000086514A (ja) 2000-03-28
ATE363283T1 (de) 2007-06-15
RU2167657C2 (ru) 2001-05-27
DE9320925U1 (de) 1995-08-31
JP3288661B2 (ja) 2002-06-04
CZ27495A3 (en) 1996-09-11
DE69334008T2 (de) 2006-10-19
DK1214937T3 (da) 2007-09-17
ES2086270T5 (es) 2001-02-01
HU9500313D0 (en) 1995-03-28
EP0701443B1 (en) 1998-01-21
EP0815860A2 (en) 1998-01-07
HK1045806B (zh) 2008-03-14
EP0815860B1 (en) 2006-04-12
DE69316660D1 (de) 1998-02-26
FI950467A (fi) 1995-03-31
HK1045806A1 (en) 2002-12-13
JP3037697B2 (ja) 2000-04-24
DK0701443T3 (da) 1998-02-09
NO310644B1 (no) 2001-08-06
CA2141572C (en) 2001-02-06
DE69334145D1 (de) 2007-07-12
ES2086270T1 (es) 1996-07-01
WO1994003170A1 (en) 1994-02-17
DE69334145T2 (de) 2008-01-24
JP2000086515A (ja) 2000-03-28
PT815860E (pt) 2006-08-31
GR3035417T3 (en) 2001-05-31
CA2141572A1 (en) 1994-02-17
DE69334008D1 (de) 2006-05-24
DE69316660T2 (de) 1998-05-07
JP2000086516A (ja) 2000-03-28
DK0701443T4 (da) 2000-12-18
JP3288662B2 (ja) 2002-06-04
AU7182296A (en) 1997-01-30
EP1214937B1 (en) 2007-05-30
NO950374D0 (no) 1995-02-01

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Legal Events

Date Code Title Description
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal