ES2086270T3 - Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos. - Google Patents
Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos.Info
- Publication number
- ES2086270T3 ES2086270T3 ES93918584T ES93918584T ES2086270T3 ES 2086270 T3 ES2086270 T3 ES 2086270T3 ES 93918584 T ES93918584 T ES 93918584T ES 93918584 T ES93918584 T ES 93918584T ES 2086270 T3 ES2086270 T3 ES 2086270T3
- Authority
- ES
- Spain
- Prior art keywords
- terfenadine
- metabolites
- optically pure
- allergic disorders
- pure isomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
Abstract
UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO DE FORMULA (I): DONDE Z ES COOH, COOCH{SUB,3} O CH{SUB,2}OH, O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, PARA USAR EN UN TRATAMIENTO ANTIHISTAMINICO QUE NO INDUZCA UNA ARRITMIA CARDIACA SIGNIFICATIVA, QUE CONSTA DE LA ADMINISTRACION DE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN COMPUESTO DE FORMULA (I) A UN PACIENTE HUMANO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92418292A | 1992-08-03 | 1992-08-03 | |
US92415692A | 1992-08-03 | 1992-08-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
ES2086270T1 ES2086270T1 (es) | 1996-07-01 |
ES2086270T3 true ES2086270T3 (es) | 1998-03-01 |
ES2086270T5 ES2086270T5 (es) | 2001-02-01 |
Family
ID=27129882
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93918584T Expired - Lifetime ES2086270T5 (es) | 1992-08-03 | 1993-08-03 | Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos. |
ES97104837T Expired - Lifetime ES2257757T3 (es) | 1992-08-03 | 1993-08-03 | Carboxilato de terfenadina y el tratamiento de trastornos alergicos. |
ES02006356T Expired - Lifetime ES2284740T3 (es) | 1992-08-03 | 1993-08-03 | Carboxilato de terfenadina y el tratamiento de la irritacion cutanea. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97104837T Expired - Lifetime ES2257757T3 (es) | 1992-08-03 | 1993-08-03 | Carboxilato de terfenadina y el tratamiento de trastornos alergicos. |
ES02006356T Expired - Lifetime ES2284740T3 (es) | 1992-08-03 | 1993-08-03 | Carboxilato de terfenadina y el tratamiento de la irritacion cutanea. |
Country Status (24)
Country | Link |
---|---|
US (1) | US5375693A (es) |
EP (4) | EP0701443B2 (es) |
JP (6) | JP3041954B2 (es) |
KR (1) | KR950702420A (es) |
AT (3) | ATE162399T1 (es) |
AU (3) | AU675240B2 (es) |
BR (1) | BR9306841A (es) |
CA (1) | CA2141572C (es) |
CZ (1) | CZ27495A3 (es) |
DE (5) | DE9320925U1 (es) |
DK (3) | DK0815860T3 (es) |
ES (3) | ES2086270T5 (es) |
FI (1) | FI950467A (es) |
GB (1) | GB2284351B (es) |
GR (3) | GR960300024T1 (es) |
HK (1) | HK1045806B (es) |
HU (1) | HU226242B1 (es) |
NO (1) | NO310644B1 (es) |
PL (1) | PL174373B1 (es) |
PT (2) | PT1214937E (es) |
RO (1) | RO116043B1 (es) |
RU (1) | RU2167657C2 (es) |
SK (1) | SK12495A3 (es) |
WO (1) | WO1994003170A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ251834A (en) * | 1992-05-11 | 1997-07-27 | Merrell Dow Pharma | Use of acid derivatives of terfenadine as antihistamines |
DE9320925U1 (de) * | 1992-08-03 | 1995-08-31 | Sepracor Inc | Terfenadin-Metabolite und deren optisch reine Isomere für die Behandlung von allergischen Störungen |
US20020007068A1 (en) | 1999-07-16 | 2002-01-17 | D'ambra Thomas E. | Piperidine derivatives and process for their production |
EP0723958A1 (en) * | 1993-06-24 | 1996-07-31 | Albany Molecular Research, Inc. | Synthesis of substantially pure terfenadine derivatives |
WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
CA2449419C (en) | 1994-05-18 | 2011-09-06 | Aventis Pharmaceuticals Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
US5455049A (en) * | 1995-01-04 | 1995-10-03 | Ascent Pharmaceuticals, Inc. | Terfenadine oral powder |
MX9706449A (es) * | 1995-02-28 | 1997-11-29 | Hoechst Marion Roussel Inc | Composicion farmaceutica para compuestos de piperidinalcanol. |
GB9513972D0 (en) * | 1995-07-08 | 1995-09-06 | Merck Sharp & Dohme | Pharmaceutical compositions |
US5906747A (en) * | 1995-11-13 | 1999-05-25 | Biosepra Inc. | Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates |
US6486177B2 (en) | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
US5908850A (en) * | 1995-12-04 | 1999-06-01 | Celgene Corporation | Method of treating attention deficit disorders with d-threo methylphenidate |
US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
US6355656B1 (en) | 1995-12-04 | 2002-03-12 | Celgene Corporation | Phenidate drug formulations having diminished abuse potential |
US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
US5733756A (en) * | 1996-01-05 | 1998-03-31 | Celgene Corporation | Lactams and processes for stereoselective enrichment of lactams, amides, and esters |
US6153754A (en) | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
US6201124B1 (en) | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
ES2124167B1 (es) * | 1996-06-04 | 1999-09-16 | Espanola Prod Quimicos | Nuevos derivados del bencimidazol con actividad antihistaminica. |
US5925761A (en) * | 1997-02-04 | 1999-07-20 | Sepracor Inc. | Synthesis of terfenadine and derivatives |
US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
ATE238773T1 (de) * | 1997-08-26 | 2003-05-15 | Aventis Pharma Inc | Arzneimittel für die kombination piperidinoalkanol-dekongestivum |
US6194431B1 (en) * | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
DE19913862C2 (de) * | 1999-03-26 | 2003-04-10 | Forschungszentrum Juelich Gmbh | Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen |
DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
US6613907B2 (en) | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
WO2002080857A2 (en) * | 2001-04-09 | 2002-10-17 | Teva Pharmaceutical Industries Ltd. | Polymorphs of fexofenadine hydrochloride |
US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
WO2003020274A1 (en) * | 2001-08-30 | 2003-03-13 | Aventis Pharmaceuticals Inc. | Treatment of atopic dermatitis |
US20040044038A1 (en) * | 2002-06-10 | 2004-03-04 | Barnaba Krochmal | Polymorphic form XVI of fexofenadine hydrochloride |
US20050026890A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
JP4515121B2 (ja) | 2004-03-15 | 2010-07-28 | 東芝テック株式会社 | ワイヤドットプリンタヘッド及びワイヤドットプリンタ |
JP4473021B2 (ja) | 2004-03-22 | 2010-06-02 | 東芝テック株式会社 | 窒化層形成方法、磁気回路形成部材、アーマチュア、ワイヤドットプリンタヘッド及びワイヤドットプリンタ |
US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
KR20070007196A (ko) * | 2004-04-26 | 2007-01-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 펙소페나딘 히드로클로라이드의 결정형 및 이의 제조 방법 |
US7498443B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
US7498345B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
WO2006037042A1 (en) * | 2004-09-28 | 2006-04-06 | Teva Pharmaceutical Industries Ltd. | Fexofenadine crystal form and processes for its preparation thereof |
AU2005313887B2 (en) * | 2004-12-09 | 2011-10-27 | Celgene Corporation | Treatment using D-threo methylphenidate |
NZ568694A (en) | 2005-11-09 | 2011-09-30 | Zalicus Inc | Method, compositions, and kits for the treatment of medical conditions |
ES2534588T3 (es) * | 2007-04-13 | 2015-04-24 | Southern Research Institute | Terfenadina como agente antiangiogénico |
US20090076080A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched fexofenadine |
WO2014052836A2 (en) | 2012-09-27 | 2014-04-03 | Dunman Paul M | Methods and compositions for treating infection |
CN115887456A (zh) | 2015-03-26 | 2023-04-04 | 杰奎琳·M·艾弗森 | 抑制与宿醉相关的症状的方法和组合物 |
DE102017130361A1 (de) | 2017-12-18 | 2019-07-04 | Lsp Innovative Automotive Systems Gmbh | Statorzahn und Stator mit guter elektrischer Isolierung und gleichzeitig sehr hoher Wärmeleitfähigkeit zur Leistungssteigerung von Elektromotoren |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US880801A (en) † | 1908-03-03 | Harold Larsen | Vibrator. | |
US922890A (en) † | 1907-03-26 | 1909-05-25 | Peder Joergen Hansen | Stream-motor. |
US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4552899A (en) † | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
US4829064A (en) † | 1987-06-08 | 1989-05-09 | Analgesic Associates | Cough/cold mixtures comprising non-sedating antihistamine drugs |
US4929605A (en) * | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
US4996061A (en) † | 1987-10-07 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol-decongestant combination |
JP3686950B2 (ja) * | 1992-04-10 | 2005-08-24 | メレル ファーマスーティカルズ インコーポレイテッド | ピペリジン誘導体類の新規な方法 |
NZ251834A (en) | 1992-05-11 | 1997-07-27 | Merrell Dow Pharma | Use of acid derivatives of terfenadine as antihistamines |
DE9320925U1 (de) | 1992-08-03 | 1995-08-31 | Sepracor Inc | Terfenadin-Metabolite und deren optisch reine Isomere für die Behandlung von allergischen Störungen |
EP0723958A1 (en) * | 1993-06-24 | 1996-07-31 | Albany Molecular Research, Inc. | Synthesis of substantially pure terfenadine derivatives |
HU226037B1 (en) * | 1993-06-25 | 2008-03-28 | Aventis Inc | Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates |
CA2128820A1 (en) * | 1993-07-27 | 1995-01-28 | Walter G. Gowan, Jr. | Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof |
CA2128821A1 (en) * | 1993-07-27 | 1995-01-28 | Dilip J. Gole | Freeze-dried pharmaceutical dosage form and process for separation thereof |
WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
-
1993
- 1993-08-03 DE DE9320925U patent/DE9320925U1/de not_active Expired - Lifetime
- 1993-08-03 EP EP93918584A patent/EP0701443B2/en not_active Expired - Lifetime
- 1993-08-03 EP EP06114048A patent/EP1688142A1/en not_active Withdrawn
- 1993-08-03 JP JP6505499A patent/JP3041954B2/ja not_active Expired - Lifetime
- 1993-08-03 HU HU9500313A patent/HU226242B1/hu unknown
- 1993-08-03 CA CA002141572A patent/CA2141572C/en not_active Expired - Lifetime
- 1993-08-03 DE DE0701443T patent/DE701443T1/de active Pending
- 1993-08-03 PT PT02006356T patent/PT1214937E/pt unknown
- 1993-08-03 ES ES93918584T patent/ES2086270T5/es not_active Expired - Lifetime
- 1993-08-03 PT PT97104837T patent/PT815860E/pt unknown
- 1993-08-03 DE DE69316660T patent/DE69316660T3/de not_active Expired - Lifetime
- 1993-08-03 SK SK124-95A patent/SK12495A3/sk unknown
- 1993-08-03 AT AT93918584T patent/ATE162399T1/de active
- 1993-08-03 DK DK97104837T patent/DK0815860T3/da active
- 1993-08-03 DK DK02006356T patent/DK1214937T3/da active
- 1993-08-03 GB GB9502183A patent/GB2284351B/en not_active Revoked
- 1993-08-03 KR KR1019950700382A patent/KR950702420A/ko not_active Application Discontinuation
- 1993-08-03 ES ES97104837T patent/ES2257757T3/es not_active Expired - Lifetime
- 1993-08-03 AU AU47986/93A patent/AU675240B2/en not_active Expired
- 1993-08-03 EP EP02006356A patent/EP1214937B1/en not_active Revoked
- 1993-08-03 RO RO95-00160A patent/RO116043B1/ro unknown
- 1993-08-03 DE DE69334145T patent/DE69334145T2/de not_active Expired - Lifetime
- 1993-08-03 DK DK93918584T patent/DK0701443T4/da active
- 1993-08-03 ES ES02006356T patent/ES2284740T3/es not_active Expired - Lifetime
- 1993-08-03 BR BR9306841A patent/BR9306841A/pt not_active Application Discontinuation
- 1993-08-03 AT AT02006356T patent/ATE363283T1/de active
- 1993-08-03 PL PL93307339A patent/PL174373B1/pl unknown
- 1993-08-03 AT AT97104837T patent/ATE322899T1/de active
- 1993-08-03 EP EP97104837A patent/EP0815860B1/en not_active Revoked
- 1993-08-03 DE DE69334008T patent/DE69334008T2/de not_active Expired - Lifetime
- 1993-08-03 RU RU95107881/14A patent/RU2167657C2/ru active
- 1993-08-03 WO PCT/US1993/007260 patent/WO1994003170A1/en active IP Right Grant
-
1994
- 1994-02-02 US US08/191,061 patent/US5375693A/en not_active Expired - Lifetime
-
1995
- 1995-02-01 NO NO19950374A patent/NO310644B1/no not_active IP Right Cessation
- 1995-02-02 FI FI950467A patent/FI950467A/fi unknown
- 1995-02-03 CZ CZ95274A patent/CZ27495A3/cs unknown
-
1996
- 1996-05-31 GR GR960300024T patent/GR960300024T1/el unknown
- 1996-11-19 AU AU71822/96A patent/AU7182296A/en not_active Abandoned
-
1998
- 1998-04-03 GR GR980400714T patent/GR3026530T3/el unknown
-
1999
- 1999-02-25 AU AU18429/99A patent/AU1842999A/en not_active Abandoned
- 1999-10-13 JP JP29122099A patent/JP3288660B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP29122899A patent/JP3288662B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP11291216A patent/JP2000086512A/ja active Pending
- 1999-10-13 JP JP11291230A patent/JP3037697B2/ja not_active Expired - Lifetime
- 1999-10-13 JP JP29122399A patent/JP3288661B2/ja not_active Expired - Lifetime
-
2001
- 2001-02-14 GR GR20010400247T patent/GR3035417T3/el unknown
-
2002
- 2002-08-17 HK HK02106014.7A patent/HK1045806B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2086270T5 (es) | Metabolitos de terfenadina y sus isomeros opticamente puros para tratar trastornos alergicos. | |
PT920865E (pt) | Utilizacao de ""norastemizole"" para o tratamento de disturbios alergicos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 701443 Country of ref document: ES |