ES2064652T3 - Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato. - Google Patents

Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato.

Info

Publication number
ES2064652T3
ES2064652T3 ES90309995T ES90309995T ES2064652T3 ES 2064652 T3 ES2064652 T3 ES 2064652T3 ES 90309995 T ES90309995 T ES 90309995T ES 90309995 T ES90309995 T ES 90309995T ES 2064652 T3 ES2064652 T3 ES 2064652T3
Authority
ES
Spain
Prior art keywords
hydrogen
tetrahidronaftaleno
difosfonato
naftaleno
gem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90309995T
Other languages
English (en)
Inventor
Lawrence Ivan Kruse
Virendra Premchand Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898920860A external-priority patent/GB8920860D0/en
Priority claimed from GB898920861A external-priority patent/GB8920861D0/en
Application filed by Symphar SA filed Critical Symphar SA
Application granted granted Critical
Publication of ES2064652T3 publication Critical patent/ES2064652T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPUESTOS DE LA ESTRUCTURA (I) EN DONDE: EN DONDE R ES HIDROGENO O C1-4 ALQUILO Y Q ES 0 O 1; R1 ES HIDROGENO O C1-4 ALQUILO; R2, R3, R4 Y R5 SON EL MISMO O DISTINTO Y SON OR7, EN DONDE R7 ES HIDROGENO O C1-8 ALQUILO; O R2 Y R3 JUNTOS, Y R4 Y R5 JUNTOS FORMAN UN ANILLO DIOXI DE C2-8 ALQUILENO; R6 ES HIDROGENO O C1-4 ALQUILO; M ES 0 O 1, Y A ES S, S(CH2)N, CH=CHCH2, (CH2)N O (CH=CH)P(CH2)TCH= EN DONDE N ES 1 A 7, P ES 0 O 1 Y T ES 0 A 4, A CONDICION DE QUE M SEA 0 SOLO CUANDO A SEA (CH=CH)P(CH2)TCH=, PROCESOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y SU USO EN TERAPIA COMO AGENTES ANTIHIPERLIPIDEMICOS.
ES90309995T 1989-09-14 1990-09-12 Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato. Expired - Lifetime ES2064652T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898920860A GB8920860D0 (en) 1989-09-14 1989-09-14 Compounds
GB898920861A GB8920861D0 (en) 1989-09-14 1989-09-14 Compounds

Publications (1)

Publication Number Publication Date
ES2064652T3 true ES2064652T3 (es) 1995-02-01

Family

ID=26295923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90309995T Expired - Lifetime ES2064652T3 (es) 1989-09-14 1990-09-12 Derivados de naftaleno- y tetrahidronaftaleno-gem-difosfonato.

Country Status (13)

Country Link
EP (1) EP0418064B1 (es)
JP (1) JPH03112994A (es)
KR (1) KR910006310A (es)
AT (1) ATE115586T1 (es)
AU (1) AU624733B2 (es)
CA (1) CA2025268A1 (es)
DE (1) DE69015072T2 (es)
DK (1) DK0418064T3 (es)
ES (1) ES2064652T3 (es)
GR (1) GR3015376T3 (es)
IE (1) IE903327A1 (es)
NZ (1) NZ235295A (es)
PT (1) PT95286A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2067974A1 (en) * 1991-05-13 1992-11-14 Scott A. Biller Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
EP0541037A3 (en) * 1991-11-06 1997-02-26 Takeda Chemical Industries Ltd Squalene synthetase inhibitory composition and use thereof
JPH06172372A (ja) * 1991-11-06 1994-06-21 Takeda Chem Ind Ltd スクアレン合成酵素阻害剤およびその用途
US5618804A (en) * 1992-07-10 1997-04-08 Toray Industries, Inc. Methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals
ITMI20111161A1 (it) 2011-06-24 2012-12-25 Ansaldo Fuel Cells Spa Sistema mcfc multi-stack e metodo per separare co2 da fumi di combustione contenenti nox e sox

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687768A (en) * 1984-12-21 1987-08-18 The Procter & Gamble Company Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism

Also Published As

Publication number Publication date
JPH03112994A (ja) 1991-05-14
AU6234590A (en) 1991-03-21
DE69015072D1 (de) 1995-01-26
EP0418064A2 (en) 1991-03-20
GR3015376T3 (en) 1995-06-30
PT95286A (pt) 1991-05-22
AU624733B2 (en) 1992-06-18
NZ235295A (en) 1993-01-27
CA2025268A1 (en) 1991-03-15
EP0418064A3 (en) 1991-06-05
KR910006310A (ko) 1991-04-29
EP0418064B1 (en) 1994-12-14
DE69015072T2 (de) 1995-04-27
ATE115586T1 (de) 1994-12-15
IE903327A1 (en) 1991-04-10
DK0418064T3 (da) 1995-04-03

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