ES2138956T3 - Imidazoquinoxalinonas, sus analogos aza y procedimiento para su preparacion. - Google Patents
Imidazoquinoxalinonas, sus analogos aza y procedimiento para su preparacion.Info
- Publication number
- ES2138956T3 ES2138956T3 ES90110191T ES90110191T ES2138956T3 ES 2138956 T3 ES2138956 T3 ES 2138956T3 ES 90110191 T ES90110191 T ES 90110191T ES 90110191 T ES90110191 T ES 90110191T ES 2138956 T3 ES2138956 T3 ES 2138956T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- aza
- analogs
- imidazoquinoxalinonas
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
ESTA INVENCION ES RELATIVA A NUEVAS IMIDOAZOQUINOXALINONAS Y SUS AZO ANALOGOS Y A UN PROCESO PARA SU PREPARACION. LOS COMPUESTOS DE ESTA INVENCION SE HAN DESCUBIERTO PARA TENER EFECTOS FARMACOLOGICOS VASODILATADORES Y OTROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/359,182 US5055465A (en) | 1989-05-31 | 1989-05-31 | Imidazoquinoxalinones, their aza analogs and process for their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2138956T3 true ES2138956T3 (es) | 2000-02-01 |
Family
ID=23412679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90110191T Expired - Lifetime ES2138956T3 (es) | 1989-05-31 | 1990-05-29 | Imidazoquinoxalinonas, sus analogos aza y procedimiento para su preparacion. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5055465A (es) |
EP (1) | EP0400583B1 (es) |
AT (1) | ATE186728T1 (es) |
DE (1) | DE69033355T2 (es) |
DK (1) | DK0400583T3 (es) |
ES (1) | ES2138956T3 (es) |
GR (1) | GR3032611T3 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5602252A (en) * | 1989-11-17 | 1997-02-11 | Berlex Laboratories, Inc. | Tricyclic pteridinones and a process for their preparation |
US5854419A (en) * | 1989-11-17 | 1998-12-29 | Schering Aktiengesellschaft | Tricyclic pteridinones and a process for their preparation |
US5182386A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
EP0647137B1 (en) * | 1992-06-22 | 2008-08-13 | The Regents Of The University Of California | Glycine receptor antagonists and the use thereof |
DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
US5306819A (en) * | 1992-08-27 | 1994-04-26 | Neurogen Corporation | Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands |
DE4310523A1 (de) * | 1993-03-31 | 1994-10-06 | Basf Ag | Imidazolo-chinoxalinone zur Behandlung zentralnervöser Erkrankungen |
US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
IL112235A (en) * | 1994-01-03 | 2000-06-29 | Acea Pharm Inc | 1,4-dihydro-pyrido¬2,3-b¾pyrazine-2,3-dione (5 or 8) oxide derivatives and pharmaceutical compositions containing them |
AU692524B2 (en) * | 1994-02-11 | 1998-06-11 | Novo Nordisk A/S | Imidazol {1, 2-9} quinoxalinone derivatives and the preparation and use |
PL319406A1 (en) * | 1994-09-30 | 1997-08-04 | Basf Ag | Novel heterocyclically substituted imidazoqunoxalinones, their production and application |
US5801183A (en) * | 1995-01-27 | 1998-09-01 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Aza and aza (N-oxy) analogs of glycine/NMDA receptor antagonists |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
DE19611476A1 (de) * | 1996-03-22 | 1997-09-25 | Basf Ag | Neue heterocyclische substituierte Imidazolo-chinoxalinone, ihre Herstellung und Verwendung |
DE19961302A1 (de) * | 1999-12-18 | 2001-06-21 | Dresden Arzneimittel | Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen |
EE200100377A (et) * | 1999-01-20 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Imidaso[1,5-a]-pürido[3,2-e]-pürasinoonide kasutamine arstimitena |
JP2002540102A (ja) * | 1999-03-22 | 2002-11-26 | ブリストル−マイヤーズ スクイブ カンパニー | cGMPホスホジエステラーゼの縮合ピリドピリダジン阻害剤 |
DE10012373A1 (de) * | 2000-03-14 | 2001-09-20 | Dresden Arzneimittel | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
US6465465B1 (en) * | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
EP1312363A1 (en) * | 2001-09-28 | 2003-05-21 | Pfizer Products Inc. | Methods of treatment and kits comprising a growth hormone secretagogue |
US7342884B2 (en) * | 2002-03-13 | 2008-03-11 | Harmonic, Inc. | Method and apparatus for one directional communications in bidirectional communications channel |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
ES2599054T3 (es) * | 2006-12-13 | 2017-01-31 | Aska Pharmaceutical Co., Ltd. | Derivados de quinoxalina |
US7875618B2 (en) * | 2007-11-30 | 2011-01-25 | Wyeth | Substituted imidazo[1,5-a]quinoxalines useful as inhibitors of phosphodiesterase 10 for the treatment of neurological and other disorders |
US20090143361A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 |
WO2009068320A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10 |
KR101779137B1 (ko) * | 2009-01-23 | 2017-09-18 | 다케다 야쿠힌 고교 가부시키가이샤 | 폴리(adp-리보스)폴리머라제(parp) 억제제 |
WO2011014681A1 (en) | 2009-07-30 | 2011-02-03 | Takeda Pharmaceutical Company Limited | Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS |
WO2011081915A2 (en) * | 2009-12-15 | 2011-07-07 | Cebix Inc. | Methods for treating erectile dysfunction in patients with insulin-dependent diabetes |
JP5822080B2 (ja) * | 2010-09-07 | 2015-11-24 | アステラス製薬株式会社 | キノキサリン化合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4138564A (en) * | 1977-08-03 | 1979-02-06 | American Home Products Corporation | Tetrahydro[1H]pyrazino[1,2-a]azaquinoxalin-5(6H)-ones and derivatives thereof |
IL59104A (en) * | 1979-02-09 | 1984-02-29 | Roussel Uclaf | Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them |
US4333394A (en) * | 1979-12-31 | 1982-06-08 | Brown Stanford M | Method for handling and baling metallic scrap material |
US4440929A (en) * | 1981-07-16 | 1984-04-03 | Usv Pharmaceutical Corporation | Imidazoquinoxaline compounds |
US4761414A (en) * | 1986-08-19 | 1988-08-02 | G. D. Searle & Co. | Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides |
-
1989
- 1989-05-31 US US07/359,182 patent/US5055465A/en not_active Expired - Fee Related
-
1990
- 1990-05-29 EP EP90110191A patent/EP0400583B1/en not_active Expired - Lifetime
- 1990-05-29 DK DK90110191T patent/DK0400583T3/da active
- 1990-05-29 DE DE69033355T patent/DE69033355T2/de not_active Expired - Fee Related
- 1990-05-29 AT AT90110191T patent/ATE186728T1/de not_active IP Right Cessation
- 1990-05-29 ES ES90110191T patent/ES2138956T3/es not_active Expired - Lifetime
-
2000
- 2000-02-09 GR GR20000400310T patent/GR3032611T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5055465A (en) | 1991-10-08 |
DK0400583T3 (da) | 2000-03-13 |
DE69033355T2 (de) | 2000-05-11 |
DE69033355D1 (de) | 1999-12-23 |
GR3032611T3 (en) | 2000-05-31 |
EP0400583A1 (en) | 1990-12-05 |
EP0400583B1 (en) | 1999-11-17 |
ATE186728T1 (de) | 1999-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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