ES2133418T3 - Procedimiento para la preparacion de derivados del taxano. - Google Patents

Procedimiento para la preparacion de derivados del taxano.

Info

Publication number
ES2133418T3
ES2133418T3 ES93924646T ES93924646T ES2133418T3 ES 2133418 T3 ES2133418 T3 ES 2133418T3 ES 93924646 T ES93924646 T ES 93924646T ES 93924646 T ES93924646 T ES 93924646T ES 2133418 T3 ES2133418 T3 ES 2133418T3
Authority
ES
Spain
Prior art keywords
radical
general formula
bacatine
saturated
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93924646T
Other languages
English (en)
Inventor
Jean-Noel Denis
Andrew Greene
Alice Kanazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2133418T3 publication Critical patent/ES2133418T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCESO DE PREPARACION DE DERIVADOS DE TAXANO DE FORMULA GENERAL /(I) POR ESTERIFICACION DE LA BACATINA III PROTEGIDA O DE 10-DESACETIL-BACATINA III PROTEGIDA MEDIANTE UN ACIDO DE FORMULA GENERAL (II). EN LAS FORMULA GENERALES (I) Y (II), AR REPRESENTA UN RADICAL ARILO, R1 Y R2 IDENTICOS O DIFERENTES REPRESENTAN UN ATOMO DE HIDROGENO, UN RADICAL ALCOILO, FENILALCOILO, FENILO, ALCOXIFENILO O DIALCOILSIFENILO, O BIEN R1 Y R2 FORMAN JUNTOS CON EL ATOO DE CARBONO AL QUE ESTAN UNIDOS UN CICLO QUE TIENE DE 4 A 7 ESLABONES, R3 REPRESENTA UN RADICAL ACETILO O UN GRUPO PROTECTOR DE LA FUNCION HIDROXI Y R4 REPRESENTA UN GRUPO PROTECTOR DE LA FUNCION HIDROXI, R REPRESENTA UN RADICAL FENILO O UN RADICAL DE FORMULA R5-O- EN LA QUE R5 REPRESENTA UN RADICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO, FENILO, HETEROCICLICLO NITROGENADO SATURADO O NO SATURADO. LOS PRODUCTOS DE FORMULA GENERAL (I) SON PARICULARMENTE UTILES PARA PREPARAR EL TAXOL, EL TAXOTERO Y SUS ANALOGOS QUE PRESENTAN PROPIEDADES ANTITUMORALES NOTABLES.
ES93924646T 1992-10-30 1993-10-28 Procedimiento para la preparacion de derivados del taxano. Expired - Lifetime ES2133418T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9213000A FR2697522B1 (fr) 1992-10-30 1992-10-30 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
ES2133418T3 true ES2133418T3 (es) 1999-09-16

Family

ID=9435013

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93924646T Expired - Lifetime ES2133418T3 (es) 1992-10-30 1993-10-28 Procedimiento para la preparacion de derivados del taxano.

Country Status (24)

Country Link
US (3) US5686623A (es)
EP (1) EP0666857B1 (es)
JP (1) JP3030088B2 (es)
KR (1) KR100255460B1 (es)
AT (1) ATE180258T1 (es)
AU (1) AU679947B2 (es)
CA (1) CA2148103C (es)
CZ (1) CZ287805B6 (es)
DE (1) DE69325031T2 (es)
DK (1) DK0666857T3 (es)
ES (1) ES2133418T3 (es)
FI (1) FI109798B (es)
FR (1) FR2697522B1 (es)
GR (1) GR3030268T3 (es)
HU (1) HUT73780A (es)
MX (1) MX9306606A (es)
NO (2) NO304114B1 (es)
NZ (1) NZ257578A (es)
PL (1) PL177746B1 (es)
RU (2) RU2118958C1 (es)
SK (1) SK281045B6 (es)
TW (1) TW427988B (es)
WO (1) WO1994010169A1 (es)
ZA (1) ZA938012B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
ES2145829T3 (es) * 1993-06-11 2000-07-16 Upjohn Co Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
CA2170661A1 (en) 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
EP1099696A3 (en) * 1995-06-06 2001-05-23 Dr. Reddy's Research Foundation Preparation of oxazolidine
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
TR200100575T2 (tr) * 1998-08-20 2001-07-23 Aventis Pharma S.A. Taksoid türevlerinin yeni kullanım alanları
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
AU2000261768A1 (en) * 2000-08-08 2002-02-18 Dr. Reddy's Research Foundation An improved process for the preparation of docetaxel
JP2002088935A (ja) 2000-09-14 2002-03-27 Nichiha Corp 外装材の縦目地ジョイナー
WO2006055837A2 (en) 2004-11-19 2006-05-26 Dr. Reddy's Laboratories Ltd. Process for preparing oxazolidine derivatives
CZ298332B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy kyseliny (4S,5R)-2,4-difenyloxazolin-4,5-dihydro-5-karboxylové
US20100069643A1 (en) * 2005-12-21 2010-03-18 Mcchesney James D Convergent Process for the Synthesis of Taxane Derivatives
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique
CN101020672B (zh) * 2006-12-28 2010-08-25 上海百灵医药科技有限公司 多烯紫杉醇的合成方法
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101379694B1 (ko) * 2011-09-30 2014-03-31 주식회사 삼양바이오팜 탁산유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
ES2145829T3 (es) * 1993-06-11 2000-07-16 Upjohn Co Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
RU2118958C1 (ru) 1998-09-20
HUT73780A (en) 1996-09-30
FI952059A0 (fi) 1995-04-28
DE69325031D1 (de) 1999-06-24
NO306062B1 (no) 1999-09-13
US6433180B1 (en) 2002-08-13
DE69325031T2 (de) 1999-10-07
US20030013889A1 (en) 2003-01-16
CZ287805B6 (en) 2001-02-14
JPH08502507A (ja) 1996-03-19
NO304114B1 (no) 1998-10-26
SK281045B6 (sk) 2000-11-07
PL177746B1 (pl) 2000-01-31
RU2188198C2 (ru) 2002-08-27
NO951587L (no) 1995-04-26
NO981813D0 (no) 1998-04-22
NO951587D0 (no) 1995-04-26
HU9501235D0 (en) 1995-06-28
EP0666857B1 (fr) 1999-05-19
FR2697522B1 (fr) 1994-11-25
KR100255460B1 (ko) 2000-05-01
ATE180258T1 (de) 1999-06-15
FR2697522A1 (fr) 1994-05-06
NO981813L (no) 1995-04-26
EP0666857A1 (fr) 1995-08-16
RU95111381A (ru) 1996-12-27
TW427988B (en) 2001-04-01
KR950704307A (ko) 1995-11-17
SK55795A3 (en) 1995-10-11
ZA938012B (en) 1994-06-09
FI109798B (fi) 2002-10-15
AU5423794A (en) 1994-05-24
PL308638A1 (en) 1995-08-21
WO1994010169A1 (fr) 1994-05-11
CZ109295A3 (en) 1995-10-18
MX9306606A (es) 1994-04-29
AU679947B2 (en) 1997-07-17
NZ257578A (en) 1996-06-25
US5686623A (en) 1997-11-11
GR3030268T3 (en) 1999-08-31
CA2148103C (fr) 2002-11-26
CA2148103A1 (fr) 1994-05-11
FI952059A (fi) 1995-04-28
JP3030088B2 (ja) 2000-04-10
DK0666857T3 (da) 1999-11-08

Similar Documents

Publication Publication Date Title
ES2133418T3 (es) Procedimiento para la preparacion de derivados del taxano.
ES2061706T3 (es) Nuevos 17-aril-esteroides, su procedimiento y productos intermedios de preparacion, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
AR004087A1 (es) Derivado del acido fenilacetico, procedimientos y productos intermedios para su obtencion y las composiciones que los contienen
MX9305764A (es) Procedimiento para la preparacion de los esteres de la bacatina iii y dela 10-desacetil bacatina iii y productos obtenidos por medio del mismo.
AR004195A1 (es) Nuevos derivados de la 5-0 desosaminil-6-0-metil-eritronolida a, su procedimiento de preparacion, compuestos intermediarios, metodo de aplicacionde los mismos para la preparacion de productos biologicamente activos.
ES2095059T3 (es) Productos intermedios en un procedimiento para la purificacion de acido clavulanico.
ES535491A0 (es) Un metodo de preparar nuevos derivados de benzoil-urea que tienen actividad anti-tumoral
ATE5321T1 (de) Verfahren zur herstellung derivierter produkte der 7-(2-aryl)-2-hydroxyimino-acetamidocephalosporans[ure.
ES2045180T3 (es) Nuevo procedimiento para la obtencion de 4-aciloxi-3-hidroxietil-azetidinonas.
ES2101513T3 (es) Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.
ES2073396T3 (es) Nuevos derivados ciclicos del acido antranilico y procedimiento para su preparacion.
PT92180A (pt) Processo para a preparacao de novas mevalonolactonas do tipo tienopiridina e de composicoes farmaceuticas que as contem
ES2054626T3 (es) Derivados de 2-azetidinona sustituidos en las posiciones 3,4 y procedimientos para su preparacion.
ES2068497T3 (es) Derivados de urea, su produccion, y composiciones farmaceuticas que los contienen.
ES2131864T3 (es) Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.
ES2086442T3 (es) Derivados de fluoroetilcamptotecina.
ES2055804T3 (es) Procedimiento de preparacion de nuevas meta-fenilendiaminas sustituidas con trialcoxi.
ES2063156T3 (es) Nuevos derivados lisogangliosidos.
PT99044A (pt) Processo para a preparacao de dissulfetos e de composicoes biocidas industriais que os contem
DE3567201D1 (en) Derivatives of 3-phenyl-2-propenamine, their preparation and medicines containing them
ES2038776T3 (es) Procedimiento de preparacion de derivados de la oxima del 1,2,5,6-tetrahidropiridin-3-carboxaldehido.
ES2058831T3 (es) Derivados de la 1-arilsulfonil-2-piperidinona, su procedimiento y los compuestos intermedios de preparacion, su aplicacion como medicamentos y composiciones que los contienen.
ES2051955T3 (es) Compuestos azaalifaticos ciclicos con funcion nitroxi, procedimiento para su produccion y medicamentos que contienen estos compuestos.
ES2058557T3 (es) Monoesteres de un acido arilacetico, su produccion y uso.
ES2095041T3 (es) Nuevos anhidridos de acidos, su preparacion y su empleo.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 666857

Country of ref document: ES