ES2063156T3 - Nuevos derivados lisogangliosidos. - Google Patents

Nuevos derivados lisogangliosidos.

Info

Publication number
ES2063156T3
ES2063156T3 ES89403310T ES89403310T ES2063156T3 ES 2063156 T3 ES2063156 T3 ES 2063156T3 ES 89403310 T ES89403310 T ES 89403310T ES 89403310 T ES89403310 T ES 89403310T ES 2063156 T3 ES2063156 T3 ES 2063156T3
Authority
ES
Spain
Prior art keywords
lisogangliosidos
new derivatives
acil
group
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89403310T
Other languages
English (en)
Inventor
Valle Francesco Della
Aurelio Romeo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2063156T3 publication Critical patent/ES2063156T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

NUEVOS N-ACIL-LISOGANGLIOSIDOS OBTENIDOS DE GANGLIOSIDOS POR DESACILACION DEL GRUPO CERAMIDA, EN DONDE EL GRUPO ACILO SE DERIVA DE UN ACIDO ALIFATICO QUE TENGA DE 2 A 24 ATOMOS DE CARBONO, SUSTITUIDO POR UNO O MAS GRUPOS POLARES. LOS N-ACIL-LISOGANGLIOSIDOS DE LA INVENCION PRESENTAN UNA ACCION INHIBIDORA DE LA ACTIVIDAD DE LA PROTEINA-QUINASA C, POR LO QUE PUEDEN UTILIZARSE EN TERAPIAS DE DIVERSAS PATOLOGIAS DEL SISTEMA NERVIOSO.
ES89403310T 1988-12-02 1989-11-29 Nuevos derivados lisogangliosidos. Expired - Lifetime ES2063156T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8848618A IT1235161B (it) 1988-12-02 1988-12-02 Derivati di lisogangliosidi

Publications (1)

Publication Number Publication Date
ES2063156T3 true ES2063156T3 (es) 1995-01-01

Family

ID=11267667

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89403310T Expired - Lifetime ES2063156T3 (es) 1988-12-02 1989-11-29 Nuevos derivados lisogangliosidos.

Country Status (15)

Country Link
EP (1) EP0373039B1 (es)
JP (1) JPH02200697A (es)
KR (1) KR910009721A (es)
AT (1) ATE103926T1 (es)
AU (1) AU630384B2 (es)
CA (1) CA2004189A1 (es)
DE (1) DE68914418T2 (es)
DK (1) DK589889A (es)
ES (1) ES2063156T3 (es)
FI (1) FI95577C (es)
HU (1) HU205129B (es)
IL (1) IL92513A0 (es)
IT (1) IT1235161B (es)
NO (1) NO173141C (es)
NZ (1) NZ231624A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1235011B (it) * 1988-07-26 1992-06-16 Fidia Farmaceutici Sintesi di derivati di glicosfingolipidi ed in particolare di gangliosidi utilizzabili per la preparazione di immunoadsorbenti ed adsorbenti per affinita' impiegabili per la purificazione di anticorpi e di tossine specifiche, e per uso diagnostico
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
IT1239060B (it) * 1990-05-04 1993-09-20 Fidia Spa Processo per la modulazione selettiva dell'espressione e della funzione di un determinante sulla superficie cellulare attraverso appropriati agenti chimici
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
EP2473176A4 (en) * 2009-09-04 2013-03-06 Univ Alberta NEUROPROTECTIVE COMPOUNDS, COMPOSITIONS, METHODS AND KITS
ES2444269T3 (es) * 2010-07-23 2014-02-24 Loctite (R & D) Limited Método para la producción de anhídrido de ácido 2-cianoacético y otros productos de reacción correspondientes.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK17885D0 (da) * 1985-01-14 1985-01-14 Karlsson Karl Anders Antiviralt middel
IT1182209B (it) * 1985-02-18 1987-09-30 Fidia Farmaceutici Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali
NZ222192A (en) * 1986-10-20 1991-03-26 Kanto Ishi Pharma Co Ltd Glycolipid containing n-glycolylneuraminic acid, and preparation thereof
IT1235011B (it) * 1988-07-26 1992-06-16 Fidia Farmaceutici Sintesi di derivati di glicosfingolipidi ed in particolare di gangliosidi utilizzabili per la preparazione di immunoadsorbenti ed adsorbenti per affinita' impiegabili per la purificazione di anticorpi e di tossine specifiche, e per uso diagnostico
GB8827967D0 (en) * 1988-11-30 1989-01-05 Ward I M Die-free drawing
NZ236059A (en) * 1989-11-17 1993-03-26 Fidia Spa Extraction of gangliosides

Also Published As

Publication number Publication date
NO173141C (no) 1993-11-03
AU630384B2 (en) 1992-10-29
DE68914418T2 (de) 1994-10-06
HU205129B (en) 1992-03-30
FI95577B (fi) 1995-11-15
EP0373039B1 (en) 1994-04-06
NO894820L (no) 1990-06-05
NO173141B (no) 1993-07-26
DK589889A (da) 1990-06-03
KR910009721A (ko) 1991-06-28
ATE103926T1 (de) 1994-04-15
NO894820D0 (no) 1989-12-01
IT8848618A0 (it) 1988-12-02
IL92513A0 (en) 1990-08-31
EP0373039A3 (en) 1991-06-05
JPH02200697A (ja) 1990-08-08
IT1235161B (it) 1992-06-22
HUT53116A (en) 1990-09-28
CA2004189A1 (en) 1990-06-02
HU896337D0 (en) 1990-02-28
AU4571889A (en) 1990-06-07
FI895765A0 (fi) 1989-12-01
EP0373039A2 (en) 1990-06-13
DK589889D0 (da) 1989-11-23
DE68914418D1 (de) 1994-05-11
FI95577C (fi) 1996-02-26
NZ231624A (en) 1992-03-26

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