IT1253832B - Derivati di gangliosidi - Google Patents
Derivati di gangliosidiInfo
- Publication number
- IT1253832B IT1253832B ITPD910139A ITPD910139A IT1253832B IT 1253832 B IT1253832 B IT 1253832B IT PD910139 A ITPD910139 A IT PD910139A IT PD910139 A ITPD910139 A IT PD910139A IT 1253832 B IT1253832 B IT 1253832B
- Authority
- IT
- Italy
- Prior art keywords
- gangliosides
- acyl
- lyso
- pharmaceutical preparations
- groups
- Prior art date
Links
- 150000002270 gangliosides Chemical class 0.000 title abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- -1 aliphatic amino acid Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invenzione riguarda dei nuovi derivati di gangliosidi e più precisamente delle carbossilamidi dei gruppi sialici dei gangliosidi, e di gangliosidi semisintetici scelti dal gruppo formato dagli N-acil-N-liso-gangliosidi, N'-acil-N'-liso-gangliosidi, N, N'-diacil-N, N'-di-lios-gangliosidi in cui i gruppi N e N'-acilici derivano da acidi della serie alifatica, in cui il gruppo amidico deriva da un aminoacido di natura alifatica con funzione acida carbossilica o solfonica, e i loro sali.L'invenzione comprende pure delle preparazioni farmaceutiche comprendenti i suddetti composti come ingredienti attivi, e l'uso terapeutico dei nuovi prodotti e delle relative preparazioni farmaceutiche.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITPD910139A IT1253832B (it) | 1991-08-01 | 1991-08-01 | Derivati di gangliosidi |
US07/922,383 US5350841A (en) | 1991-08-01 | 1992-07-31 | Ganglioside derivatives |
PT100756A PT100756B (pt) | 1991-08-01 | 1992-07-31 | Novos derivados de gangliosidos, processo para a sua preparacao e composicoes farmaceuticas que os contem |
DE69218222T DE69218222T2 (de) | 1991-08-01 | 1992-08-01 | Neue ganglioside-derivaten |
PCT/EP1992/001776 WO1993003049A1 (en) | 1991-08-01 | 1992-08-01 | New ganglioside derivatives |
ES92917164T ES2100360T3 (es) | 1991-08-01 | 1992-08-01 | Nuevos derivados de gangliosidos. |
EP92917164A EP0599908B1 (en) | 1991-08-01 | 1992-08-01 | New ganglioside derivatives |
JP5503281A JPH06509350A (ja) | 1991-08-01 | 1992-08-01 | 新規なガングリオシド誘導体 |
AT92917164T ATE150028T1 (de) | 1991-08-01 | 1992-08-01 | Neue ganglioside-derivaten |
AU24265/92A AU2426592A (en) | 1991-08-01 | 1992-08-01 | New ganglioside derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITPD910139A IT1253832B (it) | 1991-08-01 | 1991-08-01 | Derivati di gangliosidi |
Publications (3)
Publication Number | Publication Date |
---|---|
ITPD910139A0 ITPD910139A0 (it) | 1991-08-01 |
ITPD910139A1 ITPD910139A1 (it) | 1993-02-01 |
IT1253832B true IT1253832B (it) | 1995-08-29 |
Family
ID=11389659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITPD910139A IT1253832B (it) | 1991-08-01 | 1991-08-01 | Derivati di gangliosidi |
Country Status (10)
Country | Link |
---|---|
US (1) | US5350841A (it) |
EP (1) | EP0599908B1 (it) |
JP (1) | JPH06509350A (it) |
AT (1) | ATE150028T1 (it) |
AU (1) | AU2426592A (it) |
DE (1) | DE69218222T2 (it) |
ES (1) | ES2100360T3 (it) |
IT (1) | IT1253832B (it) |
PT (1) | PT100756B (it) |
WO (1) | WO1993003049A1 (it) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6407072B1 (en) * | 1988-12-02 | 2002-06-18 | Fidia S.P.A. | Lysoganglioside derivatives |
IT1232175B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Analoghi semisintetici di gangliosidi |
IT1254280B (it) * | 1992-03-13 | 1995-09-14 | Fidia Spa | Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson |
IT1267955B1 (it) * | 1993-03-04 | 1997-02-18 | Fidia S P A In Amministrazione | Derivati solfatati dei lisogangliosidi |
IT1267956B1 (it) * | 1993-03-04 | 1997-02-18 | Fidia S P A In Amministrazione | Derivati o-solfatati di gangliosidi e lisogangliosidi |
US5849717A (en) * | 1993-03-04 | 1998-12-15 | Fidia S.P.A. | O-sulfated gangliosides and lyso-ganglioside derivatives |
US5795869A (en) * | 1993-03-04 | 1998-08-18 | Fidia S.P.A. | Sulfated lyso-ganglioside derivatives |
WO1997022615A1 (fr) * | 1995-12-18 | 1997-06-26 | Daikin Industries, Ltd. | Analogues de gangliosides fluores gm3 et leurs intermediaires |
JP2005527467A (ja) | 2001-08-29 | 2005-09-15 | ネオーズ テクノロジーズ, インコーポレイテッド | 新規な合成ガングリオシド誘導体およびその組成物 |
MXPA05009480A (es) | 2003-03-06 | 2006-02-22 | Neose Technologies Inc | Metodos y composiciones para la sintesis enzimatica de gangliosidos. |
EP3175857A1 (en) | 2009-03-25 | 2017-06-07 | Seneb Biosciences Inc. | Glycolipids as treatment for disease |
WO2023102665A1 (en) * | 2021-12-09 | 2023-06-15 | The Governors Of The University Of Alberta | Cellular and tissue clearance of misfolded proteins and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1199116B (it) * | 1984-07-03 | 1988-12-30 | Fidia Farmaceutici | Derivati di gangliosidi |
IT1235161B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisogangliosidi |
IT1232175B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Analoghi semisintetici di gangliosidi |
IT1232176B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Derivati di-lisogangliosidi |
IT1238346B (it) * | 1989-11-14 | 1993-07-13 | Gangliosidi modificati e loro derivati funzionali. |
-
1991
- 1991-08-01 IT ITPD910139A patent/IT1253832B/it active IP Right Grant
-
1992
- 1992-07-31 PT PT100756A patent/PT100756B/pt not_active IP Right Cessation
- 1992-07-31 US US07/922,383 patent/US5350841A/en not_active Expired - Lifetime
- 1992-08-01 AU AU24265/92A patent/AU2426592A/en not_active Abandoned
- 1992-08-01 EP EP92917164A patent/EP0599908B1/en not_active Expired - Lifetime
- 1992-08-01 DE DE69218222T patent/DE69218222T2/de not_active Expired - Fee Related
- 1992-08-01 AT AT92917164T patent/ATE150028T1/de not_active IP Right Cessation
- 1992-08-01 WO PCT/EP1992/001776 patent/WO1993003049A1/en active IP Right Grant
- 1992-08-01 JP JP5503281A patent/JPH06509350A/ja active Pending
- 1992-08-01 ES ES92917164T patent/ES2100360T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ITPD910139A1 (it) | 1993-02-01 |
AU2426592A (en) | 1993-03-02 |
PT100756B (pt) | 1999-10-29 |
EP0599908B1 (en) | 1997-03-12 |
ITPD910139A0 (it) | 1991-08-01 |
ES2100360T3 (es) | 1997-06-16 |
JPH06509350A (ja) | 1994-10-20 |
PT100756A (pt) | 1993-09-30 |
DE69218222D1 (de) | 1997-04-17 |
EP0599908A1 (en) | 1994-06-08 |
ATE150028T1 (de) | 1997-03-15 |
WO1993003049A1 (en) | 1993-02-18 |
US5350841A (en) | 1994-09-27 |
DE69218222T2 (de) | 1997-10-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19980515 |