EA199700267A1 - Применение фумагиллола и его производных для приготовления антиинфекционных интестинальных препаратов и фармацевтическая композиция на их основе - Google Patents

Применение фумагиллола и его производных для приготовления антиинфекционных интестинальных препаратов и фармацевтическая композиция на их основе

Info

Publication number
EA199700267A1
EA199700267A1 EA199700267A EA199700267A EA199700267A1 EA 199700267 A1 EA199700267 A1 EA 199700267A1 EA 199700267 A EA199700267 A EA 199700267A EA 199700267 A EA199700267 A EA 199700267A EA 199700267 A1 EA199700267 A1 EA 199700267A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fumagillall
antiinfective
derivatives
application
basis
Prior art date
Application number
EA199700267A
Other languages
English (en)
Other versions
EA000150B1 (ru
Inventor
Жан-Мишель Молина
Франсис Деруэн
Original Assignee
Санофи
Ассистанс Пюблик-Опито Де Пари
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи, Ассистанс Пюблик-Опито Де Пари filed Critical Санофи
Publication of EA199700267A1 publication Critical patent/EA199700267A1/ru
Publication of EA000150B1 publication Critical patent/EA000150B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)

Abstract

Изобретение касается использования фумагиллола или сложных эфиров фумагиллола с (C-C)алкилкарбоновыми или (C-C)алкилдикарбоновыми кислотами, насыщенными или ненасыщенными, и их фармацевтически приемлемых солей в качестве активного начала для получения лекарств, предназначенных для борьбы с кишечными инфекциями, вызываемыми микроспоридами и/или криптоспоридами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700267A 1995-03-27 1996-03-26 Применение фумагиллола и его производных для приготовления лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе EA000150B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9503549 1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr) 1995-03-27 1996-03-26 Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (2)

Publication Number Publication Date
EA199700267A1 true EA199700267A1 (ru) 1998-04-30
EA000150B1 EA000150B1 (ru) 1998-10-29

Family

ID=9477436

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700267A EA000150B1 (ru) 1995-03-27 1996-03-26 Применение фумагиллола и его производных для приготовления лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе

Country Status (25)

Country Link
US (1) US5900431A (ru)
EP (1) EP0817626B1 (ru)
JP (1) JP3260378B2 (ru)
KR (1) KR100286920B1 (ru)
CN (1) CN1072485C (ru)
AP (1) AP646A (ru)
AT (1) ATE172641T1 (ru)
AU (1) AU706161B2 (ru)
CA (1) CA2216623C (ru)
CZ (1) CZ286821B6 (ru)
DE (1) DE69600879T2 (ru)
DK (1) DK0817626T3 (ru)
EA (1) EA000150B1 (ru)
ES (1) ES2128846T3 (ru)
FR (1) FR06C0014I2 (ru)
HU (1) HU224028B1 (ru)
IS (1) IS2048B (ru)
NO (1) NO315968B1 (ru)
NZ (1) NZ304906A (ru)
OA (1) OA10515A (ru)
PL (1) PL183378B1 (ru)
SK (1) SK283883B6 (ru)
TR (1) TR199701048T1 (ru)
UA (1) UA41446C2 (ru)
WO (1) WO1996030010A2 (ru)

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UA41446C2 (ru) * 1995-03-27 2001-09-17 Санофі - Сінтелабо Применение фумагилола и его производных для получения лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
JP2002537358A (ja) * 1999-02-26 2002-11-05 サノフィ−サンテラボ フマギリンを含有する安定な製剤
JP3265394B1 (ja) * 2001-03-14 2002-03-11 泰三 矢野 アクリル系樹脂手袋
DE10341887A1 (de) * 2003-09-09 2005-03-31 Leopold Kostal Gmbh & Co. Kg Elektrisches Schaltermodul
FR2886855B1 (fr) * 2005-06-08 2009-07-17 Agronomique Inst Nat Rech Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
MX2010005857A (es) * 2007-11-28 2010-11-22 Mersana Therapeutics Inc Conjugados de analogos de fumagillina biodegradables biocompatibles.
CN102123586A (zh) * 2008-07-18 2011-07-13 法弗根股份有限公司 治疗超重或肥胖受试者的方法
WO2010065877A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Methods of treating an overweight or obese subject
WO2010065883A2 (en) 2008-12-04 2010-06-10 Zafgen Corporation Method of treating an overweight or obese subject
EP2486004B1 (en) 2009-10-09 2017-05-03 Zafgen, Inc. Sulphone compounds for use in the treatment of obesity
BR112012016793A2 (pt) 2010-01-08 2018-07-31 Zafgen Corp compostos tipo fumagilol e métodos de fazer e usar os mesmos
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
WO2012012642A1 (en) 2010-07-22 2012-01-26 Zafgen Corporation Tricyclic compounds and methds of making and using same
CA2817199C (en) 2010-11-09 2019-01-15 Zafgen, Inc. Crystalline solids of a metap-2 inhibitor and methods of making and using same
MX2013005989A (es) 2010-11-29 2013-08-21 Zafgen Inc Tratamiento de obesidad utilizando administracion no diaria de 6-o-(4-dimetilaminoetoxi)cinamoil fumagilol.
US9321740B2 (en) 2011-01-26 2016-04-26 Zafgen, Inc. Tetrazole compounds and methods of making and using same
BR112013023056A2 (pt) 2011-03-08 2018-10-09 Zafgen Inc derivados de oxaespiro [2,5] octano e análogos
EP2705030B1 (en) 2011-05-06 2016-07-27 Zafgen, Inc. Partially saturated tricyclic compounds and methods of making and using same
AU2012253759B2 (en) 2011-05-06 2016-01-21 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
EP2705035B1 (en) 2011-05-06 2016-12-14 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
EP2763671A2 (en) 2011-10-03 2014-08-13 Zafgen, Inc. Methods of treating age related disorders
WO2013109735A1 (en) 2012-01-18 2013-07-25 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
AU2013209723B2 (en) 2012-01-18 2016-11-24 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
KR20150016303A (ko) 2012-05-07 2015-02-11 자프겐 인크. 6-o-(4-디메틸아미노에톡시) 신나모일 푸마지롤의 옥살레이트 염의 다형체 염 및 이의 제조 및 사용 방법
CA2872876A1 (en) 2012-05-08 2013-11-14 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
CN104364251B (zh) 2012-05-09 2017-02-22 扎夫根股份有限公司 烟曲霉醇型化合物及其制备和使用方法
CN104918928A (zh) 2012-11-05 2015-09-16 扎夫根股份有限公司 三环化合物及其制备方法和用途
CN104870433A (zh) 2012-11-05 2015-08-26 扎夫根股份有限公司 三环化合物及其制备方法和用途
MX2015005734A (es) 2012-11-05 2016-02-10 Zafgen Inc Metodos de tratamiento de enfermedades hepaticas.
MX362391B (es) 2013-03-14 2019-01-15 Zafgen Inc Métodos de tratamiento de enfermedad renal y otros trastornos.
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
CN106591389B (zh) * 2015-10-15 2019-10-11 中国科学院微生物研究所 一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) * 2016-02-25 2018-06-26 中国农业科学院蜜蜂研究所 一种烟曲霉素的提取方法

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US2791530A (en) * 1953-08-31 1957-05-07 Abbott Lab Stabilized fumagillin compositions
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
US5135920A (en) * 1988-11-16 1992-08-04 Takeda Chemical Industries, Ltd. Angiostatic agents
WO1992002240A2 (en) * 1990-07-27 1992-02-20 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
UA41446C2 (ru) * 1995-03-27 2001-09-17 Санофі - Сінтелабо Применение фумагилола и его производных для получения лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
CA2210600A1 (en) * 1996-07-17 1998-01-17 Takashi Houkan Inhibitor of tumor metastasis or recurrence
WO1998005293A2 (en) * 1996-08-02 1998-02-12 The Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors

Also Published As

Publication number Publication date
EA000150B1 (ru) 1998-10-29
OA10515A (fr) 2002-04-24
AP646A (en) 1998-04-27
AU706161B2 (en) 1999-06-10
NO974466L (no) 1997-09-26
JP3260378B2 (ja) 2002-02-25
CN1179715A (zh) 1998-04-22
FR06C0014I1 (ru) 2006-11-17
SK130797A3 (en) 1998-03-04
HUP9801220A3 (en) 2001-10-29
IS4557A (is) 1997-09-11
CA2216623A1 (en) 1996-10-03
PL322470A1 (en) 1998-02-02
AP9701092A0 (en) 1997-10-31
CA2216623C (en) 2005-05-31
UA41446C2 (ru) 2001-09-17
WO1996030010A3 (fr) 1996-11-28
DK0817626T3 (da) 1999-07-12
EP0817626B1 (fr) 1998-10-28
IS2048B (is) 2005-09-15
TR199701048T1 (xx) 1998-01-21
US5900431A (en) 1999-05-04
ATE172641T1 (de) 1998-11-15
EP0817626A2 (fr) 1998-01-14
KR100286920B1 (ko) 2001-04-16
MX9707150A (es) 1998-07-31
CZ304997A3 (en) 1997-12-17
HU224028B1 (hu) 2005-05-30
KR19980703271A (ko) 1998-10-15
JPH11506421A (ja) 1999-06-08
CN1072485C (zh) 2001-10-10
DE69600879D1 (de) 1998-12-03
PL183378B1 (pl) 2002-06-28
FR06C0014I2 (ru) 2006-12-29
SK283883B6 (sk) 2004-04-06
CZ286821B6 (en) 2000-07-12
NO974466D0 (no) 1997-09-26
NO315968B1 (no) 2003-11-24
DE69600879T2 (de) 1999-06-02
AU5278696A (en) 1996-10-16
WO1996030010A2 (fr) 1996-10-03
ES2128846T3 (es) 1999-05-16
NZ304906A (en) 1999-06-29
HUP9801220A2 (hu) 1999-09-28

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