HUP9801220A2 - Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerkészítmények előállítására - Google Patents

Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerkészítmények előállítására

Info

Publication number
HUP9801220A2
HUP9801220A2 HU9801220A HUP9801220A HUP9801220A2 HU P9801220 A2 HUP9801220 A2 HU P9801220A2 HU 9801220 A HU9801220 A HU 9801220A HU P9801220 A HUP9801220 A HU P9801220A HU P9801220 A2 HUP9801220 A2 HU P9801220A2
Authority
HU
Hungary
Prior art keywords
fumagillol
derivatives
intestinal infections
preparing medicaments
against intestinal
Prior art date
Application number
HU9801220A
Other languages
English (en)
Inventor
Francis Derouin
Jean-Michel Molina
Original Assignee
Assistance Publique-Hopitaux De Paris
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique-Hopitaux De Paris, Sanofi filed Critical Assistance Publique-Hopitaux De Paris
Publication of HUP9801220A2 publication Critical patent/HUP9801220A2/hu
Publication of HUP9801220A3 publication Critical patent/HUP9801220A3/hu
Publication of HU224028B1 publication Critical patent/HU224028B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

A találmány a fűmagillőlnak és a fűmagillőlnak telített vagytelítetlen, 1-12 szénatőmős alkil-karbőnsavakkal vagy 1-12 szénatőmősalkil-dikarbőnsavakkal alkőtőtt észtereinek és ezek gyógyszerészetilegalkalmazható sóinak a mikrőspőrídiűmők és/vagy kriptőspőrídiűmőkőkőzta bélfertőzések elleni gyógyszerek előállítására valóalkalmazására vőnatkőzik. ŕ
HU9801220A 1995-03-27 1996-03-26 Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerek előállítására HU224028B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9503549 1995-03-27
PCT/FR1996/000448 WO1996030010A2 (fr) 1995-03-27 1996-03-26 Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales

Publications (3)

Publication Number Publication Date
HUP9801220A2 true HUP9801220A2 (hu) 1999-09-28
HUP9801220A3 HUP9801220A3 (en) 2001-10-29
HU224028B1 HU224028B1 (hu) 2005-05-30

Family

ID=9477436

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801220A HU224028B1 (hu) 1995-03-27 1996-03-26 Fumagillol és származékai alkalmazása bélfertőzések kezelésére szolgáló gyógyszerek előállítására

Country Status (25)

Country Link
US (1) US5900431A (hu)
EP (1) EP0817626B1 (hu)
JP (1) JP3260378B2 (hu)
KR (1) KR100286920B1 (hu)
CN (1) CN1072485C (hu)
AP (1) AP646A (hu)
AT (1) ATE172641T1 (hu)
AU (1) AU706161B2 (hu)
CA (1) CA2216623C (hu)
CZ (1) CZ286821B6 (hu)
DE (1) DE69600879T2 (hu)
DK (1) DK0817626T3 (hu)
EA (1) EA000150B1 (hu)
ES (1) ES2128846T3 (hu)
FR (1) FR06C0014I2 (hu)
HU (1) HU224028B1 (hu)
IS (1) IS2048B (hu)
NO (1) NO315968B1 (hu)
NZ (1) NZ304906A (hu)
OA (1) OA10515A (hu)
PL (1) PL183378B1 (hu)
SK (1) SK283883B6 (hu)
TR (1) TR199701048T1 (hu)
UA (1) UA41446C2 (hu)
WO (1) WO1996030010A2 (hu)

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DE69600879T2 (de) * 1995-03-27 1999-06-02 Assistance Publique, Hopitaux De Paris, Paris Verwendung von fumagillol und seinen derivaten zur herstellung von arzneimitteln gegen darminfektionen
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
AU2811400A (en) * 1999-02-26 2000-09-14 Sanofi-Synthelabo Stable formulation containing fumagillin
JP3265394B1 (ja) * 2001-03-14 2002-03-11 泰三 矢野 アクリル系樹脂手袋
DE10341887A1 (de) * 2003-09-09 2005-03-31 Leopold Kostal Gmbh & Co. Kg Elektrisches Schaltermodul
FR2886855B1 (fr) * 2005-06-08 2009-07-17 Agronomique Inst Nat Rech Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
US8399512B2 (en) * 2007-11-28 2013-03-19 Mersana Therapeutics, Inc. Biocompatible biodegradable fumagillin analog conjugates
CN102123586A (zh) * 2008-07-18 2011-07-13 法弗根股份有限公司 治疗超重或肥胖受试者的方法
US20120004162A1 (en) 2008-12-04 2012-01-05 Vath James E Methods of Treating an Overweight or Obese Subject
US8642650B2 (en) 2008-12-04 2014-02-04 Zafgen, Inc. Methods of treating an overweight or obese subject
WO2013055385A2 (en) 2011-10-03 2013-04-18 Zafgen Corporation Methods of treating age related disorders
CA2777108A1 (en) 2009-10-09 2011-04-14 Zafgen Corporation Sulphone compounds and methods of making and using same
WO2011085198A1 (en) 2010-01-08 2011-07-14 Zafgen Corporation Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph)
JP5827239B2 (ja) 2010-01-08 2015-12-02 ザフゲン，インコーポレイテッド フマギロール型化合物並びにその製造方法及び使用方法
WO2011127304A2 (en) 2010-04-07 2011-10-13 Zafgen Corporation Methods of treating an overweight subject
BR112013001613A2 (pt) 2010-07-22 2016-05-24 Zafgen Inc compostos tricíclicos e métodos para fazer e usar os mesmos.
UA111479C2 (uk) 2010-11-09 2016-05-10 Зафджен, Інк. Кристалічні форми інгібітору metap-2 та способи їх отримання і застосування
WO2012075020A1 (en) 2010-11-29 2012-06-07 Zafgen Corporation Treatment of obesity using non-daily administration of 6 - 0 - (4 - dimethylaminoethoxy) cinnamoyl fumagillol
JP6058557B2 (ja) 2011-01-26 2017-01-11 ザフゲン，インコーポレイテッド テトラゾール化合物ならびにその作製方法および使用方法
WO2012122264A1 (en) 2011-03-08 2012-09-13 Zafgen Corporation Oxaspiro [2.5] octane derivatives and analogs
AU2012253760B2 (en) 2011-05-06 2016-02-04 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
KR20140053013A (ko) 2011-05-06 2014-05-07 자프겐 인크. 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
EA025526B1 (ru) 2011-05-06 2017-01-30 Зафджен Инк. Частично насыщенные трициклические соединения и способы их получения и применения
AU2013209723B2 (en) 2012-01-18 2016-11-24 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
CA2861381A1 (en) 2012-01-18 2013-07-25 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
MX2014013525A (es) 2012-05-07 2015-10-22 Zafgen Inc Sal polimorfica de la sal de oxalato de 6-o-(4-dimetilaminoetoxi)c inamoil fumagilol y metodos para elaborarla y utilizarla.
WO2013169857A1 (en) 2012-05-08 2013-11-14 Zafgen, Inc. Treating hypothalamic obesity with metap2 inhibitors
WO2013169860A1 (en) 2012-05-09 2013-11-14 Zafgen, Inc. Fumigillol type compounds and methods of making and using same
BR112015010225A2 (pt) 2012-11-05 2017-07-11 Zafgen Inc compostos tricíclicos e seus métodos de produção e utilização
CN104918615B (zh) 2012-11-05 2018-10-12 扎夫根股份有限公司 治疗肝病的方法
EP2925737B1 (en) 2012-11-05 2017-06-14 Zafgen, Inc. Tricyclic compounds for use in the treatment and/or control of obesity
AU2014236528A1 (en) 2013-03-14 2015-09-24 Zafgen, Inc. Methods of treating renal disease and other disorders
AR105671A1 (es) 2015-08-11 2017-10-25 Zafgen Inc Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso
CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
CN106591389B (zh) * 2015-10-15 2019-10-11 中国科学院微生物研究所 一种利用烟曲霉菌生产烟曲霉素的方法
CN105622593B (zh) * 2016-02-25 2018-06-26 中国农业科学院蜜蜂研究所 一种烟曲霉素的提取方法

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US2791530A (en) * 1953-08-31 1957-05-07 Abbott Lab Stabilized fumagillin compositions
JPH0629278B2 (ja) * 1985-06-26 1994-04-20 藤沢薬品工業株式会社 オキサスピロオクタン化合物
US5135920A (en) * 1988-11-16 1992-08-04 Takeda Chemical Industries, Ltd. Angiostatic agents
EP0541716A1 (en) * 1990-07-27 1993-05-19 Repligen Corporation Novel methods and compositions for treatment of angiogenic diseases
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
DE69600879T2 (de) * 1995-03-27 1999-06-02 Assistance Publique, Hopitaux De Paris, Paris Verwendung von fumagillol und seinen derivaten zur herstellung von arzneimitteln gegen darminfektionen
EP0799616A1 (en) * 1996-04-01 1997-10-08 Takeda Chemical Industries, Ltd. Oral composition comprising a fumagillol derivative
CA2210600A1 (en) * 1996-07-17 1998-01-17 Takashi Houkan Inhibitor of tumor metastasis or recurrence
AU3968597A (en) * 1996-08-02 1998-02-25 Children's Medical Center Corporation Method of regulating the female reproductive system through angiogenesis inhibitors

Also Published As

Publication number Publication date
CA2216623C (en) 2005-05-31
KR19980703271A (ko) 1998-10-15
JP3260378B2 (ja) 2002-02-25
CA2216623A1 (en) 1996-10-03
PL183378B1 (pl) 2002-06-28
FR06C0014I1 (hu) 2006-11-17
MX9707150A (es) 1998-07-31
NZ304906A (en) 1999-06-29
IS4557A (is) 1997-09-11
ATE172641T1 (de) 1998-11-15
ES2128846T3 (es) 1999-05-16
FR06C0014I2 (hu) 2006-12-29
IS2048B (is) 2005-09-15
HU224028B1 (hu) 2005-05-30
AP9701092A0 (en) 1997-10-31
EP0817626B1 (fr) 1998-10-28
AU706161B2 (en) 1999-06-10
CZ286821B6 (en) 2000-07-12
UA41446C2 (uk) 2001-09-17
SK130797A3 (en) 1998-03-04
HUP9801220A3 (en) 2001-10-29
DE69600879D1 (de) 1998-12-03
US5900431A (en) 1999-05-04
CN1179715A (zh) 1998-04-22
CZ304997A3 (en) 1997-12-17
WO1996030010A3 (fr) 1996-11-28
PL322470A1 (en) 1998-02-02
EP0817626A2 (fr) 1998-01-14
DE69600879T2 (de) 1999-06-02
NO974466D0 (no) 1997-09-26
CN1072485C (zh) 2001-10-10
AP646A (en) 1998-04-27
NO974466L (no) 1997-09-26
OA10515A (fr) 2002-04-24
KR100286920B1 (ko) 2001-04-16
SK283883B6 (sk) 2004-04-06
WO1996030010A2 (fr) 1996-10-03
TR199701048T1 (xx) 1998-01-21
NO315968B1 (no) 2003-11-24
AU5278696A (en) 1996-10-16
DK0817626T3 (da) 1999-07-12
EA199700267A1 (ru) 1998-04-30
EA000150B1 (ru) 1998-10-29
JPH11506421A (ja) 1999-06-08

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HFG4 Patent granted, date of granting

Effective date: 20050322