JPH11506421A - 腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用 - Google Patents
腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用Info
- Publication number
- JPH11506421A JPH11506421A JP8529001A JP52900196A JPH11506421A JP H11506421 A JPH11506421 A JP H11506421A JP 8529001 A JP8529001 A JP 8529001A JP 52900196 A JP52900196 A JP 52900196A JP H11506421 A JPH11506421 A JP H11506421A
- Authority
- JP
- Japan
- Prior art keywords
- fumagillol
- preparation
- pharmaceutical composition
- ester
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.マイクロスポリジアおよび/またはクリプトスポリジアによる腸感染に抗 するための薬物の調製のための、フマギロール、またはフマギロールおよび飽和 もしくは不飽和(C1−C12)アルキルカルボン酸もしくは(C1−C12)アルキルジ カルボン酸により形成されるエステル、ならびにそれらの医薬的に許容される塩 の使用。 2.エステルがフマギリンである請求項1記載の使用。 3.寄生生物エンテロシトゾーン・ビエノイシ(Enterocytozoon bieneusi) が主な原因である腸感染に抗するための薬物の調製のための、請求項1記載のフ マギロール、またはフマギロールおよび飽和もしくは不飽和(C1−C12)アルキ ルカルボン酸もしくは(C1−C12)アルキルジカルボン酸により形成されるエス テル、ならびにそれらの医薬的に許容される塩の使用。 4.エステルがフマギリンである請求項3記載の使用。 5.経口投与用薬物の調製のための請求項1または2記載の使用。 6.錠剤、ゼラチンカプセルまたは遅延作用錠剤もしくは放出調節錠剤の形態 の薬物の調製のための請求項3または4記載の使用。 7.活性成分としてフマギロール、フマギロールおよび飽和もしくは不飽和( C1−C12)アルキルカルボン酸もしくは(C1−C12)アルキルジカルボン酸によ り形成されるエステル、またはそれらの医薬的に許容される塩のうちの1つを含 有する経口投与用医薬組成物。 8.エステルがフマギリンである請求項7記載の医薬組成物。 9.活性成分1〜200mgを含有する請求項7または8記載の医薬組成物。 10.活性成分7.5〜30mgを含有する請求項9記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR95/03549 | 1995-03-27 | ||
FR9503549 | 1995-03-27 | ||
PCT/FR1996/000448 WO1996030010A2 (fr) | 1995-03-27 | 1996-03-26 | Utilisation du fumagillol et ses derives pour preparer les medicaments destines a combattre les infections intestinales |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11506421A true JPH11506421A (ja) | 1999-06-08 |
JP3260378B2 JP3260378B2 (ja) | 2002-02-25 |
Family
ID=9477436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52900196A Expired - Lifetime JP3260378B2 (ja) | 1995-03-27 | 1996-03-26 | 腸感染に対する薬物の調製のためのフマギロールおよびその誘導体の使用 |
Country Status (25)
Country | Link |
---|---|
US (1) | US5900431A (ja) |
EP (1) | EP0817626B1 (ja) |
JP (1) | JP3260378B2 (ja) |
KR (1) | KR100286920B1 (ja) |
CN (1) | CN1072485C (ja) |
AP (1) | AP646A (ja) |
AT (1) | ATE172641T1 (ja) |
AU (1) | AU706161B2 (ja) |
CA (1) | CA2216623C (ja) |
CZ (1) | CZ286821B6 (ja) |
DE (1) | DE69600879T2 (ja) |
DK (1) | DK0817626T3 (ja) |
EA (1) | EA000150B1 (ja) |
ES (1) | ES2128846T3 (ja) |
FR (1) | FR06C0014I2 (ja) |
HU (1) | HU224028B1 (ja) |
IS (1) | IS2048B (ja) |
NO (1) | NO315968B1 (ja) |
NZ (1) | NZ304906A (ja) |
OA (1) | OA10515A (ja) |
PL (1) | PL183378B1 (ja) |
SK (1) | SK283883B6 (ja) |
TR (1) | TR199701048T1 (ja) |
UA (1) | UA41446C2 (ja) |
WO (1) | WO1996030010A2 (ja) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1072485C (zh) * | 1995-03-27 | 2001-10-10 | 萨诺费合成实验室 | 夫马菌醇及其衍生物用于制备抗肠道感染药物的用途 |
EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
HU228857B1 (en) * | 1999-02-26 | 2013-06-28 | Sanofi Aventis | Stable formulation containing fumagillin |
JP3265394B1 (ja) * | 2001-03-14 | 2002-03-11 | 泰三 矢野 | アクリル系樹脂手袋 |
DE10341887A1 (de) * | 2003-09-09 | 2005-03-31 | Leopold Kostal Gmbh & Co. Kg | Elektrisches Schaltermodul |
FR2886855B1 (fr) * | 2005-06-08 | 2009-07-17 | Agronomique Inst Nat Rech | Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques |
BRPI0820229A2 (pt) * | 2007-11-28 | 2017-05-09 | A Stevenson Cheri | conjugados de análogos de fumagilina biodegradáveis biocompatíveis |
CN102123586A (zh) * | 2008-07-18 | 2011-07-13 | 法弗根股份有限公司 | 治疗超重或肥胖受试者的方法 |
WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
KR20120083905A (ko) | 2009-10-09 | 2012-07-26 | 자프겐 코포레이션 | 비만의 치료에 사용하기 위한 설폰 화합물 |
CN102791699B (zh) | 2010-01-08 | 2016-04-06 | 扎夫根公司 | 烟曲霉醇型化合物和其制造和使用方法 |
WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
US20130266578A1 (en) | 2010-04-07 | 2013-10-10 | Thomas E. Hughes | Methods of treating an overweight subject |
BR112013001613A2 (pt) | 2010-07-22 | 2016-05-24 | Zafgen Inc | compostos tricíclicos e métodos para fazer e usar os mesmos. |
MY177039A (en) | 2010-11-09 | 2020-09-03 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
JP2013543899A (ja) | 2010-11-29 | 2013-12-09 | ザフゲン,インコーポレイテッド | 6−o−(4−ジメチルアミノエトキシ)シンナモイルフマギロールの非連日投与を用いた肥満の治療 |
KR20140006888A (ko) | 2011-01-26 | 2014-01-16 | 자프겐 인크. | 테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법 |
JP5876513B2 (ja) | 2011-03-08 | 2016-03-02 | ザフゲン,インコーポレイテッド | オキサスピロ[2.5]オクタン誘導体および類似体 |
JP6035327B2 (ja) | 2011-05-06 | 2016-11-30 | ザフゲン,インコーポレイテッド | 三環式ピラゾールスルホンアミド化合物ならびにその製造および使用方法 |
BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
EP2763671A2 (en) | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
KR20140112565A (ko) | 2012-01-18 | 2014-09-23 | 자프겐 인크. | 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법 |
CA2861381A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
EP2847176A1 (en) | 2012-05-07 | 2015-03-18 | Zafgen, Inc. | Polymorphic salt of the oxalate salt of 6 - o - ( 4 - dimethylaminoethoxy) cinnarnoyl fumagillol and methods of making and using same |
AU2013259617A1 (en) | 2012-05-08 | 2014-11-27 | Zafgen, Inc. | Treating hypothalamic obesity with MetAP2 inhibitors |
AU2013259620B2 (en) | 2012-05-09 | 2017-05-18 | Zafgen, Inc. | Fumigillol type compounds and methods of making and using same |
CA2890344A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
AU2013337287B2 (en) | 2012-11-05 | 2017-03-23 | Zafgen, Inc. | Methods of treating liver diseases |
WO2014071363A1 (en) | 2012-11-05 | 2014-05-08 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
CN105228610A (zh) | 2013-03-14 | 2016-01-06 | 扎夫根股份有限公司 | 治疗肾疾病和其它病症的方法 |
CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
CN106591389B (zh) * | 2015-10-15 | 2019-10-11 | 中国科学院微生物研究所 | 一种利用烟曲霉菌生产烟曲霉素的方法 |
CN105622593B (zh) * | 2016-02-25 | 2018-06-26 | 中国农业科学院蜜蜂研究所 | 一种烟曲霉素的提取方法 |
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US2791530A (en) * | 1953-08-31 | 1957-05-07 | Abbott Lab | Stabilized fumagillin compositions |
JPH0629278B2 (ja) * | 1985-06-26 | 1994-04-20 | 藤沢薬品工業株式会社 | オキサスピロオクタン化合物 |
US5135920A (en) * | 1988-11-16 | 1992-08-04 | Takeda Chemical Industries, Ltd. | Angiostatic agents |
CA2082804A1 (en) * | 1990-07-27 | 1992-01-28 | Theodore Maione | Methods and compositions for treatment of angiogenic diseases |
US5328930A (en) * | 1993-03-01 | 1994-07-12 | Emory University | Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin |
CN1072485C (zh) * | 1995-03-27 | 2001-10-10 | 萨诺费合成实验室 | 夫马菌醇及其衍生物用于制备抗肠道感染药物的用途 |
EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
CA2210600A1 (en) * | 1996-07-17 | 1998-01-17 | Takashi Houkan | Inhibitor of tumor metastasis or recurrence |
AU3968597A (en) * | 1996-08-02 | 1998-02-25 | Children's Medical Center Corporation | Method of regulating the female reproductive system through angiogenesis inhibitors |
-
1996
- 1996-03-26 CN CN96192923A patent/CN1072485C/zh not_active Expired - Lifetime
- 1996-03-26 AP APAP/P/1997/001092A patent/AP646A/en active
- 1996-03-26 UA UA97094765A patent/UA41446C2/uk unknown
- 1996-03-26 HU HU9801220A patent/HU224028B1/hu active IP Right Grant
- 1996-03-26 WO PCT/FR1996/000448 patent/WO1996030010A2/fr active IP Right Grant
- 1996-03-26 KR KR1019970706675A patent/KR100286920B1/ko not_active IP Right Cessation
- 1996-03-26 SK SK1307-97A patent/SK283883B6/sk not_active IP Right Cessation
- 1996-03-26 NZ NZ304906A patent/NZ304906A/xx not_active IP Right Cessation
- 1996-03-26 DK DK96909200T patent/DK0817626T3/da active
- 1996-03-26 ES ES96909200T patent/ES2128846T3/es not_active Expired - Lifetime
- 1996-03-26 CA CA002216623A patent/CA2216623C/en not_active Expired - Lifetime
- 1996-03-26 EP EP96909200A patent/EP0817626B1/fr not_active Expired - Lifetime
- 1996-03-26 TR TR97/01048T patent/TR199701048T1/xx unknown
- 1996-03-26 JP JP52900196A patent/JP3260378B2/ja not_active Expired - Lifetime
- 1996-03-26 AT AT96909200T patent/ATE172641T1/de active
- 1996-03-26 US US08/913,360 patent/US5900431A/en not_active Expired - Lifetime
- 1996-03-26 CZ CZ19973049A patent/CZ286821B6/cs not_active IP Right Cessation
- 1996-03-26 DE DE69600879T patent/DE69600879T2/de not_active Expired - Lifetime
- 1996-03-26 AU AU52786/96A patent/AU706161B2/en not_active Expired
- 1996-03-26 PL PL96322470A patent/PL183378B1/pl unknown
- 1996-03-26 EA EA199700267A patent/EA000150B1/ru not_active IP Right Cessation
-
1997
- 1997-09-11 IS IS4557A patent/IS2048B/is unknown
- 1997-09-26 OA OA70088A patent/OA10515A/fr unknown
- 1997-09-26 NO NO19974466A patent/NO315968B1/no not_active IP Right Cessation
-
2006
- 2006-04-04 FR FR06C0014C patent/FR06C0014I2/fr active Active
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EXPY | Cancellation because of completion of term |