CY1110261T1 - Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα - Google Patents
Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικαInfo
- Publication number
- CY1110261T1 CY1110261T1 CY20081100594T CY081100594T CY1110261T1 CY 1110261 T1 CY1110261 T1 CY 1110261T1 CY 20081100594 T CY20081100594 T CY 20081100594T CY 081100594 T CY081100594 T CY 081100594T CY 1110261 T1 CY1110261 T1 CY 1110261T1
- Authority
- CY
- Cyprus
- Prior art keywords
- drugs
- taught
- toxicity
- anticoagulants
- chemical compounds
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
- 150000001893 coumarin derivatives Chemical class 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001988 toxicity Effects 0.000 abstract 2
- 231100000419 toxicity Toxicity 0.000 abstract 2
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical class OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 108090000371 Esterases Proteins 0.000 abstract 1
- 108090000604 Hydrolases Proteins 0.000 abstract 1
- 102000004157 Hydrolases Human genes 0.000 abstract 1
- 208000015294 blood coagulation disease Diseases 0.000 abstract 1
- 230000009852 coagulant defect Effects 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η εφεύρεση αυτή απεικονίζει χημικές ενώσεις οι οποίες μεταβολίζονται ευκολότερα από τα συστήματα μείωσης της τοξικότητας των φαρμάκων με χημικές μεταβολές που προκαλούνται στο σώμα. Ιδιαίτερα, διδάσκονται ανάλογα της βαρφαρίνης τα οποία έχουν σχεδιαστεί να περιλαμβάνουν εστέρες μέσα στη δομή των χημικών ενώσεων. Η εφεύρεση διδάσκει μεθόδους για τη μείωση της τοξικότητας των φαρμάκων, που περιλαμβάνουν την εισαγωγή εστερομάδων μέσα σε φάρμακα κατά τη διάρκεια της σύνθεσης του φαρμάκου. Η εφεύρεση αυτή απεικονίζει επίσης μεθόδους για την θεραπευτική αντιμετώπιση διαταραχών της πήξης, οι οποίες περιλαμβάνουν τη χορήγηση χημικών ενώσεων οι οποίες έχουν σχεδιαστεί να μεταβολίζονται από ευρισκόμενες στον ορό ή ενδοκυτταρικές υδρολάσες και εστεράσες. Διδάσκονται επίσης φαρμακευτικές συνθέσεις των αναλόγων βαρφαρίνης που περιλαμβάνουν τον εστέρα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28607901P | 2001-04-24 | 2001-04-24 | |
PCT/US2002/013163 WO2002085882A1 (en) | 2001-04-24 | 2002-04-24 | Coumarin derivatives to be used as anticoagulants |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110261T1 true CY1110261T1 (el) | 2012-05-23 |
Family
ID=23096978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100594T CY1110261T1 (el) | 2001-04-24 | 2008-06-05 | Παραγωγα της κουμαρινης που χρησιμοποιουνται σαν αντιπηκτικα |
Country Status (12)
Country | Link |
---|---|
US (2) | US6864279B2 (el) |
EP (1) | EP1383756B1 (el) |
JP (2) | JP4662690B2 (el) |
AT (1) | ATE388143T1 (el) |
AU (1) | AU2002256361B2 (el) |
CA (1) | CA2445160A1 (el) |
CY (1) | CY1110261T1 (el) |
DE (1) | DE60225434T2 (el) |
DK (1) | DK1383756T3 (el) |
ES (1) | ES2301635T3 (el) |
PT (1) | PT1383756E (el) |
WO (1) | WO2002085882A1 (el) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7145020B2 (en) * | 2001-04-24 | 2006-12-05 | Aryx Therapeutics | Materials and methods for treating coagulation disorders |
AU2002256361B2 (en) * | 2001-04-24 | 2008-01-24 | Arxy Therapeutics | Coumarin derivatives to be used as anticoagulants |
EP1425030A2 (en) * | 2001-08-24 | 2004-06-09 | Aryx Therapeutics | Non-oxidatively metabolized compounds and compositions, synthetic pathways therefor, and uses thereof |
DK1735296T3 (da) * | 2004-04-08 | 2010-02-01 | Aryx Therapeutics | Materialer og fremgangsmåder til behandling af koagulationslidelser |
RU2335501C2 (ru) * | 2004-04-08 | 2008-10-10 | Арикс Терапьютикс | Средства и способы для лечения нарушений свертываемости |
EP2161261B1 (en) | 2004-04-08 | 2013-08-28 | Armetheon, Inc. | Materials and methods for treating coagulation disorders |
KR100794515B1 (ko) | 2005-07-12 | 2008-01-16 | 제일약품주식회사 | 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물 |
WO2007008037A1 (en) * | 2005-07-12 | 2007-01-18 | Jeil Pharmaceutical Co., Ltd. | Novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease |
EP2092946A3 (en) * | 2006-01-30 | 2010-12-22 | CaridianBCT, Inc. | Adjusting PH in a method of separating whole blood |
AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
EP2172198B1 (en) | 2007-07-20 | 2014-04-16 | Chugai Seiyaku Kabushiki Kaisha | p27 PROTEIN INDUCER |
WO2010056914A1 (en) * | 2008-11-12 | 2010-05-20 | Microbiotix, Inc. | Bacterial helicase inhibitor compounds and uses thereof |
US9549912B2 (en) | 2009-11-23 | 2017-01-24 | Armetheon, Inc. | Methods for treating atrial fibrillation |
US20110136779A1 (en) * | 2009-11-23 | 2011-06-09 | Milner Peter G | Methods for stroke reduction in atrial fibrillation patients |
EP2521724B1 (en) * | 2009-12-11 | 2016-11-23 | Nono Inc. | Agents and methods for treating ischemic and other diseases |
LV14606B (lv) | 2011-05-17 | 2013-01-20 | Tetra, Sia | Jauns XII faktora inhibitors |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2465293A (en) * | 1942-08-29 | 1949-03-22 | Wisconsin Alumni Res Found | Synthesis of 4-hydroxycoumarins |
NL286657A (el) | 1961-12-19 | |||
NL286658A (el) | 1961-12-19 | |||
FR1463767A (fr) * | 1963-04-03 | 1966-07-22 | Clin Byla Ets | Dérivés de la coumarine et leur préparation |
GB8531388D0 (en) | 1985-12-20 | 1986-02-05 | Shell Int Research | 4-hydroxycoumarin derivatives |
JPS63165368A (ja) * | 1986-01-07 | 1988-07-08 | Yamanouchi Pharmaceut Co Ltd | 新規複素環化合物およびその製造法 |
JP3258659B2 (ja) * | 1991-03-06 | 2002-02-18 | ジー.デイー.サール アンド カンパニー | 血小板凝集阻害剤として有用なフェニルアミジン誘導体類 |
JPH0826011B2 (ja) * | 1991-04-25 | 1996-03-13 | アサヒビール株式会社 | アミノメチルイソクロマン誘導体およびその製造方法 |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
JPH06340649A (ja) * | 1993-05-31 | 1994-12-13 | Lab Farmaceut Rovi Sa | クマリンから誘導される新規な抗血栓剤及びその製造法 |
DE59402281D1 (de) * | 1993-06-28 | 1997-05-07 | Bayer Ag | Massefärben von Kunststoffen |
IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicycle compounds and pharmaceuticals containing them |
US5510375A (en) * | 1993-11-19 | 1996-04-23 | Warner-Lambert Company | Coumarin derivatives as protease inhibitors and antiviral agents |
ZA965853B (en) | 1995-07-13 | 1998-01-12 | Du Pont Merck Pharma | Asymmetric synthesis of r and s warfarin and its analogs. |
ES2213786T3 (es) * | 1995-12-29 | 2004-09-01 | 3-Dimensional Pharmaceuticals, Inc. | Inhibidores de la amidino-proteasa. |
NZ332073A (en) * | 1996-03-29 | 2000-05-26 | Dimensional Pharm Inc | Substituted hydrazinecarboximines as non-peptidic protease inhibitors |
FR2765579A1 (fr) | 1997-07-01 | 1999-01-08 | Lipha | Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides |
AU2002256361B2 (en) * | 2001-04-24 | 2008-01-24 | Arxy Therapeutics | Coumarin derivatives to be used as anticoagulants |
US7145020B2 (en) * | 2001-04-24 | 2006-12-05 | Aryx Therapeutics | Materials and methods for treating coagulation disorders |
RU2335501C2 (ru) * | 2004-04-08 | 2008-10-10 | Арикс Терапьютикс | Средства и способы для лечения нарушений свертываемости |
DK1735296T3 (da) * | 2004-04-08 | 2010-02-01 | Aryx Therapeutics | Materialer og fremgangsmåder til behandling af koagulationslidelser |
-
2002
- 2002-04-24 AU AU2002256361A patent/AU2002256361B2/en not_active Ceased
- 2002-04-24 DE DE60225434T patent/DE60225434T2/de not_active Expired - Lifetime
- 2002-04-24 US US10/132,750 patent/US6864279B2/en not_active Expired - Fee Related
- 2002-04-24 DK DK02725817T patent/DK1383756T3/da active
- 2002-04-24 CA CA002445160A patent/CA2445160A1/en not_active Abandoned
- 2002-04-24 WO PCT/US2002/013163 patent/WO2002085882A1/en active Application Filing
- 2002-04-24 ES ES02725817T patent/ES2301635T3/es not_active Expired - Lifetime
- 2002-04-24 PT PT02725817T patent/PT1383756E/pt unknown
- 2002-04-24 JP JP2002583409A patent/JP4662690B2/ja not_active Expired - Fee Related
- 2002-04-24 AT AT02725817T patent/ATE388143T1/de not_active IP Right Cessation
- 2002-04-24 EP EP02725817A patent/EP1383756B1/en not_active Expired - Lifetime
-
2008
- 2008-05-22 US US12/125,623 patent/US20080221204A1/en not_active Abandoned
- 2008-06-05 CY CY20081100594T patent/CY1110261T1/el unknown
-
2010
- 2010-01-28 JP JP2010016130A patent/JP2010143937A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1383756B1 (en) | 2008-03-05 |
ES2301635T3 (es) | 2008-07-01 |
JP2010143937A (ja) | 2010-07-01 |
US6864279B2 (en) | 2005-03-08 |
DE60225434D1 (de) | 2008-04-17 |
JP4662690B2 (ja) | 2011-03-30 |
AU2002256361B2 (en) | 2008-01-24 |
DK1383756T3 (da) | 2008-06-23 |
EP1383756A1 (en) | 2004-01-28 |
JP2004527547A (ja) | 2004-09-09 |
DE60225434T2 (de) | 2009-03-12 |
CA2445160A1 (en) | 2002-10-31 |
US20080221204A1 (en) | 2008-09-11 |
ATE388143T1 (de) | 2008-03-15 |
WO2002085882A1 (en) | 2002-10-31 |
US20030199573A1 (en) | 2003-10-23 |
PT1383756E (pt) | 2008-06-19 |
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