DE60225434D1 - Cumarin derivate und ihre verwendung als anticoagulantien - Google Patents

Cumarin derivate und ihre verwendung als anticoagulantien

Info

Publication number
DE60225434D1
DE60225434D1 DE60225434T DE60225434T DE60225434D1 DE 60225434 D1 DE60225434 D1 DE 60225434D1 DE 60225434 T DE60225434 T DE 60225434T DE 60225434 T DE60225434 T DE 60225434T DE 60225434 D1 DE60225434 D1 DE 60225434D1
Authority
DE
Germany
Prior art keywords
compounds
taught
drawn
designed
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60225434T
Other languages
English (en)
Other versions
DE60225434T2 (de
Inventor
Pascal Druzgala
Xiaoming Zhang
Jurg R Pfister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARYx Therapeutics Inc
Original Assignee
ARYx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ARYx Therapeutics Inc filed Critical ARYx Therapeutics Inc
Application granted granted Critical
Publication of DE60225434D1 publication Critical patent/DE60225434D1/de
Publication of DE60225434T2 publication Critical patent/DE60225434T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60225434T 2001-04-24 2002-04-24 Cumarin derivate und ihre verwendung als antikoagulantien Expired - Lifetime DE60225434T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28607901P 2001-04-24 2001-04-24
US286079P 2001-04-24
PCT/US2002/013163 WO2002085882A1 (en) 2001-04-24 2002-04-24 Coumarin derivatives to be used as anticoagulants

Publications (2)

Publication Number Publication Date
DE60225434D1 true DE60225434D1 (de) 2008-04-17
DE60225434T2 DE60225434T2 (de) 2009-03-12

Family

ID=23096978

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60225434T Expired - Lifetime DE60225434T2 (de) 2001-04-24 2002-04-24 Cumarin derivate und ihre verwendung als antikoagulantien

Country Status (12)

Country Link
US (2) US6864279B2 (de)
EP (1) EP1383756B1 (de)
JP (2) JP4662690B2 (de)
AT (1) ATE388143T1 (de)
AU (1) AU2002256361B2 (de)
CA (1) CA2445160A1 (de)
CY (1) CY1110261T1 (de)
DE (1) DE60225434T2 (de)
DK (1) DK1383756T3 (de)
ES (1) ES2301635T3 (de)
PT (1) PT1383756E (de)
WO (1) WO2002085882A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
DK1383756T3 (da) * 2001-04-24 2008-06-23 Aryx Therapeutics Cumarinderivater til anvendelse som antikoagulanter
JP2005525292A (ja) * 2001-08-24 2005-08-25 アリックス セラピューティクス 非酸化的に代謝される化合物および組成物、それらの合成経路、ならびに使用方法
EP2161261B1 (de) * 2004-04-08 2013-08-28 Armetheon, Inc. Materialien und Verfahren zur Behandlung von Gerinnselerkrankungen
PT1735296E (pt) * 2004-04-08 2010-02-09 Aryx Therapeutics Materiais e métodos para tratamento de distúrbios da coagulação
MXPA06011637A (es) * 2004-04-08 2007-05-04 Aryx Therapeutics Materiales y metodos para el tratamiento de trastornos de la coagulacion.
KR100794515B1 (ko) 2005-07-12 2008-01-16 제일약품주식회사 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물
WO2007008037A1 (en) * 2005-07-12 2007-01-18 Jeil Pharmaceutical Co., Ltd. Novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease
CN101374560A (zh) * 2006-01-30 2009-02-25 甘布罗Bct公司 在分离全血的方法中调节pH
AR059339A1 (es) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
JP5325103B2 (ja) 2007-07-20 2013-10-23 中外製薬株式会社 ｐ２７蛋白質誘導剤
WO2010056914A1 (en) * 2008-11-12 2010-05-20 Microbiotix, Inc. Bacterial helicase inhibitor compounds and uses thereof
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
CA2781888C (en) * 2009-12-11 2019-06-18 Nono Inc. Agents and methods for treating ischemic and other diseases
LV14606B (lv) 2011-05-17 2013-01-20 Tetra, Sia Jauns XII faktora inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465293A (en) * 1942-08-29 1949-03-22 Wisconsin Alumni Res Found Synthesis of 4-hydroxycoumarins
BE626118A (de) 1961-12-19
BE626119A (de) 1961-12-19
FR1463767A (fr) * 1963-04-03 1966-07-22 Clin Byla Ets Dérivés de la coumarine et leur préparation
GB8531388D0 (en) 1985-12-20 1986-02-05 Shell Int Research 4-hydroxycoumarin derivatives
JPS63165368A (ja) * 1986-01-07 1988-07-08 Yamanouchi Pharmaceut Co Ltd 新規複素環化合物およびその製造法
DE69200766T2 (de) * 1991-03-06 1995-05-04 G.D. Searle & Co., Chicago, Ill. Phenylamidinderivate als plättchenaggregationsinhibitoren.
JPH0826011B2 (ja) * 1991-04-25 1996-03-13 アサヒビール株式会社 アミノメチルイソクロマン誘導体およびその製造方法
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
JPH06340649A (ja) * 1993-05-31 1994-12-13 Lab Farmaceut Rovi Sa クマリンから誘導される新規な抗血栓剤及びその製造法
EP0632102B1 (de) * 1993-06-28 1997-04-02 Bayer Ag Massefärben von Kunststoffen
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
ZA965853B (en) 1995-07-13 1998-01-12 Du Pont Merck Pharma Asymmetric synthesis of r and s warfarin and its analogs.
CA2256309C (en) * 1995-12-29 2006-08-15 3-Dimensional Pharmaceuticals, Inc. Amidino protease inhibitors
EP0906091B1 (de) * 1996-03-29 2006-10-04 Ortho-McNeil Pharmaceuticals, Inc. Amidinohydrazone als protease-inhibitoren
FR2765579A1 (fr) 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
DK1383756T3 (da) * 2001-04-24 2008-06-23 Aryx Therapeutics Cumarinderivater til anvendelse som antikoagulanter
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
PT1735296E (pt) * 2004-04-08 2010-02-09 Aryx Therapeutics Materiais e métodos para tratamento de distúrbios da coagulação
MXPA06011637A (es) * 2004-04-08 2007-05-04 Aryx Therapeutics Materiales y metodos para el tratamiento de trastornos de la coagulacion.

Also Published As

Publication number Publication date
JP4662690B2 (ja) 2011-03-30
US20080221204A1 (en) 2008-09-11
EP1383756A1 (de) 2004-01-28
CA2445160A1 (en) 2002-10-31
ES2301635T3 (es) 2008-07-01
JP2004527547A (ja) 2004-09-09
WO2002085882A1 (en) 2002-10-31
EP1383756B1 (de) 2008-03-05
AU2002256361B2 (en) 2008-01-24
JP2010143937A (ja) 2010-07-01
PT1383756E (pt) 2008-06-19
US6864279B2 (en) 2005-03-08
CY1110261T1 (el) 2012-05-23
DE60225434T2 (de) 2009-03-12
US20030199573A1 (en) 2003-10-23
ATE388143T1 (de) 2008-03-15
DK1383756T3 (da) 2008-06-23

Similar Documents

Publication Publication Date Title
ATE388143T1 (de) Cumarin derivate und ihre verwendung als anticoagulantien
DE69534564D1 (de) Verwendung von 2-hydroxy-5-phenylazobenzoesäure-derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs
BR9915727A (pt) ésteres derivados de compostos de fenil-ciclohexila substituìdos
EA200601846A1 (ru) Содержащие бензоксазины лекарственные комбинации для лечения заболеваний дыхательных путей
ATE327748T1 (de) Alkandiol derivate zur behandlung von knochenkrankheiten
BR0312464A (pt) Inibidores de tirosina quinases
MA30694B1 (fr) Derives de n-(amino-heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique.
BR0206955A (pt) Ligantes de receptores de canabinóides
BR9810841A (pt) Inibidores de metaloprotease alicìclicos
DE60003791D1 (de) Felbamat-derivate
BR0012450A (pt) Benzimidazóis substituìdos
MY148937A (en) Medicaments with hm74a receptor activity
TNSN07145A1 (fr) Derives de 2-amido-4-phenylthiazole, leur preparation et leur application en therapeutique
ATE277929T1 (de) Immunsuppressive wirkungen von pteridinderivaten
BR0209320A (pt) ésteres de uridina farmaceuticamente ativos
EA200301204A1 (ru) Фармацевтически активные производные нуклеозида, способ их получения, их применение (варианты) и содержащая их фармацевтическая композиция, способ профилактики и/или лечения заболеваний и нарушений млекопитающих (варианты), комбинация лекарственных средств и ее применение (варианты)
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
BR0315580A (pt) Derivados de metileno uréia
BRPI0414864A (pt) composição farmacêutica multiparticulada compreendendo ácido micofenólico ou micofenolato de sódio e combinação com rapamicida
SE0402925D0 (sv) Novel Compounds
WO2003024943A3 (en) Aryl derivatives for the treatment of diabetes, hyperlipidemia, hypercholesterolemia and atherosclerosis
PA8542601A1 (es) Bifenilcarboxamidas reductoras de lipidos
WO2001081328A3 (en) Thiazolidinedione analogues and their use for the treatment of diabetes
EA200702199A1 (ru) Новые соединения для лечения воспалительных заболеваний
WO2004096237A3 (en) Phosphonate analogs for treating metabolic diseases

Legal Events

Date Code Title Description
8364 No opposition during term of opposition