DE69534564D1 - Verwendung von 2-hydroxy-5-phenylazobenzoesäure-derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs - Google Patents

Verwendung von 2-hydroxy-5-phenylazobenzoesäure-derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs

Info

Publication number
DE69534564D1
DE69534564D1 DE69534564T DE69534564T DE69534564D1 DE 69534564 D1 DE69534564 D1 DE 69534564D1 DE 69534564 T DE69534564 T DE 69534564T DE 69534564 T DE69534564 T DE 69534564T DE 69534564 D1 DE69534564 D1 DE 69534564D1
Authority
DE
Germany
Prior art keywords
hydroxy
chemotherapy
chemople
prevention
active agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69534564T
Other languages
English (en)
Other versions
DE69534564T2 (de
Inventor
Lorin K Johnson
Marvin H Sleisenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salix Pharmaceuticals Inc
Original Assignee
Salix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salix Pharmaceuticals Inc filed Critical Salix Pharmaceuticals Inc
Publication of DE69534564D1 publication Critical patent/DE69534564D1/de
Application granted granted Critical
Publication of DE69534564T2 publication Critical patent/DE69534564T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69534564T 1994-01-07 1995-01-06 Verwendung von 2-hydroxy-5-phenylazobenzoesäure-derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs Expired - Lifetime DE69534564T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/178,578 US5498608A (en) 1994-01-07 1994-01-07 Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
US178578 1994-01-07
PCT/US1995/000055 WO1995018622A1 (en) 1994-01-07 1995-01-06 Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents

Publications (2)

Publication Number Publication Date
DE69534564D1 true DE69534564D1 (de) 2005-12-08
DE69534564T2 DE69534564T2 (de) 2006-07-27

Family

ID=22653104

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534564T Expired - Lifetime DE69534564T2 (de) 1994-01-07 1995-01-06 Verwendung von 2-hydroxy-5-phenylazobenzoesäure-derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs

Country Status (18)

Country Link
US (1) US5498608A (de)
EP (1) EP0738152B1 (de)
JP (4) JPH09510958A (de)
CN (1) CN1140994A (de)
AT (1) ATE308327T1 (de)
AU (1) AU691869B2 (de)
CA (1) CA2180571C (de)
CZ (1) CZ286460B6 (de)
DE (1) DE69534564T2 (de)
DK (1) DK0738152T3 (de)
ES (1) ES2248796T3 (de)
FI (1) FI962735A (de)
HU (1) HUT74512A (de)
NO (1) NO962841L (de)
NZ (1) NZ279062A (de)
RO (1) RO116525B1 (de)
RU (1) RU2161487C2 (de)
WO (1) WO1995018622A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498608A (en) * 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
SE9700934D0 (sv) * 1997-03-14 1997-03-14 Astra Ab New formulation
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
JP2002522381A (ja) 1998-08-06 2002-07-23 ストレンメル，ボルフガング 粘膜保護用医薬としてのホスファチジルコリン
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
WO2002000621A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Composes inhibiteurs de la spla2 de type x
PT1642885E (pt) 2000-08-29 2009-12-17 Biocon Ltd Utilização de uma composição farmacêutica contendo um derviado de ácido para-aminofenilacético para o tratamento de estados inflamatórios do tracto gastrointestinal
TWI314457B (de) * 2001-03-19 2009-09-11 Shionogi & Co
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
KR20050075005A (ko) 2002-11-13 2005-07-19 카이론 코포레이션 암을 치료하는 방법 및 관련 방법
PL2361620T3 (pl) 2004-02-06 2016-12-30 Zastosowanie aminosalicylanów w zespole jelita drażliwego z dominującą postacią biegunkową
WO2005082340A2 (en) 2004-02-20 2005-09-09 Chiron Corporation Modulation of inflammatory and metastatic processes
FR2867981B1 (fr) 2004-03-24 2008-10-31 Genevrier Sa Lab Utilisation des chondroitine mono-et disulfates en therapeutique
ATE472999T1 (de) * 2004-05-28 2010-07-15 Salix Pharmaceuticals Inc Prävention, behandlung und linderung strahlungsinduzierter enteritis
DE602005022175D1 (de) * 2004-05-28 2010-08-19 Salix Pharmaceuticals Inc Prävention, behandlung und linderung strahlungsinduzierter enteritis
EP1773767B1 (de) 2004-07-07 2016-03-09 Biocon Limited Synthese von azogebundenen, das immunsystem regulierenden verbindungen
ES2440799T3 (es) 2005-05-13 2014-01-30 Novartis Ag Métodos para tratar cáncer resistente a los fármacos
US7452872B2 (en) * 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
EP2529729A1 (de) 2005-08-24 2012-12-05 Salix Pharmaceuticals, Inc. Balsazidformulierungen und Herstellung davon
RU2354384C1 (ru) * 2007-12-28 2009-05-10 Михаил Владимирович Кутушов Применение органических красителей в качестве средства для лечения онкологических заболеваний
WO2010030781A2 (en) * 2008-09-10 2010-03-18 Numed International, Inc. Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancer
EP2298321A1 (de) 2009-08-26 2011-03-23 Nordic Pharma Neuartige pharmazeutische Zusammensetzungen zur Behandlung von IBD
MX358142B (es) 2010-04-26 2018-08-06 Salix Pharmaceuticals Ltd Formulaciones y usos del derivado del ácido 2 - hidroxi -5 - fenilazobenzóico para el tratamiento de varones.
CN116173220A (zh) * 2022-03-02 2023-05-30 上海赛金生物医药有限公司 Ctla-4抑制剂和非类固醇抗炎药的抗癌联合治疗方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2080796B (en) * 1980-07-21 1983-10-12 Biorex Laboratories Ltd 2-hydroxy-5-phenylazobenzoic acid derivatives
US4412992A (en) * 1980-07-21 1983-11-01 Biorex Laboratories Limited 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
NZ212419A (en) * 1984-06-25 1988-08-30 Mucan Diagnostics Pty Ltd In vitro diagnostic test for detecting cancer cells producing mucin antigens
US5162202A (en) * 1989-12-12 1992-11-10 Shamsuddin Abulkalam M Rectal mucus test and kit for detecting cancerous and precancerous conditions
US5498608A (en) * 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents

Also Published As

Publication number Publication date
CZ196796A3 (en) 1996-12-11
ES2248796T3 (es) 2006-03-16
ATE308327T1 (de) 2005-11-15
RU2161487C2 (ru) 2001-01-10
AU1557595A (en) 1995-08-01
EP0738152B1 (de) 2005-11-02
FI962735A0 (fi) 1996-07-03
CZ286460B6 (en) 2000-04-12
CN1140994A (zh) 1997-01-22
EP0738152A4 (de) 2000-12-13
NO962841D0 (no) 1996-07-05
HU9601846D0 (en) 1996-09-30
FI962735A (fi) 1996-08-26
JP2006096738A (ja) 2006-04-13
DK0738152T3 (da) 2006-01-30
DE69534564T2 (de) 2006-07-27
EP0738152A1 (de) 1996-10-23
AU691869B2 (en) 1998-05-28
US5498608A (en) 1996-03-12
JP2005320326A (ja) 2005-11-17
HUT74512A (en) 1997-01-28
WO1995018622A1 (en) 1995-07-13
RO116525B1 (ro) 2001-03-30
NZ279062A (en) 1999-11-29
CA2180571A1 (en) 1995-07-13
CA2180571C (en) 2001-03-20
NO962841L (no) 1996-08-29
JP2010235629A (ja) 2010-10-21
JP4601466B2 (ja) 2010-12-22
JPH09510958A (ja) 1997-11-04

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Legal Events

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8364 No opposition during term of opposition