ATE308327T1 - Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs - Google Patents

Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs

Info

Publication number
ATE308327T1
ATE308327T1 AT95907293T AT95907293T ATE308327T1 AT E308327 T1 ATE308327 T1 AT E308327T1 AT 95907293 T AT95907293 T AT 95907293T AT 95907293 T AT95907293 T AT 95907293T AT E308327 T1 ATE308327 T1 AT E308327T1
Authority
AT
Austria
Prior art keywords
colon cancer
hydroxy
chemotherapy
chemoprevention
active ingredients
Prior art date
Application number
AT95907293T
Other languages
English (en)
Inventor
Lorin K Johnson
Marvin H Sleisenger
Original Assignee
Salix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salix Pharmaceuticals Inc filed Critical Salix Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE308327T1 publication Critical patent/ATE308327T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95907293T 1994-01-07 1995-01-06 Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs ATE308327T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/178,578 US5498608A (en) 1994-01-07 1994-01-07 Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
PCT/US1995/000055 WO1995018622A1 (en) 1994-01-07 1995-01-06 Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents

Publications (1)

Publication Number Publication Date
ATE308327T1 true ATE308327T1 (de) 2005-11-15

Family

ID=22653104

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95907293T ATE308327T1 (de) 1994-01-07 1995-01-06 Verwendung von 2-hydroxy-5-phenylazobenzoesäure- derivaten als wirkstoffe zur chemoprävention und chemotherapie von kolonkrebs

Country Status (18)

Country Link
US (1) US5498608A (de)
EP (1) EP0738152B1 (de)
JP (4) JPH09510958A (de)
CN (1) CN1140994A (de)
AT (1) ATE308327T1 (de)
AU (1) AU691869B2 (de)
CA (1) CA2180571C (de)
CZ (1) CZ286460B6 (de)
DE (1) DE69534564T2 (de)
DK (1) DK0738152T3 (de)
ES (1) ES2248796T3 (de)
FI (1) FI962735L (de)
HU (1) HUT74512A (de)
NO (1) NO962841L (de)
NZ (1) NZ279062A (de)
RO (1) RO116525B1 (de)
RU (1) RU2161487C2 (de)
WO (1) WO1995018622A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498608A (en) * 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents
US6166024A (en) * 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
US6231888B1 (en) 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
SE9700934D0 (sv) * 1997-03-14 1997-03-14 Astra Ab New formulation
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
US6677319B1 (en) 1998-08-06 2004-01-13 Wolfgang Stremmel Phosphatidylcholine as medication with protective effect large intestinal mucosa
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
JPWO2002000621A1 (ja) * 2000-06-29 2004-04-22 塩野義製薬株式会社 Ｘ型ｓＰＬＡ２阻害作用を有する化合物
AU8531101A (en) 2000-08-29 2002-03-13 Nobex Corp Immunoregulatory compounds and derivatives and methods of treating diseases therewith
TWI314457B (de) * 2001-03-19 2009-09-11 Shionogi & Co
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
MXPA05004754A (es) 2002-11-13 2005-08-02 Chiron Corp Metodos para tratar cancer y metodos relacionados.
EP2361620B1 (de) * 2004-02-06 2016-04-06 PHARMATEL (R&D) PTY LIMITED as Trustee for the PHARMATEL (R & D) TRUST Verwendung von aminosalicylaten beim reizdarmsyndrom mit durchfall als vorherrschendem symptom
US7875624B2 (en) 2004-02-20 2011-01-25 Novartis Vaccines And Diagnostics, Inc. Modulating and measuring cellular adhesion
FR2867981B1 (fr) 2004-03-24 2008-10-31 Genevrier Sa Lab Utilisation des chondroitine mono-et disulfates en therapeutique
KR101386601B1 (ko) * 2004-05-28 2014-04-17 샐릭스 파마슈티컬스 인코포레이티드 방사선 유발성 장염의 예방, 치료 및 개선 방법
JP5009152B2 (ja) * 2004-05-28 2012-08-22 サリックス ファーマシューティカルズ， インコーポレイテッド 放射線誘発性腸炎の予防、処置、および回復
ES2565848T3 (es) 2004-07-07 2016-04-07 Biocon Limited Síntesis de compuestos inmunorreguladores unidos por grupos azoicos
CN101222850B (zh) 2005-05-13 2012-10-03 诺瓦提斯公司 治疗对药物有抗性的癌症的方法
NZ603744A (en) 2005-08-24 2014-06-27 Salix Pharmaceuticals Inc Balsalazide formulations and manufacture and use thereof
US7452872B2 (en) 2005-08-24 2008-11-18 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
US8921344B2 (en) * 2006-11-03 2014-12-30 Salix Pharmaceuticals, Inc. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives
RU2314105C2 (ru) * 2005-12-01 2008-01-10 Ростовский научно-исследовательский онкологический институт Федерального агентства по здравоохранению и социальному развитию Способ лечения рака
RU2354384C1 (ru) * 2007-12-28 2009-05-10 Михаил Владимирович Кутушов Применение органических красителей в качестве средства для лечения онкологических заболеваний
US8569466B2 (en) * 2008-09-10 2013-10-29 Nnochiri Ekwuribe Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancers
EP2298321A1 (de) 2009-08-26 2011-03-23 Nordic Pharma Neuartige pharmazeutische Zusammensetzungen zur Behandlung von IBD
AU2011245455A1 (en) 2010-04-26 2012-11-15 Salix Pharmaceuticals, Ltd. Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives for the treatment of males
CN116173220B (zh) * 2022-03-02 2025-01-10 上海赛金生物医药有限公司 Ctla-4抑制剂和非类固醇抗炎药的抗癌联合治疗方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8002322L (sv) * 1980-03-26 1981-09-27 Pharmacia Ab Medel for behandling av inflammatoriska tarmsjukdomar
US4412992A (en) * 1980-07-21 1983-11-01 Biorex Laboratories Limited 2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
GB2080796B (en) * 1980-07-21 1983-10-12 Biorex Laboratories Ltd 2-hydroxy-5-phenylazobenzoic acid derivatives
NZ212419A (en) * 1984-06-25 1988-08-30 Mucan Diagnostics Pty Ltd In vitro diagnostic test for detecting cancer cells producing mucin antigens
US5162202A (en) * 1989-12-12 1992-11-10 Shamsuddin Abulkalam M Rectal mucus test and kit for detecting cancerous and precancerous conditions
IE68933B1 (en) * 1991-06-07 1996-07-24 Cedona Pharm Bv Pharmaceutical preparation
US5498608A (en) * 1994-01-07 1996-03-12 Salix Pharmaceuticals Use of 2-hydroxy-5-phenylazobenzoic acid derivatives as colon cancer chemopreventative and chemotherapeutic agents

Also Published As

Publication number Publication date
CZ286460B6 (en) 2000-04-12
HUT74512A (en) 1997-01-28
JP2006096738A (ja) 2006-04-13
JP4601466B2 (ja) 2010-12-22
CN1140994A (zh) 1997-01-22
NO962841L (no) 1996-08-29
NO962841D0 (no) 1996-07-05
DE69534564D1 (de) 2005-12-08
AU1557595A (en) 1995-08-01
EP0738152A1 (de) 1996-10-23
CZ196796A3 (en) 1996-12-11
FI962735A7 (fi) 1996-08-26
RO116525B1 (ro) 2001-03-30
JPH09510958A (ja) 1997-11-04
JP2010235629A (ja) 2010-10-21
EP0738152B1 (de) 2005-11-02
CA2180571C (en) 2001-03-20
US5498608A (en) 1996-03-12
CA2180571A1 (en) 1995-07-13
FI962735A0 (fi) 1996-07-03
EP0738152A4 (de) 2000-12-13
DK0738152T3 (da) 2006-01-30
JP2005320326A (ja) 2005-11-17
ES2248796T3 (es) 2006-03-16
HU9601846D0 (en) 1996-09-30
DE69534564T2 (de) 2006-07-27
WO1995018622A1 (en) 1995-07-13
RU2161487C2 (ru) 2001-01-10
AU691869B2 (en) 1998-05-28
FI962735L (fi) 1996-08-26
NZ279062A (en) 1999-11-29

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