DE69713526D1 - Lösliche prodrugs von paclitaxel - Google Patents
Lösliche prodrugs von paclitaxelInfo
- Publication number
- DE69713526D1 DE69713526D1 DE69713526T DE69713526T DE69713526D1 DE 69713526 D1 DE69713526 D1 DE 69713526D1 DE 69713526 T DE69713526 T DE 69713526T DE 69713526 T DE69713526 T DE 69713526T DE 69713526 D1 DE69713526 D1 DE 69713526D1
- Authority
- DE
- Germany
- Prior art keywords
- paclitaxel
- onium salts
- methods
- novel
- prodrugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229930012538 Paclitaxel Natural products 0.000 title abstract 5
- 229960001592 paclitaxel Drugs 0.000 title abstract 5
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 5
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1997/010746 WO1998058927A1 (en) | 1997-06-20 | 1997-06-20 | Soluble prodrugs of paclitaxel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69713526D1 true DE69713526D1 (de) | 2002-07-25 |
Family
ID=22261122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69713526T Expired - Lifetime DE69713526D1 (de) | 1997-06-20 | 1997-06-20 | Lösliche prodrugs von paclitaxel |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1001769B1 (de) |
| JP (1) | JP2002505682A (de) |
| AT (1) | ATE219363T1 (de) |
| AU (1) | AU3574097A (de) |
| CA (1) | CA2294606A1 (de) |
| DE (1) | DE69713526D1 (de) |
| HU (1) | HUP0002521A3 (de) |
| IL (1) | IL133585A0 (de) |
| SK (1) | SK182599A3 (de) |
| WO (1) | WO1998058927A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU777620B2 (en) * | 1999-04-09 | 2004-10-21 | Jessie L.S. Au | Methods and compositions for enhancing delivery of therapeutic agents to tissues |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
| US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
| US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| JP2004520398A (ja) * | 2001-01-18 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 経口生物学的利用能が改善されたパクリタキセルの化学療法マイクロエマルジョン組成物 |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| EP1633317A4 (de) | 2003-05-16 | 2008-08-20 | Intermune Inc | Synthetische chemokin-rezeptor-liganden und anwendungsverfahren dafür |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US8691780B2 (en) | 2005-02-17 | 2014-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby |
| JP5523313B2 (ja) | 2007-07-03 | 2014-06-18 | チルドレンズ ホスピタル アンド リサーチ センター アット オークランド | ポリシアル酸誘導体、製造方法、ならびにがん抗原産生の増強およびターゲティングにおける使用 |
| EP2296645B1 (de) | 2008-05-22 | 2014-11-19 | Galera Therapeutics, LLC | Antitumorale kombinationstherapie |
| WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
| JP2014514300A (ja) * | 2011-04-08 | 2014-06-19 | スファエラ ファーマ ピーティーイー リミテッド | 置換メチルホルミル試薬並びに化合物の物理化学的性質及び／又は薬物動態学的性質を改質するためのそれらの使用方法 |
| EP3539563A1 (de) | 2012-07-19 | 2019-09-18 | Redwood Bioscience, Inc. | Für cd22 spezifischer antikörper und verfahren zur verwendung davon |
| CN104884056A (zh) | 2012-11-12 | 2015-09-02 | 雷德伍德生物科技股份有限公司 | 用于制备缀合物的化合物和方法 |
| JP6450690B2 (ja) | 2013-02-15 | 2019-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | キメラ抗原受容体及びその使用方法 |
| JP6410790B2 (ja) | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法 |
| EP3074010A4 (de) | 2013-11-27 | 2017-10-25 | Redwood Bioscience, Inc. | Hydrazinylpyrrolverbindungen und verfahren zur herstellung eines konjugats |
| JP6615769B2 (ja) | 2014-02-19 | 2019-12-04 | アルデア ファーマシューティカルズ インコーポレイテッド | ミトコンドリアアルデヒドデヒドロゲナーゼ２（ａｌｄｈ２）に結合する多環式アミド |
| US10654875B2 (en) | 2015-11-12 | 2020-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
| US20210206826A1 (en) | 2015-11-19 | 2021-07-08 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| EP3231421A1 (de) | 2016-04-11 | 2017-10-18 | Greenaltech, S.L. | Verwendungen eines carotenoids bei der behandlung oder prävention von durch stress verursachten störungen |
| CA3019398A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| SI3463308T1 (sl) | 2016-06-01 | 2022-04-29 | Servier IP UK Limited | Formulacije polialkilenoksidne asparaginaze in postopki za pripravo in uporabo le-teh |
| EP3571229A1 (de) | 2017-01-18 | 2019-11-27 | F1 Oncology, Inc. | Chimäre antigenrezeptoren gegen axl oder ror2 und verfahren zur verwendung davon |
| EP3388082A1 (de) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Kombinationskrebsimmuntherapie mit makrocyclischem pentaaza-ringkomplex |
| JP2021512110A (ja) | 2018-01-31 | 2021-05-13 | ガレラ・ラブス・リミテッド・ライアビリティ・カンパニーGalera Labs, Llc | ペンタアザ大環状環複合体および白金を基にした抗癌剤による組み合わせ癌療法 |
| WO2019200181A1 (en) | 2018-04-11 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
| EP3823674A4 (de) | 2018-07-18 | 2022-12-28 | Manzanita Pharmaceuticals, Inc. | Konjugate zur abgabe eines krebsmittels an nervenzellen, verwendungsverfahren und verfahren zu deren herstellung |
| JP2022527860A (ja) | 2019-04-02 | 2022-06-06 | ケンジョッケティ バイオテクノロジー，インク． | 排出ポンプ－癌抗原マルチ特異性抗体ならびにそれに関する組成物、試薬、キットおよび方法 |
| WO2021155028A1 (en) | 2020-01-29 | 2021-08-05 | Kenjockety Biotechnology, Inc. | Anti-mdr1 antibodies and uses thereof |
| WO2021247426A1 (en) | 2020-06-04 | 2021-12-09 | Kenjockety Biotechnology, Inc. | Anti-abcg2 antibodies and uses thereof |
| WO2021247423A1 (en) | 2020-06-04 | 2021-12-09 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| EP4208483A1 (de) | 2020-09-02 | 2023-07-12 | Kenjockety Biotechnology, Inc. | Anti-abcc1-antikörper und verwendungen davon |
| EP4244257A1 (de) | 2020-11-13 | 2023-09-20 | Kenjockety Biotechnology, Inc. | Anti-mrp4 (codiert durch abcc4-gen) antikörper und verwendungen davon |
| CA3238353A1 (en) | 2021-12-13 | 2023-06-22 | William Robert ARATHOON | Anti-abcb1 antibodies |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4013595A (en) * | 1995-10-27 | 1997-05-15 | Scripps Research Institute, The | Method for treating cancer using taxoid onium salt prodrugs |
| HUP0003546A3 (en) * | 1997-05-27 | 2002-12-28 | Baker Norton Pharma | Compositions for administering taxanes orally to human patients |
-
1997
- 1997-06-20 AT AT97932226T patent/ATE219363T1/de not_active IP Right Cessation
- 1997-06-20 DE DE69713526T patent/DE69713526D1/de not_active Expired - Lifetime
- 1997-06-20 IL IL13358597A patent/IL133585A0/xx unknown
- 1997-06-20 WO PCT/US1997/010746 patent/WO1998058927A1/en not_active Application Discontinuation
- 1997-06-20 CA CA002294606A patent/CA2294606A1/en not_active Abandoned
- 1997-06-20 EP EP97932226A patent/EP1001769B1/de not_active Expired - Lifetime
- 1997-06-20 JP JP50434699A patent/JP2002505682A/ja not_active Ceased
- 1997-06-20 AU AU35740/97A patent/AU3574097A/en not_active Abandoned
- 1997-06-20 HU HU0002521A patent/HUP0002521A3/hu unknown
- 1997-06-20 SK SK1825-99A patent/SK182599A3/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2294606A1 (en) | 1998-12-30 |
| HUP0002521A2 (hu) | 2001-06-28 |
| JP2002505682A (ja) | 2002-02-19 |
| EP1001769A1 (de) | 2000-05-24 |
| SK182599A3 (en) | 2000-07-11 |
| AU3574097A (en) | 1999-01-04 |
| WO1998058927A1 (en) | 1998-12-30 |
| EP1001769A4 (de) | 2000-05-24 |
| HUP0002521A3 (en) | 2002-04-29 |
| IL133585A0 (en) | 2001-04-30 |
| EP1001769B1 (de) | 2002-06-19 |
| ATE219363T1 (de) | 2002-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |