DK1383756T3 - Cumarinderivater til anvendelse som antikoagulanter - Google Patents

Cumarinderivater til anvendelse som antikoagulanter

Info

Publication number
DK1383756T3
DK1383756T3 DK02725817T DK02725817T DK1383756T3 DK 1383756 T3 DK1383756 T3 DK 1383756T3 DK 02725817 T DK02725817 T DK 02725817T DK 02725817 T DK02725817 T DK 02725817T DK 1383756 T3 DK1383756 T3 DK 1383756T3
Authority
DK
Denmark
Prior art keywords
compounds
taught
drawn
designed
analogs
Prior art date
Application number
DK02725817T
Other languages
English (en)
Inventor
Pascal Druzgala
Xiaoming Zhang
Jurg R Pfister
Original Assignee
Aryx Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aryx Therapeutics filed Critical Aryx Therapeutics
Application granted granted Critical
Publication of DK1383756T3 publication Critical patent/DK1383756T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK02725817T 2001-04-24 2002-04-24 Cumarinderivater til anvendelse som antikoagulanter DK1383756T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28607901P 2001-04-24 2001-04-24
PCT/US2002/013163 WO2002085882A1 (en) 2001-04-24 2002-04-24 Coumarin derivatives to be used as anticoagulants

Publications (1)

Publication Number Publication Date
DK1383756T3 true DK1383756T3 (da) 2008-06-23

Family

ID=23096978

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02725817T DK1383756T3 (da) 2001-04-24 2002-04-24 Cumarinderivater til anvendelse som antikoagulanter

Country Status (12)

Country Link
US (2) US6864279B2 (da)
EP (1) EP1383756B1 (da)
JP (2) JP4662690B2 (da)
AT (1) ATE388143T1 (da)
AU (1) AU2002256361B2 (da)
CA (1) CA2445160A1 (da)
CY (1) CY1110261T1 (da)
DE (1) DE60225434T2 (da)
DK (1) DK1383756T3 (da)
ES (1) ES2301635T3 (da)
PT (1) PT1383756E (da)
WO (1) WO2002085882A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1383756E (pt) * 2001-04-24 2008-06-19 Aryx Therapeutics Derivados de cumarina a utilizar como anticoagulantes
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
JP2005525292A (ja) * 2001-08-24 2005-08-25 アリックス セラピューティクス 非酸化的に代謝される化合物および組成物、それらの合成経路、ならびに使用方法
WO2005100336A1 (en) * 2004-04-08 2005-10-27 Aryx Therapeutics Materials and methods for treating coagulation disorders
CN1950353B (zh) 2004-04-08 2011-06-01 ARYx医疗有限公司 治疗凝血紊乱的药物和方法
EP2161261B1 (en) 2004-04-08 2013-08-28 Armetheon, Inc. Materials and methods for treating coagulation disorders
KR100794515B1 (ko) 2005-07-12 2008-01-16 제일약품주식회사 항염증 활성을 갖는 크로멘-2-온 모핵 히드록사민 산유도체, 이의 제조방법 및 이를 포함하는 염증 질환의치료를 위한 조성물
WO2007008037A1 (en) * 2005-07-12 2007-01-18 Jeil Pharmaceutical Co., Ltd. Novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease
KR20080091109A (ko) * 2006-01-30 2008-10-09 감브로 비씨티, 인크. 전혈 분리 방법에 있어서 ｐＨ 조정
AR059339A1 (es) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
EP2172198B1 (en) 2007-07-20 2014-04-16 Chugai Seiyaku Kabushiki Kaisha p27 PROTEIN INDUCER
WO2010056914A1 (en) * 2008-11-12 2010-05-20 Microbiotix, Inc. Bacterial helicase inhibitor compounds and uses thereof
US9549912B2 (en) 2009-11-23 2017-01-24 Armetheon, Inc. Methods for treating atrial fibrillation
US20110136779A1 (en) * 2009-11-23 2011-06-09 Milner Peter G Methods for stroke reduction in atrial fibrillation patients
AU2010327936B2 (en) 2009-12-11 2015-08-20 Nono Inc. Agents and methods for treating ischemic and other diseases
LV14606B (lv) 2011-05-17 2013-01-20 Tetra, Sia Jauns XII faktora inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2465293A (en) * 1942-08-29 1949-03-22 Wisconsin Alumni Res Found Synthesis of 4-hydroxycoumarins
NL286657A (da) * 1961-12-19
NL286658A (da) * 1961-12-19
FR1463767A (fr) 1963-04-03 1966-07-22 Clin Byla Ets Dérivés de la coumarine et leur préparation
GB8531388D0 (en) * 1985-12-20 1986-02-05 Shell Int Research 4-hydroxycoumarin derivatives
JPS63165368A (ja) * 1986-01-07 1988-07-08 Yamanouchi Pharmaceut Co Ltd 新規複素環化合物およびその製造法
US5481021A (en) * 1991-03-06 1996-01-02 G. D. Searle & Co. Phenyl amidines derivatives useful as platelet aggregation inhibitors
JPH0826011B2 (ja) * 1991-04-25 1996-03-13 アサヒビール株式会社 アミノメチルイソクロマン誘導体およびその製造方法
IL108459A0 (en) * 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
JPH06340649A (ja) * 1993-05-31 1994-12-13 Lab Farmaceut Rovi Sa クマリンから誘導される新規な抗血栓剤及びその製造法
DE59402281D1 (de) * 1993-06-28 1997-05-07 Bayer Ag Massefärben von Kunststoffen
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US5510375A (en) * 1993-11-19 1996-04-23 Warner-Lambert Company Coumarin derivatives as protease inhibitors and antiviral agents
ZA965853B (en) * 1995-07-13 1998-01-12 Du Pont Merck Pharma Asymmetric synthesis of r and s warfarin and its analogs.
PT883405E (pt) * 1995-12-29 2004-06-30 Dimensional Pharm Inc Inibidores de amidino-protease
ATE341317T1 (de) * 1996-03-29 2006-10-15 Ortho Mcneil Pharm Inc Amidinohydrazone als protease-inhibitoren
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
PT1383756E (pt) * 2001-04-24 2008-06-19 Aryx Therapeutics Derivados de cumarina a utilizar como anticoagulantes
WO2005100336A1 (en) * 2004-04-08 2005-10-27 Aryx Therapeutics Materials and methods for treating coagulation disorders
CN1950353B (zh) * 2004-04-08 2011-06-01 ARYx医疗有限公司 治疗凝血紊乱的药物和方法

Also Published As

Publication number Publication date
EP1383756A1 (en) 2004-01-28
WO2002085882A1 (en) 2002-10-31
EP1383756B1 (en) 2008-03-05
US20030199573A1 (en) 2003-10-23
DE60225434T2 (de) 2009-03-12
US20080221204A1 (en) 2008-09-11
DE60225434D1 (de) 2008-04-17
JP2004527547A (ja) 2004-09-09
JP2010143937A (ja) 2010-07-01
JP4662690B2 (ja) 2011-03-30
CA2445160A1 (en) 2002-10-31
AU2002256361B2 (en) 2008-01-24
CY1110261T1 (el) 2012-05-23
ATE388143T1 (de) 2008-03-15
US6864279B2 (en) 2005-03-08
PT1383756E (pt) 2008-06-19
ES2301635T3 (es) 2008-07-01

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