BR112013023056A2 - derivados de oxaespiro [2,5] octano e análogos - Google Patents
derivados de oxaespiro [2,5] octano e análogosInfo
- Publication number
- BR112013023056A2 BR112013023056A2 BR112013023056A BR112013023056A BR112013023056A2 BR 112013023056 A2 BR112013023056 A2 BR 112013023056A2 BR 112013023056 A BR112013023056 A BR 112013023056A BR 112013023056 A BR112013023056 A BR 112013023056A BR 112013023056 A2 BR112013023056 A2 BR 112013023056A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxospiro
- analogs
- octane derivatives
- octane
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450301P | 2011-03-08 | 2011-03-08 | |
| PCT/US2012/028068 WO2012122264A1 (en) | 2011-03-08 | 2012-03-07 | Oxaspiro [2.5] octane derivatives and analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013023056A2 true BR112013023056A2 (pt) | 2018-10-09 |
Family
ID=45856034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013023056A BR112013023056A2 (pt) | 2011-03-08 | 2012-03-07 | derivados de oxaespiro [2,5] octano e análogos |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9328082B2 (pt) |
| EP (1) | EP2683706B1 (pt) |
| JP (1) | JP5876513B2 (pt) |
| KR (1) | KR101875988B1 (pt) |
| CN (1) | CN103534244B (pt) |
| AU (1) | AU2012225531B2 (pt) |
| BR (1) | BR112013023056A2 (pt) |
| CA (1) | CA2829204C (pt) |
| MX (1) | MX342257B (pt) |
| WO (1) | WO2012122264A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815309B2 (en) | 2010-01-08 | 2014-08-26 | Zafgen, Inc. | Methods of treating a subject with benign prostate hyperplasia |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| US9320805B2 (en) | 2010-05-25 | 2016-04-26 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| CA2829204C (en) | 2011-03-08 | 2019-12-24 | Zafgen, Inc. | Oxaspiro[2.5]octane derivatives and analogs |
| EP2763671A2 (en) * | 2011-10-03 | 2014-08-13 | Zafgen, Inc. | Methods of treating age related disorders |
| MX2014013599A (es) | 2012-05-08 | 2015-05-11 | Zafgen Inc | Tratamiento de la obesidad hipotalamica con inhibidores de metap2. |
| MX356755B (es) | 2012-05-09 | 2018-06-11 | Zafgen Inc | Compuestos de tipo fumagilol y metodos para su elaboración y uso. |
| AU2014236528A1 (en) | 2013-03-14 | 2015-09-24 | Zafgen, Inc. | Methods of treating renal disease and other disorders |
| MX371095B (es) | 2013-04-10 | 2020-01-16 | Syndevrx Inc | Inhibidores de metionina aminopeptidasa-2 y metodos de tratamiento de la obesidad. |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| JP2019501898A (ja) | 2015-12-10 | 2019-01-24 | シンデブルックス，インコーポレイティド | フマギロール誘導体およびその多形体 |
| KR20180100663A (ko) | 2016-01-11 | 2018-09-11 | 신데브알엑스, 인크. | 대사 기능장애에 의하여 유도된 종양에 대한 치료 |
| CN113453721A (zh) | 2018-10-26 | 2021-09-28 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| PH26256A (en) | 1988-08-12 | 1992-04-01 | Fujisawa Pharmaceutical Co | Oxaspiro [2,5] octane derivative |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| KR0138530B1 (ko) | 1988-09-01 | 1998-05-15 | 우메모또 요시마사 | 푸마길롤 유도체 |
| US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5288722A (en) | 1989-03-06 | 1994-02-22 | Takeda Chemical Industries, Ltd. | 6-amino-6-desoxyfumagillols, production and use thereof |
| DE69001187T2 (de) | 1989-03-06 | 1993-07-08 | Takeda Chemical Industries Ltd | 6-epifumagillole, ihre herstellung und ihre verwendung. |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) * | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| TW282399B (pt) | 1990-05-25 | 1996-08-01 | Takeda Pharm Industry Co Ltd | |
| DE69330690T2 (de) | 1992-01-30 | 2002-06-20 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung hoch-wasserlöslicher Zyklodextrinkomplexe |
| ATE153854T1 (de) | 1992-12-16 | 1997-06-15 | Takeda Chemical Industries Ltd | Stabile pharmazeutische zubereitung mit fumagillolderivaten |
| EA000150B1 (ru) | 1995-03-27 | 1998-10-29 | Санофи | Применение фумагиллола и его производных для приготовления лекарств, предназначенных для борьбы с кишечными инфекциями, и фармацевтическая композиция на их основе |
| WO1997013509A1 (fr) | 1995-10-11 | 1997-04-17 | Fujisawa Pharmaceutical Co., Ltd. | Inhibiteur de permeation vasculaire |
| EP0799616A1 (en) | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| AU3968597A (en) | 1996-08-02 | 1998-02-25 | Children's Medical Center Corporation | Method of regulating the female reproductive system through angiogenesis inhibitors |
| WO1998056372A1 (en) | 1997-06-09 | 1998-12-17 | Massachusetts Institute Of Technology | TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF |
| EP1024801B1 (en) | 1997-10-31 | 2004-06-23 | Children's Medical Center Corporation | Method for regulating size and growth of vascularized normal tissue |
| KR100357541B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 5-데메톡시 푸마질롤 유도체 및 그 제조방법 |
| KR100357542B1 (ko) | 1998-05-15 | 2002-10-18 | 주식회사종근당 | 푸마질롤 유도체 및 그 제조방법 |
| JP2000116337A (ja) | 1998-10-09 | 2000-04-25 | Nippon Shokuhin Kako Co Ltd | ペットフード |
| US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| SK15522001A3 (sk) | 1999-04-28 | 2002-06-04 | Aventis Pharma Deutschland Gmbh | Deriváty kyselín s tromi arylovými zvyškami ako ligandy receptorov PPAR a farmaceutické kompozície, ktoré ich obsahujú |
| US6323228B1 (en) | 2000-09-15 | 2001-11-27 | Abbott Laboratories | 3-substituted indole angiogenesis inhibitors |
| US6548477B1 (en) | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| WO2002042295A2 (en) | 2000-11-01 | 2002-05-30 | Praecis Pharmaceuticals Inc. | Peptides as met-ap2 inhibitors |
| WO2002078699A1 (en) | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Compounds and methods |
| EP1436286B1 (en) | 2001-09-27 | 2009-08-19 | Equispharm Co., Ltd. | Fumagillol derivatives and preparing method thereof |
| US6803382B2 (en) | 2001-11-09 | 2004-10-12 | Galderma Research & Development, S.N.C. | Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof |
| KR100451485B1 (ko) | 2002-03-28 | 2004-10-06 | 주식회사종근당 | 푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물 |
| US6989392B2 (en) | 2002-06-18 | 2006-01-24 | Abbott Laboratories | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists |
| US20040067266A1 (en) | 2002-10-07 | 2004-04-08 | Toppo Frank R. | Weight loss compound |
| US20040157836A1 (en) | 2002-10-08 | 2004-08-12 | Comess Kenneth M. | Sulfonamides having antiangiogenic and anticancer activity |
| WO2004078113A2 (en) | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents |
| CA2550873A1 (en) | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
| KR100552043B1 (ko) * | 2004-02-28 | 2006-02-20 | 주식회사종근당 | 푸마질롤 유도체를 포함하는 비만치료용 조성물 |
| MX2007000142A (es) | 2004-06-30 | 2007-03-26 | Combinatorx Inc | Metodos y reactivos para el tratamiento de desordenes metabolicos. |
| US20060045865A1 (en) | 2004-08-27 | 2006-03-02 | Spherics, Inc. | Controlled regional oral delivery |
| CN101142210A (zh) | 2005-01-26 | 2008-03-12 | 株式会社钟根堂 | 烟曲霉醇衍生物或制备烟曲霉醇衍生物的方法、以及包含该衍生物的药物组合物 |
| FR2886855B1 (fr) | 2005-06-08 | 2009-07-17 | Agronomique Inst Nat Rech | Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques |
| US20070078172A1 (en) | 2005-06-16 | 2007-04-05 | Jenrin Discovery | Mao-b inhibitors useful for treating obesity |
| JP2010531896A (ja) | 2007-06-26 | 2010-09-30 | チルドレンズ メディカル センター コーポレーション | 治療的投与のためのＭｅｔＡＰ−２阻害剤ポリマーソーム |
| JP5557746B2 (ja) | 2007-11-28 | 2014-07-23 | メルサナ セラピューティックス，インク． | 生体適合性生分解性フマギリンアナログ複合体 |
| AU2009270799B2 (en) * | 2008-07-18 | 2016-05-19 | Zafgen, Inc. | Methods of treating an overweight or obese subject |
| ES2641471T3 (es) | 2008-10-06 | 2017-11-10 | The Johns Hopkins University | Compuestos de quinolina como inhibidores de la angiogénesis, metionina aminopeptidasa humana, y SirT1, y procedimientos de tratamiento de trastornos |
| WO2010065879A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065881A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| CN102639494B (zh) | 2009-10-09 | 2016-11-09 | 扎夫根公司 | 砜化合物及其制备和使用方法 |
| US20130210821A1 (en) | 2010-05-27 | 2013-08-15 | James E. Vath | Methods for Treating Obesity |
| EP2595988B1 (en) | 2010-07-22 | 2014-12-17 | Zafgen, Inc. | Tricyclic compounds and methds of making and using same |
| MX339201B (es) | 2010-10-12 | 2016-05-13 | Zafgen Inc | Compuestos de sulfonamida y métodos para elaborarlos y usarlos. |
| WO2012075026A1 (en) | 2010-11-29 | 2012-06-07 | Zafgen Corporation | Methods of treating obesity using an effective dose of a metap-2 inhibitor |
| JP2013543899A (ja) | 2010-11-29 | 2013-12-09 | ザフゲン，インコーポレイテッド | ６−ｏ−（４−ジメチルアミノエトキシ）シンナモイルフマギロールの非連日投与を用いた肥満の治療 |
| US20130316994A1 (en) | 2010-11-29 | 2013-11-28 | Zafgen, Inc. | Methods of Reducing Risk of Hepatobiliary Dysfunction During Rapid Weight Loss with METAP-2 Inhibitors |
| US9321740B2 (en) | 2011-01-26 | 2016-04-26 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| CA2829204C (en) | 2011-03-08 | 2019-12-24 | Zafgen, Inc. | Oxaspiro[2.5]octane derivatives and analogs |
| JP6035327B2 (ja) | 2011-05-06 | 2016-11-30 | ザフゲン，インコーポレイテッド | 三環式ピラゾールスルホンアミド化合物ならびにその製造および使用方法 |
| BR112013028534A2 (pt) | 2011-05-06 | 2016-09-06 | Zafgen Inc | compostos tricíclicos parcialmente saturados e métodos para produção e utilização dos mesmos |
| US9187494B2 (en) | 2011-05-06 | 2015-11-17 | Zafgen, Inc. | Aryl-substituted tricyclic sulfonamides as methionyl aminopeptidase 2 modulators |
-
2012
- 2012-03-07 CA CA2829204A patent/CA2829204C/en not_active Expired - Fee Related
- 2012-03-07 MX MX2013010277A patent/MX342257B/es active IP Right Grant
- 2012-03-07 AU AU2012225531A patent/AU2012225531B2/en not_active Ceased
- 2012-03-07 EP EP12709761.6A patent/EP2683706B1/en active Active
- 2012-03-07 WO PCT/US2012/028068 patent/WO2012122264A1/en active Application Filing
- 2012-03-07 KR KR1020137026393A patent/KR101875988B1/ko active IP Right Grant
- 2012-03-07 BR BR112013023056A patent/BR112013023056A2/pt not_active Application Discontinuation
- 2012-03-07 CN CN201280022154.XA patent/CN103534244B/zh not_active Expired - Fee Related
- 2012-03-07 JP JP2013557830A patent/JP5876513B2/ja not_active Expired - Fee Related
- 2012-03-07 US US14/003,906 patent/US9328082B2/en not_active Expired - Fee Related
-
2016
- 2016-03-14 US US15/068,942 patent/US20170044122A1/en not_active Abandoned
-
2017
- 2017-05-31 US US15/609,813 patent/US10259796B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR101875988B1 (ko) | 2018-07-06 |
| US20180354924A1 (en) | 2018-12-13 |
| US10259796B2 (en) | 2019-04-16 |
| JP5876513B2 (ja) | 2016-03-02 |
| CN103534244B (zh) | 2016-10-12 |
| US9328082B2 (en) | 2016-05-03 |
| CA2829204C (en) | 2019-12-24 |
| AU2012225531B2 (en) | 2017-03-30 |
| CA2829204A1 (en) | 2012-09-13 |
| EP2683706B1 (en) | 2018-02-21 |
| CN103534244A (zh) | 2014-01-22 |
| JP2014507477A (ja) | 2014-03-27 |
| AU2012225531A1 (en) | 2013-09-26 |
| KR20140027134A (ko) | 2014-03-06 |
| US20170044122A1 (en) | 2017-02-16 |
| EP2683706A1 (en) | 2014-01-15 |
| WO2012122264A1 (en) | 2012-09-13 |
| MX342257B (es) | 2016-09-21 |
| MX2013010277A (es) | 2014-02-03 |
| US20150045427A1 (en) | 2015-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013023056A2 (pt) | derivados de oxaespiro [2,5] octano e análogos | |
| SG10201601802YA (en) | Dispiropyrrolidine derivatives | |
| CO6890099A2 (es) | Nuevos derivados dihidroquinolina-2-ona | |
| GB201107176D0 (en) | Pyrrolnitrin derivatives | |
| IL247636A0 (en) | History of heteroaryl piperidine | |
| PT2734499T (pt) | Derivados de merocianina | |
| CO7020919A2 (es) | Derivados de tetrahidro-quinazolinona | |
| IL231950B (en) | Aryl-quinoline derivatives | |
| EP2721029A4 (en) | IMIDAZOPYRIDIN-2-ONE DERIVATIVES | |
| BR302012001179S1 (pt) | "configuração aplicada em farol" | |
| CO6960557A2 (es) | Derivados de 2-yodo-imidazol | |
| CO6811866A2 (es) | Derivados de benzamida sustituida | |
| CO6920301A2 (es) | Derivados insecticidas de 2-metoxibenzamida | |
| BR302012001925S1 (pt) | "configuração aplicada em calota" | |
| BRDI7105439S (pt) | "configuração aplicada em aparelho de preparo de bebidas" | |
| SI2766342T1 (sl) | Derivati fenil-gvanidina | |
| BR302012001168S1 (pt) | "configuração aplicada em farol" | |
| CO6852074A2 (es) | Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida | |
| ZA201308049B (en) | 3-ureidoisoquinolin-8-yl derivatives | |
| ES2397885B1 (es) | Derivados de colismicina. | |
| BR112013019806A2 (pt) | derivado de tetrahidroisoquinolina. | |
| BR302012002841S1 (pt) | "configuração aplicada em pneumático" | |
| ES1075814Y (es) | Perfeccionamiento de punching-ball corredizo | |
| TH1301002001B (th) | องค์ประกอบสารกันแดด | |
| DK2785675T3 (da) | 5,5-dimethyl-2-propyl-hexahydro-2,4a-methanonaphthalen-1-on som duftmiddel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |