ES2148254T3 - Peptidos antimicrobianos ciclicos y preparacion de los mismos. - Google Patents

Peptidos antimicrobianos ciclicos y preparacion de los mismos.

Info

Publication number
ES2148254T3
ES2148254T3 ES94107406T ES94107406T ES2148254T3 ES 2148254 T3 ES2148254 T3 ES 2148254T3 ES 94107406 T ES94107406 T ES 94107406T ES 94107406 T ES94107406 T ES 94107406T ES 2148254 T3 ES2148254 T3 ES 2148254T3
Authority
ES
Spain
Prior art keywords
preparation
same
hydroxy
hydrogen
antimicrobial peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94107406T
Other languages
English (en)
Inventor
Hidenori Ohki
Masaki Tomishima
Akira Yamada
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939310091A external-priority patent/GB9310091D0/en
Priority claimed from GB939325269A external-priority patent/GB9325269D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2148254T3 publication Critical patent/ES2148254T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN COMPUESTO POLIPEPTIDO CON LA FORMULA GENERAL INDICADA, DONDE R1 ES HIDROGENO; R2, UN GRUPO ACILO; R3, HIDROXILO O ACILOXILO; R4, HIDROXILO O HIDROXISULFONILOXILO; R5, HIDROGENO O ALQUILO INFERIOR QUE PUEDE TENER UNO O MAS SUSTITUYENTES DISPONIBLES Y R6 ES HIDROGENO, HIDROXILO O ALQUILTIO (INFERIOR) DE ACILO Y SU SAL FARMACEUTICAMENTE ACEPTABLE; TAMBIEN SE DESCRIBE SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN COMO INGREDIENTES ACTIVOS.
ES94107406T 1993-05-17 1994-05-12 Peptidos antimicrobianos ciclicos y preparacion de los mismos. Expired - Lifetime ES2148254T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310091A GB9310091D0 (en) 1993-05-17 1993-05-17 New polypeptide compound and a process for preparation thereof
GB939325269A GB9325269D0 (en) 1993-12-10 1993-12-10 New polypeptide compound and a process for preparation thereof

Publications (1)

Publication Number Publication Date
ES2148254T3 true ES2148254T3 (es) 2000-10-16

Family

ID=26302903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94107406T Expired - Lifetime ES2148254T3 (es) 1993-05-17 1994-05-12 Peptidos antimicrobianos ciclicos y preparacion de los mismos.

Country Status (18)

Country Link
US (2) US5569646A (es)
EP (1) EP0644199B1 (es)
JP (1) JP3551469B2 (es)
KR (1) KR100346489B1 (es)
CN (1) CN1057306C (es)
AT (1) ATE194846T1 (es)
AU (1) AU681119B2 (es)
CA (1) CA2123921A1 (es)
DE (1) DE69425304T2 (es)
DK (1) DK0644199T3 (es)
ES (1) ES2148254T3 (es)
GR (1) GR3034366T3 (es)
HU (1) HUT68385A (es)
IL (1) IL109615A (es)
PH (1) PH30811A (es)
PT (1) PT644199E (es)
RU (1) RU2164230C2 (es)
TW (1) TW301655B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5854276A (en) * 1995-06-29 1998-12-29 Fujisawa Pharmaceutical Co., Ltd. Substance WF16616, process for production thereof, and use thereof
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
US6117641A (en) 1996-04-11 2000-09-12 Mitotix, Inc. Assays and reagents for identifying anti-fungal agents and uses related thereto
JP2001513622A (ja) 1996-04-11 2001-09-04 マイトティックス インコーポレーテッド 抗菌剤の同定のためのアッセイおよび試薬、並びにそれらに関連する利用
US6727082B1 (en) 1996-04-11 2004-04-27 Gpc Biotech Inc. Assays and reagents for identifying anti-fungal agents, and uses related thereto
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
JP3561917B2 (ja) * 1998-02-09 2004-09-08 藤沢薬品工業株式会社 新規化合物
US6730776B1 (en) * 1998-03-16 2004-05-04 Fujisawa Pharmaceutical Co., Ltd. WF14573 or its salt, production thereof and use thereof
WO1999055727A1 (en) 1998-04-23 1999-11-04 Aventis Pharma Deutschland Gmbh A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues
WO2000020441A2 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Cyclic peptides as antifungal agents
AUPP999799A0 (en) 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
AUPR362001A0 (en) * 2001-03-08 2001-04-05 Fujisawa Pharmaceutical Co., Ltd. New compound
US20100256048A1 (en) * 2007-10-29 2010-10-07 Astellas Pharma Inc. Polypeptide compound
US9260479B2 (en) * 2009-03-16 2016-02-16 The Governing Council Of The University Of Toronto Cyclic amino acid molecules and methods of preparing the same
US8927801B2 (en) * 2009-04-13 2015-01-06 The Procter & Gamble Company Absorbent articles comprising wetness indicators
JP2014088326A (ja) * 2011-02-22 2014-05-15 Astellas Pharma Inc ポリペプチド化合物
CN102512379B (zh) * 2011-12-16 2017-03-08 深圳市健元医药科技有限公司 一种新型棘白菌素类抗真菌药物组合物及其制备方法
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102786591B (zh) * 2012-08-31 2014-03-12 哈尔滨工业大学 定向诱导合成金属硫蛋白的工艺
US11046695B2 (en) 2015-11-11 2021-06-29 Zealand Pharma A/S Fragment synthesis of substituted cyclic peptides
ES2884107T3 (es) 2016-11-11 2021-12-10 Zealand Pharma As Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
IL270465B (en) 2017-05-10 2022-09-01 Encycle Therapeutics Inc Cyclic peptides targeting alpha4beta7 integrin
CN112759627B (zh) * 2021-03-12 2021-10-01 河南科技大学 一种抗白色念珠菌多肽及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
IE912046A1 (en) * 1990-06-18 1991-12-18 Fujisawa Pharmaceutical Co New polypeptide compound and a process for preparation¹thereof
WO1994009033A1 (en) * 1992-10-16 1994-04-28 Merck & Co., Inc. An improved process for cyclohexapeptidyl bisamine compounds

Also Published As

Publication number Publication date
IL109615A (en) 2000-12-06
CN1100104A (zh) 1995-03-15
CA2123921A1 (en) 1994-11-18
IL109615A0 (en) 1994-08-26
TW301655B (es) 1997-04-01
PH30811A (en) 1997-10-17
DK0644199T3 (da) 2000-09-18
HU9401515D0 (en) 1994-08-29
JP3551469B2 (ja) 2004-08-04
US5693750A (en) 1997-12-02
DE69425304T2 (de) 2000-12-21
JPH06340693A (ja) 1994-12-13
US5569646A (en) 1996-10-29
AU6199494A (en) 1994-11-24
GR3034366T3 (en) 2000-12-29
AU681119B2 (en) 1997-08-21
CN1057306C (zh) 2000-10-11
DE69425304D1 (de) 2000-08-24
EP0644199B1 (en) 2000-07-19
HUT68385A (en) 1995-06-28
RU2164230C2 (ru) 2001-03-20
ATE194846T1 (de) 2000-08-15
PT644199E (pt) 2001-01-31
EP0644199A1 (en) 1995-03-22
KR100346489B1 (ko) 2002-11-18

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