DE69425304T2 - Zyklische antimikrobielle Peptide und deren Herstellung - Google Patents

Zyklische antimikrobielle Peptide und deren Herstellung

Info

Publication number
DE69425304T2
DE69425304T2 DE69425304T DE69425304T DE69425304T2 DE 69425304 T2 DE69425304 T2 DE 69425304T2 DE 69425304 T DE69425304 T DE 69425304T DE 69425304 T DE69425304 T DE 69425304T DE 69425304 T2 DE69425304 T2 DE 69425304T2
Authority
DE
Germany
Prior art keywords
production
hydroxy
hydrogen
antimicrobial peptides
cyclic antimicrobial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69425304T
Other languages
English (en)
Other versions
DE69425304D1 (de
Inventor
Hidenori Ohki
Masaki Tomishima
Akira Yamada
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939310091A external-priority patent/GB9310091D0/en
Priority claimed from GB939325269A external-priority patent/GB9325269D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69425304D1 publication Critical patent/DE69425304D1/de
Application granted granted Critical
Publication of DE69425304T2 publication Critical patent/DE69425304T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69425304T 1993-05-17 1994-05-12 Zyklische antimikrobielle Peptide und deren Herstellung Expired - Fee Related DE69425304T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939310091A GB9310091D0 (en) 1993-05-17 1993-05-17 New polypeptide compound and a process for preparation thereof
GB939325269A GB9325269D0 (en) 1993-12-10 1993-12-10 New polypeptide compound and a process for preparation thereof

Publications (2)

Publication Number Publication Date
DE69425304D1 DE69425304D1 (de) 2000-08-24
DE69425304T2 true DE69425304T2 (de) 2000-12-21

Family

ID=26302903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69425304T Expired - Fee Related DE69425304T2 (de) 1993-05-17 1994-05-12 Zyklische antimikrobielle Peptide und deren Herstellung

Country Status (18)

Country Link
US (2) US5569646A (de)
EP (1) EP0644199B1 (de)
JP (1) JP3551469B2 (de)
KR (1) KR100346489B1 (de)
CN (1) CN1057306C (de)
AT (1) ATE194846T1 (de)
AU (1) AU681119B2 (de)
CA (1) CA2123921A1 (de)
DE (1) DE69425304T2 (de)
DK (1) DK0644199T3 (de)
ES (1) ES2148254T3 (de)
GR (1) GR3034366T3 (de)
HU (1) HUT68385A (de)
IL (1) IL109615A (de)
PH (1) PH30811A (de)
PT (1) PT644199E (de)
RU (1) RU2164230C2 (de)
TW (1) TW301655B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5854276A (en) * 1995-06-29 1998-12-29 Fujisawa Pharmaceutical Co., Ltd. Substance WF16616, process for production thereof, and use thereof
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US6117641A (en) * 1996-04-11 2000-09-12 Mitotix, Inc. Assays and reagents for identifying anti-fungal agents and uses related thereto
US6727082B1 (en) 1996-04-11 2004-04-27 Gpc Biotech Inc. Assays and reagents for identifying anti-fungal agents, and uses related thereto
JP2001513622A (ja) 1996-04-11 2001-09-04 マイトティックス インコーポレーテッド 抗菌剤の同定のためのアッセイおよび試薬、並びにそれらに関連する利用
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
US6232290B1 (en) * 1998-02-09 2001-05-15 Fujisawa Pharmaceutical Co., Ltd. Cyclic hexapeptides with antimicrobial activity
JP2002509444A (ja) * 1998-03-16 2002-03-26 藤沢薬品工業株式会社 Ｗｆ１４５７３またはその塩、それらの製法および用途
CA2327474A1 (en) 1998-04-23 1999-11-04 Aventis Pharma Deutschland Gmbh A process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues
WO2000020441A2 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Cyclic peptides as antifungal agents
AUPP999799A0 (en) * 1999-04-27 1999-05-20 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
AUPR362001A0 (en) * 2001-03-08 2001-04-05 Fujisawa Pharmaceutical Co., Ltd. New compound
KR20100075892A (ko) 2007-10-29 2010-07-05 아스테라스 세이야쿠 가부시키가이샤 폴리펩티드 화합물
ES2634431T3 (es) * 2009-03-16 2017-09-27 The Governing Council Of The University Of Toronto Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas
US8927801B2 (en) * 2009-04-13 2015-01-06 The Procter & Gamble Company Absorbent articles comprising wetness indicators
JP2014088326A (ja) * 2011-02-22 2014-05-15 Astellas Pharma Inc ポリペプチド化合物
CN102512379B (zh) * 2011-12-16 2017-03-08 深圳市健元医药科技有限公司 一种新型棘白菌素类抗真菌药物组合物及其制备方法
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102786591B (zh) * 2012-08-31 2014-03-12 哈尔滨工业大学 定向诱导合成金属硫蛋白的工艺
WO2017079821A1 (en) 2015-11-11 2017-05-18 Encycle Therapeutics, Inc. Fragment synthesis of cyclic peptides
JP7035044B2 (ja) 2016-11-11 2022-03-14 ジーランド ファーマ エー／エス α４β７インテグリンを標的とする環状ペプチド多量体
IL270465B (en) 2017-05-10 2022-09-01 Encycle Therapeutics Inc Cyclic peptides targeting alpha4beta7 integrin
CN112759627B (zh) * 2021-03-12 2021-10-01 河南科技大学 一种抗白色念珠菌多肽及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Peptides, of antibiotics, processes for their preparation and pharmaceutical preparations containing them
WO1994009033A1 (en) * 1992-10-16 1994-04-28 Merck & Co., Inc. An improved process for cyclohexapeptidyl bisamine compounds

Also Published As

Publication number Publication date
JP3551469B2 (ja) 2004-08-04
GR3034366T3 (en) 2000-12-29
ATE194846T1 (de) 2000-08-15
PH30811A (en) 1997-10-17
DE69425304D1 (de) 2000-08-24
US5693750A (en) 1997-12-02
ES2148254T3 (es) 2000-10-16
AU681119B2 (en) 1997-08-21
HU9401515D0 (en) 1994-08-29
US5569646A (en) 1996-10-29
AU6199494A (en) 1994-11-24
EP0644199B1 (de) 2000-07-19
TW301655B (de) 1997-04-01
RU2164230C2 (ru) 2001-03-20
DK0644199T3 (da) 2000-09-18
IL109615A (en) 2000-12-06
IL109615A0 (en) 1994-08-26
HUT68385A (en) 1995-06-28
CA2123921A1 (en) 1994-11-18
EP0644199A1 (de) 1995-03-22
CN1100104A (zh) 1995-03-15
KR100346489B1 (ko) 2002-11-18
CN1057306C (zh) 2000-10-11
PT644199E (pt) 2001-01-31
JPH06340693A (ja) 1994-12-13

Similar Documents

Publication Publication Date Title
ATE194846T1 (de) Zyklische antimikrobielle peptide und deren herstellung
DE122007000081I1 (de) 3-Piperidinyl-2,5-benzisoxazole
FI923619A0 (fi) Cykliska peptider och deras anvaendning.
FI906204A0 (fi) Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
DE69021176D1 (de) Polypeptid und Verfahren zu dessen Herstellung.
DE68909139D1 (de) Substanz FR901228 und deren Herstellung.
HUT61780A (en) Process for producing new peptides and pharmaceutical compositions comprising same as active ingredient
AU1398892A (en) Pyrazolopyridine compound and processes for preparation thereof
FI860878A0 (fi) Aminosyraderivat och foerfarande foer deras framstaellning.
AU3583989A (en) New cephem compounds and processes for preparation thereof
ES2097736T3 (es) Peptido ciclico con actividad antagonista de sustancia p y sustancia k.
ES2061579T3 (es) Compuestos cefem y procedimientos para su preparacion.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee