DE122007000081I1 - 3-Piperidinyl-2,5-benzisoxazole - Google Patents

3-Piperidinyl-2,5-benzisoxazole

Info

Publication number
DE122007000081I1
DE122007000081I1 DE122007000081C DE122007000081C DE122007000081I1 DE 122007000081 I1 DE122007000081 I1 DE 122007000081I1 DE 122007000081 C DE122007000081 C DE 122007000081C DE 122007000081 C DE122007000081 C DE 122007000081C DE 122007000081 I1 DE122007000081 I1 DE 122007000081I1
Authority
DE
Germany
Prior art keywords
compounds
benzisoxazoles
piperidinyl
4alkyl
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE122007000081C
Other languages
English (en)
Other versions
DE122007000081I2 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE122007000081I1 publication Critical patent/DE122007000081I1/de
Publication of DE122007000081I2 publication Critical patent/DE122007000081I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE122007000081C 1988-11-07 1989-10-30 3-Piperidinyl-1,2-benzisoxazole Active DE122007000081I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26785788A 1988-11-07 1988-11-07

Publications (2)

Publication Number Publication Date
DE122007000081I1 true DE122007000081I1 (de) 2008-02-28
DE122007000081I2 DE122007000081I2 (de) 2010-01-28

Family

ID=23020416

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68922577T Expired - Lifetime DE68922577T2 (de) 1988-11-07 1989-10-30 3-Piperidinyl-1,2-benzisoxazole.
DE122007000081C Active DE122007000081I2 (de) 1988-11-07 1989-10-30 3-Piperidinyl-1,2-benzisoxazole

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68922577T Expired - Lifetime DE68922577T2 (de) 1988-11-07 1989-10-30 3-Piperidinyl-1,2-benzisoxazole.

Country Status (21)

Country Link
EP (1) EP0368388B1 (de)
JP (1) JP2758045B2 (de)
KR (1) KR0146053B1 (de)
AT (1) ATE122349T1 (de)
AU (1) AU614437B2 (de)
CA (1) CA2000786C (de)
CL (1) CL43432B (de)
CY (2) CY1926A (de)
DE (2) DE68922577T2 (de)
DK (1) DK169923B1 (de)
ES (1) ES2075036T3 (de)
FI (1) FI92201C (de)
HK (1) HK131696A (de)
IE (1) IE66370B1 (de)
IL (1) IL92208A0 (de)
LU (1) LU91362I2 (de)
NL (1) NL300298I2 (de)
NO (2) NO173015C (de)
NZ (1) NZ231062A (de)
PT (1) PT92206B (de)
ZA (1) ZA898436B (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
AU672182B2 (en) * 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
ES2236700T3 (es) 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
SI0730594T1 (en) * 1993-11-23 1999-12-31 Janssen Pharmaceutica N.V. 9-HYDROXY-PYRIDO (1,2-a)PYRIMIDIN-4-ONE ETHER DERIVATIVES
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US6500833B1 (en) 1998-05-18 2002-12-31 Sepracor Inc. (+)-Hydroxyrisperidone compositions and methods
WO1999059589A1 (en) * 1998-05-18 1999-11-25 Sepracor Inc. (-)-hydroxyrisperidone compositions and methods
WO2000010572A1 (en) * 1998-08-18 2000-03-02 Sepracor Inc. Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
ES2197801B1 (es) 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
CN100390146C (zh) 2002-11-13 2008-05-28 斯索恩有限公司 制备利培酮的方法和用于该方法的中间体
CN101014601B (zh) * 2004-09-09 2011-09-14 詹森药业有限公司 制备9-羟基-3-(2-羟基乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮及其晶体
US20070197591A1 (en) 2005-12-12 2007-08-23 Sandra Boom Use of paliperidone for the treatment of a mental disorder in a psychiatric patient with reduced hepatic function
US20080177067A1 (en) 2006-08-14 2008-07-24 Ben-Zion Dolitzky Crystal forms of 9-hydroxy-risperidone (paliperidone)
EP2133352A3 (de) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Kristallform von 9-Hydroxy-Risperidon (Paliperidon)
EP2133351A3 (de) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Kristallform von 9-Hydroxy-Risperidon (Paliperidon)
KR20090079189A (ko) * 2006-08-23 2009-07-21 테바 파마슈티컬 인더스트리즈 리미티드 Ｃｍｈｔｐ 및 이의 중간체의 합성 방법
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
CN101600716A (zh) * 2007-01-08 2009-12-09 阿特维斯集团公司 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法
KR101244185B1 (ko) * 2007-04-19 2013-03-25 유씬 리 정신 장애 치료용 신규 화합물, 그의 제조 방법 및 용도
WO2009010988A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
WO2009015828A1 (en) * 2007-07-27 2009-02-05 Synthon B.V. Paliperidone derivatives
WO2009045489A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp, a paliperidone intermediate
JP2010540676A (ja) * 2007-10-09 2010-12-24 シプラ・リミテッド パリペリドン及びその医薬として許容し得る塩の製造方法、並びに該方法に使用する中間体
EP2235009B1 (de) * 2007-12-10 2013-10-30 Synthon B.V. Synthese von paliperidon
US20100311969A1 (en) * 2008-02-05 2010-12-09 Watson Pharma Private Limited Process For Preparation of Paliperidone
US20110087024A1 (en) * 2008-04-21 2011-04-14 Glenmark House process for the preparation of paliperidone intermediates
US8309717B2 (en) 2008-05-29 2012-11-13 Inke, S.A. Process to prepare paliperidone and intermediates thereof
EP2300467A4 (de) * 2008-06-16 2012-04-25 Msn Lab Ltd Neuartige und verbesserte verfahren zur herstellung von paliperidon
WO2010003703A2 (en) * 2008-07-11 2010-01-14 Synthon B.V. Paliperidone ketone
EP2321311B1 (de) * 2008-07-11 2012-09-19 Synthon B.V. Synthese von paliperidon
SI22856A (sl) * 2008-07-31 2010-02-26 Krka, Tovarna Zdravil, D.D., Novo Mesto Proces za pripravo paliperidona
EP2161019A1 (de) 2008-09-05 2010-03-10 KRKA, D.D., Novo Mesto Verlängerte Freisetzung von einer pharmazeutischen Mehrteilchenzusammensetzung mit Paliperidon
EP2199293A1 (de) 2008-12-22 2010-06-23 Chemo Ibérica, S.A. Einschrittverfahren zur Herstellung von Paliperidon und sein Oxalat -salz
EP2202234A1 (de) 2008-12-24 2010-06-30 Laboratorios Lesvi, S.L. Reinigung von Paliperidon
SI2275423T1 (sl) 2009-07-13 2012-06-29 Krka D.D., Novo Mesto Postopek za sintezo paliperidona
WO2011018246A2 (en) 2009-08-13 2011-02-17 Synthon B.V. Controlled release paliperidone composition
EP2343296A1 (de) 2009-12-01 2011-07-13 Chemo Ibérica, S.A. Verfahren zur Aufreinigung von Paliperidon
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
WO2012035554A1 (en) * 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. An improved process for the preparation of highly pure paliperidone
JP5916746B2 (ja) 2010-11-15 2016-05-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのピリダジン誘導体、組成物、および方法
CN102153552B (zh) * 2011-03-01 2012-08-22 吉林大学 两种帕潘立酮药物共晶及其制备方法
CN102206210B (zh) * 2011-04-01 2014-07-02 常州市第四制药厂有限公司 一种6-氟-3-(4-哌啶基)-1，2-苯并异噁唑盐酸盐的生产方法
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN106068256B (zh) 2013-12-20 2020-10-23 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂*衍生物、组合物和方法
EP3310785A4 (de) 2015-06-19 2018-12-26 Agenebio, Inc. Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung kognitiver beeinträchtigung
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio Inc derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019162746A1 (en) * 2018-02-21 2019-08-29 Zenvision Pharma Llp Novel derivatives of paliperidone and process for the preparation thereof
CA3104478A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN116003404A (zh) * 2022-12-14 2023-04-25 杭州同舟生物技术有限公司 一种利培酮人工半抗原、人工抗原及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
AU4443689A (en) 1990-05-10
ATE122349T1 (de) 1995-05-15
CY2007025I1 (el) 2009-11-04
ZA898436B (en) 1991-07-31
CL43432B (es) 2005-06-03
DK551989A (da) 1990-05-08
JP2758045B2 (ja) 1998-05-25
NL300298I2 (nl) 2008-03-03
NO894411L (no) 1990-05-08
IL92208A0 (en) 1990-07-26
DE68922577T2 (de) 1995-09-28
PT92206B (pt) 1995-07-06
NO173015C (no) 1993-10-13
KR910009700A (ko) 1991-06-28
ES2075036T3 (es) 1995-10-01
CY2007025I2 (el) 2009-11-04
NO2007017I1 (no) 2008-01-14
EP0368388B1 (de) 1995-05-10
NL300298I1 (nl) 2007-12-03
IE66370B1 (en) 1995-12-27
DK169923B1 (da) 1995-04-03
KR0146053B1 (ko) 1998-08-17
EP0368388A3 (de) 1991-07-17
DK551989D0 (da) 1989-11-06
JPH02191276A (ja) 1990-07-27
LU91362I2 (fr) 2007-11-12
NO2007017I2 (no) 2010-01-25
NO894411D0 (no) 1989-11-06
EP0368388A2 (de) 1990-05-16
HK131696A (en) 1996-07-26
CA2000786C (en) 1999-01-26
FI92201C (fi) 1994-10-10
CY1926A (en) 1989-10-30
FI92201B (fi) 1994-06-30
IE893564L (en) 1990-05-07
AU614437B2 (en) 1991-08-29
DE122007000081I2 (de) 2010-01-28
NZ231062A (en) 1991-09-25
PT92206A (pt) 1990-05-31
NO173015B (no) 1993-07-05
CA2000786A1 (en) 1990-05-07
FI895261A0 (fi) 1989-11-06
DE68922577D1 (de) 1995-06-14

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