PT92206A - Processo para a preparacao de derivados de 3-piperidinil-1,2-benzizoxazois e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados de 3-piperidinil-1,2-benzizoxazois e de composicoes farmaceuticas que os contem

Info

Publication number
PT92206A
PT92206A PT92206A PT9220689A PT92206A PT 92206 A PT92206 A PT 92206A PT 92206 A PT92206 A PT 92206A PT 9220689 A PT9220689 A PT 9220689A PT 92206 A PT92206 A PT 92206A
Authority
PT
Portugal
Prior art keywords
pharmaceutical compositions
piperidinyl
compositions containing
benzizoxazoes
derivatives
Prior art date
Application number
PT92206A
Other languages
English (en)
Other versions
PT92206B (pt
Inventor
Ludo Edmond Josephine Kennis
Jan Vandenberk
Cornelus Gerardus Mari Janssen
Alfonsus Guilelmus Knaeps
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT92206A publication Critical patent/PT92206A/pt
Publication of PT92206B publication Critical patent/PT92206B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT92206A 1988-11-07 1989-11-06 Processo para a preparacao de derivados de 3-piperidinil-1,2-benzizoxazois e de composicoes farmaceuticas que os contem PT92206B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26785788A 1988-11-07 1988-11-07

Publications (2)

Publication Number Publication Date
PT92206A true PT92206A (pt) 1990-05-31
PT92206B PT92206B (pt) 1995-07-06

Family

ID=23020416

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92206A PT92206B (pt) 1988-11-07 1989-11-06 Processo para a preparacao de derivados de 3-piperidinil-1,2-benzizoxazois e de composicoes farmaceuticas que os contem

Country Status (21)

Country Link
EP (1) EP0368388B1 (pt)
JP (1) JP2758045B2 (pt)
KR (1) KR0146053B1 (pt)
AT (1) ATE122349T1 (pt)
AU (1) AU614437B2 (pt)
CA (1) CA2000786C (pt)
CL (1) CL43432B (pt)
CY (2) CY1926A (pt)
DE (2) DE122007000081I2 (pt)
DK (1) DK169923B1 (pt)
ES (1) ES2075036T3 (pt)
FI (1) FI92201C (pt)
HK (1) HK131696A (pt)
IE (1) IE66370B1 (pt)
IL (1) IL92208A0 (pt)
LU (1) LU91362I2 (pt)
NL (1) NL300298I2 (pt)
NO (2) NO173015C (pt)
NZ (1) NZ231062A (pt)
PT (1) PT92206B (pt)
ZA (1) ZA898436B (pt)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
NZ245260A (en) * 1991-11-27 1995-06-27 Novo Nordisk As Piperidine derivatives, preparation and pharmaceutical compositions thereof
ES2050069B1 (es) * 1992-07-10 1994-12-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
ES2236700T3 (es) * 1993-11-19 2005-07-16 Janssen Pharmaceutica N.V. 1,2-benzazoles microencapsulados.
EP0730594B1 (en) * 1993-11-23 1999-09-08 Janssen Pharmaceutica N.V. 9-HYDROXY-PYRIDO [1,2-a]PYRIMIDIN-4-ONE ETHER DERIVATIVES
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
ES2141671B1 (es) * 1997-12-26 2001-01-01 Vita Invest Sa Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
US6326362B1 (en) 1998-05-18 2001-12-04 Sepracor Inc. (-)-phosphonorisperidone and (-)-sulforisperidone compositions and methods
AU3900499A (en) * 1998-05-18 1999-12-06 Sepracor, Inc. (+)-hydroxyrisperidone compositions and methods
AU5489299A (en) 1998-08-18 2000-03-14 Sepracor, Inc. Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
ES2197801B1 (es) * 2002-03-05 2005-03-16 Ferrer Internacional,S.A Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
KR20040025224A (ko) * 2002-09-18 2004-03-24 주식회사 대웅 2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘-3-일)아세트알데히드 및 그 제조방법
WO2004043923A1 (en) 2002-11-13 2004-05-27 Synthon B.V. Process for making risperidone and intermediates therefor
US7723518B2 (en) 2004-09-09 2010-05-25 Janssen Pharmaceutica N.V. Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one
US20070197591A1 (en) 2005-12-12 2007-08-23 Sandra Boom Use of paliperidone for the treatment of a mental disorder in a psychiatric patient with reduced hepatic function
DE202007018474U1 (de) * 2006-08-14 2008-08-07 Teva Pharmaceutical Industries Ltd. Kirstallformen von 9-Hydroxy-Risperidon (Paliperidon)
EP2133351A3 (en) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Crystal form of 9-hydroxy-risperidone (paliperidone)
EP2133352A3 (en) * 2006-08-14 2010-01-13 Teva Pharmaceutical Industries Ltd. Crystal form of 9-hydroxy-risperidone (paliperidone)
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
WO2008024415A2 (en) * 2006-08-23 2008-02-28 Teva Pharmaceutical Insustries Ltd. Process for the synthesis of cmhtp and intermediates thereof
CN101600716A (zh) * 2007-01-08 2009-12-09 阿特维斯集团公司 用于制备9-羟基-3-(2-氯乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮盐酸盐的改进方法
WO2008128436A1 (en) * 2007-04-19 2008-10-30 Youxin Li Novel compounds for treatment of psychotic disorders, preparation methods and uses thereof
WO2009010988A1 (en) * 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
EP2178872A1 (en) * 2007-07-27 2010-04-28 Synthon B.V. Paliperidone derivatives
WO2009045489A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp, a paliperidone intermediate
AU2008309411B2 (en) * 2007-10-09 2013-01-31 Cipla Limited Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes
US7977480B2 (en) 2007-12-10 2011-07-12 Synthon Bv Synthesis of paliperidone
US20100311969A1 (en) * 2008-02-05 2010-12-09 Watson Pharma Private Limited Process For Preparation of Paliperidone
WO2009130710A2 (en) * 2008-04-21 2009-10-29 Glenmark Generics Limited A process for the preparation of paliperidone intermediates
WO2009144288A1 (en) * 2008-05-29 2009-12-03 Inke, S.A. Process to prepare paliperidone and intermediates thereof
EP2300467A4 (en) * 2008-06-16 2012-04-25 Msn Lab Ltd NEW AND IMPROVED METHODS FOR THE MANUFACTURE OF PALIPERIDONE
US20100010218A1 (en) * 2008-07-11 2010-01-14 Jiri Bartl Synthesis of paliperidone
US7932385B2 (en) 2008-07-11 2011-04-26 Synthon Bv Paliperidone ketone
SI22856A (sl) * 2008-07-31 2010-02-26 Krka, Tovarna Zdravil, D.D., Novo Mesto Proces za pripravo paliperidona
EP2161019A1 (en) 2008-09-05 2010-03-10 KRKA, D.D., Novo Mesto Prolonged release multiparticulate pharmaceutical composition comprising paliperidone
EP2199293A1 (en) 2008-12-22 2010-06-23 Chemo Ibérica, S.A. One-step process for preparing paliperidone and its oxalate salt
EP2202234A1 (en) 2008-12-24 2010-06-30 Laboratorios Lesvi, S.L. Purification of paliperidone
SI2275423T1 (sl) 2009-07-13 2012-06-29 Krka D.D., Novo Mesto Postopek za sintezo paliperidona
WO2011018246A2 (en) 2009-08-13 2011-02-17 Synthon B.V. Controlled release paliperidone composition
EP2343296A1 (en) 2009-12-01 2011-07-13 Chemo Ibérica, S.A. A process for the purification of paliperidone
US20120259116A1 (en) * 2009-12-17 2012-10-11 Rajiv Kumar Novel Process for the Preparation of Paliperidone
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
WO2012035554A1 (en) * 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. An improved process for the preparation of highly pure paliperidone
EA027840B1 (ru) 2010-11-15 2017-09-29 Эйджинбайо, Инк. Производные пиридазина, композиции и способы лечения когнитивного нарушения
CN102153552B (zh) * 2011-03-01 2012-08-22 吉林大学 两种帕潘立酮药物共晶及其制备方法
CN102206210B (zh) * 2011-04-01 2014-07-02 常州市第四制药厂有限公司 一种6-氟-3-(4-哌啶基)-1，2-苯并异噁唑盐酸盐的生产方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2015095783A1 (en) 2013-12-20 2015-06-25 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
EA036844B1 (ru) 2015-06-19 2020-12-28 Эйджинбайо, Инк. Производные бензодиазепина, композиции и способы для лечения когнитивного нарушения
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11377445B2 (en) 2018-02-21 2022-07-05 Zenvision Pharma Llp Derivatives of paliperidone and process for the preparation thereof
WO2019246300A1 (en) 2018-06-19 2019-12-26 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
CN116003404A (zh) * 2022-12-14 2023-04-25 杭州同舟生物技术有限公司 一种利培酮人工半抗原、人工抗原及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
IE66370B1 (en) 1995-12-27
AU614437B2 (en) 1991-08-29
KR910009700A (ko) 1991-06-28
FI895261A0 (fi) 1989-11-06
CY1926A (en) 1989-10-30
DE68922577D1 (de) 1995-06-14
NO173015C (no) 1993-10-13
KR0146053B1 (ko) 1998-08-17
EP0368388A2 (en) 1990-05-16
FI92201C (fi) 1994-10-10
NO2007017I2 (no) 2010-01-25
CA2000786C (en) 1999-01-26
EP0368388B1 (en) 1995-05-10
ZA898436B (en) 1991-07-31
NO173015B (no) 1993-07-05
NL300298I2 (nl) 2008-03-03
ATE122349T1 (de) 1995-05-15
DE68922577T2 (de) 1995-09-28
NO894411D0 (no) 1989-11-06
DE122007000081I1 (de) 2008-02-28
EP0368388A3 (en) 1991-07-17
JPH02191276A (ja) 1990-07-27
DK551989D0 (da) 1989-11-06
NL300298I1 (nl) 2007-12-03
CL43432B (es) 2005-06-03
CY2007025I1 (el) 2009-11-04
DK169923B1 (da) 1995-04-03
NO894411L (no) 1990-05-08
JP2758045B2 (ja) 1998-05-25
CY2007025I2 (el) 2009-11-04
AU4443689A (en) 1990-05-10
DK551989A (da) 1990-05-08
IL92208A0 (en) 1990-07-26
NZ231062A (en) 1991-09-25
NO2007017I1 (no) 2008-01-14
FI92201B (fi) 1994-06-30
LU91362I2 (fr) 2007-11-12
PT92206B (pt) 1995-07-06
ES2075036T3 (es) 1995-10-01
IE893564L (en) 1990-05-07
HK131696A (en) 1996-07-26
DE122007000081I2 (de) 2010-01-28
CA2000786A1 (en) 1990-05-07

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Legal Events

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MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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