SI2275423T1 - Postopek za sintezo paliperidona - Google Patents

Postopek za sintezo paliperidona

Info

Publication number
SI2275423T1
SI2275423T1 SI200930239T SI200930239T SI2275423T1 SI 2275423 T1 SI2275423 T1 SI 2275423T1 SI 200930239 T SI200930239 T SI 200930239T SI 200930239 T SI200930239 T SI 200930239T SI 2275423 T1 SI2275423 T1 SI 2275423T1
Authority
SI
Slovenia
Prior art keywords
paliperidone
synthesis
purification
invention describes
improved process
Prior art date
Application number
SI200930239T
Other languages
English (en)
Inventor
Milos Ruzic
Anica Pecavar
Darja Prudic
Igor Plaper
Andrej Klobcar
Jernej Hvala
Miha Plevnik
Original Assignee
Krka D.D., Novo Mesto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41050429&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2275423(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Krka D.D., Novo Mesto filed Critical Krka D.D., Novo Mesto
Publication of SI2275423T1 publication Critical patent/SI2275423T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200930239T 2009-07-13 2009-07-13 Postopek za sintezo paliperidona SI2275423T1 (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09009122A EP2275423B9 (en) 2009-07-13 2009-07-13 Process for the synthesis of paliperidone

Publications (1)

Publication Number Publication Date
SI2275423T1 true SI2275423T1 (sl) 2012-06-29

Family

ID=41050429

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200930239T SI2275423T1 (sl) 2009-07-13 2009-07-13 Postopek za sintezo paliperidona
SI201031073T SI2454256T1 (sl) 2009-07-13 2010-07-13 Postopek za sintezo paliperidona

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201031073T SI2454256T1 (sl) 2009-07-13 2010-07-13 Postopek za sintezo paliperidona

Country Status (4)

Country Link
EP (2) EP2275423B9 (sl)
AT (1) ATE544766T1 (sl)
SI (2) SI2275423T1 (sl)
WO (1) WO2011006638A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012035554A1 (en) * 2010-09-14 2012-03-22 Megafine Pharma (P) Ltd. An improved process for the preparation of highly pure paliperidone
AU2012264476B2 (en) 2011-05-30 2016-12-08 Cipla Limited Process for the preparation of paliperidone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3148379A1 (de) 1981-12-07 1983-06-09 Hunter Douglas Industries B.V., 3008 Rotterdam "lamellenjalousie mit vertikalen lamellen"
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
CA2000786C (en) 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
FR2654104B1 (fr) 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US7915412B2 (en) 2006-08-14 2011-03-29 Teva Pharmaceutical Industries, Ltd. Process for the synthesis of 9-hydroxy risperidone (paliperidone)
JP2008546851A (ja) 2006-08-14 2008-12-25 テバ ファーマシューティカル インダストリーズ リミティド 純粋なパリペリドンとその製造法
EP1924583A2 (en) 2006-08-23 2008-05-28 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp and intermediates thereof
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
WO2009010988A1 (en) 2007-07-19 2009-01-22 Natco Pharma Limited An improved, industrially viable process for the preparation of high purity paliperidone
WO2009045489A2 (en) 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Process for the synthesis of cmhtp, a paliperidone intermediate
US8242269B2 (en) 2007-10-09 2012-08-14 Cipla Limited Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes

Also Published As

Publication number Publication date
WO2011006638A1 (en) 2011-01-20
EP2275423B1 (en) 2012-02-08
EP2275423B8 (en) 2012-06-20
ATE544766T1 (de) 2012-02-15
EP2454256B1 (en) 2015-09-16
EP2275423A1 (en) 2011-01-19
EP2454256A1 (en) 2012-05-23
SI2454256T1 (sl) 2016-01-29
EP2275423B9 (en) 2012-08-15

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