MX9303706A - 9-amino-piridazino[4', 5': 3, 4]pirrolo-[2, 1-a]isoquinolinas y su empleo para la produccion de preparados farmaceuticos. - Google Patents

9-amino-piridazino[4', 5': 3, 4]pirrolo-[2, 1-a]isoquinolinas y su empleo para la produccion de preparados farmaceuticos.

Info

Publication number
MX9303706A
MX9303706A MX9303706A MX9303706A MX9303706A MX 9303706 A MX9303706 A MX 9303706A MX 9303706 A MX9303706 A MX 9303706A MX 9303706 A MX9303706 A MX 9303706A MX 9303706 A MX9303706 A MX 9303706A
Authority
MX
Mexico
Prior art keywords
isoquinolines
amino
agents
piridazino
pirrolo
Prior art date
Application number
MX9303706A
Other languages
English (en)
Inventor
Dietrich Arndts
Walter Losel
Otto Roos
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19924220380 external-priority patent/DE4220380A1/de
Priority claimed from DE4220361A external-priority patent/DE4220361A1/de
Priority claimed from DE19924220384 external-priority patent/DE4220384A1/de
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of MX9303706A publication Critical patent/MX9303706A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

El invento se refiere a la utilización de 9-aminopiridazino[4', 5':3, 4]pirrolo[2, 1-a]isoquinolinas de fórmula (I), así como de sus sales fisiológicamente compatibles con ácidos, bases y agentes formadores de complejos para la producción de agentes destinados al tratamiento de procesos inflamatorios crónicos, de la colitis ulcerosa y de la enfermedad de Crohn, así como de agentes con efecto antiproliferativo. Los significados de los sustituyentes R1 hasta R9 se indican en la memoria descriptiva. Además el invento se refiere a nuevos compuestos de fórmula general (I), que también están definidos en la memoria descriptiva y a su utilización como agentes protectores del cerebro.
MX9303706A 1992-06-22 1993-06-21 9-amino-piridazino[4', 5': 3, 4]pirrolo-[2, 1-a]isoquinolinas y su empleo para la produccion de preparados farmaceuticos. MX9303706A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19924220380 DE4220380A1 (de) 1992-06-22 1992-06-22 Verwendung von 9-Amino-pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinolinen zur Herstellung von Mitteln zur Behandlung der Colitis Ulcerosa und des Morbus Crohn
DE4220361A DE4220361A1 (de) 1992-06-22 1992-06-22 Verwendung von 9-Amino-pyridazino[4',5':3,4]-pyrrolo-[2,1-a]isochinolinen zur Herstellung von Mitteln mit antiproliferativer Wirkung
DE19924220384 DE4220384A1 (de) 1992-06-22 1992-06-22 Verwendung von 9-Amino-pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinolinen zur Herstellung von Mitteln zur Behandlung chronisch inflammatorischer Prozesse

Publications (1)

Publication Number Publication Date
MX9303706A true MX9303706A (es) 1994-01-31

Family

ID=27203872

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9303706A MX9303706A (es) 1992-06-22 1993-06-21 9-amino-piridazino[4', 5': 3, 4]pirrolo-[2, 1-a]isoquinolinas y su empleo para la produccion de preparados farmaceuticos.

Country Status (11)

Country Link
US (2) US5565452A (es)
EP (1) EP0647226B1 (es)
JP (1) JP3468520B2 (es)
CN (1) CN1082046A (es)
AT (1) ATE157665T1 (es)
AU (1) AU4327293A (es)
CA (1) CA2138791A1 (es)
DE (1) DE59307281D1 (es)
IL (1) IL106089A0 (es)
MX (1) MX9303706A (es)
WO (1) WO1994000451A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
NZ555911A (en) * 2002-01-07 2008-07-31 Eisai R&D Man Co Ltd Deazapurines and uses thereof
CN106995443B (zh) * 2014-05-09 2022-01-11 皮梅拉股份有限公司 新组合物、用途和制备它们的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3401018A1 (de) * 1984-01-13 1985-07-18 Boehringer Ingelheim KG, 6507 Ingelheim Verfahren zur herstellung von 5,6-dihydro-pyrrolo(2,1-a)isochinolinen
US4764898A (en) * 1984-12-13 1988-08-16 Nippon Telegraph And Telephone Corporation Vortex memory device
DE3664772D1 (en) * 1985-01-14 1989-09-07 Boehringer Ingelheim Kg 12-amino pyridazinoû4',5':3,4¨pyrroloû2,1-a¨isoquinolines, process for their preparation and use
DE3619099A1 (de) * 1986-06-06 1987-12-10 Boehringer Ingelheim Kg Verwendung von 12-amino-pyrridazino(4',5' : 3,4)pyrrolo-(2,1-a)-isochinolinen als cardio- und neuroprotektive mittel

Also Published As

Publication number Publication date
US5677304A (en) 1997-10-14
EP0647226A1 (de) 1995-04-12
JPH07508016A (ja) 1995-09-07
US5565452A (en) 1996-10-15
EP0647226B1 (de) 1997-09-03
AU4327293A (en) 1994-01-24
WO1994000451A1 (de) 1994-01-06
DE59307281D1 (de) 1997-10-09
ATE157665T1 (de) 1997-09-15
CA2138791A1 (en) 1994-01-06
CN1082046A (zh) 1994-02-16
JP3468520B2 (ja) 2003-11-17
IL106089A0 (en) 1993-10-20

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees