IT1182209B - Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali - Google Patents
Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebraliInfo
- Publication number
- IT1182209B IT1182209B IT47698/85A IT4769885A IT1182209B IT 1182209 B IT1182209 B IT 1182209B IT 47698/85 A IT47698/85 A IT 47698/85A IT 4769885 A IT4769885 A IT 4769885A IT 1182209 B IT1182209 B IT 1182209B
- Authority
- IT
- Italy
- Prior art keywords
- infarti
- monosialoganglioside
- cerebral
- derivatives
- therapeutic use
- Prior art date
Links
- 230000002490 cerebral effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- QPJBWNIQKHGLAU-IQZHVAEDSA-N ganglioside GM1 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 QPJBWNIQKHGLAU-IQZHVAEDSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47698/85A IT1182209B (it) | 1985-02-18 | 1985-02-18 | Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali |
| GR851238A GR851238B (it) | 1985-02-18 | 1985-05-21 | |
| AU42747/85A AU584090B2 (en) | 1985-02-18 | 1985-05-21 | Therapeutic use of GM1 in severe cerebral ischemic strokes pathologies |
| ZA853834A ZA853834B (en) | 1985-02-18 | 1985-05-21 | Therapeutic use of gm1 in severe cerebral ischemic strokes pathologies |
| DE19853519095 DE3519095A1 (de) | 1985-02-18 | 1985-05-28 | Verwendung von gm(pfeil abwaerts)1(pfeil abwaerts) oder eines davon abgeleiteten inneren esters zur therapie von gehirnschlaegen |
| EP85401042A EP0195169A3 (en) | 1985-02-18 | 1985-05-28 | Therapeutic use of the monosialoganglioside gm1 in severe cerebral ischemic strokes pathologies |
| JP60135846A JPS61189223A (ja) | 1985-02-18 | 1985-06-20 | 脳血流量増加剤 |
| LU85973A LU85973A1 (fr) | 1985-02-18 | 1985-06-26 | Utilisation therapeutique de gm1 dans des pathologies cerebrales severes dues a une ischemie |
| BE1/11281A BE902752A (nl) | 1985-02-18 | 1985-06-27 | Utilisation therapeutique de gm1 dans des pathologies cerebrales severes dues a une ischemie. |
| US07/338,516 US4940694A (en) | 1985-02-18 | 1988-10-20 | Therapeutic use of GM1 in severe cerebral ischemic strokes pathologies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47698/85A IT1182209B (it) | 1985-02-18 | 1985-02-18 | Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IT8547698A0 IT8547698A0 (it) | 1985-02-18 |
| IT8547698A1 IT8547698A1 (it) | 1986-08-18 |
| IT1182209B true IT1182209B (it) | 1987-09-30 |
Family
ID=11261961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT47698/85A IT1182209B (it) | 1985-02-18 | 1985-02-18 | Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4940694A (it) |
| EP (1) | EP0195169A3 (it) |
| JP (1) | JPS61189223A (it) |
| AU (1) | AU584090B2 (it) |
| BE (1) | BE902752A (it) |
| DE (1) | DE3519095A1 (it) |
| GR (1) | GR851238B (it) |
| IT (1) | IT1182209B (it) |
| LU (1) | LU85973A1 (it) |
| ZA (1) | ZA853834B (it) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) * | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| IT1208751B (it) * | 1986-06-30 | 1989-07-10 | Fidia Farmaceutici | Possibile uso dei gangliosidi esogeni in malattie tumorali come fattore protettivo contro la neurotossicita' da farmaci antitumorali |
| IT1212041B (it) * | 1987-11-02 | 1989-11-08 | Fidia Farmaceutici | Gangliosidi esteri interni come agenti terapeutici capaci di eliminare il dolore nelle neuropatie periferiche |
| US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1235161B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisogangliosidi |
| US5190925A (en) * | 1989-06-08 | 1993-03-02 | Fidia, S.P.A. | Use of gangliosides in the treatment of autonomic dysfunction in Chagas' disease |
| IT1238346B (it) * | 1989-11-14 | 1993-07-13 | Gangliosidi modificati e loro derivati funzionali. | |
| IT1249034B (it) * | 1990-06-29 | 1995-02-11 | Fidia Spa | Impiego del monosialoganglioside gm1 e del suo derivato estere interno per impedire l'instaurarsi della tolleranza nell'uomo all'effetto analgesico della morfina e analoghi |
| WO1993002686A1 (en) * | 1991-07-31 | 1993-02-18 | The Regents Of The University Of California | Gangliosides with immunosuppressive ceramide moieties |
| IT1254706B (it) | 1991-12-23 | 1995-10-09 | Fidia Spa | Uso terapeutico del ganglioside gm1 nel trattamento del danno al midollo spinale |
| US5519035A (en) * | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
| US6083920A (en) * | 1995-12-21 | 2000-07-04 | Ayurcore, Inc. | Compositions for modulating intracellular inositol trisphosphate concentration |
| JP2005527467A (ja) | 2001-08-29 | 2005-09-15 | ネオーズ テクノロジーズ， インコーポレイテッド | 新規な合成ガングリオシド誘導体およびその組成物 |
| EP1603932B1 (en) * | 2003-03-06 | 2012-10-03 | Seneb Biosciences Inc. | Methods and compositions for the enzymatic synthesis of gangliosides |
| US7932236B2 (en) * | 2004-11-09 | 2011-04-26 | Seneb Biosciences, Inc. | Glycolipids |
| DE102006062706B4 (de) * | 2006-03-30 | 2012-12-06 | Krohne Ag | Ultraschalldurchflußmeßgerät |
| WO2010111530A1 (en) | 2009-03-25 | 2010-09-30 | Seneb Biosciences, Inc. | Glycolipids as treatment for disease |
| WO2011028797A2 (en) * | 2009-09-01 | 2011-03-10 | Lazarus Therapeutics, Inc. | Treatment of glaucoma and other retinopathies with gangliosides |
| CN103087120B (zh) * | 2013-02-26 | 2015-12-02 | 北京四环制药有限公司 | 单唾液酸四己糖神经节苷脂的制备方法及其应用 |
| US20210315821A1 (en) * | 2018-08-10 | 2021-10-14 | United States Government As Represented By The Department Of Veterans Affairs | Nanoliposome compositions and methods of using the same |
| US20220088133A1 (en) * | 2020-09-11 | 2022-03-24 | United States Government As Represented By The Department Of Veterans Affairs | Nanoliposome Compositions And Methods Of Treating Stroke |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2478104B1 (fr) * | 1980-03-17 | 1986-08-08 | Merieux Inst | Nouveaux derives de gangliosides, leur preparation et leur application |
| US4435389A (en) * | 1980-07-07 | 1984-03-06 | Kabushiki Kaisha Yakult Honsha | Composition for promoting growth of bifidobacteria |
| US4476119A (en) * | 1981-08-04 | 1984-10-09 | Fidia S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
| CH658458A5 (fr) * | 1981-12-17 | 1986-11-14 | Lucchini Lab Sa | Procede pour l'obtention du lacto-n-norhexaosyl ceramide. |
| US4631294A (en) * | 1985-07-05 | 1986-12-23 | University E.M., Inc. | Treatment of cerebral ischemia with dichloroacetate |
| EP0727222A1 (de) * | 1991-07-16 | 1996-08-21 | Schering Aktiengesellschaft | Verfahren zur Herstellung von mikronisierte Wirkstoffe enthaltende halbfeste Zubereitungen |
-
1985
- 1985-02-18 IT IT47698/85A patent/IT1182209B/it active
- 1985-05-21 GR GR851238A patent/GR851238B/el unknown
- 1985-05-21 ZA ZA853834A patent/ZA853834B/xx unknown
- 1985-05-21 AU AU42747/85A patent/AU584090B2/en not_active Ceased
- 1985-05-28 EP EP85401042A patent/EP0195169A3/en not_active Withdrawn
- 1985-05-28 DE DE19853519095 patent/DE3519095A1/de not_active Ceased
- 1985-06-20 JP JP60135846A patent/JPS61189223A/ja active Pending
- 1985-06-26 LU LU85973A patent/LU85973A1/fr unknown
- 1985-06-27 BE BE1/11281A patent/BE902752A/nl not_active IP Right Cessation
-
1988
- 1988-10-20 US US07/338,516 patent/US4940694A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IT8547698A1 (it) | 1986-08-18 |
| AU4274785A (en) | 1986-08-21 |
| AU584090B2 (en) | 1989-05-18 |
| US4940694A (en) | 1990-07-10 |
| BE902752A (nl) | 1985-12-30 |
| LU85973A1 (fr) | 1986-01-22 |
| IT8547698A0 (it) | 1985-02-18 |
| EP0195169A2 (en) | 1986-09-24 |
| ZA853834B (en) | 1986-09-24 |
| DE3519095A1 (de) | 1986-08-21 |
| GR851238B (it) | 1985-11-25 |
| JPS61189223A (ja) | 1986-08-22 |
| EP0195169A3 (en) | 1988-08-31 |
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Legal Events
| Date | Code | Title | Description |
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| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19990210 |