RU95111381A - Способ получения производных таксана и промежуточные соединения синтеза - Google Patents

Способ получения производных таксана и промежуточные соединения синтеза

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Publication number
RU95111381A
RU95111381A RU95111381/04A RU95111381A RU95111381A RU 95111381 A RU95111381 A RU 95111381A RU 95111381/04 A RU95111381/04 A RU 95111381/04A RU 95111381 A RU95111381 A RU 95111381A RU 95111381 A RU95111381 A RU 95111381A
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RU
Russia
Prior art keywords
phenyl
alkyl
group
protected
derivatives
Prior art date
Application number
RU95111381/04A
Other languages
English (en)
Other versions
RU2118958C1 (ru
Inventor
Дени Жан-Ноель
Be]
Грин Эндрю
Каназава Алис
Us]
Br]
Original Assignee
Рон-Пуленк Роре С.А. (FR)
Рон-Пуленк Роре С.А.
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Application filed by Рон-Пуленк Роре С.А. (FR), Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А. (FR)
Publication of RU95111381A publication Critical patent/RU95111381A/ru
Application granted granted Critical
Publication of RU2118958C1 publication Critical patent/RU2118958C1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу получения производных таксана общей формулы I, указанной в описании изобретения, путем этерификации защищенного баккатина III или защищенного 10-дезацетил-баккатина III с помощью кислоты общей формулы II, указанной в описании. Соединения общей формулы I особо применимы для приготовления таксола, таксотера и их аналогов, которые обладают заметным противоопухолевым действием.

Claims (1)

  1. Изобретение относится к способу получения производных таксана общей формулы I, указанной в описании изобретения, путем этерификации защищенного баккатина III или защищенного 10-дезацетил-баккатина III с помощью кислоты общей формулы II, указанной в описании. Соединения общей формулы I особо применимы для приготовления таксола, таксотера и их аналогов, которые обладают заметным противоопухолевым действием.
RU95111381/04A 1992-10-30 1993-10-28 Способ получения производных таксана и промежуточные соединения синтеза RU2118958C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9213000 1992-10-30
FR9213000A FR2697522B1 (fr) 1992-10-30 1992-10-30 Procédé de préparation de dérivés du taxane.

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU98103160/04A Division RU2188198C2 (ru) 1992-10-30 1993-10-28 Производные таксана

Publications (2)

Publication Number Publication Date
RU95111381A true RU95111381A (ru) 1996-12-27
RU2118958C1 RU2118958C1 (ru) 1998-09-20

Family

ID=9435013

Family Applications (2)

Application Number Title Priority Date Filing Date
RU98103160/04A RU2188198C2 (ru) 1992-10-30 1993-10-28 Производные таксана
RU95111381/04A RU2118958C1 (ru) 1992-10-30 1993-10-28 Способ получения производных таксана и промежуточные соединения синтеза

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU98103160/04A RU2188198C2 (ru) 1992-10-30 1993-10-28 Производные таксана

Country Status (24)

Country Link
US (3) US5686623A (ru)
EP (1) EP0666857B1 (ru)
JP (1) JP3030088B2 (ru)
KR (1) KR100255460B1 (ru)
AT (1) ATE180258T1 (ru)
AU (1) AU679947B2 (ru)
CA (1) CA2148103C (ru)
CZ (1) CZ287805B6 (ru)
DE (1) DE69325031T2 (ru)
DK (1) DK0666857T3 (ru)
ES (1) ES2133418T3 (ru)
FI (1) FI109798B (ru)
FR (1) FR2697522B1 (ru)
GR (1) GR3030268T3 (ru)
HU (1) HUT73780A (ru)
MX (1) MX9306606A (ru)
NO (2) NO304114B1 (ru)
NZ (1) NZ257578A (ru)
PL (1) PL177746B1 (ru)
RU (2) RU2188198C2 (ru)
SK (1) SK281045B6 (ru)
TW (1) TW427988B (ru)
WO (1) WO1994010169A1 (ru)
ZA (1) ZA938012B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
PT982301E (pt) * 1993-06-11 2004-02-27 Upjohn Co Utilizacao antineoplasica de delta-6,7-taxois e composicoes farmaceuticas que oscontem
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
EP1099696A3 (en) * 1995-06-06 2001-05-23 Dr. Reddy's Research Foundation Preparation of oxazolidine
US6410756B1 (en) 1996-10-24 2002-06-25 Institut National De La Recherche Scientifique Family of Canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
US6150537A (en) * 1997-12-12 2000-11-21 Emory University Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
EP0982028A1 (en) * 1998-08-20 2000-03-01 Aventis Pharma S.A. New use of taxoid derivatives
IL141231A0 (en) * 1998-08-20 2002-03-10 Aventis Pharma Sa New use of taxoid derivatives
JP4502338B2 (ja) * 1999-09-17 2010-07-14 株式会社横浜国際バイオ研究所 タキソイド化合物の製造法
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2002012216A1 (en) * 2000-08-08 2002-02-14 Dr. Reddy's Research Foundation An improved process for the preparation of docetaxel
JP2002088935A (ja) 2000-09-14 2002-03-27 Nichiha Corp 外装材の縦目地ジョイナー
US8338617B2 (en) 2004-11-19 2012-12-25 Dr. Reddy's Laboratories Limited Process for preparing oxazolidine derivatives
CZ298332B6 (cs) * 2005-09-26 2007-08-29 Zentiva, A. S Zpusob prípravy kyseliny (4S,5R)-2,4-difenyloxazolin-4,5-dihydro-5-karboxylové
CA2634746A1 (en) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
WO2008074178A1 (fr) * 2006-11-23 2008-06-26 Shanghai Bailing Pharmaceutical Technology Co., Ltd Nouveau procédé de préparation de paclitaxel semi-synthétique
CN101020672B (zh) * 2006-12-28 2010-08-25 上海百灵医药科技有限公司 多烯紫杉醇的合成方法
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
KR101379694B1 (ko) * 2011-09-30 2014-03-31 주식회사 삼양바이오팜 탁산유도체의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696459B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
PT982301E (pt) * 1993-06-11 2004-02-27 Upjohn Co Utilizacao antineoplasica de delta-6,7-taxois e composicoes farmaceuticas que oscontem

Also Published As

Publication number Publication date
EP0666857A1 (fr) 1995-08-16
RU2118958C1 (ru) 1998-09-20
ZA938012B (en) 1994-06-09
HU9501235D0 (en) 1995-06-28
CA2148103A1 (fr) 1994-05-11
NO951587L (no) 1995-04-26
WO1994010169A1 (fr) 1994-05-11
PL308638A1 (en) 1995-08-21
EP0666857B1 (fr) 1999-05-19
JPH08502507A (ja) 1996-03-19
FR2697522B1 (fr) 1994-11-25
KR950704307A (ko) 1995-11-17
DK0666857T3 (da) 1999-11-08
NO981813L (no) 1995-04-26
CZ109295A3 (en) 1995-10-18
NO951587D0 (no) 1995-04-26
NZ257578A (en) 1996-06-25
NO306062B1 (no) 1999-09-13
TW427988B (en) 2001-04-01
HUT73780A (en) 1996-09-30
DE69325031D1 (de) 1999-06-24
KR100255460B1 (ko) 2000-05-01
US20030013889A1 (en) 2003-01-16
CZ287805B6 (en) 2001-02-14
ATE180258T1 (de) 1999-06-15
US6433180B1 (en) 2002-08-13
RU2188198C2 (ru) 2002-08-27
NO304114B1 (no) 1998-10-26
SK55795A3 (en) 1995-10-11
FI952059A (fi) 1995-04-28
CA2148103C (fr) 2002-11-26
PL177746B1 (pl) 2000-01-31
FR2697522A1 (fr) 1994-05-06
US5686623A (en) 1997-11-11
FI109798B (fi) 2002-10-15
NO981813D0 (no) 1998-04-22
AU5423794A (en) 1994-05-24
FI952059A0 (fi) 1995-04-28
MX9306606A (es) 1994-04-29
DE69325031T2 (de) 1999-10-07
SK281045B6 (sk) 2000-11-07
JP3030088B2 (ja) 2000-04-10
AU679947B2 (en) 1997-07-17
GR3030268T3 (en) 1999-08-31
ES2133418T3 (es) 1999-09-16

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Effective date: 20031029