DE69333064D1 - Taxol derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Taxol derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE69333064D1 DE69333064D1 DE69333064T DE69333064T DE69333064D1 DE 69333064 D1 DE69333064 D1 DE 69333064D1 DE 69333064 T DE69333064 T DE 69333064T DE 69333064 T DE69333064 T DE 69333064T DE 69333064 D1 DE69333064 D1 DE 69333064D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- radical
- pharmaceutical compositions
- compositions containing
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9214813A FR2698871B1 (fr) | 1992-12-09 | 1992-12-09 | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR9214813 | 1992-12-09 | ||
PCT/FR1993/001201 WO1994013654A1 (fr) | 1992-12-09 | 1993-12-07 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69333064D1 true DE69333064D1 (de) | 2003-07-31 |
DE69333064T2 DE69333064T2 (de) | 2004-08-19 |
Family
ID=9436375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69333064T Expired - Lifetime DE69333064T2 (de) | 1992-12-09 | 1993-12-07 | Taxol derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (30)
Country | Link |
---|---|
US (9) | US7074821B1 (de) |
EP (1) | EP0673372B1 (de) |
JP (2) | JP2785248B2 (de) |
KR (1) | KR100346328B1 (de) |
CN (1) | CN1055467C (de) |
AT (1) | ATE243688T1 (de) |
AU (2) | AU685415B2 (de) |
BG (1) | BG61726B1 (de) |
BR (1) | BR9307613A (de) |
CA (1) | CA2150944C (de) |
CZ (1) | CZ289851B6 (de) |
DE (1) | DE69333064T2 (de) |
DK (1) | DK0673372T3 (de) |
ES (1) | ES2202319T3 (de) |
FI (1) | FI110941B (de) |
FR (1) | FR2698871B1 (de) |
HU (1) | HU227872B1 (de) |
MX (1) | MX9307748A (de) |
NO (1) | NO310555B1 (de) |
NZ (1) | NZ258592A (de) |
OA (1) | OA10166A (de) |
PL (3) | PL175539B1 (de) |
PT (1) | PT673372E (de) |
RO (1) | RO112281B1 (de) |
RU (1) | RU2139864C1 (de) |
SG (1) | SG67338A1 (de) |
SK (1) | SK282139B6 (de) |
TW (1) | TW408120B (de) |
UA (1) | UA51612C2 (de) |
WO (1) | WO1994013654A1 (de) |
Families Citing this family (66)
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FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
FR2698361B1 (fr) * | 1992-11-20 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5. |
US5814658A (en) * | 1992-12-09 | 1998-09-29 | Rhone-Poulenc Rorer S.A. | Taxoids, their preparation and pharmaceutical compositions containing them |
FR2698871B1 (fr) | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
IL107950A (en) | 1992-12-15 | 2001-04-30 | Upjohn Co | b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them |
US5973160A (en) * | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
ES2145829T3 (es) * | 1993-06-11 | 2000-07-16 | Upjohn Co | Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen. |
FR2706457B1 (fr) * | 1993-06-16 | 1995-07-28 | Rhone Poulenc Rorer Sa | Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs. |
FR2712288B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
IL127599A (en) * | 1994-01-28 | 2004-06-01 | Upjohn Co | Process for preparing isotaxol analogs |
FR2721023B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux Taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2721024B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2726272B1 (fr) * | 1994-10-26 | 1996-12-06 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
CA2170661A1 (en) | 1995-03-22 | 1996-09-23 | John K. Thottathil | Novel methods for the preparation of taxanes using oaxzolidine intermediates |
FR2732342B1 (fr) * | 1995-04-03 | 1997-04-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2732968B1 (fr) * | 1995-04-14 | 1997-05-16 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2742438B1 (fr) * | 1995-12-14 | 1998-01-16 | Rhone Poulenc Rorer Sa | Dihydrate du (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy- 3-phenylpropionate de 4,10beta-diacetoxy-2alpha-benzoyloxy- 5beta,2o-epoxy-1-hydroxy-9-oxo-19-nor-cyclopropa(g)tax-11- ene-13alpha-yle, et son procede de preparation |
FR2742357B1 (fr) * | 1995-12-19 | 1998-01-09 | Rhone Poulenc Rorer Sa | Nanoparticules stabilisees et filtrables dans des conditions steriles |
FR2742753B1 (fr) * | 1995-12-22 | 1998-01-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
DK0914116T3 (da) * | 1996-05-22 | 2000-11-20 | Protarga Inc | Kompositstoffer omfattende konjugater af cis-docosahexaensyre og Taxotere |
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DK0914102T3 (da) | 1996-05-24 | 2006-01-09 | Angiotech Pharm Inc | Præparater og fremgangsmåder til behandling eller forebyggelse af syddomme i legemskanaler |
FR2750989B1 (fr) * | 1996-07-09 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de monoacylation d'hydroxy taxanes |
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US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
AU739303B2 (en) | 1997-08-21 | 2001-10-11 | Florida State University | Method for the synthesis of taxanes |
US6831057B2 (en) * | 1997-10-28 | 2004-12-14 | The University Of North Carolina At Chapel Hill | Use of NF-κB inhibition in combination therapy for cancer |
US6150537A (en) * | 1997-12-12 | 2000-11-21 | Emory University | Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents |
EP1068192B1 (de) * | 1998-01-14 | 2002-06-12 | Bristol-Myers Squibb Company | Neue kristallkomplexe von baccatin iii mit imidazol, 2-methylimidazol or isopropanol |
US6156789A (en) * | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
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US7235583B1 (en) | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
CA2365776A1 (en) * | 1999-05-03 | 2000-11-09 | Alain Renard | Method for treating abnormal cell proliferation in the brain |
FR2794771B1 (fr) * | 1999-06-11 | 2001-08-10 | Aventis Pharma Sa | Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis) |
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DE60131537T2 (de) | 2000-06-22 | 2008-10-23 | Nitromed, Inc., Lexington | Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung |
EP1318794A2 (de) * | 2000-09-22 | 2003-06-18 | Bristol-Myers Squibb Company | Methode zur reduktion der toxizität von kombinationschemotherapien |
EP1562927B1 (de) * | 2002-10-09 | 2009-05-13 | Chatham Biotec Ltd. | Thio-analoga von paclitaxel und deren vorprodukte |
US7787855B2 (en) * | 2003-03-31 | 2010-08-31 | Motorola, Inc. | Establishing emergency sessions in packet data networks for wireless devices having invalid subscriber identities |
US6956124B2 (en) | 2003-04-14 | 2005-10-18 | Aventis Pharma S.A. | Process for the preparation of 4,10β-diacetoxy-2α-benzoyloxy-5β,20-epoxy-1,13α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
CA2865410C (en) * | 2005-11-18 | 2022-04-26 | Mark Gelfand | System and method to modulate phrenic nerve to prevent sleep apnea |
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CN100588643C (zh) * | 2006-11-02 | 2010-02-10 | 南京航空航天大学 | 一种含有二取代金刚烷基的维甲酸类化合物制备方法 |
US20090076127A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched larotaxel |
CN101863861A (zh) * | 2009-04-16 | 2010-10-20 | 山东靶点药物研究有限公司 | 一种简便高效地制备紫杉醇类似物Larotaxel的方法 |
DK2493466T3 (da) | 2009-10-29 | 2021-04-26 | Sanofi Mature Ip | Hidtil ukendt antitumoral anvendelse af cabazitaxel |
CA2798180A1 (en) | 2010-05-03 | 2011-11-10 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
PT2753355T (pt) | 2011-09-08 | 2019-02-01 | Univ New York | Vírus herpes simplex oncolítico e suas utilizações terapêuticas |
US9745631B2 (en) | 2011-12-20 | 2017-08-29 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
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FR2718963B1 (fr) | 1994-04-25 | 1996-05-24 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmaceutique à base de taxoïdes. |
DE69504843T2 (de) | 1994-06-28 | 1999-02-11 | Pharmacia & Upjohn Co., Kalamazoo, Mich. | 7-äther-taxol ähnliche verbindungen antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen |
FR2721928A1 (fr) | 1994-07-04 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
US6201140B1 (en) | 1994-07-28 | 2001-03-13 | Bristol-Myers Squibb Company | 7-0-ethers of taxane derivatives |
FR2726272B1 (fr) | 1994-10-26 | 1996-12-06 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5635531A (en) | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
US6156789A (en) | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
EP0982028A1 (de) | 1998-08-20 | 2000-03-01 | Aventis Pharma S.A. | Neue Verwendung von Taxoidverbindungen |
-
1992
- 1992-12-09 FR FR9214813A patent/FR2698871B1/fr not_active Expired - Lifetime
-
1993
- 1993-07-12 UA UA95062617A patent/UA51612C2/uk unknown
- 1993-12-07 PL PL93324756A patent/PL175539B1/pl unknown
- 1993-12-07 EP EP94901993A patent/EP0673372B1/de not_active Expired - Lifetime
- 1993-12-07 DK DK94901993T patent/DK0673372T3/da active
- 1993-12-07 KR KR1019950702380A patent/KR100346328B1/ko not_active IP Right Cessation
- 1993-12-07 RU RU95114534A patent/RU2139864C1/ru not_active IP Right Cessation
- 1993-12-07 RO RO95-01107A patent/RO112281B1/ro unknown
- 1993-12-07 ES ES94901993T patent/ES2202319T3/es not_active Expired - Lifetime
- 1993-12-07 PL PL93309293A patent/PL174830B1/pl unknown
- 1993-12-07 CA CA002150944A patent/CA2150944C/fr not_active Expired - Fee Related
- 1993-12-07 SG SG1996007594A patent/SG67338A1/en unknown
- 1993-12-07 BR BR9307613A patent/BR9307613A/pt not_active Application Discontinuation
- 1993-12-07 AU AU56531/94A patent/AU685415B2/en not_active Expired
- 1993-12-07 SK SK752-95A patent/SK282139B6/sk not_active IP Right Cessation
- 1993-12-07 WO PCT/FR1993/001201 patent/WO1994013654A1/fr active IP Right Grant
- 1993-12-07 DE DE69333064T patent/DE69333064T2/de not_active Expired - Lifetime
- 1993-12-07 CZ CZ19951455A patent/CZ289851B6/cs not_active IP Right Cessation
- 1993-12-07 HU HU9501662A patent/HU227872B1/hu not_active IP Right Cessation
- 1993-12-07 JP JP6513859A patent/JP2785248B2/ja not_active Expired - Fee Related
- 1993-12-07 PL PL93324755A patent/PL175111B1/pl unknown
- 1993-12-07 PT PT94901993T patent/PT673372E/pt unknown
- 1993-12-07 AT AT94901993T patent/ATE243688T1/de active
- 1993-12-07 NZ NZ258592A patent/NZ258592A/en not_active IP Right Cessation
- 1993-12-08 TW TW082110390A patent/TW408120B/zh not_active IP Right Cessation
- 1993-12-08 MX MX9307748A patent/MX9307748A/es unknown
- 1993-12-08 US US08/162,984 patent/US7074821B1/en not_active Expired - Fee Related
- 1993-12-09 CN CN93121690A patent/CN1055467C/zh not_active Expired - Fee Related
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1995
- 1995-06-07 US US08/474,417 patent/US5571917A/en not_active Expired - Lifetime
- 1995-06-07 US US08/479,199 patent/US5580998A/en not_active Expired - Lifetime
- 1995-06-07 US US08/487,232 patent/US5587493A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,551 patent/US5576450A/en not_active Expired - Fee Related
- 1995-06-07 US US08/483,697 patent/US5599942A/en not_active Expired - Lifetime
- 1995-06-07 US US08/479,198 patent/US5580997A/en not_active Expired - Fee Related
- 1995-06-07 US US08/483,693 patent/US5550261A/en not_active Expired - Lifetime
- 1995-06-07 US US08/475,621 patent/US5532388A/en not_active Expired - Fee Related
- 1995-06-08 NO NO19952264A patent/NO310555B1/no not_active IP Right Cessation
- 1995-06-08 FI FI952825A patent/FI110941B/fi not_active IP Right Cessation
- 1995-06-09 OA OA60675A patent/OA10166A/fr unknown
- 1995-06-09 BG BG99713A patent/BG61726B1/bg unknown
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1997
- 1997-10-16 AU AU41870/97A patent/AU704663B2/en not_active Expired
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1998
- 1998-02-19 JP JP10052669A patent/JPH10291930A/ja active Pending
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