RU95110932A - 2-аминоалкил-5-аминоалкиламино замещенные изохиноиндазол-6-(2н)-оны, способ их получения, фармкомпозиция и способ лечения опухоли - Google Patents

2-аминоалкил-5-аминоалкиламино замещенные изохиноиндазол-6-(2н)-оны, способ их получения, фармкомпозиция и способ лечения опухоли

Info

Publication number
RU95110932A
RU95110932A RU95110932/04A RU95110932A RU95110932A RU 95110932 A RU95110932 A RU 95110932A RU 95110932/04 A RU95110932/04 A RU 95110932/04A RU 95110932 A RU95110932 A RU 95110932A RU 95110932 A RU95110932 A RU 95110932A
Authority
RU
Russia
Prior art keywords
calkyl
group
hydrogen
substituted
phenylalkyl
Prior art date
Application number
RU95110932/04A
Other languages
English (en)
Other versions
RU2130937C1 (ru
Inventor
Крапчо А.Пол
Us]
Мента Эрнесто
Олива Амброджио
It]
Спинелли Сильвано
Original Assignee
Дзе Юниверсити оф Вермонт (US)
Дзе Юниверсити оф Вермонт
Берингер Маннгейм Италиа С.п.А. (IT)
Берингер Маннгейм Италиа С.п.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/103,641 external-priority patent/US5519029A/en
Application filed by Дзе Юниверсити оф Вермонт (US), Дзе Юниверсити оф Вермонт, Берингер Маннгейм Италиа С.п.А. (IT), Берингер Маннгейм Италиа С.п.А. filed Critical Дзе Юниверсити оф Вермонт (US)
Publication of RU95110932A publication Critical patent/RU95110932A/ru
Application granted granted Critical
Publication of RU2130937C1 publication Critical patent/RU2130937C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Соединения общей формулы, данной в описании, в виде свободных оснований и их солей с фармацевтически приемлемыми кислотами. Эти соединения показывают антиопухолевую активность.

Claims (1)

  1. Соединения общей формулы, данной в описании, в виде свободных оснований и их солей с фармацевтически приемлемыми кислотами. Эти соединения показывают антиопухолевую активность.
RU95110932A 1992-09-08 1993-09-08 2-аминоалкил-5-аминоалкиламинозамещенные изохиноиндазол-6-(2н)-оны, способ их получения, фармацевтическая композиция и способ лечения опухоли RU2130937C1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US94160792A 1992-09-08 1992-09-08
US07/941607 1992-09-08
US07/941,607 1992-09-08
US08/103,641 1993-08-11
US08/103641 1993-08-11
US08/103,641 US5519029A (en) 1992-09-08 1993-08-11 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
PCT/US1993/008241 WO1994006795A1 (en) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity

Publications (2)

Publication Number Publication Date
RU95110932A true RU95110932A (ru) 1996-12-27
RU2130937C1 RU2130937C1 (ru) 1999-05-27

Family

ID=26800681

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110932A RU2130937C1 (ru) 1992-09-08 1993-09-08 2-аминоалкил-5-аминоалкиламинозамещенные изохиноиндазол-6-(2н)-оны, способ их получения, фармацевтическая композиция и способ лечения опухоли

Country Status (17)

Country Link
EP (1) EP0662076B1 (ru)
JP (1) JP3497168B2 (ru)
CN (1) CN1051549C (ru)
AT (1) ATE200491T1 (ru)
AU (1) AU680431B2 (ru)
CZ (1) CZ288366B6 (ru)
DE (1) DE69330131T2 (ru)
DK (1) DK0662076T3 (ru)
ES (1) ES2155452T3 (ru)
FI (1) FI109538B (ru)
GR (1) GR3036175T3 (ru)
HU (1) HU220616B1 (ru)
NO (1) NO302618B1 (ru)
PT (1) PT662076E (ru)
RU (1) RU2130937C1 (ru)
SG (1) SG52494A1 (ru)
WO (1) WO1994006795A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
AU713107B2 (en) * 1995-07-06 1999-11-25 University Of Vermont, The New pyrido-thiopyranoindazoles with antitumor activity
IT1277576B1 (it) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
IT1286509B1 (it) * 1996-11-29 1998-07-15 Boehringer Mannheim Italia Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69211A (en) * 1982-07-23 1987-01-30 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0662076B1 (en) 2001-04-11
HUT70145A (en) 1995-09-28
PT662076E (pt) 2001-09-28
WO1994006795A1 (en) 1994-03-31
DE69330131T2 (de) 2001-08-30
SG52494A1 (en) 1998-09-28
CN1101046A (zh) 1995-04-05
EP0662076A1 (en) 1995-07-12
DK0662076T3 (da) 2001-05-07
FI109538B (fi) 2002-08-30
JPH08503933A (ja) 1996-04-30
AU4844193A (en) 1994-04-12
CN1051549C (zh) 2000-04-19
NO950877D0 (no) 1995-03-07
ATE200491T1 (de) 2001-04-15
GR3036175T3 (en) 2001-10-31
FI951023A (fi) 1995-03-31
AU680431B2 (en) 1997-07-31
JP3497168B2 (ja) 2004-02-16
ES2155452T3 (es) 2001-05-16
NO950877L (no) 1995-05-08
FI951023A0 (fi) 1995-03-06
HU9500676D0 (en) 1995-04-28
NO302618B1 (no) 1998-03-30
HU220616B1 (hu) 2002-03-28
CZ59895A3 (en) 1995-11-15
RU2130937C1 (ru) 1999-05-27
DE69330131D1 (de) 2001-05-17
CZ288366B6 (en) 2001-06-13

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20100909