DE69330131D1 - 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung - Google Patents

2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung

Info

Publication number
DE69330131D1
DE69330131D1 DE69330131T DE69330131T DE69330131D1 DE 69330131 D1 DE69330131 D1 DE 69330131D1 DE 69330131 T DE69330131 T DE 69330131T DE 69330131 T DE69330131 T DE 69330131T DE 69330131 D1 DE69330131 D1 DE 69330131D1
Authority
DE
Germany
Prior art keywords
alkyl
group
phenylalkyl
hydrogen
nr2r3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69330131T
Other languages
English (en)
Other versions
DE69330131T2 (de
Inventor
Paul Krapcho
Ernesto Menta
Ambrogio Oliva
Silvano Spinelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novuspharma SpA
University of Vermont
Original Assignee
Novuspharma SpA
University of Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/103,641 external-priority patent/US5519029A/en
Application filed by Novuspharma SpA, University of Vermont filed Critical Novuspharma SpA
Application granted granted Critical
Publication of DE69330131D1 publication Critical patent/DE69330131D1/de
Publication of DE69330131T2 publication Critical patent/DE69330131T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE69330131T 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung Expired - Lifetime DE69330131T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94160792A 1992-09-08 1992-09-08
US08/103,641 US5519029A (en) 1992-09-08 1993-08-11 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
PCT/US1993/008241 WO1994006795A1 (en) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity

Publications (2)

Publication Number Publication Date
DE69330131D1 true DE69330131D1 (de) 2001-05-17
DE69330131T2 DE69330131T2 (de) 2001-08-30

Family

ID=26800681

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330131T Expired - Lifetime DE69330131T2 (de) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung

Country Status (17)

Country Link
EP (1) EP0662076B1 (de)
JP (1) JP3497168B2 (de)
CN (1) CN1051549C (de)
AT (1) ATE200491T1 (de)
AU (1) AU680431B2 (de)
CZ (1) CZ288366B6 (de)
DE (1) DE69330131T2 (de)
DK (1) DK0662076T3 (de)
ES (1) ES2155452T3 (de)
FI (1) FI109538B (de)
GR (1) GR3036175T3 (de)
HU (1) HU220616B1 (de)
NO (1) NO302618B1 (de)
PT (1) PT662076E (de)
RU (1) RU2130937C1 (de)
SG (1) SG52494A1 (de)
WO (1) WO1994006795A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
AU713107B2 (en) * 1995-07-06 1999-11-25 University Of Vermont, The New pyrido-thiopyranoindazoles with antitumor activity
IT1277576B1 (it) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
IT1286509B1 (it) * 1996-11-29 1998-07-15 Boehringer Mannheim Italia Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56782B1 (en) * 1982-07-23 1991-12-18 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones

Also Published As

Publication number Publication date
WO1994006795A1 (en) 1994-03-31
CN1101046A (zh) 1995-04-05
NO302618B1 (no) 1998-03-30
FI109538B (fi) 2002-08-30
JP3497168B2 (ja) 2004-02-16
AU680431B2 (en) 1997-07-31
DE69330131T2 (de) 2001-08-30
CZ59895A3 (en) 1995-11-15
DK0662076T3 (da) 2001-05-07
EP0662076A1 (de) 1995-07-12
ES2155452T3 (es) 2001-05-16
NO950877L (no) 1995-05-08
RU95110932A (ru) 1996-12-27
HU220616B1 (hu) 2002-03-28
ATE200491T1 (de) 2001-04-15
RU2130937C1 (ru) 1999-05-27
CZ288366B6 (en) 2001-06-13
FI951023A0 (fi) 1995-03-06
CN1051549C (zh) 2000-04-19
HUT70145A (en) 1995-09-28
EP0662076B1 (de) 2001-04-11
PT662076E (pt) 2001-09-28
AU4844193A (en) 1994-04-12
HU9500676D0 (en) 1995-04-28
GR3036175T3 (en) 2001-10-31
FI951023A (fi) 1995-03-31
JPH08503933A (ja) 1996-04-30
NO950877D0 (no) 1995-03-07
SG52494A1 (en) 1998-09-28

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Legal Events

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