IT1277576B1 - 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale - Google Patents

2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale

Info

Publication number
IT1277576B1
IT1277576B1 IT95MI001904A ITMI951904A IT1277576B1 IT 1277576 B1 IT1277576 B1 IT 1277576B1 IT 95MI001904 A IT95MI001904 A IT 95MI001904A IT MI951904 A ITMI951904 A IT MI951904A IT 1277576 B1 IT1277576 B1 IT 1277576B1
Authority
IT
Italy
Prior art keywords
amino
ethyl
isochinolin
hydroxyethyl
tumor agent
Prior art date
Application number
IT95MI001904A
Other languages
English (en)
Inventor
Ernesto Menta
Ambrogio Oliva
Silvano Spinelli
Paul Krapcho
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of ITMI951904A0 publication Critical patent/ITMI951904A0/it
Priority to IT95MI001904A priority Critical patent/IT1277576B1/it
Priority to HU9901348A priority patent/HUP9901348A3/hu
Priority to KR1019980701865A priority patent/KR19990044614A/ko
Priority to US09/029,742 priority patent/US6034092A/en
Priority to CZ1998750A priority patent/CZ286654B6/cs
Priority to IL12361996A priority patent/IL123619A0/xx
Priority to JP9511638A priority patent/JPH11512409A/ja
Priority to CN96196912A priority patent/CN1196055A/zh
Priority to EP96931049A priority patent/EP0876369A1/en
Priority to AU69882/96A priority patent/AU6988296A/en
Priority to BR9610601-8A priority patent/BR9610601A/pt
Priority to PCT/EP1996/003935 priority patent/WO1997010245A1/en
Priority to ZA967706A priority patent/ZA967706B/xx
Priority to ARP960104329A priority patent/AR003997A1/es
Publication of ITMI951904A1 publication Critical patent/ITMI951904A1/it
Application granted granted Critical
Publication of IT1277576B1 publication Critical patent/IT1277576B1/it
Priority to NO981093A priority patent/NO981093L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT95MI001904A 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale IT1277576B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
EP96931049A EP0876369A1 (en) 1995-09-13 1996-09-09 2- 2- (2-HYDROXYETHYL)AMINO]ETHYL]-5- 2-METHYLAMINO)ETHYL]AMINO]INDAZOLO 4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT
BR9610601-8A BR9610601A (pt) 1995-09-13 1996-09-09 2-[2-[(2-hidroxietil)amino]etil]-5-[[2-metilamino)-etil]ami no]-indazol[4,3-gh]isoquinolin-6(2h)-ona como agente antitumoral.
US09/029,742 US6034092A (en) 1995-09-13 1996-09-09 2-[2-[(2-hydroxyethyl)amino]ethy [l]-5-[[2-methylamino)ethyl]amino]indazolo4,3-gh]isoquinolin-6(2H)-one as antitumor agent
CZ1998750A CZ286654B6 (cs) 1995-09-13 1996-09-09 2-/2-/(2-hydroxyethyl) amino/ethyl/-5-//(2-methylamino)ethyl/amino/indazol/4,3-gh/isochinolin-6(2H) on, způsob jeho výroby a farmaceutický prostředek s jeho obsahem
IL12361996A IL123619A0 (en) 1995-09-13 1996-09-09 2-[2- [(2-Hydroxyehtyl) amino] ethyl]-5- [[2-Methylamino) ethyl] amino] indazolo [4,3-gh] isoquinolin-6 (2H)-one as antitumor agent
JP9511638A JPH11512409A (ja) 1995-09-13 1996-09-09 抗腫瘍剤・２−［２−［２−（ヒドロキシエチル）アミノ］エチル］−５−［［２−メチルアミノ）−エチル］アミノ］インダゾロ［４，３−ｇｈ］イソキノリン−６（２Ｈ）−オン
CN96196912A CN1196055A (zh) 1995-09-13 1996-09-09 作为抗肿瘤剂的2－[[(2－羟乙基)氨基]乙基]－5－[[(2－甲基氨基)乙基]氨基]吲唑并[4,3－gh]异喹啉－6(2H)－酮
HU9901348A HUP9901348A3 (en) 1995-09-13 1996-09-09 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as antitumor agent, use and production thereof, intermediates and medicaments containing the same
AU69882/96A AU6988296A (en) 1995-09-13 1996-09-09 2-{2-{(2-hydroxyethyl)amino}ethyl}-5-{{2-methylamino)ethyl}a mino}indazolo{4,3-gh}isoquinolin-6(2h)-one as antitumor agent
KR1019980701865A KR19990044614A (ko) 1995-09-13 1996-09-09 항암제로서의 2-[2-[(2-하이드록시에틸)아미노]에틸]-5-[(2-메틸아미노)에틸]아미노]인다졸로[4,3-ｇｈ]이소퀴놀린-6(2Ｈ)-온
PCT/EP1996/003935 WO1997010245A1 (en) 1995-09-13 1996-09-09 2-[2-[(2-HYDROXYETHYL)AMINO]ETHYL]-5-[[2-METHYLAMINO)ETHYL]AMINO]INDAZOLO[4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT
ZA967706A ZA967706B (en) 1995-09-13 1996-09-12 2-[2-[/2-hydroxethyl)amino]ethyl]-5-[[2-methylamino)-ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as anti-tumor agent
ARP960104329A AR003997A1 (es) 1995-09-13 1996-09-12 2-[2-[(2-hidroxietil)amino]etil]-5-[[2-(metilamino)-etil]amino]indazol[4,3- gh]isoquinolin-6(2h)-ona, procesos para la preparacion del mismo y delintermediario y composiciones farmaceuticas que contienen el compuesto principal.
NO981093A NO981093L (no) 1995-09-13 1998-03-12 2-£2£(2-hydroksyetyl)amino|etyl|-5-££2-metylamino)etyl|amino|-indazolo£4,3-gh|isokinolin-6(2H)-on som antitumor middel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale

Publications (3)

Publication Number Publication Date
ITMI951904A0 ITMI951904A0 (it) 1995-09-13
ITMI951904A1 ITMI951904A1 (it) 1997-03-13
IT1277576B1 true IT1277576B1 (it) 1997-11-11

Family

ID=11372237

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale

Country Status (15)

Country Link
US (1) US6034092A (it)
EP (1) EP0876369A1 (it)
JP (1) JPH11512409A (it)
KR (1) KR19990044614A (it)
CN (1) CN1196055A (it)
AR (1) AR003997A1 (it)
AU (1) AU6988296A (it)
BR (1) BR9610601A (it)
CZ (1) CZ286654B6 (it)
HU (1) HUP9901348A3 (it)
IL (1) IL123619A0 (it)
IT (1) IT1277576B1 (it)
NO (1) NO981093L (it)
WO (1) WO1997010245A1 (it)
ZA (1) ZA967706B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747039B2 (en) * 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
JP2008528616A (ja) * 2005-01-28 2008-07-31 ザンサス ファーマシューティカルズ， インコーポレイテッド 炎症性疾患および脱髄性疾患を処置するための化合物
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56782B1 (en) * 1982-07-23 1991-12-18 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones
DK0662076T3 (da) * 1992-09-08 2001-05-07 Univ Vermont 2-aminoalkyl-5-aminoalkylamino-substituerede isoquinoindazol-6(2H)-oner med antitumorvikning
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles

Also Published As

Publication number Publication date
CZ286654B6 (cs) 2000-05-17
ITMI951904A1 (it) 1997-03-13
CZ75098A3 (cs) 1998-07-15
HUP9901348A2 (hu) 1999-08-30
KR19990044614A (ko) 1999-06-25
BR9610601A (pt) 1999-12-21
EP0876369A1 (en) 1998-11-11
NO981093D0 (no) 1998-03-12
HUP9901348A3 (en) 2000-03-28
ITMI951904A0 (it) 1995-09-13
US6034092A (en) 2000-03-07
ZA967706B (en) 1997-03-25
JPH11512409A (ja) 1999-10-26
AU6988296A (en) 1997-04-01
CN1196055A (zh) 1998-10-14
WO1997010245A1 (en) 1997-03-20
AR003997A1 (es) 1998-09-30
NO981093L (no) 1998-03-12
IL123619A0 (en) 1998-10-30

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