HUP9901348A2 - Tumor elleni hatású 2-[2-[(2-hidroxi-etil)-amino]-etil]-5-[[2-(metil-amino)-etil]-amino]-indazolo[4,3-gh]izokinolin-6(2H)-on-származékok, előállításuk, intermedierek és e vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Tumor elleni hatású 2-[2-[(2-hidroxi-etil)-amino]-etil]-5-[[2-(metil-amino)-etil]-amino]-indazolo[4,3-gh]izokinolin-6(2H)-on-származékok, előállításuk, intermedierek és e vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9901348A2
HUP9901348A2 HU9901348A HUP9901348A HUP9901348A2 HU P9901348 A2 HUP9901348 A2 HU P9901348A2 HU 9901348 A HU9901348 A HU 9901348A HU P9901348 A HUP9901348 A HU P9901348A HU P9901348 A2 HUP9901348 A2 HU P9901348A2
Authority
HU
Hungary
Prior art keywords
ethyl
amino
production
methylamino
hydroxyethyl
Prior art date
Application number
HU9901348A
Other languages
English (en)
Inventor
Paul Krapcho
Ernesto Menta
Ambrogio Oliva
Silvano Spinelli
Original Assignee
Novuspharma S.P.A.
The University Of Vermont And State Agricultural College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novuspharma S.P.A., The University Of Vermont And State Agricultural College filed Critical Novuspharma S.P.A.
Publication of HUP9901348A2 publication Critical patent/HUP9901348A2/hu
Publication of HUP9901348A3 publication Critical patent/HUP9901348A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány 2-[2-[(2-hidrőxi-etil)-aminő]-etil]-5-[[2-(metil-aminő)-etil]-aminő]-indazőlő[4,3-gh]izőkinőlin-6(2H)-őnra és gyógyászatilagelfőgadható savaddíciós sóira vőnatkőzik. Ezek a vegyületek erőstűmőrelleni hatásúak. A találmány tárgya tővábbá eljárás az említettvegyületek, illetve az ezek előállításában hasznősítőtt köztitermékekelőállítására. A találmány ilyen vegyületeket hatóanyagként tartalmazógyógyászati készítményekre is vőnatkőzik. ŕ
HU9901348A 1995-09-13 1996-09-09 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as antitumor agent, use and production thereof, intermediates and medicaments containing the same HUP9901348A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001904A IT1277576B1 (it) 1995-09-13 1995-09-13 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale

Publications (2)

Publication Number Publication Date
HUP9901348A2 true HUP9901348A2 (hu) 1999-08-30
HUP9901348A3 HUP9901348A3 (en) 2000-03-28

Family

ID=11372237

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901348A HUP9901348A3 (en) 1995-09-13 1996-09-09 2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-methylamino)ethyl]amino]indazolo[4,3-gh]isoquinolin-6(2h)-one as antitumor agent, use and production thereof, intermediates and medicaments containing the same

Country Status (15)

Country Link
US (1) US6034092A (hu)
EP (1) EP0876369A1 (hu)
JP (1) JPH11512409A (hu)
KR (1) KR19990044614A (hu)
CN (1) CN1196055A (hu)
AR (1) AR003997A1 (hu)
AU (1) AU6988296A (hu)
BR (1) BR9610601A (hu)
CZ (1) CZ286654B6 (hu)
HU (1) HUP9901348A3 (hu)
IL (1) IL123619A0 (hu)
IT (1) IT1277576B1 (hu)
NO (1) NO981093L (hu)
WO (1) WO1997010245A1 (hu)
ZA (1) ZA967706B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747039B2 (en) * 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CA2596144A1 (en) * 2005-01-28 2006-08-03 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory and demyelinating diseases
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69211A (en) * 1982-07-23 1987-01-30 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them
EP0662076B1 (en) * 1992-09-08 2001-04-11 The University Of Vermont 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity
US5519029A (en) * 1992-09-08 1996-05-21 Boehringer Mannheim Italia, S.P.A. 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles

Also Published As

Publication number Publication date
CN1196055A (zh) 1998-10-14
NO981093D0 (no) 1998-03-12
ZA967706B (en) 1997-03-25
WO1997010245A1 (en) 1997-03-20
IL123619A0 (en) 1998-10-30
HUP9901348A3 (en) 2000-03-28
BR9610601A (pt) 1999-12-21
JPH11512409A (ja) 1999-10-26
CZ286654B6 (cs) 2000-05-17
EP0876369A1 (en) 1998-11-11
AU6988296A (en) 1997-04-01
ITMI951904A1 (it) 1997-03-13
IT1277576B1 (it) 1997-11-11
ITMI951904A0 (it) 1995-09-13
CZ75098A3 (cs) 1998-07-15
NO981093L (no) 1998-03-12
AR003997A1 (es) 1998-09-30
US6034092A (en) 2000-03-07
KR19990044614A (ko) 1999-06-25

Similar Documents

Publication Publication Date Title
US4863900A (en) Method for reducing viral transmission with poly-L-histidine
HUP0004383A2 (hu) Hatóanyagként klodronátot és vivőanyagként szilíciumozott mikrokristályos cellulózt tartalmazó gyógyszerészeti készítmény
UA29450C2 (uk) Похідні гідроксамової кислоти, спосіб їх одержання, спосіб впливу на хвороби та фармацевтична або ветеринарна композиція, що їх містить
WO1999001103A3 (fr) Derives de peptides, sels de ces derives acceptables sur le plan pharmaceutique, procede de production de ces derives, utilisation de ces derniers et composition pharmaceutique
NO166448C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner.
CA2192899A1 (en) Composition containing l-carnitine and hydroxycitric acid
CA2216796A1 (en) Quinazoline derivatives
HUP0100815A2 (hu) Neurológiai és neuropszichiátriai rendellenességek kezelésére szolgáló gyógyszerkészítmények
CA2033725A1 (en) Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
ATE122668T1 (de) Diarylsubstituierte heterocyclische verbindung, ihre herstellung und arzneimittel und kosmetika daraus.
CA2098302A1 (en) Medicaments
HUP0002296A2 (hu) Sertralinsók és a sertralin elnyújtott felszabadulását biztosító dózisformák
HUP9901437A2 (hu) Gyógyszerkészítmény, mely amoxicillint és klavulánsavat tartalmaz
EP0382066A3 (de) Verwendung von Dihydroliponsäure als Analgetikum, Antiphlogistikum und/oder Zytoprotektivum
HUP0003571A2 (hu) 6,9-Hídkötésű eritromicin-származékok
DE69525649D1 (de) Lamotrigin haltiges arzneimittel
AU1277792A (en) Compositions for topical administration containing fluticasone propionate and oxiconazole or its salts
HUT70531A (en) Arylmorpholine derivatives, pharmaceutical compositions containing them as active agent and process for preparing them
HUP9802897A2 (hu) Optikailag aktív piridil-4H-1,2,4-oxadiazin-származék, annak alkalmazása vaszkuláris betegségek kezelésére, valamint ilyen származékot hatóanyagként tartalmazó gyógyászati készítmény
HUP9901348A2 (hu) Tumor elleni hatású 2-[2-[(2-hidroxi-etil)-amino]-etil]-5-[[2-(metil-amino)-etil]-amino]-indazolo[4,3-gh]izokinolin-6(2H)-on-származékok, előállításuk, intermedierek és e vegyületeket tartalmazó gyógyszerkészítmények
KR960010003A (ko) L-카르니틴염과 이를 함유한 피부질환 치료용 화장품 조성물 및 약제 조성물
NZ303993A (en) Pharmaceutical compositions containing aminotetralin derivatives for treating cardiac disorders
HUP9701293A2 (hu) Új, kellemetlen íztől mentes sók és ezeket tartalmazó gyógyszerkészítmények
TR199900013T2 (xx) Yeni bile�ikler.
DE69512419D1 (de) IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-2-CARBONSÄURE DERIVATE, IHRE HERSTELLUNG UND SIE ENTHALTENDE ARZNEIMITTEL